Heterologous immunity between viruses.

PubWeight™: 2.20‹?› | Rank: Top 2%

🔗 View Article (PMC 2917921)

Published in Immunol Rev on May 01, 2010

Authors

Raymond M Welsh1, Jenny W Che, Michael A Brehm, Liisa K Selin

Author Affiliations

1: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. raymond.welsh@umassmed.edu

Articles citing this

Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity (2013) 3.38

From vaccines to memory and back. Immunity (2010) 3.30

Deconstructing the peptide-MHC specificity of T cell recognition. Cell (2014) 3.24

Expanding roles for CD4⁺ T cells in immunity to viruses. Nat Rev Immunol (2012) 2.94

Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis (2012) 2.33

Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med (2015) 1.83

Norovirus GII.4 strain antigenic variation. J Virol (2010) 1.73

Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep (2013) 1.37

Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol (2014) 1.31

Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells. PLoS Pathog (2014) 1.20

Microbial virulence as an emergent property: consequences and opportunities. PLoS Pathog (2011) 1.16

Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future. Viruses (2012) 1.12

The two-faced T cell epitope: examining the host-microbe interface with JanusMatrix. Hum Vaccin Immunother (2013) 1.11

Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination. J Immunol (2013) 1.06

Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response. J Allergy Clin Immunol (2015) 1.03

Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice. J Immunol (2013) 1.01

Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Sci Rep (2011) 1.00

Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope. PLoS Pathog (2012) 0.99

CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals. PLoS One (2014) 0.98

Heterologous immunity: immunopathology, autoimmunity and protection during viral infections. Autoimmunity (2011) 0.98

Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire. PLoS Comput Biol (2012) 0.97

HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. J Immunol (2012) 0.97

Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination. Sci Transl Med (2016) 0.97

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A (2013) 0.96

Immune modulation during latent herpesvirus infection. Immunol Rev (2012) 0.96

Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathog (2012) 0.95

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification. Immunogenetics (2015) 0.93

Humanized mice for the study of infectious diseases. Curr Opin Immunol (2013) 0.92

Inflammatory IL-15 is required for optimal memory T cell responses. J Clin Invest (2015) 0.88

H7N9 T-cell epitopes that mimic human sequences are less immunogenic and may induce Treg-mediated tolerance. Hum Vaccin Immunother (2015) 0.88

Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc Natl Acad Sci U S A (2012) 0.88

Distinctive features of CD4+ T cell dysfunction in chronic viral infections. Curr Opin HIV AIDS (2014) 0.87

MHV68 latency modulates the host immune response to influenza A virus. Inflammation (2013) 0.87

PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol (2013) 0.87

Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool. Immunol Rev (2015) 0.86

Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells. J Immunol (2013) 0.86

Pathogen evolution and the immunological niche. Ann N Y Acad Sci (2014) 0.85

Negative impact of IFN-γ on early host immune responses to retroviral infection. J Immunol (2012) 0.85

Co-infections determine patterns of mortality in a population exposed to parasite infection. Sci Adv (2015) 0.85

Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma. J Virol (2012) 0.84

Towards the knowledge-based design of universal influenza epitope ensemble vaccines. Bioinformatics (2016) 0.83

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection. Med Microbiol Immunol (2012) 0.82

CD11c⁺ cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice. Eur J Immunol (2014) 0.82

A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol (2015) 0.82

Measles-mumps-rubella vaccination and respiratory syncytial virus-associated hospital contact. Vaccine (2014) 0.81

The two faces of heterologous immunity: protection or immunopathology. J Leukoc Biol (2013) 0.80

Cross-reactivity of T cells and its role in the immune system. Crit Rev Immunol (2012) 0.80

Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-γ. J Immunol (2013) 0.80

Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection. J Virol (2014) 0.80

Indoleamine 2,3-dioxygenase (IDO) activity during the primary immune response to influenza infection modifies the memory T cell response to influenza challenge. Viral Immunol (2014) 0.80

Cytomegalovirus and HIV: A Dangerous Pas de Deux. J Infect Dis (2016) 0.79

Cross-protective immune responses elicited by live attenuated influenza vaccines. Yonsei Med J (2013) 0.79

Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice. PLoS One (2012) 0.79

CrossTope: a curate repository of 3D structures of immunogenic peptide: MHC complexes. Database (Oxford) (2013) 0.79

Cross-reactive responses to modified M1₅₈-₆₆ peptides by CD8⁺ T cells that use noncanonical BV genes can describe unknown repertoires. Eur J Immunol (2012) 0.79

The oral commensal Streptococcus mitis shows a mixed memory Th cell signature that is similar to and cross-reactive with Streptococcus pneumoniae. PLoS One (2014) 0.79

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics. PLoS One (2016) 0.78

The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak. BMC Infect Dis (2014) 0.78

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives. J Transl Med (2016) 0.78

Human T cell responses to Japanese encephalitis virus in health and disease. J Exp Med (2016) 0.78

Antigen-dependent and -independent contributions to primary memory CD8 T cell activation and protection following infection. Sci Rep (2015) 0.78

Coevolutionary immune system dynamics driving pathogen speciation. PLoS One (2014) 0.77

Some unmet challenges in the immunology of viral infections. Discov Med (2010) 0.77

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance. PLoS Pathog (2017) 0.77

Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides-As Antigens for Th Cells. Front Immunol (2015) 0.76

MHC basis of T cell-dependent heterologous immunity to arenaviruses. Virology (2014) 0.76

Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J Biol Chem (2015) 0.76

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation. Immunology (2015) 0.76

Type I Interferon Elevates Co-Regulatory Receptor Expression on CMV- and EBV-Specific CD8 T Cells in Chronic Hepatitis C. Front Immunol (2015) 0.75

Simultaneous vaccination with MMR and DTaP-IPV-Hib and rate of hospital admissions with any infections: A nationwide register based cohort study. Vaccine (2016) 0.75

MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T-cells in healthy adults. Blood (2016) 0.75

Computer simulations of heterologous immunity: highlights of an interdisciplinary cooperation. Autoimmunity (2011) 0.75

Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation. Front Immunol (2016) 0.75

The CD8 T-cell response during tolerance induction in liver transplantation. Clin Transl Immunology (2016) 0.75

Vaccination and heterologous immunity: educating the immune system. Trans R Soc Trop Med Hyg (2015) 0.75

Immune parameters to consider when choosing T-cell receptors for therapy. Front Immunol (2013) 0.75

Heterologous immunity and persistent murine cytomegalovirus infection. J Virol (2016) 0.75

Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS One (2016) 0.75

Inclusion of Epitopes That Expand High-Avidity CD4+ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis. J Immunol (2016) 0.75

Host response: Mice and humans in the bubble. Nat Microbiol (2016) 0.75

A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire. Cell Rep (2016) 0.75

Bolstering the Number and Function of HSV-1-Specific CD8(+) Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease. J Immunol (2017) 0.75

Alloimmunity But Not Viral Immunity Promotes Allograft Loss in a Mouse Model of Polyomavirus-Associated Allograft Injury. Transplant Direct (2017) 0.75

Articles cited by this

(truncated to the top 100)

MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol (1979) 15.58

THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med (1964) 13.28

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med (1997) 12.08

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol (2001) 9.23

Turnover of naive- and memory-phenotype T cells. J Exp Med (1994) 8.07

Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu Rev Immunol (1999) 7.18

A direct estimate of the human alphabeta T cell receptor diversity. Science (1999) 6.85

An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol (1969) 6.85

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol (2001) 6.78

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med (2005) 6.59

Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med (2003) 6.25

Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa. BMJ (2000) 5.42

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses. J Exp Med (1977) 5.20

Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature. J Infect Dis (2005) 5.19

A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today (1998) 5.07

Early programming of T cell populations responding to bacterial infection. J Immunol (2000) 4.57

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol (2006) 4.52

Viral strategies of immune evasion. Science (1998) 4.48

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest (2008) 4.30

Herpesvirus latency confers symbiotic protection from bacterial infection. Nature (2007) 4.27

Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14

Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol (2002) 3.96

The many important facets of T-cell repertoire diversity. Nat Rev Immunol (2004) 3.83

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature (1998) 3.78

T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity (2004) 3.69

Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol (2001) 3.59

Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade. Rev Infect Dis (1989) 3.53

T cell homeostatic proliferation elicits effective antitumor autoimmunity. J Clin Invest (2002) 3.41

Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci U S A (1999) 3.30

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J Exp Med (1996) 3.26

Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries. BMJ (1995) 3.21

No one is naive: the significance of heterologous T-cell immunity. Nat Rev Immunol (2002) 3.20

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. J Exp Med (2003) 3.20

Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J Immunol (2000) 3.14

Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR. Nat Immunol (2001) 3.08

The repertoire of T cells shaped by a single MHC/peptide ligand. Cell (1996) 3.04

Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci U S A (1991) 2.90

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J Exp Med (1994) 2.87

Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity. Immunol Rev (2006) 2.79

Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells. J Virol (2001) 2.77

Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. Immunity (1999) 2.55

Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med (1998) 2.53

Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree. Tuber Lung Dis (1999) 2.50

Memory CD8 T-cell compartment grows in size with immunological experience. Nature (2008) 2.49

Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44

Immunological memory to viral infections. Annu Rev Immunol (2004) 2.40

Antibody-dependent enhancement of infection and the pathogenesis of viral disease. Clin Infect Dis (1994) 2.37

Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity (1996) 2.27

Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity (2008) 2.26

Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J Immunol (2008) 2.25

Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J Immunol (2005) 2.22

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat Immunol (2002) 2.21

High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response. J Exp Med (1993) 2.20

Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol (2009) 2.15

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J Exp Med (1996) 2.14

Virus-induced polyclonal cytotoxic T lymphocyte stimulation. J Immunol (1989) 2.13

Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. J Virol (1995) 2.07

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol (1986) 2.06

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A (1995) 2.06

Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol (2003) 2.05

T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med (2004) 1.99

Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J Exp Med (1998) 1.93

Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses. J Virol (2001) 1.87

Viral infection and renal transplant rejection. Br Med J (1972) 1.87

Essential flexibility in the T-cell recognition of antigen. Nature (1996) 1.86

The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes. J Immunol (1977) 1.86

Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med (2005) 1.85

Induction of alloreactive cytotoxic T cells by acute virus infection of mice. J Immunol (1986) 1.84

Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro. J Exp Med (1996) 1.83

Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J Exp Med (2004) 1.79

Characterization of the T cell-mediated cellular cytotoxicity during acute infectious mononucleosis. J Immunol (1989) 1.77

The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol (2007) 1.77

Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest (2005) 1.76

Respiratory manifestations of chicken pox; special consideration of the features of primary varicella pneumonia. AMA Arch Intern Med (1956) 1.75

Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J Exp Med (1997) 1.74

Specificity and degeneracy of T cells. Mol Immunol (2004) 1.71

Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells. Immunity (2001) 1.69

Heterologous T cell immunity in severe hepatitis C virus infection. J Exp Med (2005) 1.68

Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68

Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol (2007) 1.66

Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection. J Immunol (2000) 1.66

Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice. J Virol (2006) 1.66

Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol (2002) 1.64

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 1.64

Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol (2000) 1.64

Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections. J Immunol (2003) 1.61

Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. J Exp Med (1999) 1.58

Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J Exp Med (2000) 1.57

Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes. J Immunol (2006) 1.57

Multiple HLA class I-dependent cytotoxicities constitute the "non-HLA-restricted" response in infectious mononucleosis. Eur J Immunol (1987) 1.55

Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol (2002) 1.55

IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol (2006) 1.54

In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice. J Immunol (1995) 1.52

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. J Clin Invest (2004) 1.51

CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen. J Immunol (1998) 1.50

Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells. J Exp Med (1985) 1.49

Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am J Pathol (1995) 1.48

Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells. J Virol (1993) 1.47

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. Immunity (1998) 1.45

Articles by these authors

Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol (2012) 3.41

No one is naive: the significance of heterologous T-cell immunity. Nat Rev Immunol (2002) 3.20

Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity. Immunol Rev (2006) 2.79

Natural killer cells act as rheostats modulating antiviral T cells. Nature (2011) 2.68

Immunological memory to viral infections. Annu Rev Immunol (2004) 2.40

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat Immunol (2002) 2.21

Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol (2003) 2.05

Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A (2006) 1.91

Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med (2005) 1.85

Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Immunity (2003) 1.85

Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest (2005) 1.76

A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol (2013) 1.67

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 1.64

TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol (2006) 1.57

IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol (2006) 1.54

CD8 memory T cells: cross-reactivity and heterologous immunity. Semin Immunol (2004) 1.50

Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol (2011) 1.45

Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A (2010) 1.41

Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol (2002) 1.35

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol (2007) 1.34

A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses. J Immunol (2003) 1.32

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood (2014) 1.23

Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology (2012) 1.12

Complex T cell memory repertoires participate in recall responses at extremes of antigenic load. J Immunol (2006) 1.11

CD8 T cell responses to viral infections in sequence. Cell Microbiol (2004) 1.10

Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol (2006) 1.10

Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One (2010) 1.09

Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish. Gen Comp Endocrinol (2010) 1.07

CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections. J Immunol (2010) 1.05

Humanized mice as a preclinical tool for infectious disease and biomedical research. Ann N Y Acad Sci (2011) 1.04

Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry. J Virol (2006) 1.01

Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques. PLoS One (2012) 1.01

Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. J Immunol (2010) 1.00

Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope. PLoS Pathog (2012) 0.99

Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol (2008) 0.98

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet (2012) 0.97

A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses. Vaccine (2008) 0.96

Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther (2013) 0.95

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res (2013) 0.95

Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice. Pancreas (2011) 0.93

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One (2009) 0.92

Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci (2011) 0.92

Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity. J Am Soc Nephrol (2007) 0.91

Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire. Am J Pathol (2010) 0.91

Attrition of memory CD8 T cells. Nature (2009) 0.90

Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. J Immunol (2006) 0.89

Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol (2010) 0.88

PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol (2013) 0.87

A mucosal vaccination approach for herpes simplex virus type 2. Vaccine (2010) 0.87

Anti-IFN-γ and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cells. J Immunol (2013) 0.87

A DNA vaccine prime followed by a liposome-encapsulated protein boost confers enhanced mucosal immune responses and protection. J Immunol (2008) 0.85

Blimp hovers over T cell immunity. Immunity (2009) 0.85

Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. BMC Immunol (2013) 0.85

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes (2008) 0.84

Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope. J Immunol (2004) 0.84

Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice. Mol Ther Nucleic Acids (2013) 0.83

Bi-specific MHC heterodimers for characterization of cross-reactive T cells. J Biol Chem (2010) 0.83

Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules. Stem Cell Res (2013) 0.83

Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection. J Virol (2009) 0.83

Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity. J Immunol (2009) 0.82

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. J Immunol (2009) 0.81

Salicylate prevents virus-induced type 1 diabetes in the BBDR rat. PLoS One (2013) 0.81

Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development. Methods Mol Biol (2014) 0.81

Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. J Immunol (2006) 0.81

Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death. Immunology (2013) 0.80

Systematic simulation of cross-reactivity predicts ambiguity in Tk memory: it may save lives of the infected, but limits specificities vital for further responses. Autoimmunity (2011) 0.79

Heterologous immunity and the CD8 T cell network. Springer Semin Immunopathol (2002) 0.78

T-cell activation and transplantation tolerance. Transplant Rev (Orlando) (2011) 0.78

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance. Ann N Y Acad Sci (2008) 0.76

Computer simulations of heterologous immunity: highlights of an interdisciplinary cooperation. Autoimmunity (2011) 0.75

Embedding T cells in the matrix. Nat Med (2004) 0.75