Published in Proc Natl Acad Sci U S A on June 15, 1993
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A (1994) 6.46
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J (1996) 4.11
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest (2000) 2.12
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest (1995) 1.74
Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci U S A (1996) 1.51
PPARs and the cardiovascular system. Antioxid Redox Signal (2009) 1.28
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem J (1995) 1.22
Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α. Cell Rep (2013) 1.19
Integrated physiology and systems biology of PPARα. Mol Metab (2014) 1.12
Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins. Biochem J (2004) 1.09
Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One (2010) 1.07
The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites. EMBO J (2010) 1.03
A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha. EMBO J (1998) 0.99
Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism. J Hepatol (2011) 0.97
Crosstalk of oncogenic and prostanoid signaling pathways. J Cancer Res Clin Oncol (2004) 0.92
Expression of a peroxisome proliferator-activated receptor gene (xPPARalpha) from Xenopus laevis in tobacco (Nicotiana tabacum) plants. Planta (2006) 0.87
β-catenin directly sequesters adipocytic and insulin sensitizing activities but not osteoblastic activity of PPARγ2 in marrow mesenchymal stem cells. PLoS One (2012) 0.86
Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids. J Lipid Res (2012) 0.83
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. Nucleic Acids Res (2004) 0.81
Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. J Lipid Res (2014) 0.80
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts. BMC Pharmacol (2004) 0.80
Regulation of hepatic level of fatty-acid-binding protein by hormones and clofibric acid in the rat. Biochem J (1994) 0.79
Regulation of IGFBP-2 expression during fasting. Biochem J (2015) 0.79
PPARα signaling in the hippocampus: crosstalk between fat and memory. J Neuroimmune Pharmacol (2015) 0.79
Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines. PLoS One (2014) 0.78
The regulation of catalase activity by PPAR γ is affected by α-synuclein. Ann Clin Transl Neurol (2014) 0.77
8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice. J Lipids (2016) 0.75
Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats. J Clin Biochem Nutr (2012) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res (1991) 13.54
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (1990) 11.92
Biogenesis of peroxisomes. Annu Rev Cell Biol (1985) 8.12
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res (1988) 7.28
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (1992) 6.69
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell (1992) 5.87
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell (1992) 4.95
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci U S A (1992) 4.38
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene. EMBO J (1992) 3.92
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell (1991) 3.87
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci U S A (1992) 2.85
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc Natl Acad Sci U S A (1986) 2.57
Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol (1992) 2.09
Multiple cell type-specific proteins differentially regulate target sequence recognition by the alpha retinoic acid receptor. Cell (1990) 1.75
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc Natl Acad Sci U S A (1992) 1.68
A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements. J Biol Chem (1990) 1.54
Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. Biochem Biophys Res Commun (1991) 1.51
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res (1989) 1.11
An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ Health Perspect (1991) 1.00
Differential induction of peroxisomal and microsomal fatty-acid-oxidising enzymes by peroxisome proliferators in rat liver and kidney. Characterisation of a renal cytochrome P-450 and implications for peroxisome proliferation. Eur J Biochem (1989) 0.94
Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
A conserved tripeptide sorts proteins to peroxisomes. J Cell Biol (1989) 6.59
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science (2001) 5.40
Use of oral corticosteroids and risk of fractures. J Bone Miner Res (2000) 4.75
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature (1989) 4.46
A three-hybrid system to detect RNA-protein interactions in vivo. Proc Natl Acad Sci U S A (1996) 4.44
The minimum amount of homology required for homologous recombination in mammalian cells. Mol Cell Biol (1984) 4.39
A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J (1991) 3.83
Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species. Proc Natl Acad Sci U S A (1989) 3.70
Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants. Mol Cell Biol (1986) 3.68
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron (1999) 3.49
Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J Cell Biol (1987) 3.47
Checkpoint controls in Schizosaccharomyces pombe: rad1. EMBO J (1992) 3.14
Homologous and nonhomologous recombination in monkey cells. Mol Cell Biol (1983) 3.10
Peroxisomal protein import is conserved between yeast, plants, insects and mammals. EMBO J (1990) 2.93
Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair. Nucleic Acids Res (1992) 2.84
Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins. J Cell Biol (1988) 2.77
Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med (1999) 2.74
Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs. J Virol (1994) 2.64
Firefly luciferase is targeted to peroxisomes in mammalian cells. Proc Natl Acad Sci U S A (1987) 2.57
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis (2008) 2.55
Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res (2001) 2.50
Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly. Yeast (1992) 2.31
Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc Natl Acad Sci U S A (1994) 2.26
A unified nomenclature for peroxisome biogenesis factors. J Cell Biol (1996) 2.25
Introduction of liposome-encapsulated SV40 DNA into cells. J Biol Chem (1980) 2.23
Broadband observations of the naked-eye gamma-ray burst GRB 080319B. Nature (2008) 2.16
Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford) (2000) 2.13
Relativistic jet activity from the tidal disruption of a star by a massive black hole. Nature (2011) 2.12
An inducible mammalian amber suppressor: propagation of a poliovirus mutant. Cell (1987) 2.08
Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab (2006) 2.05
Fold and function predictions for Mycoplasma genitalium proteins. Fold Des (1998) 2.02
Import of stably folded proteins into peroxisomes. Mol Biol Cell (1995) 2.01
Molecular cloning and expression of the major protein kinase C substrate of platelets. Nature (1988) 2.00
Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. EMBO J (1996) 1.99
Recombination events after transient infection and stable integration of DNA into mouse cells. Mol Cell Biol (1985) 1.99
Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases. J Eur Acad Dermatol Venereol (2011) 1.99
A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1. Mol Cell Biol (1990) 1.98
Synthesis of a major integral membrane polypeptide of rat liver peroxisomes on free polysomes. Proc Natl Acad Sci U S A (1984) 1.98
Use of oral corticosteroids in the United Kingdom. QJM (2000) 1.95
Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates. J Cell Biol (1998) 1.95
Diffusion tensor imaging and cognitive function in older adults with no dementia. Neurology (2011) 1.89
The life cycle of the peroxisome. Nat Rev Mol Cell Biol (2001) 1.85
GeneKeyDB: a lightweight, gene-centric, relational database to support data mining environments. BMC Bioinformatics (2005) 1.83
Synthesis of rat liver microsomal cytochrome b5 by free ribosomes. J Cell Biol (1980) 1.81
The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc Natl Acad Sci U S A (1992) 1.79
Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes. J Cell Biol (1991) 1.77
Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins. J Cell Biol (1990) 1.76
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J (1998) 1.74
The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results. Pharmacoepidemiol Drug Saf (2000) 1.70
Enlarged peroxisomes are present in oleic acid-grown Yarrowia lipolytica overexpressing the PEX16 gene encoding an intraperoxisomal peripheral membrane peroxin. J Cell Biol (1997) 1.70
The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal. EMBO J (1995) 1.70
The rad21 gene product of Schizosaccharomyces pombe is a nuclear, cell cycle-regulated phosphoprotein. J Biol Chem (1995) 1.70
Do satellites detect trends in surface solar radiation? Science (2005) 1.69
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice. Cancer Res (1994) 1.69
Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene. EMBO J (1985) 1.68
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc Natl Acad Sci U S A (1992) 1.68
Galactose transfer to endogenous acceptors within Golgi fractions of rat liver. J Cell Biol (1982) 1.68
Cloning of cDNA coding for peroxisomal acyl-CoA oxidase from the yeast Candida tropicalis pK233. Proc Natl Acad Sci U S A (1985) 1.67
Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. Mol Cell Biol (1998) 1.66
Scalable templated growth of graphene nanoribbons on SiC. Nat Nanotechnol (2010) 1.66
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Arthritis Rheum (2008) 1.66
The expanding burden of cardiometabolic risk in China: the China Health and Nutrition Survey. Obes Rev (2012) 1.66
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem (1999) 1.65
Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints. Gene (1992) 1.63
Elements in the long terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene. Nucleic Acids Res (1983) 1.63
How proteins penetrate peroxisomes. Cell (1995) 1.63
Analysis of gene expression using simian virus 40 vectors. Anal Biochem (1983) 1.62
An MRI-based parcellation method for the temporal lobe. Neuroimage (2000) 1.62
An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways. Leukemia (2011) 1.61
Introduction of UAG, UAA, and UGA nonsense mutations at a specific site in the Escherichia coli chloramphenicol acetyltransferase gene: use in measurement of amber, ochre, and opal suppression in mammalian cells. Mol Cell Biol (1986) 1.60
Cloning and analysis of a gene involved in DNA repair and recombination, the rad1 gene of Schizosaccharomyces pombe. Mol Cell Biol (1990) 1.60
The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell (2001) 1.58
Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo. J Biol Chem (1994) 1.58
Urinary ovarian and gonadotropin hormone levels in premenopausal women with low bone mass. J Bone Miner Res (1998) 1.57
Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules. J Cell Biol (1997) 1.56
Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. Leukemia (2011) 1.55
Firefly luciferase as a tool in molecular and cell biology. Anal Biochem (1988) 1.55
Cytosol-dependent peroxisomal protein import in a permeabilized cell system. J Cell Biol (1993) 1.55
Control of sigma factor activity during Bacillus subtilis sporulation. Mol Microbiol (1999) 1.54
Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis. Mol Cell Biol (1998) 1.54
Extrachromosomal and chromosomal gene conversion in mammalian cells. Mol Cell Biol (1986) 1.52
The carboxyl-terminal tripeptide Ala-Lys-Ile is essential for targeting Candida tropicalis trifunctional enzyme to yeast peroxisomes. J Biol Chem (1991) 1.50
Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol (1993) 1.50
Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci (1999) 1.49
Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc Natl Acad Sci U S A (1998) 1.49
Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Ann Oncol (2012) 1.49
Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. J Biol Chem (1996) 1.49