GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 361243)

Published in Mol Cell Biol on October 01, 1990

Authors

J M Ruppert1, B Vogelstein, K Arheden, K W Kinzler

Author Affiliations

1: Johns Hopkins Oncology Center, Baltimore, Maryland.

Articles citing this

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29

The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet (2000) 2.42

Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet (2005) 2.40

Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations. Hum Mutat (2010) 1.88

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81

Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch. Neuron (2011) 1.72

GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc Natl Acad Sci U S A (1999) 1.63

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol Cell Biol (1991) 1.62

GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res (2003) 1.55

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc Natl Acad Sci U S A (1998) 1.49

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol (2008) 1.48

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics (1995) 1.47

The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; No phenotype prediction from the position of GLI3 mutations. Am J Hum Genet (1999) 1.44

Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev Biol (1999) 1.41

Evolution of sex determination in caenorhabditis: unusually high divergence of tra-1 and its functional consequences. Genetics (1996) 1.36

Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev (2010) 1.33

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol Cell Biol (1994) 1.28

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci U S A (1997) 1.16

A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet (2008) 1.16

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev (2002) 1.15

Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro. Nucleic Acids Res (1993) 1.11

The mapping of a gene for craniosynostosis: evidence for linkage of the Saethre-Chotzen syndrome to distal chromosome 7p. J Med Genet (1992) 1.11

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol (2010) 1.07

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol (2010) 1.06

New insights into genotype-phenotype correlation for GLI3 mutations. Eur J Hum Genet (2014) 1.05

Developmental pathways: Sonic hedgehog-Patched-GLI. Environ Health Perspect (1999) 1.03

Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3. J Neurosci (2006) 1.02

The genetics of human limb development. Am J Hum Genet (1994) 0.97

Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. Cancer Res (2011) 0.92

Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome. J Virol (1998) 0.92

Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. J Carcinog (2009) 0.91

Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. J Biol Chem (2009) 0.91

Expanded mutational spectrum of the GLI3 gene substantiates genotype-phenotype correlations. J Appl Genet (2012) 0.89

Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer. Cancer Biol Ther (2010) 0.84

The acrocallosal syndrome and Greig syndrome are not allelic disorders. J Med Genet (1992) 0.82

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. J Biol Chem (2014) 0.80

Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One (2012) 0.79

Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons. Pediatr Surg Int (2004) 0.79

Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein. J Virol (1999) 0.78

New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1991) 0.75

Association between PKA gene polymorphism and NTDs in high risk Chinese population in Shanxi. Int J Clin Exp Pathol (2013) 0.75

Genome-wide association study of language performance in Alzheimer's disease. Brain Lang (2017) 0.75

Articles cited by this

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19

Rapid and sensitive protein similarity searches. Science (1985) 76.83

"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58

A simple and very efficient method for generating cDNA libraries. Gene (1983) 55.36

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc Natl Acad Sci U S A (1987) 37.15

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res (1987) 36.83

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01

Empirical predictions of protein conformation. Annu Rev Biochem (1978) 25.48

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39

How eukaryotic transcriptional activators work. Nature (1988) 19.34

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature (1977) 12.57

Using mini-prep plasmid DNA for sequencing double stranded templates with Sequenase. Biotechniques (1988) 10.14

A new class of yeast transcriptional activators. Cell (1987) 9.53

Zinc fingers: gilt by association. Cell (1988) 9.21

Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science (1989) 8.98

Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins. EMBO J (1984) 7.60

Classification of human colorectal adenocarcinoma cell lines. Cancer Res (1976) 7.00

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins. Nature (1984) 6.79

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell (1988) 6.62

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science (1987) 6.20

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc Natl Acad Sci U S A (1988) 5.25

Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature (1982) 5.21

The primary structure of transcription factor TFIIIA has 12 consecutive repeats. FEBS Lett (1985) 4.73

Identification of an amplified, highly expressed gene in a human glioma. Science (1987) 4.21

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell (1989) 4.17

A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J (1988) 3.98

Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit. Nature (1988) 3.93

Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab Invest (1984) 3.86

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75

Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell (1988) 3.74

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol (1990) 3.64

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell (1989) 3.05

The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature (1988) 2.87

The GLI-Kruppel family of human genes. Mol Cell Biol (1988) 2.52

Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum. Mol Cell Biol (1987) 2.40

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties. Cancer Res (1985) 2.12

Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal. Nucleic Acids Res (1989) 1.99

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev (1990) 1.89

Amplification of the gli gene in childhood sarcomas. Cancer Res (1989) 1.84

Behind the Fos and Jun leucine zipper. Cancer Cells (1989) 1.28

Effect of polyamine depletion on c-myc expression in human colon carcinoma cells. J Biol Chem (1988) 1.19

In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. Hum Genet (1989) 1.18

Homoeo boxes, POU proteins and the limits to promiscuity. Nature (1988) 1.11

Chromosomal progression of malignant human gliomas from biopsy to establishment as permanent lines in vitro. Cancer Genet Cytogenet (1987) 1.08

Rapid purification of DNA from agarose gels by centrifugation through a disposable plastic column. Anal Biochem (1987) 1.03

pBD7, a novel cell-free expression vector with efficient translation initiation signal. Nucleic Acids Res (1987) 1.01

Double synchronization of human lymphocyte cultures: selection for high-resolution banded metaphases in the first and second division. Cytogenet Cell Genet (1985) 0.90

Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization. Cytogenet Cell Genet (1988) 0.82

Articles by these authors

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01

"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58

Serial analysis of gene expression. Science (1995) 60.15

A genetic model for colorectal tumorigenesis. Cell (1990) 44.37

WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72

Surfing the p53 network. Nature (2000) 35.36

p53 mutations in human cancers. Science (1991) 31.96

Preparative and analytical purification of DNA from agarose. Proc Natl Acad Sci U S A (1979) 27.20

Lessons from hereditary colorectal cancer. Cell (1996) 25.73

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61

A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58

Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80

Genetic instabilities in human cancers. Nature (1998) 22.76

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87

Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91

Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40

Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15

Definition of a consensus binding site for p53. Nat Genet (1992) 12.76

Genetic instability in colorectal cancers. Nature (1997) 12.51

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53

Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41

A model for p53-induced apoptosis. Nature (1997) 11.38

Characterization of the yeast transcriptome. Cell (1997) 11.33

Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20

Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18

Genes expressed in human tumor endothelium. Science (2000) 10.75

Digital PCR. Proc Natl Acad Sci U S A (1999) 10.54

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66

Gene expression profiles in normal and cancer cells. Science (1997) 9.65

APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50

Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28

Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (1990) 8.32

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90

p53 function and dysfunction. Cell (1992) 7.73

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20

Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A (1987) 7.12

Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73

p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66

Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61

Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60

Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun (1985) 6.57

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (1991) 6.15

Analysis of human transcriptomes. Nat Genet (1999) 6.14

Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13

The multistep nature of cancer. Trends Genet (1993) 6.12

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11

Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88

Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (1997) 5.87

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature (1999) 5.44

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26

p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20