Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.

PubWeight™: 2.32‹?› | Rank: Top 2%

🔗 View Article (PMID 8598040)

Published in Cell on February 23, 1996

Authors

T Miyazaki1, P Wolf, S Tourne, C Waltzinger, A Dierich, N Barois, H Ploegh, C Benoist, D Mathis

Author Affiliations

1: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite Louis Pasteur, France.

Articles citing this

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med (2001) 3.47

Pathways of antigen processing. Annu Rev Immunol (2013) 2.82

Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75

Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? J Exp Med (2000) 2.55

Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31

CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J Exp Med (1999) 2.04

How many thymocytes audition for selection? J Exp Med (1997) 1.90

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol (2009) 1.78

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med (1996) 1.77

Quantitative impact of thymic clonal deletion on the T cell repertoire. J Exp Med (1997) 1.64

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol (1999) 1.58

Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta. Mol Cell Biol (1999) 1.50

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med (2000) 1.49

Murine cytomegalovirus inhibits interferon gamma-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. J Exp Med (1998) 1.49

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J (1997) 1.47

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest (2017) 1.41

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Nat Immunol (2006) 1.41

Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J Clin Invest (2001) 1.36

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J Exp Med (1999) 1.36

Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes. J Cell Biol (1997) 1.30

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med (2002) 1.27

Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med (1997) 1.25

Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell (2012) 1.21

Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J Immunol (2010) 1.18

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J Exp Med (1996) 1.17

CD8 lineage commitment in the absence of CD8. Immunity (1997) 1.16

Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J Immunol (2009) 1.14

Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. Glycobiology (2008) 1.14

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. EMBO J (1998) 1.13

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest (2010) 1.13

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J Exp Med (2000) 1.07

Selection of antigen-specific T cells by a single IEk peptide combination. J Exp Med (1997) 1.04

An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations. J Immunol (2011) 1.04

Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH. Proc Natl Acad Sci U S A (1997) 1.02

Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background. J Exp Med (1997) 1.01

Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development. J Exp Med (2002) 1.00

Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. BMC Evol Biol (2013) 0.97

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes. Expert Rev Mol Med (2012) 0.95

MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes. Exp Mol Pathol (2008) 0.95

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. Proc Natl Acad Sci U S A (1997) 0.94

Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc Natl Acad Sci U S A (1998) 0.94

Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med (1998) 0.94

A T cell receptor-specific blockade of positive selection. J Exp Med (1999) 0.93

Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules. PLoS Pathog (2007) 0.93

Negative selection of thymocytes expressing the D10 TCR. Proc Natl Acad Sci U S A (2002) 0.92

Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance. J Clin Invest (2003) 0.92

T cell receptor specificity for major histocompatibility complex proteins. Curr Opin Immunol (2008) 0.92

Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex. J Exp Med (1998) 0.92

DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms. Immunology (2010) 0.91

HLA-DO and Its Role in MHC Class II Antigen Presentation. Front Immunol (2013) 0.90

Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells. Hum Immunol (2009) 0.90

Functional HLA-DM on the surface of B cells and immature dendritic cells. EMBO J (2000) 0.90

The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice. PLoS One (2013) 0.87

Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain. J Exp Med (1998) 0.86

T cell immunodominance is dictated by the positively selecting self-peptide. Elife (2014) 0.86

Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A (2012) 0.85

The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol (2009) 0.84

H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med (2000) 0.84

HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation. PLoS One (2013) 0.84

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer (2000) 0.84

An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J Immunol (2008) 0.82

Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. EMBO J (2000) 0.81

Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage. J Exp Med (1998) 0.81

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4. J Exp Med (2005) 0.81

Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc Natl Acad Sci U S A (2002) 0.81

Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. J Immunol (2015) 0.81

Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading. Methods Mol Biol (2013) 0.81

Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. Proc Natl Acad Sci U S A (2000) 0.81

Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains. Mol Immunol (2008) 0.80

Nitric oxide inhibits INFgamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes--class II MHC, Ii and H-2M. Class II TransActivator. Inflammation (2000) 0.79

Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide. Proc Natl Acad Sci U S A (2001) 0.77

Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection. Infect Immun (2015) 0.77

Disruption of multivesicular body vesicles does not affect major histocompatibility complex (MHC) class II-peptide complex formation and antigen presentation by dendritic cells. J Biol Chem (2013) 0.76

Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection. Proc Natl Acad Sci U S A (2003) 0.75

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases. Open Biol (2016) 0.75

On the issue of peptide recognition in T cell development. Self Nonself (2010) 0.75

Spontaneous proliferation of H2M-/- CD4 T cells results in unusual acute hepatocellular necrosis. PLoS One (2014) 0.75

Inflammatory and anti-inflammatory states of adipose tissue in transgenic mice bearing a single T-cell receptor. Int Immunol (2017) 0.75

Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity (2017) 0.75

Articles by these authors

In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00

The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82

Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34

Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A (1980) 7.77

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature (1996) 7.15

Following a diabetogenic T cell from genesis through pathogenesis. Cell (1993) 6.46

Organ-specific disease provoked by systemic autoimmunity. Cell (1996) 6.44

A multiplicity of CCAAT box-binding proteins. Cell (1987) 6.37

Mice lacking MHC class II molecules. Cell (1991) 6.25

Herpes simplex virus turns off the TAP to evade host immunity. Nature (1995) 5.93

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science (1996) 5.55

Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A (1981) 5.38

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity (1999) 5.38

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24

Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development (2000) 5.03

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science (1999) 4.97

beta-Cell death during progression to diabetes. Nature (2001) 4.61

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98

T helper cell subsets in insulin-dependent diabetes. Science (1995) 3.92

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med (1999) 3.85

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med (1998) 3.70

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu Rev Immunol (1990) 3.68

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature (1984) 3.68

The dendritic cell populations of mouse lymph nodes. J Immunol (2001) 3.57

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol (2001) 3.53

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell (1991) 3.53

Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet (1996) 3.42

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell (1989) 3.29

Superantigens interact with MHC class II molecules outside of the antigen groove. Cell (1990) 3.20

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet (2000) 3.10

Structure of transcribing chromatin. Prog Nucleic Acid Res Mol Biol (1980) 3.09

Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development (1994) 2.98

The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron (1998) 2.87

Another view of the selective model of thymocyte selection. Cell (1993) 2.85

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J (1991) 2.84

The nature and significance of platelet products in human plasma. Br J Haematol (1967) 2.84

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A (1983) 2.84

Function of retinoic acid receptor gamma in the mouse. Cell (1993) 2.83

Distinct functions of the two isoforms of dopamine D2 receptors. Nature (2000) 2.83

Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A (1999) 2.83

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A (1997) 2.81

Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet (2001) 2.79

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A (1993) 2.78

Generation, translocation, and presentation of MHC class I-restricted peptides. Annu Rev Biochem (1995) 2.76

Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature (1996) 2.74

Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis. Br J Dermatol (2013) 2.70

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med (1995) 2.70

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A (1987) 2.55

Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A (1996) 2.53

Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J (1990) 2.49

Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science (1993) 2.42

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity (1997) 2.38

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature (1995) 2.37

Cassette vectors directing expression of T cell receptor genes in transgenic mice. J Immunol Methods (1995) 2.37

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest (1999) 2.34

Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science (1994) 2.32

Mice lacking the MHC class II-associated invariant chain. Cell (1993) 2.30

Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Mol Cell (2000) 2.29

Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am J Hum Genet (2000) 2.21

How much TCR does a T cell need? Immunity (2001) 2.18

Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev (1996) 2.17

Frequency and therapeutic implications of "skip metastases" in the neck from squamous carcinoma of the oral tongue. Head Neck (1997) 2.16

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene. EMBO J (2001) 2.11

Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides. Nature (1984) 2.10

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell (1993) 2.09

Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development (2000) 2.09

Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy. Hum Mol Genet (2000) 2.09