Published in Science on March 26, 1993
Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev (2005) 5.69
Subcellular localization of the Vif protein of human immunodeficiency virus type 1. J Virol (1994) 2.35
Inhibition of Ras for cancer treatment: the search continues. Future Med Chem (2011) 2.14
Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. EMBO J (1995) 1.64
A large pheromone and receptor gene complex determines multiple B mating type specificities in Coprinus cinereus. Genetics (1998) 1.58
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function. Microbiol Mol Biol Rev (1998) 1.49
Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation. Microbiol Rev (1995) 1.48
The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein. EMBO J (1999) 1.37
Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains. J Virol (1995) 1.36
Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol Cell Biol (1995) 1.30
Use of a prenylation inhibitor as a novel antiviral agent. J Virol (1998) 1.26
Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Mol Cell Biol (2001) 1.24
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Hum Mutat (2014) 1.21
The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. J Interferon Cytokine Res (2010) 1.21
Primary structure of a photoactive yellow protein from the phototrophic bacterium Ectothiorhodospira halophila, with evidence for the mass and the binding site of the chromophore. Protein Sci (1993) 1.19
A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase. Proc Natl Acad Sci U S A (1995) 1.18
Isoprenylation mediates direct protein-protein interactions between hepatitis large delta antigen and hepatitis B virus surface antigen. J Virol (1993) 1.15
Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. J Mol Biol (2009) 1.13
Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A (1995) 1.09
RIC, a calmodulin-binding Ras-like GTPase. EMBO J (1996) 1.07
Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control. Plant Cell (1996) 1.04
Multifunctional prenylated peptides for live cell analysis. J Am Chem Soc (2009) 1.04
Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry (2009) 1.04
Isoprenylation masks a conformational epitope and enhances trans-dominant inhibitory function of the large hepatitis delta antigen. J Virol (1994) 1.03
Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42. Proc Natl Acad Sci U S A (1994) 1.02
Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations. Biophys J (2007) 1.01
Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma. Mod Pathol (2012) 1.00
Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch. Cell Mol Neurobiol (2006) 0.99
Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation (2010) 0.98
Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. PLoS Comput Biol (2011) 0.93
Localization of a heterotrimeric G protein gamma subunit to focal adhesions and associated stress fibers. J Cell Biol (1994) 0.92
Prenylcysteine alpha-carboxyl methyltransferase in suspension-cultured tobacco cells Plant Physiol (1998) 0.91
Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Proc Natl Acad Sci U S A (1999) 0.91
Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins. J Cell Biol (1997) 0.88
Molecular and biochemical characterization of tomato farnesyl-protein transferase. Plant Physiol (1996) 0.88
Phosphorylation of the hepatitis delta virus antigens. J Virol (1997) 0.87
Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol (1995) 0.86
Unique properties of the large antigen of hepatitis delta virus. J Virol (1999) 0.85
Alendronate (ALN) combined with osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats. J Orthop Surg Res (2011) 0.85
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J (2011) 0.85
Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association. Biophys J (2013) 0.84
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells. Br J Cancer (2000) 0.83
Microarray analysis of retinal gene expression in Egr-1 knockout mice. Mol Vis (2009) 0.83
Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Eukaryot Cell (2006) 0.83
Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments. J Cell Biol (1994) 0.83
Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice. Mol Carcinog (2012) 0.83
Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis. Int J Mol Sci (2012) 0.82
Role of C-terminal domains of the G protein beta subunit in the activation of effectors. Proc Natl Acad Sci U S A (2000) 0.82
Farnesyl analogues inhibit vasoconstriction in animal and human arteries. J Clin Invest (1996) 0.81
Multiple post-translational modifications affect heterologous protein synthesis. J Biol Chem (2012) 0.81
Function of the farnesyl moiety in visual signalling. Biochem J (2000) 0.81
Solid-state NMR characterization of the putative membrane anchor of TWD1 from Arabidopsis thaliana. Eur Biophys J (2006) 0.80
Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. J Biol Chem (2012) 0.79
Interaction of the C-terminal region of the Ggamma protein with model membranes. Biophys J (2007) 0.79
Getting a handle on protein prenylation. Nat Chem Biol (2009) 0.78
Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci U S A (2015) 0.76
The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution. BMC Pharmacol (2002) 0.76
N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes. Arch Dermatol Res (2016) 0.75
Generation of self-clusters of galectin-1 in the farnesyl-bound form. Sci Rep (2016) 0.75
Interaction Between Mevalonate Pathway and Retinoic Acid-Induced Differentiation. J Biomed Biotechnol (2001) 0.75