PubRank

D A Cheresh

Author PubWeight™ 245.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993 13.21
2 Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994 12.83
3 Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994 9.51
4 Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997 7.14
5 Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 1996 6.52
6 Definition of two angiogenic pathways by distinct alpha v integrins. Science 1995 6.00
7 Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999 4.55
8 CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol 1998 4.22
9 Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A 1987 4.17
10 Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med 1998 3.85
11 Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 1995 3.69
12 Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol 1994 3.42
13 Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol 1991 3.00
14 Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 2001 2.99
15 Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest 1992 2.92
16 Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 1998 2.89
17 The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999 2.88
18 Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol 1998 2.87
19 Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A 1996 2.67
20 Integrins and cancer. Curr Opin Cell Biol 1996 2.44
21 An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci 1995 2.38
22 Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol 1993 2.38
23 Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest 1991 2.32
24 Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci U S A 1994 2.30
25 Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery 2001 2.30
26 Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J Biol Chem 1993 2.27
27 Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. J Biol Chem 1990 2.27
28 The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest 1995 2.23
29 Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol 1998 2.20
30 Vitronectin and its receptors. Curr Opin Cell Biol 1993 2.17
31 Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med 2001 2.16
32 Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest 1996 2.10
33 Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol 1994 2.08
34 The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. J Cell Biol 1990 2.07
35 Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem 1999 2.04
36 Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest 1999 2.03
37 Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res 1984 2.01
38 Integrins and angiogenesis. Curr Top Dev Biol 2004 2.00
39 Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res 2000 2.00
40 Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit. J Biol Chem 1987 1.93
41 Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery 2001 1.90
42 Induction of the angiogenic phenotype by Hox D3. J Cell Biol 1997 1.84
43 Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J Cell Biol 1995 1.81
44 Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res 1998 1.80
45 Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci U S A 2001 1.79
46 Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol 1992 1.78
47 Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc Natl Acad Sci U S A 2000 1.76
48 Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol 2001 1.72
49 Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene 2006 1.71
50 Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth. Cancer Res 1987 1.68
51 Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol 1996 1.67
52 Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res 1999 1.66
53 The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. J Biol Chem 1988 1.59
54 Adhesion events in angiogenesis. Curr Opin Cell Biol 2001 1.59
55 Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem 1996 1.55
56 Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest 1997 1.53
57 Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor. J Biol Chem 1990 1.52
58 RGD-dependent linkage between plant cell wall and plasma membrane: consequences for growth. J Cell Biol 1989 1.51
59 Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J Cell Biol 1996 1.50
60 cDNA sequence of the human integrin beta 5 subunit. J Biol Chem 1990 1.49
61 Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J Cell Biol 1996 1.48
62 Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res 1989 1.45
63 Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem 1996 1.42
64 Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins. J Cell Biol 1986 1.42
65 Role of alpha v integrins during angiogenesis. Cancer J 2000 1.41
66 Use of the 10-day-old chick embryo model for studying angiogenesis. Methods Mol Biol 1999 1.40
67 Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells. Proc Natl Acad Sci U S A 1984 1.39
68 O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant. Science 1984 1.38
69 Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. J Biol Chem 1990 1.36
70 A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside. J Biol Chem 1984 1.31
71 Integrins, angiogenesis and vascular cell survival. Chem Biol 1996 1.30
72 Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J Cell Sci 1995 1.29
73 Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood 1991 1.28
74 Cell adhesion and angiogenesis. Trends Cell Biol 1996 1.27
75 A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins. J Cell Biol 1997 1.26
76 Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest 1992 1.26
77 Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol Ther 2001 1.25
78 Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand. J Biol Chem 1991 1.24
79 Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin. Development 1994 1.22
80 Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990 1.21
81 Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol 1987 1.17
82 Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression. Mol Biol Cell 1995 1.16
83 Human tumor antigens. Adv Immunol 1987 1.14
84 Adenovirus entry into host cells: a role for alpha(v) integrins. Trends Cell Biol 1994 1.12
85 Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. J Biol Chem 1989 1.12
86 Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene 2011 1.11
87 Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol 1996 1.09
88 Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol 1999 1.08
89 Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells. J Cell Biol 1991 1.07
90 Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments. J Biol Chem 1992 1.06
91 Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases. Proc Natl Acad Sci U S A 1999 1.05
92 Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta5. J Virol 2000 1.05
93 The role of alphav integrins during angiogenesis. Mol Med 1998 1.03
94 REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun 1995 1.03
95 Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proc Natl Acad Sci U S A 1985 1.01
96 EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene 2011 1.00
97 Extracellular matrix and integrin composition of the normal bladder wall. World J Urol 1996 0.98
98 Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia. Am J Pathol 1996 0.98
99 Design, synthesis and biological evaluation of nonpeptide integrin antagonists. Bioorg Med Chem 1998 0.97
100 Interaction of an acute phase reactant, alpha 1-acid glycoprotein (orosomucoid), with the lymphoid cell surface: a model for non-specific immune suppression. Immunology 1984 0.96
101 Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). J Am Chem Soc 2001 0.96
102 A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3. J Biol Chem 1994 0.95
103 Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase. J Biol Chem 1999 0.95
104 Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis. Cancer Res 1986 0.94
105 Disialoganglioside GD2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin. J Cell Biol 1986 0.93
106 Regulation of cell migration by the integrin beta subunit ectodomain. J Cell Sci 1996 0.92
107 Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding. J Biol Chem 1991 0.92
108 Characterization of a membrane surface glycoprotein associated with T-cell activation. J Immunol 1985 0.92
109 Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit. Endocrinology 1996 0.90
110 A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries. Proc Natl Acad Sci U S A 1998 0.90
111 Localization of beta 1, beta 3, alpha 5, alpha v, and alpha IIb subunits of the integrin family in spreading human erythroleukemia cells. Blood 1990 0.88
112 Human tumour-associated antigens: targets for monoclonal antibody-mediated cancer therapy. Cancer Surv 1985 0.87
113 Role of alpha V integrins and vitronectin in human melanoma cell growth. Cold Spring Harb Symp Quant Biol 1992 0.87
114 Potentiation of lymphocyte responses by monoclonal antibodies to the ganglioside GD3. Cancer Res 1986 0.86
115 Targeted delivery of mutant Raf kinase to neovessels causes tumor regression. Cold Spring Harb Symp Quant Biol 2002 0.85
116 Death to a blood vessel, death to a tumor. Nat Med 1998 0.83
117 Blood leukocytes bind platelet glycoprotein (IIb-IIIa)' but do not express the vitronectin receptor. Int Immunol 1990 0.83
118 Increased lysis of melanoma by in vivo-elicited human lymphokine-activated killer cells after addition of antiganglioside antibodies in vitro. Cancer Res 1990 0.83
119 A role for angiogenesis in rheumatoid arthritis. Braz J Med Biol Res 1999 0.83
120 Alpha(v)beta3 and alpha(v)beta5 integrin expression in meningiomas. Neurosurgery 2000 0.83
121 beta1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway. Neuroscience 2000 0.81
122 Reduced intimal thickening following alpha(v)beta3 blockade is associated with smooth muscle cell apoptosis. Cell Adhes Commun 1998 0.81
123 Blocked herpes simplex virus type 2-specific DNA synthesis in simian virus 40-transformed hamster cells permissive for herpes simplex virus type 1. Infect Immun 1983 0.80
124 Selective type IV collagen defects in the urothelial basement membrane in interstitial cystitis. J Urol 1995 0.80
125 Mitogen-induced blastogenesis and receptor mobility inhibition by breast cancer serum with elevated orosomucoid (alpha 1-acid glycoprotein) levels. J Natl Cancer Inst 1982 0.79
126 Structural and functional properties of ganglioside antigens on human tumors of neuroectodermal origin. Surv Synth Pathol Res 1985 0.78
127 Anti-glycosphingolipid autoantibodies in rheumatologic disorders. J Clin Lab Anal 1994 0.75
128 Enhancement of cytotoxic and proliferative responses of lymphocytes from melanoma patients by incubation with monoclonal antibodies against ganglioside GD3. Cancer Immunol Immunother 1987 0.75
129 Maximizing differences in the concanavalin A-induced blastogenic responses of lymphocytes from breast cancer patients and controls by the use of alpha-methyl-D-mannoside. J Natl Cancer Inst 1982 0.75
130 Getting unglued about integrins. The Molecular Basis of Cellular Adhesion: A UCLA symposium, sponsored by Genentech and Glaxo Steamboat Springs, CO, USA, January 20-26, 1990. New Biol 1990 0.75
131 A structural basis for bidirectional integrin signalling. Princess Takamatsu Symp 1994 0.75