Telomeres, telomerase and cancer.

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42

Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82

Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell (2000) 1.60

Fluorescent dyes specific for quadruplex DNA. Nucleic Acids Res (1998) 1.51

Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci U S A (1997) 1.51

Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA. Nucleic Acids Res (2000) 1.20

Telomeres, telomerase, and tumorigenesis--a review. MedGenMed (2004) 1.11

Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09

Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1. J Cell Biol (2012) 1.09

RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res (2011) 1.08

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell (2006) 1.07

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J Biol Chem (2009) 1.04

Telomerase activity in 144 brain tumours. Br J Cancer (1998) 0.97

Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res (2009) 0.95

Diet-related telomere shortening and chromosome stability. Mutagenesis (2011) 0.92

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One (2010) 0.92

Epigenetic regulation of telomerase in retinoid-induced differentiation of human leukemia cells. Int J Oncol (2008) 0.88

Telomeres and telomere dynamics: relevance to cancers of the GI tract. Expert Rev Gastroenterol Hepatol (2013) 0.87

Telomere length and common disease: study design and analytical challenges. Hum Genet (2015) 0.87

Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop. Exp Cell Res (2006) 0.86

9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells. J Cell Biochem (2009) 0.85

Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. Nucleic Acids Res (2007) 0.84

Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton. Int J Oncol (2013) 0.83

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity. PLoS One (2015) 0.82

Telomerase lost? Chromosoma (2015) 0.80

Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. J Biomed Sci (2009) 0.80

Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus. Gene (2015) 0.78

Telomerase expression shows differences across multiple regions of oligodendroglioma versus high grade astrocytomas but shows correlation with Mib-1 labelling. J Clin Pathol (1998) 0.78

Structure and function of the telomeric CST complex. Comput Struct Biotechnol J (2016) 0.77

Suramin increased telomerase activity in the c6 glioma/wistar experimental brain tumor model. Int J Biomed Sci (2007) 0.76

Disruption of Survivin in K562 cells elevates telomerase activity and protects cells against apoptosis induced by the Bcr-abl kinase inhibitor STI571. Cancer Ther (2008) 0.75

The combination of TRAIL treatment and cancer cell selective expression of TRAIL-death receptor DR4 induces cell death in TRAIL-resistant cancer cells. Yonsei Med J (2006) 0.75

The status of telomerase enzyme activity in benign and malignant gynaecologic pathologies. Balkan Med J (2013) 0.75

Immortalization of Primary Keratinocytes and Its Application to Skin Research. Biomol Ther (Seoul) (2015) 0.75

Evaluation of the Expression of the Inhibitor of Apoptosis Protein Family and Human Telomerase Reverse Transcriptase in Patients With Advanced Colorectal Adenoma. J Cancer Prev (2017) 0.75

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Structure and function of telomeres. Nature (1991) 14.82

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32

The molecular structure of centromeres and telomeres. Annu Rev Biochem (1984) 7.51

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (1990) 6.82

DNA sequences of telomeres maintained in yeast. Nature (1984) 6.52

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol (1978) 6.45

Cloning yeast telomeres on linear plasmid vectors. Cell (1982) 6.39

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell (1987) 4.85

Telomeres and their control. Annu Rev Genet (2000) 4.74

A conserved secondary structure for telomerase RNA. Cell (1991) 4.52

Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (1995) 4.34

The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A (1998) 4.17

Functional evidence for an RNA template in telomerase. Science (1990) 3.88

Telomerase in yeast. Science (1995) 3.38

Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell (1991) 3.21

The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin. J Biol Chem (1985) 3.04

Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell (1984) 2.89

An overhanging 3' terminus is a conserved feature of telomeres. Mol Cell Biol (1989) 2.85

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev (1996) 2.76

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev (1997) 2.73

Block in anaphase chromosome separation caused by a telomerase template mutation. Science (1997) 2.65

Dynamics of telomere length variation in Tetrahymena thermophila. Cell (1987) 2.56

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42

Developmentally controlled telomere addition in wild-type and mutant paramecia. Mol Cell Biol (1988) 2.41

Template boundary in a yeast telomerase specified by RNA structure. Science (2000) 2.39

Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev (1997) 2.37

Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36

Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1988) 2.32

Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element. Cell (1986) 2.29

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature (1996) 2.24

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol Cell Biol (1989) 2.21

Telomeres: do the ends justify the means? Cell (1984) 1.95

Sequence-specific DNA primer effects on telomerase polymerization activity. Mol Cell Biol (1993) 1.92

Altering specific telomerase RNA template residues affects active site function. Genes Dev (1995) 1.92

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol (2001) 1.89

Architecture of telomerase RNA. EMBO J (1994) 1.88

Genomic reorganization in ciliated protozoans. Annu Rev Genet (1986) 1.86

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol (1996) 1.79

Allele-specific, selective amplification of a ribosomal RNA gene in Tetrahymena thermophila. Cell (1982) 1.75

Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase. Mol Cell Biol (1996) 1.75

A drug-resistant mutation in the ribosomal DNA of Tetrahymena. Proc Natl Acad Sci U S A (1985) 1.75

The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein. Proc Natl Acad Sci U S A (1999) 1.74

De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J (1997) 1.67

Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena. Cell (1981) 1.64

Specific telomerase RNA residues distant from the template are essential for telomerase function. Genes Dev (1998) 1.63

Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. Proc Natl Acad Sci U S A (1988) 1.63

The internally located telomeric sequences in the germ-line chromosomes of Tetrahymena are at the ends of transposon-like elements. Cell (1985) 1.63

Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena. Proc Natl Acad Sci U S A (1981) 1.62

Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum. Nucleic Acids Res (1987) 1.62

Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate. Cell (1981) 1.61

DNA termini in ciliate macronuclei. Cold Spring Harb Symp Quant Biol (1983) 1.59

Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun (2008) 1.53

Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila. Mol Cell Biol (1985) 1.51

Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. Mol Biol Cell (2003) 1.48

Conserved arrangements of repeated DNA sequences in nontranscribed spacers of ciliate ribosomal RNA genes: evidence for molecular coevolution. Nucleic Acids Res (1985) 1.47

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci U S A (2001) 1.43

A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts. Proc Natl Acad Sci U S A (1994) 1.41

Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector. Proc Natl Acad Sci U S A (1989) 1.37

Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila. Mol Cell Biol (1990) 1.36

Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Mol Psychiatry (2011) 1.36

Telomeric sequence diversity within the genus Saccharomyces. Curr Genet (1998) 1.31

A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains. Proc Natl Acad Sci U S A (1997) 1.27

Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain. Mol Cell Biol (1998) 1.22

Rap1 protein regulates telomere turnover in yeast. Proc Natl Acad Sci U S A (1998) 1.20

In vivo and in vitro studies of telomeres and telomerase. Cold Spring Harb Symp Quant Biol (1993) 1.19

A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase. EMBO J (1998) 1.18

Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J Cell Biol (1999) 1.18

Chromatin structure of the telomeric region and 3'-nontranscribed spacer of Tetrahymena ribosomal RNA genes. J Biol Chem (1986) 1.16

Not so peculiar: fission yeast telomere repeats. Trends Biochem Sci (1998) 1.16

A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila. Genes Dev (1994) 1.13

The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila. Mol Cell Biol (1989) 1.12

Telomere fusions caused by mutating the terminal region of telomeric DNA. Proc Natl Acad Sci U S A (2000) 1.12

The nucleotide and amino acid sequences of the N (5') terminal region of gene G of bacteriophage phiphiX 174. J Mol Biol (1975) 1.10

Methylation of ribosomal RNA genes in the macronucleus of Tetrahymena thermophila. Nucleic Acids Res (1983) 1.09

RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase. Cell (1990) 1.04

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena. Nucleic Acids Res (1994) 1.04

Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes (Lond) (2011) 1.03

Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres. Mol Cell Biol (2000) 1.03

Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition. J Biol Chem (1972) 1.03

An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila. Genes Dev (1995) 1.01

Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation. Gene (1988) 0.99

Conservation of sequences adjacent to the telomeric C4A2 repeats of ciliate macronuclear ribosomal RNA gene molecules. Nucleic Acids Res (1986) 0.99

Three telomerases with completely non-telomeric template replacements are catalytically active. EMBO J (2000) 0.98

Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome. Genetics (1994) 0.98

Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis. J Protozool (1989) 0.96

A promoter region mutation affecting replication of the Tetrahymena ribosomal DNA minichromosome. Mol Cell Biol (1998) 0.96

Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats. J Eukaryot Microbiol (1995) 0.94

Two types of telomeric chromatin in Tetrahymena thermophila. J Mol Biol (1998) 0.92

Replication of an rRNA gene origin plasmid in the Tetrahymena thermophila macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter. Mol Cell Biol (1995) 0.91

Tandem repeats of the 5' non-transcribed spacer of Tetrahymena rDNA function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation. Nucleic Acids Res (1995) 0.89

Developmentally regulated telomere addition in Tetrahymena thermophila. Nucleic Acids Res (1988) 0.88

Telomerase: Dr Jekyll or Mr Hyde? Curr Opin Genet Dev (1999) 0.87

Transcription by Escherichia coli RNA polymerase of a single-stranded fragment by bacteriophage phiX174 DNA 48 residues in length. J Mol Biol (1975) 0.86

Tetrahymena micronuclear sequences that function as telomeres in yeast. Nucleic Acids Res (1989) 0.86

Telomerase in kinetoplastid parasitic protozoa. Proc Natl Acad Sci U S A (1999) 0.85

DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. Proc Natl Acad Sci U S A (1994) 0.85

Metabolism of glutamine and ammonia in rat liver: the effects of N-acetylglutamate and phosphate. Arch Biochem Biophys (1972) 0.83