Published in Development on October 01, 2000
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight. Nat Rev Cancer (2013) 2.60
Vascular actions of estrogens: functional implications. Pharmacol Rev (2008) 2.52
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2007) 2.32
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors. Neuron (2010) 2.26
Hormone action in the mammary gland. Cold Spring Harb Perspect Biol (2010) 2.10
The blood-testis barrier and its implications for male contraception. Pharmacol Rev (2011) 2.10
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J (2008) 1.96
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest (2010) 1.90
Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A (2003) 1.87
Nonclassical estrogen receptor alpha signaling mediates negative feedback in the female mouse reproductive axis. Proc Natl Acad Sci U S A (2007) 1.86
FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest (2003) 1.84
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A (2007) 1.82
Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS One (2008) 1.81
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest (2011) 1.81
17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol (2005) 1.80
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol (2010) 1.79
Estrogen in the adult male reproductive tract: a review. Reprod Biol Endocrinol (2003) 1.77
Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A (2011) 1.68
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67
Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci U S A (2002) 1.63
Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice. Proc Natl Acad Sci U S A (2001) 1.62
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest (2011) 1.55
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A (2004) 1.51
Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A (2004) 1.51
Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant. Proc Natl Acad Sci U S A (2008) 1.51
The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology (2006) 1.48
The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids (2007) 1.46
Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem (2008) 1.44
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J (2010) 1.42
The role of estrogen receptor α and β in regulating vascular smooth muscle cell proliferation is based on sex. J Surg Res (2011) 1.41
Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Mol Endocrinol (2010) 1.40
A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest (2003) 1.40
Sex hormones establish a reserve pool of adult muscle stem cells. Nat Cell Biol (2016) 1.39
The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc Natl Acad Sci U S A (2002) 1.38
Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annu Rev Cell Dev Biol (2009) 1.36
The role of steroids in follicular growth. Reprod Biol Endocrinol (2006) 1.36
Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol (2005) 1.35
Membrane-initiated estrogen signaling in hypothalamic neurons. Mol Cell Endocrinol (2008) 1.31
New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock-out and knock-in mice. Mol Cell Endocrinol (2008) 1.28
Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Diabetes (2012) 1.28
Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol (2006) 1.28
G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology (2008) 1.27
Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer (2010) 1.26
Sex steroid actions in male bone. Endocr Rev (2014) 1.26
Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res (2010) 1.25
Oestrogens and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.23
Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J Bone Miner Res (2005) 1.23
The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A (2009) 1.23
Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing. Endocrinology (2008) 1.22
Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res (2013) 1.22
G protein-coupled receptor 30: estrogen receptor or collaborator? Endocrinology (2009) 1.22
Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1). Biol Reprod (2009) 1.21
Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions. Proc Natl Acad Sci U S A (2013) 1.21
Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol Cell Endocrinol (2008) 1.19
Rapid signaling by steroid receptors. Am J Physiol Regul Integr Comp Physiol (2008) 1.18
Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone. Proc Natl Acad Sci U S A (2011) 1.17
Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Environ Health Perspect (2012) 1.16
Rapid recruitment of temporally distinct vascular gene sets by estrogen. Mol Endocrinol (2008) 1.16
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
Estrogen receptor beta protects against acoustic trauma in mice. J Clin Invest (2008) 1.16
Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Rep (2014) 1.15
Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology (2012) 1.13
Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females. Endocrinology (2007) 1.13
Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.12
Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci (2013) 1.12
Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β. J Biol Chem (2013) 1.11
Low-dose BPA exposure alters the mesenchymal and epithelial transcriptomes of the mouse fetal mammary gland. PLoS One (2013) 1.11
Trophoblast-uterine interactions at implantation. Reprod Biol Endocrinol (2004) 1.07
The pathway to femaleness: current knowledge on embryonic development of the ovary. Mol Cell Endocrinol (2005) 1.07
Estrogen, efferent ductules, and the epididymis. Biol Reprod (2010) 1.07
STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantation. Mol Endocrinol (2013) 1.06
Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. Mol Cell Biochem (2008) 1.06
Multiple ERbeta antisera label in ERbeta knockout and null mouse tissues. J Neurosci Methods (2010) 1.05
Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis (2008) 1.04
Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliv Rev (2010) 1.02
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis (2009) 1.02
Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. J Clin Invest (2006) 1.01
Impact of isotype-selective estrogen receptor agonists on ovarian function. Proc Natl Acad Sci U S A (2004) 1.01
Derailed estrogen signaling and breast cancer: an authentic couple. Endocr Rev (2012) 1.01
Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med (2010) 1.01
Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology (2008) 1.01
Estrogenic regulation of the GnRH neuron. Front Endocrinol (Lausanne) (2012) 1.00
Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance. Reproduction (2009) 1.00
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J (2015) 1.00
Insights into rapid modulation of neuroplasticity by brain estrogens. Pharmacol Rev (2013) 0.99
Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function. PLoS One (2012) 0.99
Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism. Toxicol Sci (2009) 0.99
Control of CNS neuronal excitability by estrogens via membrane-initiated signaling. Mol Cell Endocrinol (2009) 0.99
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Sci Transl Med (2015) 0.99
Sex hormones and their receptors in bone homeostasis: insights from genetically modified mouse models. Osteoporos Int (2009) 0.98
GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription. Mol Endocrinol (2011) 0.98
Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A (2011) 0.96
Hormonal regulation of female reproduction. Horm Metab Res (2012) 0.96
Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation. Cancer Res (2010) 0.96
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