Published in Mol Biol Evol on January 01, 1996
Hitchhiking under positive Darwinian selection. Genetics (2000) 14.72
Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc Natl Acad Sci U S A (2001) 6.35
Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol (2007) 6.18
Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation. Nat Rev Genet (2009) 5.45
Benchmarking tools for the alignment of functional noncoding DNA. BMC Bioinformatics (2004) 4.00
The population genetics of the origin and divergence of the Drosophila simulans complex species. Genetics (2000) 3.78
Nature of deleterious mutation load in Drosophila. Genetics (1996) 3.62
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines. Genome Res (2009) 3.47
A genome-wide departure from the standard neutral model in natural populations of Drosophila. Genetics (2000) 3.37
Testing models of selection and demography in Drosophila simulans. Genetics (2002) 3.37
The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation. Genetics (2000) 3.24
Reduced X-linked nucleotide polymorphism in Drosophila simulans. Proc Natl Acad Sci U S A (2000) 3.13
Evolution of codon usage bias in Drosophila. Proc Natl Acad Sci U S A (1997) 3.05
DNA variability and recombination rates at X-linked loci in humans. Genetics (1998) 3.01
Inferring the fitness effects of DNA mutations from polymorphism and divergence data: statistical power to detect directional selection under stationarity and free recombination. Genetics (1999) 2.89
Natural selection and the frequency distributions of "silent" DNA polymorphism in Drosophila. Genetics (1997) 2.89
Strong selective sweep associated with a transposon insertion in Drosophila simulans. Proc Natl Acad Sci U S A (2004) 2.65
Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A (2002) 2.52
The X chromosome is a hot spot for sexually antagonistic fitness variation. Proc Biol Sci (2002) 2.43
Genomic variation in natural populations of Drosophila melanogaster. Genetics (2012) 2.33
Inferring parameters of mutation, selection and demography from patterns of synonymous site evolution in Drosophila. Genetics (2001) 2.29
Extreme genomic variation in a natural population. Proc Natl Acad Sci U S A (2007) 2.24
Nucleotide diversity and linkage disequilibrium in loblolly pine. Proc Natl Acad Sci U S A (2004) 2.23
Genetic variation in the zebrafish. Genome Res (2006) 2.22
The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces. Genetics (2000) 2.11
The HKA test revisited: a maximum-likelihood-ratio test of the standard neutral model. Genetics (2004) 2.08
Molecular population genetics of male accessory gland proteins in Drosophila. Genetics (2000) 2.02
Patterns of DNA variability at X-linked loci in Mus domesticus. Genetics (1997) 2.01
Speciation and domestication in maize and its wild relatives: evidence from the globulin-1 gene. Genetics (1998) 1.97
Population, evolutionary and genomic consequences of interference selection. Genetics (2002) 1.97
Heterozygosity, heteromorphy, and phylogenetic trees in asexual eukaryotes. Genetics (1996) 1.97
EMS-induced polygenic mutation rates for nine quantitative characters in Drosophila melanogaster. Genetics (1998) 1.95
Neutral substitutions occur at a faster rate in exons than in noncoding DNA in primate genomes. Genome Res (2003) 1.94
Nucleotide polymorphism and linkage disequilibrium within and among natural populations of European aspen (Populus tremula L., Salicaceae). Genetics (2004) 1.92
Nucleotide variation at the CHALCONE ISOMERASE locus in Arabidopsis thaliana. Genetics (2000) 1.85
Molecular population genetics of the Arabidopsis CAULIFLOWER regulatory gene: nonneutral evolution and naturally occurring variation in floral homeotic function. Proc Natl Acad Sci U S A (1998) 1.82
Recombination and gene flux caused by gene conversion and crossing over in inversion heterokaryotypes. Genetics (1997) 1.79
Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans. Genetics (2000) 1.78
Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila. Genome Res (2004) 1.78
Microsatellite variation and recombination rate in the human genome. Genetics (2000) 1.71
Codon usage in twelve species of Drosophila. BMC Evol Biol (2007) 1.70
DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure. Genetics (2001) 1.64
Single nucleotide polymorphism markers for genetic mapping in Drosophila melanogaster. Genome Res (2001) 1.63
Nucleotide variation and conservation at the dpp locus, a gene controlling early development in Drosophila. Genetics (1997) 1.60
Genetic diversity in Leavenworthia populations with different inbreeding levels. Proc Biol Sci (1998) 1.58
Lack of nucleotide polymorphism in the Y-linked sperm flagellar dynein gene Dhc-Yh3 of Drosophila melanogaster and D. simulans. Genetics (1999) 1.56
The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Genetics (2005) 1.56
Muller's ratchet and the pattern of variation at a neutral locus. Genetics (2002) 1.54
Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation. Genetics (2004) 1.53
Historical selection, amino acid polymorphism and lineage-specific divergence at the G6pd locus in Drosophila melanogaster and D. simulans. Genetics (1996) 1.52
Contrasting patterns of nonneutral evolution in proteins encoded in nuclear and mitochondrial genomes. Genetics (2000) 1.52
An adaptive hypothesis for the evolution of the Y chromosome. Genetics (1998) 1.52
Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster. Genetics (1996) 1.51
Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. Genetics (2001) 1.50
Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture. Genetics (1999) 1.49
Population genetics of Caenorhabditis elegans: the paradox of low polymorphism in a widespread species. Genetics (2003) 1.49
A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence. Genome Res (2012) 1.48
Positive and negative selection on noncoding DNA in Drosophila simulans. Mol Biol Evol (2008) 1.47
The effect of mating system differences on nucleotide diversity at the phosphoglucose isomerase locus in the plant genus Leavenworthia. Genetics (1999) 1.47
Effect of inversion polymorphism on the neutral nucleotide variability of linked chromosomal regions in Drosophila. Genetics (2000) 1.46
Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster. Genetics (2001) 1.46
DNA variation in the basic chitinase locus (ChiB) region of the wild plant Arabidopsis thaliana. Genetics (1999) 1.45
Estimating divergence parameters with small samples from a large number of loci. Genetics (2009) 1.45
DNA polymorphism, haplotype structure and balancing selection in the Leavenworthia PgiC locus. Genetics (1999) 1.44
Contrasting patterns of nucleotide sequence variation at the glucose dehydrogenase (Gld) locus in different populations of Drosophila melanogaster. Genetics (1997) 1.44
Detecting the footprint of positive selection in a european population of Drosophila melanogaster: multilocus pattern of variation and distance to coding regions. Genetics (2004) 1.42
Nucleotide diversity and linkage disequilibrium in cold-hardiness- and wood quality-related candidate genes in Douglas fir. Genetics (2005) 1.41
Molecular population genetics and evolution of Drosophila meiosis genes. Genetics (2008) 1.41
DNA sequence variation and the recombinational landscape in Drosophila pseudoobscura: a study of the second chromosome. Genetics (1999) 1.40
DNA polymorphism at the cytosolic phosphoglucose isomerase (PgiC) locus of the wild plant Arabidopsis thaliana. Genetics (2000) 1.39
Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans. Genetics (2002) 1.35
Identification and analysis of single nucleotide polymorphisms (SNPs) in the mosquito Anopheles funestus, malaria vector. BMC Genomics (2007) 1.34
Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans. Genetics (2005) 1.34
Standard and generalized McDonald-Kreitman test: a website to detect selection by comparing different classes of DNA sites. Nucleic Acids Res (2008) 1.34
Haldane's rule and X-chromosome size in Drosophila. Genetics (1997) 1.34
The evolutionary analysis of "orphans" from the Drosophila genome identifies rapidly diverging and incorrectly annotated genes. Genetics (2001) 1.32
Genomic variation and its impact on gene expression in Drosophila melanogaster. PLoS Genet (2012) 1.31
Recombination and speciation: loci near centromeres are more differentiated than loci near telomeres between subspecies of the European rabbit (Oryctolagus cuniculus). Genetics (2008) 1.30
SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system. BMC Genomics (2008) 1.28
Background selection in single genes may explain patterns of codon bias. Genetics (2006) 1.28
Decoding of superimposed traces produced by direct sequencing of heterozygous indels. PLoS Comput Biol (2008) 1.27
Quantifying the variation in the effective population size within a genome. Genetics (2011) 1.23
Molecular variation at the In(2L)t proximal breakpoint site in natural populations of Drosophila melanogaster and D. simulans. Genetics (2000) 1.22
A new strategy for genome assembly using short sequence reads and reduced representation libraries. Genome Res (2010) 1.22
Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein. Genetics (2000) 1.22
Adaptive evolution of a candidate gene for aging in Drosophila. Proc Natl Acad Sci U S A (2000) 1.21
Reduced recombination rate and genetic differentiation between the M and S forms of Anopheles gambiae s.s. Genetics (2006) 1.20
From DNA to fitness differences: sequences and structures of adaptive variants of Colias phosphoglucose isomerase (PGI). Mol Biol Evol (2005) 1.18
Genetic variation and differentiation at microsatellite loci in Drosophila simulans. Evidence for founder effects in new world populations. Genetics (1998) 1.17
Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species. Genome Biol Evol (2010) 1.14
Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family. Genetics (2013) 1.13
Nucleotide polymorphism and natural selection at the pantophysin (Pan I) locus in the Atlantic cod, Gadus morhua (L.). Genetics (2001) 1.13
The evolution of antifungal peptides in Drosophila. Genetics (2005) 1.13
A selective sweep associated with a recent gene transposition in Drosophila miranda. Genetics (2000) 1.12
DNA variability and divergence at the notch locus in Drosophila melanogaster and D. simulans: a case of accelerated synonymous site divergence. Genetics (2004) 1.12
Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism. Genetics (1999) 1.11
Contrasted polymorphism patterns in a large sample of populations from the evolutionary genetics model Drosophila simulans. Genetics (2006) 1.10
No evidence for an association between common nonsynonymous polymorphisms in delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster. Genetics (2004) 1.10
Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster. Genome Res (2012) 1.09
Nuclear gene genealogies reveal historical, demographic and selective factors associated with speciation in field crickets. Genetics (2003) 1.09
Enzyme variability in the Drosophila willistoni group. IV. Genic variation in natural populations of Drosophila willistoni. Genetics (1972) 9.38
Polymorphisms in continental and island populations of Drosophila willistoni. Proc Natl Acad Sci U S A (1971) 6.28
The objective evaluation of dysmenorrhea therapy. Am J Obstet Gynecol (1980) 4.38
Interspecific cytoplasmic gene flow in the absence of nuclear gene flow: evidence from Drosophila. Proc Natl Acad Sci U S A (1983) 2.95
Codon usage bias and tRNA abundance in Drosophila. J Mol Evol (1997) 2.77
Speciation within Anopheles gambiae--the glass is half full. Science (2002) 2.41
Evidence for selection by male mating success in natural populations of Drosophila pseudoobscura. Proc Natl Acad Sci U S A (1979) 2.38
Gene length and codon usage bias in Drosophila melanogaster, Saccharomyces cerevisiae and Escherichia coli. Nucleic Acids Res (1998) 2.37
Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia. Am Rev Respir Dis (1978) 2.28
Inhibition of theophylline clearance by cimetidine but not ranitidine. Arch Intern Med (1984) 2.17
Analysis of bacterial function by multi-colour fluorescence flow cytometry and single cell sorting. J Microbiol Methods (2000) 2.13
Rates and patterns of scnDNA and mtDNA divergence within the Drosophila melanogaster subgroup. Genetics (1988) 2.06
Genetic polymorphisms in varied environments. Science (1971) 2.04
Attempts to molecularly distinguish cryptic taxa in Anopheles gambiae s.s. Insect Mol Biol (2001) 2.02
Temperature related genetic divergence in Drosophila body size. J Hered (1974) 1.94
Enzyme variability in the Drosophila Willistoni group. V. Genic variation in natural populations of Drosophila equinoxialis. Genet Res (1972) 1.92
Allozymes as diagnostic characters of sibling species of Drosophila. Proc Natl Acad Sci U S A (1972) 1.75
Inadequately written prescriptions. "As directed" prescriptions analyzed. JAMA (1973) 1.71
Selective introgression of paracentric inversions between two sibling species of the Anopheles gambiae complex. Genetics (1997) 1.70
Impact of pharmacometric reviews on new drug approval and labeling decisions--a survey of 31 new drug applications submitted between 2005 and 2006. Clin Pharmacol Ther (2007) 1.70
Genetics and the origin of a vector population: Aedes aegypti, a case study. Science (1980) 1.67
Evidence of heterosis associated with an enzyme locus in a natural population of Drosophila. Proc Natl Acad Sci U S A (1970) 1.64
Oral infection of Aedes aegypti with yellow fever virus: geographic variation and genetic considerations. Am J Trop Med Hyg (1985) 1.58
Apparent selection of enzyme alleles in laboratory populations of Drosophila. Genetics (1973) 1.54
Codon usage and the origin of P elements. Mol Biol Evol (1996) 1.52
Molecular phylogeny of the Anopheles gambiae complex suggests genetic introgression between principal malaria vectors. Proc Natl Acad Sci U S A (1994) 1.48
A world-wide survey of genetic variation in the yellow fever mosquito, Aedes aegypti. Genet Res (1979) 1.47
Identification and specific blockade of two receptors for histamine in the cardiovascular system. J Pharmacol Exp Ther (1976) 1.47
The genetics of inviability and male sterility in hybrids between Anopheles gambiae and An. arabiensis. Genetics (2004) 1.42
Inbreeding and mating patterns in Drosophila pseudoobscura. Behav Genet (1979) 1.34
Enzyme variability in the Drosophila willistoni group. VI. Levels of polymorphism and the physiological function of enzymes. Biochem Genet (1972) 1.34
Microgeographic differentiation of chromosomal and enzyme polymorphisms in Drosophila persimilis. Genetics (1977) 1.31
Evolution of the mitochondrial DNA control region in the Anopheles gambiae complex. Insect Mol Biol (1996) 1.31
Flounder effects and linkage disequilibria in experimental populations of Drosophila. Proc Natl Acad Sci U S A (1974) 1.31
Synonymous substitution rates in Drosophila: mitochondrial versus nuclear genes. J Mol Evol (1997) 1.30
Population genetics of Drosophila amylase. I. Genetic control of tissue-specific expression in D. pseudoobscura. Genetics (1979) 1.27
Human plasminogen. Methods Enzymol (1981) 1.26
Rates of nucleotide substitution in Drosophila mitochondrial DNA and nuclear DNA are similar. Proc Natl Acad Sci U S A (1986) 1.24
The influence of cigarette smoking and sex on theophylline disposition. Am Rev Respir Dis (1977) 1.21
Phylogeny of all major groups of cetaceans based on DNA sequences from three mitochondrial genes. Mol Biol Evol (1994) 1.20
Origin and evolutionary relationships of giant Galápagos tortoises. Proc Natl Acad Sci U S A (1999) 1.20
Cimetidine decreases theophylline clearance. Am Rev Respir Dis (1981) 1.19
Inversion monophyly in African anopheline malaria vectors. Genetics (1996) 1.15
Mitochondrial DNA rates and biogeography in European newts (genus Euproctus). Syst Biol (1997) 1.14
Intraindividual variability in theophylline pharmacokinetics: statistical verification in 39 of 60 healthy young adults. J Pharmacokinet Biopharm (1982) 1.14
Reassociation kinetics of Anopheles gambiae (Diptera: Culicidae) DNA. J Med Entomol (1992) 1.14
Immunological characteristics of a synthetic peptide associated with a catalytic domain of mutans streptococcal glucosyltransferase. Infect Immun (1994) 1.14
Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila. EMBO J (1990) 1.13
Multiple origins of cytologically identical chromosome inversions in the Anopheles gambiae complex. Genetics (1998) 1.12
Population genetics of Drosophila amylase. IV. Selection in laboratory populations maintained on different carbohydrates. Genetics (1983) 1.11
Population genetics of Drosophila amylase. II. Geographic patterns in D. pseudoobscura. Genetics (1979) 1.11
A molecular phylogeny for the Drosophila melanogaster subgroup and the problem of polymorphism data. Mol Biol Evol (1996) 1.10
Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers. Clin Pharmacol Ther (1992) 1.09
Rates of dispersal of Drosophila pseudoobscura and its relatives. Proc R Soc Lond B Biol Sci (1974) 1.07
Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. Am J Clin Nutr (2001) 1.06
Histamine H2-antagonist drug interactions in perspective: mechanistic concepts and clinical implications. Am J Med (1984) 1.06
Mechanism of the vasodilatory effect of carvedilol in normal volunteers: a comparison with labetalol. J Cardiovasc Pharmacol (1987) 1.05
Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J Nutr (2001) 1.05
Extreme rates and heterogeneity in insect DNA evolution. J Mol Evol (1990) 1.03
Isoproterenol-induced cardiac hypertrophy: modifications in characteristics of beta-adrenergic receptor, adenylate cyclase, and ventricular contraction. Endocrinology (1979) 1.01
A molecular phylogeny of four endangered Madagascar tortoises based on MtDNA sequences. Mol Phylogenet Evol (1999) 1.00
Clinical pharmacology of carvedilol in normal volunteers. Clin Pharmacol Ther (1987) 0.98
Genetics of natural populations, XLIII. Further studies on rates of dispersal of Drosophila pseudoobscura and its relatives. Genetics (1976) 0.98
Phylogeny of species of Triatoma (Hemiptera: Reduviidae) based on mitochondrial DNA sequences. J Med Entomol (1998) 0.97
Macrogeographic genetic variation in a human commensal: Aedes aegypti, the yellow fever mosquito. Genet Res (1983) 0.96
Venous irritation related to intravenous administration of phenytoin versus fosphenytoin. Pharmacotherapy (1994) 0.95
Intraspecific DNA divergence in Drosophila: a study on parthenogenetic D. mercatorum. Mol Biol Evol (1987) 0.95
LV and myocyte structure and function after early recovery from tachycardia-induced cardiomyopathy. Am J Physiol (1995) 0.95
Monophyly/paraphyly/polyphyly and gene/species trees: an example from Drosophila. Mol Biol Evol (1991) 0.94
Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin Sci (Lond) (2001) 0.94
Therapeutic problems of ulcerative colitis with hyperthyroidism. Am J Gastroenterol (1968) 0.93
Impact of population pharmacokinetic-pharmacodynamic analyses on the drug development process: experience at Parke-Davis. Clin Pharmacokinet (2000) 0.93
Higher level relationships of the arctoid Carnivora based on sequence data and "total evidence". Mol Phylogenet Evol (1994) 0.93
Evolution of the Adh locus in the Drosophila willistoni group: the loss of an intron, and shift in codon usage. Mol Biol Evol (1993) 0.93
Calibration of the change in thermal stability of DNA duplexes and degree of base pair mismatch. J Mol Evol (1988) 0.92
Heterosis at an enzyme locus of Drosophila: evidence from experimental populations. Heredity (Edinb) (1974) 0.92
Compositional divergence and convergence in arbuscular mycorrhizal fungal communities. Ecology (2012) 0.91
Influence of allopurinol on theophylline disposition in adults. Clin Pharmacol Ther (1980) 0.91
Pharmacokinetics of ondansetron in patients with hepatic insufficiency. J Clin Pharmacol (1996) 0.90
The pharmacokinetic basis for H2-antagonist drug interactions: concepts and implications. J Clin Gastroenterol (1983) 0.90
Comparison of quantitative methods to assess hepatic function: Pugh's classification, indocyanine green, antipyrine, and dextromethorphan. Pharmacotherapy (1996) 0.90
Interspecific and intraspecific comparisons of the period locus in the Drosophila willistoni sibling species. Mol Biol Evol (1997) 0.89
More on heparin lock. N Engl J Med (1977) 0.89
Characterization of vascular histamine receptors in the rat. Br J Pharmacol (1979) 0.88
Prolonged vitamin C supplementation and recovery from demanding exercise. Int J Sport Nutr Exerc Metab (2001) 0.88
Concordance of arthritis and iritis in identical twins with ulcerative colitis. J Natl Med Assoc (1974) 0.88
Evaluation of the absorption from 15 commercial theophylline products indicating deficiencies in currently applied bioavailability criteria. J Pharmacokinet Biopharm (1980) 0.88
Activation of human neo-plasminogen-Val442 by urokinase and streptokinase and a kinetic characterization of neoplasmin-Val442. J Biol Chem (1980) 0.87
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo. Toxicon (1997) 0.87
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines. J Med Chem (1988) 0.87
Carotid sinus reflex coronary vasoconstriction during controlled myocardial oxygen metabolism in the dog. Circ Res (1979) 0.87
Effects of histamine on vascular sympathetic neuroeffector transmission. J Pharmacol Exp Ther (1979) 0.87
The existence of independent domain structures in human Lys77-plasminogen. J Biol Chem (1981) 0.87
Long-distance genome walking using the long and accurate polymerase chain reaction. Biotechniques (1998) 0.86
Complementary DNA-DNA hybridization in Drosophila. J Mol Evol (1992) 0.86
Antihypertensive effects of a novel endothelin-A receptor antagonist in rats. Hypertension (1995) 0.85
Antioxidants may contribute in the fight against ageing: an in vitro model. Mech Ageing Dev (2000) 0.85
Genetic structure of the East African domestic populations of Aedes aegypti. Nature (1978) 0.85