Published in Hum Genet on May 19, 2015
Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging (Albany NY) (2016) 0.80
Early-Life Experiences and Telomere Length in Adult Rhesus Monkeys: An Exploratory Study. Psychosom Med (2016) 0.79
Maternal pre-pregnancy body mass index and newborn telomere length. BMC Med (2016) 0.76
Organic Pollutants and Telomere Length: A New Facet of Carcinogenesis. EBioMedicine (2015) 0.75
Leukocyte telomere length is inversely associated with post-load but not with fasting plasma glucose levels. Exp Biol Med (Maywood) (2017) 0.75
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A (1988) 11.81
Switching and signaling at the telomere. Cell (2001) 11.25
Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24
Association between telomere length in blood and mortality in people aged 60 years or older. Lancet (2003) 10.56
Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19
Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet (1994) 7.04
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91
Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol (2004) 6.78
Heterogeneity in telomere length of human chromosomes. Hum Mol Genet (1996) 6.55
Telomere end-replication problem and cell aging. J Mol Biol (1992) 5.37
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proc Natl Acad Sci U S A (1989) 4.08
Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00
Replication and protection of telomeres. Nature (2007) 3.98
Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst (2013) 3.92
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68
Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67
Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev (2007) 3.63
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell (2006) 3.45
Telomere length and possible link to X chromosome. Lancet (2004) 3.36
Mapping of a major locus that determines telomere length in humans. Am J Hum Genet (2004) 3.33
The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2011) 3.29
Telomere length in the newborn. Pediatr Res (2002) 3.26
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
Telomere length, stem cells and aging. Nat Chem Biol (2007) 3.10
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol (2014) 2.91
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell (2005) 2.89
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ (2014) 2.72
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61
The effect on melanoma risk of genes previously associated with telomere length. J Natl Cancer Inst (2014) 2.60
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet (1998) 2.56
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med (2007) 2.47
Leukocyte telomere length predicts cancer risk in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev (2007) 2.39
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet (2007) 2.37
Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol (2013) 2.34
Measurement of telomeric DNA content in human tissues. Biotechniques (1997) 2.31
Telomere length in prospective and retrospective cancer case-control studies. Cancer Res (2010) 2.30
Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23
The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell (2009) 2.22
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci Lett (2006) 2.14
Telomere lengths are characteristic in each human individual. Exp Gerontol (2002) 2.13
Apolipoprotein E isoforms, serum cholesterol, and cancer. Lancet (1986) 2.05
Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci (2000) 1.97
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci U S A (2007) 1.80
X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene. Am J Hum Genet (1999) 1.80
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72
Telomeres and chromosome instability. DNA Repair (Amst) (2006) 1.70
Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer (2009) 1.70
Telomere length in small-for-gestational-age babies. BJOG (2006) 1.66
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res (2011) 1.49
Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol (2011) 1.48
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nat Genet (2015) 1.46
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet (2008) 1.43
Telomeres, telomerase and cancer. Sci Am (1996) 1.40
Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett (2003) 1.38
Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology. Urol Oncol (2006) 1.38
Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. Cancer Causes Control (2009) 1.32
Oxidative stress and smoking-induced vascular injury. Prog Cardiovasc Dis (2003) 1.31
Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet Genome Res (2006) 1.24
Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. J Gerontol A Biol Sci Med Sci (2011) 1.24
Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev (2010) 1.19
Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One (2014) 1.17
Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study. Genes Chromosomes Cancer (2013) 1.16
Association of telomere length in older men with mortality and midlife body mass index and smoking. J Gerontol A Biol Sci Med Sci (2011) 1.14
Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev (2012) 1.14
Association between telomere length and type 2 diabetes mellitus: a meta-analysis. PLoS One (2013) 1.10
The tail of the telomere. J Am Chem Soc (2008) 1.07
Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. PLoS One (2013) 1.07
Living forever and dying in the attempt. Exp Gerontol (2003) 1.07
The reserve-capacity hypothesis: evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair. Exp Gerontol (2002) 1.05
Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res (2014) 1.04
Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma. Cancer (2013) 1.03
Telomeres. Exp Gerontol (2006) 1.02
Estimating telomere length from whole genome sequence data. Nucleic Acids Res (2014) 1.00
Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk. Cancer Epidemiol Biomarkers Prev (2012) 1.00
Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing. Cardiovasc Res (2008) 0.99
Telomere-binding factors and general DNA repair. Nat Genet (2005) 0.99
Telomere length and pancreatic cancer: a case-control study. Cancer Epidemiol Biomarkers Prev (2012) 0.98
Association between leukocyte telomere length and glioma risk: a case-control study. Neuro Oncol (2013) 0.92
Telomere length and outcome in heart failure. Ann Med (2010) 0.90
Telomere length heterogeneity and chromosome instability. Cancer Lett (2004) 0.88
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet (2009) 3.89
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet (2008) 3.41
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res (2007) 3.08
Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol (2011) 3.04
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67
FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Hum Mol Genet (2009) 2.62
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet (2012) 2.45
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet (2013) 2.39
Telomere length in prospective and retrospective cancer case-control studies. Cancer Res (2010) 2.30
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet (2007) 2.27
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA (2004) 2.20
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2009) 2.13
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer (2009) 2.13
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet (2005) 2.05
Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res (2002) 1.95
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population. J Invest Dermatol (2004) 1.87
Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nat Genet (2011) 1.84
Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst (2012) 1.82
Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res (2007) 1.82
19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Hum Mol Genet (2013) 1.78
Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med (2006) 1.68
Genetic variation in the HSD17B1 gene and risk of prostate cancer. PLoS Genet (2005) 1.67
No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study. Radiother Oncol (2010) 1.63
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet (2005) 1.62
Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet (2009) 1.58
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 1.56
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet (2013) 1.56
IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Am J Hum Genet (2010) 1.55
A combined analysis of genome-wide association studies in breast cancer. Breast Cancer Res Treat (2010) 1.54
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Res (2010) 1.51
Telomerase and the search for the end of cancer. Trends Mol Med (2012) 1.46
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nat Genet (2011) 1.46
Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer (2005) 1.44
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2010) 1.41
No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.40
Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Breast Cancer Res (2007) 1.40
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet (2013) 1.39
Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet (2010) 1.39
Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet (2013) 1.38
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. J Natl Cancer Inst (2008) 1.36
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res (2010) 1.31
Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci U S A (2007) 1.29
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium. Cancer Res (2007) 1.29
Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev (2009) 1.29
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol (2012) 1.29
11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat (2012) 1.26
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Res Treat (2007) 1.24
Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. J Gerontol A Biol Sci Med Sci (2011) 1.24
Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis (2006) 1.24
Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations. Hum Mol Genet (2007) 1.24
Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk. PLoS Med (2006) 1.23
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.23
The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet (2012) 1.23
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk. Breast Cancer Res (2007) 1.22
Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res (2006) 1.21
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One (2011) 1.20
Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Cancer Epidemiol Biomarkers Prev (2010) 1.20
Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping. BMC Med Genomics (2012) 1.20
Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility. PLoS Genet (2010) 1.19