PubRank

K W Kinzler

Author PubWeight™ 780.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Serial analysis of gene expression. Science 1995 60.15
2 WAF1, a potential mediator of p53 tumor suppression. Cell 1993 38.72
3 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997 24.61
4 A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 1998 24.58
5 Identification of c-MYC as a target of the APC pathway. Science 1998 24.25
6 Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997 22.80
7 Genetic instabilities in human cancers. Nature 1998 22.76
8 Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998 17.91
9 Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992 17.40
10 Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995 13.15
11 Definition of a consensus binding site for p53. Nat Genet 1992 12.76
12 Genetic instability in colorectal cancers. Nature 1997 12.51
13 A model for p53-induced apoptosis. Nature 1997 11.38
14 Characterization of the yeast transcriptome. Cell 1997 11.33
15 Mutations of mitotic checkpoint genes in human cancers. Nature 1998 11.20
16 Genes expressed in human tumor endothelium. Science 2000 10.75
17 Digital PCR. Proc Natl Acad Sci U S A 1999 10.54
18 Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992 10.12
19 Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998 9.66
20 Gene expression profiles in normal and cancer cells. Science 1997 9.65
21 APC mutations occur early during colorectal tumorigenesis. Nature 1992 9.50
22 A public database for gene expression in human cancers. Cancer Res 1999 8.81
23 Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990 8.32
24 PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001 7.95
25 Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 1993 7.90
26 p53 function and dysfunction. Cell 1992 7.73
27 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1997 7.20
28 Association of the APC tumor suppressor protein with catenins. Science 1993 7.17
29 Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A 1987 7.12
30 Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 1992 6.73
31 p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 1995 6.66
32 Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993 6.61
33 Identification of p53 as a sequence-specific DNA-binding protein. Science 1991 6.60
34 Analysis of human transcriptomes. Nat Genet 1999 6.14
35 Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999 6.13
36 The multistep nature of cancer. Trends Genet 1993 6.12
37 Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996 6.11
38 Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998 5.88
39 Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997 5.87
40 Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998 5.80
41 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999 5.44
42 Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 1995 5.26
43 Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994 5.12
44 PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999 5.12
45 Role of BAX in the apoptotic response to anticancer agents. Science 2000 5.07
46 Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996 4.87
47 Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 1997 4.86
48 Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998 4.67
49 Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res 1992 4.21
50 Identification of an amplified, highly expressed gene in a human glioma. Science 1987 4.21
51 Genetic instability and darwinian selection in tumours. Trends Cell Biol 1999 4.12
52 Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 1996 4.09
53 Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 1993 4.07
54 APC binds to the novel protein EB1. Cancer Res 1995 3.98
55 Breast cancer. What's mice got to do with it? Nature 1996 3.86
56 A phosphatase associated with metastasis of colorectal cancer. Science 2001 3.86
57 Securin is required for chromosomal stability in human cells. Cell 2001 3.71
58 Combinatorial chemoprevention of intestinal neoplasia. Nat Med 2000 3.66
59 Scrambled exons. Cell 1991 3.65
60 Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 1992 3.58
61 Mismatch repair deficiency in phenotypically normal human cells. Science 1995 3.55
62 Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci U S A 2001 3.51
63 Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet 1997 3.41
64 Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 1999 3.40
65 Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A 2000 3.38
66 Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A 1994 3.36
67 Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res 2001 3.29
68 Conversion of diploidy to haploidy. Nature 2000 3.28
69 Mutations of GTBP in genetically unstable cells. Science 1995 3.23
70 Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A 1999 3.07
71 Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995 3.07
72 DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci U S A 1997 3.03
73 Deletion of p16 and p15 genes in brain tumors. Cancer Res 1994 3.03
74 p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993 2.99
75 CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 2000 2.94
76 Detecting colorectal cancer in stool with the use of multiple genetic targets. J Natl Cancer Inst 2001 2.93
77 Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci U S A 1998 2.83
78 Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 1996 2.81
79 Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci U S A 1996 2.75
80 Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 1994 2.65
81 Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 2001 2.65
82 Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci U S A 2001 2.62
83 Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994 2.62
84 Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nat Biotechnol 2001 2.59
85 The GLI-Kruppel family of human genes. Mol Cell Biol 1988 2.52
86 Mad-related genes in the human. Nat Genet 1996 2.51
87 Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 2001 2.47
88 In vivo cloning of PCR products in E. coli. Nucleic Acids Res 1993 2.40
89 Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med 1995 2.40
90 APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci U S A 1996 2.18
91 Allelotype of pancreatic adenocarcinoma. Cancer Res 1994 2.11
92 Association between wild type and mutant APC gene products. Cancer Res 1993 2.08
93 Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci U S A 2001 2.06
94 Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 1999 2.01
95 Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 1991 1.96
96 Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell 1998 1.90
97 A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995 1.86
98 Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res 1994 1.82
99 p53 tagged sites from human genomic DNA. Hum Mol Genet 1994 1.82
100 Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev 2000 1.80
101 Expression of the APC tumor suppressor protein in oligodendroglia. Glia 1996 1.77
102 Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A 2001 1.76
103 GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol Cell Biol 1990 1.76
104 Genotyping by mass spectrometric analysis of short DNA fragments. Nat Biotechnol 1998 1.76
105 Inactivation of both APC alleles in human and mouse tumors. Cancer Res 1994 1.75
106 Frequency of Smad gene mutations in human cancers. Cancer Res 1997 1.73
107 Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. Cancer Res 1998 1.73
108 Monoallelic mutation analysis (MAMA) for identifying germline mutations. Nat Genet 1995 1.68
109 Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A 2001 1.68
110 Analysing uncharted transcriptomes with SAGE. Trends Genet 2000 1.68
111 Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res 1995 1.67
112 Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res 2001 1.64
113 Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis 1996 1.62
114 Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol 1992 1.62
115 The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol Cell Biol 1991 1.62
116 NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Mol Cell Biol 1999 1.59
117 CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene 1999 1.57
118 Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc Natl Acad Sci U S A 1998 1.55
119 Genomic organization of the human PMS2 gene family. Genomics 1995 1.50
120 Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. Cancer Res 1996 1.49
121 Polymerase delta variants in RER colorectal tumours. Nat Genet 1995 1.47
122 Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol 1996 1.47
123 Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology 1994 1.41
124 Counting alleles reveals a connection between chromosome 18q loss and vascular invasion. Nat Biotechnol 2001 1.41
125 Identifying markers for pancreatic cancer by gene expression analysis. Cancer Epidemiol Biomarkers Prev 1998 1.36
126 Amplification units containing human N-myc and c-myc genes. Proc Natl Acad Sci U S A 1986 1.31
127 The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res 2000 1.28
128 Life (and death) in a malignant tumour. Nature 1996 1.25
129 Has the breast cancer gene been found? Cell 1994 1.23
130 The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev 1994 1.23
131 Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias. Gastroenterology 1995 1.23
132 Tech.sight. Genetic testing--present and future. Science 2000 1.22
133 The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. Cancer Res 2001 1.20
134 Carcinogens leave fingerprints. Nature 1992 1.19
135 Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia 2011 1.18
136 In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. Hum Genet 1989 1.18
137 APC gene mutations in the mutation cluster region are rare in esophageal cancers. Gastroenterology 1994 1.14
138 Evaluation of the FHIT gene in colorectal cancers. Cancer Res 1996 1.14
139 p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. Cancer Lett 2000 1.11
140 A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol 1998 1.11
141 Relationship between gene amplification and chromosomal deviations in malignant human gliomas. Cancer Genet Cytogenet 1987 1.04
142 Amplification of cyclin genes in colorectal carcinomas. Cancer Res 1993 1.04
143 Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers. Cancer Res 2001 1.04
144 Achilles' heel of cancer? Nature 2001 1.03
145 Analysis of masked mutations in familial adenomatous polyposis. Proc Natl Acad Sci U S A 1999 1.01
146 Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin. Nat Med 2000 1.00
147 Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors. Princess Takamatsu Symp 1991 0.99
148 A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics 1992 0.99
149 Going mad with Smads. N Engl J Med 1999 0.97
150 Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor. Cancer Res 1996 0.96
151 APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis. Gut 1997 0.95
152 Absence of secretory phospholipase A2 gene alterations in human colorectal cancer. Cancer Res 1995 0.95
153 Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. Calcif Tissue Int 2001 0.95
154 PAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A 1995 0.95
155 Colorectal cancer and the intersection between basic and clinical research. Cold Spring Harb Symp Quant Biol 1994 0.94
156 Less death in the dying. Cell Death Differ 1997 0.94
157 Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Genomics 1995 0.93
158 Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res 2001 0.93
159 Molecular cloning of the N-terminus of GTBP. Genomics 1996 0.92
160 Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors. Tohoku J Exp Med 1992 0.90
161 Tumour-suppressor genes. X-rays strike p53 again. Nature 1994 0.87
162 Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12. Cancer Res 1990 0.86
163 Through the glass lightly. Science 1995 0.85
164 Three dinucleotide repeat polymorphisms proximal to the D2S123 locus. Hum Mol Genet 1994 0.85
165 Mammalian cells resistant to tumor suppressor genes. Proc Natl Acad Sci U S A 1996 0.85
166 Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics 1993 0.81
167 SAM 1.1 and JOSH 4.4: two RFLPs within the human DCC gene. Hum Mol Genet 1992 0.81
168 Converting cancer genes into killer genes. Proc Natl Acad Sci U S A 1996 0.80
169 The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies. Cytogenet Cell Genet 1995 0.79
170 Cancer. A gene for neurofibromatosis 2. Nature 1993 0.78
171 Cancer, crash sites, and the new genetics of neoplasia. Gastroenterology 1999 0.78
172 Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Jpn J Cancer Res 1992 0.77