Published in Chin Med J (Engl) on November 01, 1995
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res (2008) 52.43
The Ensembl genome database project. Nucleic Acids Res (2002) 40.87
Gene-expression profiles in hereditary breast cancer. N Engl J Med (2001) 29.80
Ensembl 2009. Nucleic Acids Res (2008) 25.38
The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis. Nucleic Acids Res (2005) 24.85
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Ensembl 2008. Nucleic Acids Res (2007) 20.67
A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42
Ensembl 2007. Nucleic Acids Res (2006) 20.10
The Ribosomal Database Project (RDP-II): previewing a new autoaligner that allows regular updates and the new prokaryotic taxonomy. Nucleic Acids Res (2003) 18.64
The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data. Nucleic Acids Res (2006) 16.26
Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet (1996) 15.73
Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature (2000) 15.53
Ensembl 2005. Nucleic Acids Res (2005) 15.13
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35
Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26
Ensembl 2004. Nucleic Acids Res (2004) 11.88
Ensembl 2006. Nucleic Acids Res (2006) 11.66
Expression profiling using cDNA microarrays. Nat Genet (1999) 11.58
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature (1999) 10.97
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Data management and analysis for gene expression arrays. Nat Genet (1998) 8.60
Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res (2001) 8.34
Ratio-based decisions and the quantitative analysis of cDNA microarray images. J Biomed Opt (1997) 8.32
Effect of computer-based alerts on the treatment and outcomes of hospitalized patients. Arch Intern Med (1994) 8.20
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature (1998) 7.26
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (1999) 5.95
Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature (1999) 5.77
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature (1988) 5.60
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (1997) 5.45
Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet (1998) 5.35
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34
Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 5.20
A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet (2001) 5.06
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 5.04
ABFs, a family of ABA-responsive element binding factors. J Biol Chem (2000) 4.98
Cross-bridge model of muscle contraction. Quantitative analysis. Biophys J (1980) 4.91
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74
Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res (1998) 4.68
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature (2000) 4.66
Gene therapy vectors based on adeno-associated virus type 1. J Virol (1999) 4.63
Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling. Cancer Res (2001) 4.51
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet (2001) 4.48
Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle. Am J Physiol (1996) 4.44
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med (1988) 4.31
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development (1999) 4.21
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol (1988) 4.20
Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology (1998) 4.13
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science (1994) 3.96
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem (2000) 3.90
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Res (2000) 3.83
A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1. J Virol (1998) 3.65
Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study. Proc Natl Acad Sci U S A (1984) 3.63
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A (2003) 3.53
Mammalian AMP-activated protein kinase subfamily. J Biol Chem (1996) 3.47
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science (1999) 3.47
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res (1999) 3.40
Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature (1996) 3.37
Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev (1996) 3.32
Cooperative effects in models of steady-state transport across membranes. 3. Simulation of potassium ion transport in nerve. Proc Natl Acad Sci U S A (1970) 3.30
The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res (2001) 3.30
Mechanism of the cardiotoxic actions of terfenadine. JAMA (1993) 3.27
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci U S A (1998) 3.27
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science (1998) 3.26
Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae. Mol Biol Cell (1996) 3.23
Identification of intact peanut lectin in peripheral venous blood. Lancet (1998) 3.11
Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol (2000) 3.08
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol (1993) 3.07
A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA (2000) 3.06
Scanning two-photon fluctuation correlation spectroscopy: particle counting measurements for detection of molecular aggregation. Biophys J (1996) 3.04
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res (2000) 3.01
The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci (1995) 2.99
An SNP map of human chromosome 22. Nature (2000) 2.99
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun (2001) 2.98
IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol (1998) 2.97
Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection. Am J Med (1993) 2.96
Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene (2008) 2.94
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc Natl Acad Sci U S A (1998) 2.92
Comparison of the ABI 7700 system (TaqMan) and competitive PCR for quantification of IS6110 DNA in sputum during treatment of tuberculosis. J Clin Microbiol (1998) 2.91
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet (1996) 2.87
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation. Science (1995) 2.87
Phase changes at the end of a microtubule with a GTP cap. Proc Natl Acad Sci U S A (1984) 2.87
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci U S A (1998) 2.85
Structural and magnetic phase diagram of CeFeAsO(1- x)F(x) and its relation to high-temperature superconductivity. Nat Mater (2008) 2.83
Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin. J Am Acad Dermatol (2001) 2.80