Published in Science on January 05, 1990
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A (1992) 5.53
Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol (1994) 4.43
Antioncogenes and human cancer. Proc Natl Acad Sci U S A (1993) 4.09
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J (1992) 3.98
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci U S A (1990) 3.70
Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol (1991) 3.45
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A (1991) 3.43
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36
Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. EMBO J (1990) 2.94
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J (1991) 2.85
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol (1992) 2.76
DNA copy number losses in human neoplasms. Am J Pathol (1999) 2.73
Measurement of locus copy number by hybridisation with amplifiable probes. Nucleic Acids Res (2000) 2.70
Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci U S A (1991) 2.43
Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest (1993) 2.29
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev (1997) 2.26
Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc Natl Acad Sci U S A (1990) 2.22
Splicing with inverted order of exons occurs proximal to large introns. EMBO J (1992) 2.10
Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Proc Natl Acad Sci U S A (1992) 2.08
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci U S A (1991) 2.07
A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol (1993) 2.06
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol Cell Biol (1991) 2.04
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A (2008) 1.95
Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin. J Cell Biol (1991) 1.94
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci U S A (2001) 1.92
Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia. J Cell Biol (1993) 1.91
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90
Loss of heterozygosity analysis using whole genome amplification, cell sorting, and fluorescence-based PCR. Genome Res (1999) 1.90
E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol (1993) 1.89
BTG1, a member of a new family of antiproliferative genes. EMBO J (1992) 1.89
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell (2016) 1.88
Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology (2007) 1.83
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology (2007) 1.82
Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae. Genetics (1998) 1.78
Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A (1997) 1.76
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci U S A (1990) 1.74
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci U S A (2003) 1.69
Mutations in p53 as potential molecular markers for human breast cancer. Proc Natl Acad Sci U S A (1991) 1.65
Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci U S A (1993) 1.64
Colorectal cancer: genetics of development and metastasis. J Gastroenterol (2006) 1.63
Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol (1992) 1.62
Homozygous deletions within human chromosome band 9p21 in melanoma. Proc Natl Acad Sci U S A (1992) 1.58
Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci U S A (1993) 1.58
Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region. EMBO J (1992) 1.58
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer (2003) 1.57
Splice-mediated insertion of an Alu sequence inactivates ornithine delta-aminotransferase: a role for Alu elements in human mutation. Proc Natl Acad Sci U S A (1991) 1.56
Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer (1994) 1.53
Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci U S A (1991) 1.52
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J (2005) 1.52
A genome screen of multiplex sibships with prostate cancer. Am J Hum Genet (2000) 1.51
Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol (2011) 1.50
Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas. J Gastroenterol (2005) 1.47
The CDKN2A (p16) gene and human cancer. Mol Med (1997) 1.46
DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ Health Perspect (1993) 1.45
Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. Proc Natl Acad Sci U S A (1995) 1.44
Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect (1991) 1.44
APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab (2008) 1.41
Molecular analysis of the 18q- syndrome--and correlation with phenotype. Am J Hum Genet (1993) 1.40
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am J Pathol (1999) 1.36
Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med (2009) 1.36
Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. Br J Cancer (1993) 1.36
During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles. Nucleic Acids Res (1996) 1.36
A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer (2010) 1.33
CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol (1997) 1.32
Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803. J Clin Oncol (2011) 1.31
Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A (1993) 1.31
Molecular biology of colorectal neoplasia. Gut (1993) 1.31
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A (2001) 1.30
Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol (2000) 1.30
T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin. Proc Natl Acad Sci U S A (1999) 1.28
Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol (1994) 1.26
Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. Gut (1995) 1.26
Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proc Natl Acad Sci U S A (2001) 1.24
Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br J Cancer (1995) 1.24
Genotypic analysis of multiple loci in somatic cells by whole genome amplification. Nucleic Acids Res (1995) 1.24
DCC constrains tumour progression via its dependence receptor activity. Nature (2011) 1.21
Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation. Gut (1992) 1.19
Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut (2002) 1.18
Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol (2011) 1.18
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol (1993) 1.18
Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification. Br J Cancer (2006) 1.18
Molecular markers to individualize adjuvant therapy for colon cancer. Nat Rev Clin Oncol (2010) 1.17
Establishment of a highly sensitive and specific exon-trapping system. Proc Natl Acad Sci U S A (1992) 1.17
Netrin-1 is a survival factor during commissural neuron navigation. Proc Natl Acad Sci U S A (2008) 1.16
Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization. Am J Pathol (1993) 1.15
Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified. Proc Natl Acad Sci U S A (1990) 1.15
Microsatellite instability in adenocarcinomas of the upper gastrointestinal tract. Relation to clinicopathological data and family history. Am J Pathol (1995) 1.15
cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS One (2012) 1.14
Loss of heterozygosity for alleles on chromosome II in cervical carcinoma. Am J Hum Genet (1991) 1.14
Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A (2009) 1.13
A gene for familial juvenile polyposis maps to chromosome 18q21.1. Am J Hum Genet (1998) 1.12
Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations. Am J Pathol (1993) 1.12
No SMAD4 hypermethylation in colorectal cancer. Br J Cancer (2000) 1.10
Challenges in the management of stage II colon cancer. Semin Oncol (2011) 1.09
Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene. Proc Natl Acad Sci U S A (1990) 1.08
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. Nature (2012) 1.08
Serial analysis of gene expression. Science (1995) 60.15
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Genetic instabilities in human cancers. Nature (1998) 22.76
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Definition of a consensus binding site for p53. Nat Genet (1992) 12.76
Genetic instability in colorectal cancers. Nature (1997) 12.51
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
A model for p53-induced apoptosis. Nature (1997) 11.38
Characterization of the yeast transcriptome. Cell (1997) 11.33
Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (1996) 11.13
Genes expressed in human tumor endothelium. Science (2000) 10.75
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res (1999) 10.65
Digital PCR. Proc Natl Acad Sci U S A (1999) 10.54
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Gene expression profiles in normal and cancer cells. Science (1997) 9.65
APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50
Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol (1983) 8.24
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90
p53 function and dysfunction. Cell (1992) 7.73
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A (1987) 7.12
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A (2001) 6.99
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66
Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun (1985) 6.57
Phosphorylation and activation of p70s6k by PDK1. Science (1998) 6.53
Mammalian TOR: a homeostatic ATP sensor. Science (2001) 6.41
Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol (2001) 6.30
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (1991) 6.15
Analysis of human transcriptomes. Nat Genet (1999) 6.14
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med (1993) 6.13
The multistep nature of cancer. Trends Genet (1993) 6.12
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (1997) 5.87
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80
CARD15 mutations in Blau syndrome. Nat Genet (2001) 5.79
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70
Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med (2000) 5.68
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J (1997) 5.57
Allelotype of colorectal carcinomas. Science (1989) 5.54
Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature (1996) 5.44
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature (1999) 5.44
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26
Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med (2001) 5.22
Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature (1983) 5.14
Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med (1994) 5.12
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell (1999) 5.12
Role of BAX in the apoptotic response to anticancer agents. Science (2000) 5.07
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. EMBO J (1992) 5.05
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci U S A (1992) 4.91
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet (1997) 4.86