Published in Immunity on January 01, 1996
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. J Exp Med (1998) 5.33
Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med (2002) 5.16
T cell affinity maturation by selective expansion during infection. J Exp Med (1999) 3.08
Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J Exp Med (1998) 2.32
Heterologous immunity between viruses. Immunol Rev (2010) 2.20
CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest (2000) 2.19
Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J Exp Med (1998) 2.13
The future is now: single-cell genomics of bacteria and archaea. FEMS Microbiol Rev (2013) 2.10
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A (1997) 1.99
The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant. J Virol (1999) 1.97
Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J Exp Med (1998) 1.93
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope. Proc Natl Acad Sci U S A (2004) 1.92
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest (2010) 1.87
The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J Virol (1999) 1.67
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 1.64
Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J Exp Med (1999) 1.58
One naive T cell, multiple fates in CD8+ T cell differentiation. J Exp Med (2010) 1.55
Qualitative differences between naïve and memory T cells. Immunology (2002) 1.48
Functional management of an antiviral cytotoxic T-cell response. J Virol (1997) 1.30
Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc Natl Acad Sci U S A (2001) 1.22
The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones. J Exp Med (1999) 1.19
Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis. J Exp Med (1996) 1.15
Mapping the life histories of T cells. Nat Rev Immunol (2010) 1.12
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol (2007) 1.12
Hallmarks of Tissue-Resident Lymphocytes. Cell (2016) 1.10
Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J Virol (1998) 1.01
New methods for assessing T-cell responses. Clin Diagn Lab Immunol (2000) 1.00
Improved assessment of T-cell receptor (TCR) VB repertoire in clinical specimens: combination of TCR-CDR3 spectratyping with flow cytometry-based TCR VB frequency analysis. Clin Diagn Lab Immunol (2002) 0.98
Heterogeneity in immune responses: from populations to single cells. Trends Immunol (2014) 0.98
Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol (2008) 0.98
Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A (2013) 0.96
The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions. Immunology (2001) 0.92
Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection. J Immunol (2010) 0.92
Longitudinal analysis of the T-cell receptor (TCR)-VA and -VB repertoire in CD8+ T cells from individuals immunized with recombinant hepatitis B surface antigen. Clin Exp Immunol (2002) 0.90
T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med (2003) 0.90
Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog (2013) 0.89
Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology (2003) 0.89
Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes. Immunol Cell Biol (2009) 0.87
Direct staining with major histocompatibility complex class II dextramers permits detection of antigen-specific, autoreactive CD4 T cells in situ. PLoS One (2014) 0.87
Comparative T cell receptor repertoire selection by antigen after adoptive transfer: a glimpse at an antigen-specific preimmune repertoire. Proc Natl Acad Sci U S A (2000) 0.86
T-cell-mediated autoimmunity: novel techniques to characterize autoreactive T-cell receptors. Am J Pathol (2003) 0.86
Interrogating the relationship between naïve and immune antiviral T cell repertoires. Curr Opin Virol (2013) 0.85
Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection. Proc Natl Acad Sci U S A (2014) 0.83
Parallel single cancer cell whole genome amplification using button-valve assisted mixing in nanoliter chambers. PLoS One (2014) 0.82
Human leucocyte antigen-A2 restricted and Mycobacterium tuberculosis 19-kDa antigen-specific CD8+ T-cell responses are oligoclonal and exhibit a T-cell cytotoxic type 2 response cytokine-secretion pattern. Immunology (2001) 0.81
Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination. J Biomed Biotechnol (2010) 0.79
Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Virology (2008) 0.78
Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo. J Virol (1999) 0.76
The PROSITE database, its status in 1999. Nucleic Acids Res (1999) 24.88
The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res (2001) 24.45
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10
Improving the sensitivity of the sequence profile method. Protein Sci (1994) 13.54
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 10.92
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science (2000) 10.40
ESTScan: a program for detecting, evaluating, and reconstructing potential coding regions in EST sequences. Proc Int Conf Intell Syst Mol Biol (1999) 9.18
The PROSITE database, its status in 1997. Nucleic Acids Res (1997) 8.12
Compilation and analysis of eukaryotic POL II promoter sequences. Nucleic Acids Res (1986) 6.68
InterPro--an integrated documentation resource for protein families, domains and functional sites. Bioinformatics (2000) 6.42
The PROSITE database, its status in 1995. Nucleic Acids Res (1996) 5.53
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N Engl J Med (1996) 5.36
Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J Exp Med (1990) 4.90
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science (1998) 4.58
Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences. Nature (1980) 4.51
PROSITE: recent developments. Nucleic Acids Res (1994) 4.46
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science (1998) 4.24
The eukaryotic promoter database (EPD). Nucleic Acids Res (2000) 4.21
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet (2001) 3.86
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J (1993) 3.75
Methods and algorithms for statistical analysis of protein sequences. Proc Natl Acad Sci U S A (1992) 3.63
The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem Sci (1996) 3.57
Searching for regulatory elements in human noncoding sequences. Curr Opin Struct Biol (1997) 3.30
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet (1999) 3.12
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem (2000) 2.90
The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci (1995) 2.78
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis. J Clin Invest (1997) 2.76
The PCI domain: a common theme in three multiprotein complexes. Trends Biochem Sci (1998) 2.73
IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol (1999) 2.69
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science (2001) 2.52
Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunol Today (1998) 2.49
A conserved domain is present in different families of vesicular fusion proteins: a new superfamily. Proc Natl Acad Sci U S A (1997) 2.42
Modeling sequencing errors by combining Hidden Markov models. Bioinformatics (2003) 2.34
Statistical methods and insights for protein and DNA sequences. Annu Rev Biophys Biophys Chem (1991) 2.32
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection. J Clin Invest (1998) 2.30
The Eukaryotic Promoter Database EPD. Nucleic Acids Res (1998) 2.24
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc Natl Acad Sci U S A (2000) 2.21
Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex. Nature (1987) 2.13
[Vacuum-assisted abdominal closure: its role in the treatment of complex abdominal and perineal wounds. Experience in 48 patients]. J Chir (Paris) (2007) 2.12
A precise map of splice junctions in the mRNAs of minute virus of mice, an autonomous parvovirus. J Virol (1986) 2.11
Studies on DNA replication in the bacteriophage T4 in vitro system. Cold Spring Harb Symp Quant Biol (1983) 2.09
Immunological conditions of children with BCG disseminated infection. Lancet (1995) 2.05
Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation. N Engl J Med (2001) 2.05
HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet (2003) 2.02
The CARD domain: a new apoptotic signalling motif. Trends Biochem Sci (1997) 2.02
Value of open lung biopsy in immunocompromised children. J Pediatr (2000) 1.96
Fatal disseminated Mycobacterium smegmatis infection in a child with inherited interferon gamma receptor deficiency. Clin Infect Dis (1997) 1.96
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol (1993) 1.95
A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors. Int Immunol (1993) 1.93
trEST, trGEN and Hits: access to databases of predicted protein sequences. Nucleic Acids Res (2001) 1.93
Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages. J Immunol (1991) 1.90
Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis. Annu Rev Genomics Hum Genet (2007) 1.88
The Eukaryotic Promoter Database (EPD): recent developments. Nucleic Acids Res (1999) 1.81
Properties of the T4 bacteriophage DNA replication apparatus: the T4 dda DNA helicase is required to pass a bound RNA polymerase molecule. Cell (1983) 1.80
Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase. J Exp Med (1988) 1.77
The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. Protein Sci (1998) 1.74
Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients. J Pediatr (1999) 1.73
Escherichia coli phage T4 topoisomerase. Methods Enzymol (1983) 1.71
Transcription of a cloned Xenopus laevis H4 histone gene in the homologous frog oocyte system depends on an evolutionary conserved sequence motif in the -50 region. Nucleic Acids Res (1983) 1.70
The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse. Nucleic Acids Res (1986) 1.70
Making sense of score statistics for sequence alignments. Brief Bioinform (2001) 1.67
Signal search analysis: a new method to localize and characterize functionally important DNA sequences. Nucleic Acids Res (1984) 1.60
Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guérin and Mycobacterium abscessus infection. J Infect Dis (2000) 1.58
Significant similarity and dissimilarity in homologous proteins. Mol Biol Evol (1992) 1.57
Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes. Nucleic Acids Res (1987) 1.53
Experimental analysis and computer prediction of CTF/NFI transcription factor DNA binding sites. J Mol Biol (2000) 1.49
SEView: a Java applet for browsing molecular sequence data. In Silico Biol (1998) 1.47
Correlation of granuloma structure with clinical outcome defines two types of idiopathic disseminated BCG infection. J Pathol (1997) 1.47
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? J Clin Invest (1997) 1.43
Genetic basis for clinical expression in multiple sclerosis. Brain (2002) 1.43
Severe aplastic anemia of neonatal onset: a single-center retrospective study of six children. J Pediatr (1998) 1.43
Periodicity of DNA folding in higher order chromatin structures. EMBO J (1990) 1.39
TWEAK stimulation of astrocytes and the proinflammatory consequences. Glia (2000) 1.38
A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol Cell Biol (1996) 1.37
Cytotoxic T lymphocyte mediated cytolysis. Biochemistry (1988) 1.36
Evaluation of computer tools for the prediction of transcription factor binding sites on genomic DNA. In Silico Biol (1998) 1.35
Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis. J Infect Dis (2001) 1.34
Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice. J Virol (1986) 1.32
Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood. Pediatr Res (2001) 1.31
Invasive pulmonary infection due to Scedosporium apiospermum in two children with chronic granulomatous disease. Clin Infect Dis (1998) 1.30
Mendelian susceptibility to mycobacterial infection in man. Curr Opin Immunol (1998) 1.29
Natural DNA sequences can form left-handed helices in low salt solution under conditions of topological constraint. J Mol Biol (1982) 1.28
Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion. Immunol Rev (2000) 1.28
Quantile distributions of amino acid usage in protein classes. Protein Eng (1992) 1.27
Primary monolayer cultures of adult rat liver parenchymal cells suitable for study of the regulation of enzyme synthesis. In Vitro (1977) 1.27
Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. J Cell Sci (1996) 1.26
Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule. J Immunol (1992) 1.24
In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma. J Clin Invest (2000) 1.24
The rsp5-domain is shared by proteins of diverse functions. FEBS Lett (1995) 1.23
Structure of replicating herpes simplex virus DNA. J Virol (1981) 1.20
Short time exposure to lipopolysaccharide is sufficient to activate human monocytes. J Immunol (1993) 1.20
Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection. Am J Pathol (2000) 1.18
The roles of calcium and cyclic AMP in cell proliferation. Ann N Y Acad Sci (1980) 1.17
Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene. Mol Cell Biol (1996) 1.17
Mycobacterial diseases in primary immunodeficiencies. Curr Opin Allergy Clin Immunol (2001) 1.17
Genetic predisposition to clinical tuberculosis: bridging the gap between simple and complex inheritance. Am J Hum Genet (2000) 1.17
Clinical consequences of defects in the IL-12-dependent interferon-gamma (IFN-gamma) pathway. Clin Exp Immunol (2000) 1.16