Published in Science on April 05, 1996
Norwalk virus open reading frame 3 encodes a minor structural protein. J Virol (2000) 2.96
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut (2003) 2.37
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Rotaviruses: from pathogenesis to vaccination. Gastroenterology (2009) 2.05
Pathogenesis of intestinal and systemic rotavirus infection. J Virol (2004) 1.84
The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production. Proc Natl Acad Sci U S A (1997) 1.78
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J (2010) 1.71
Trypsin cleavage stabilizes the rotavirus VP4 spike. J Virol (2001) 1.68
Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol (2002) 1.67
Full genomic analysis of human rotavirus strain B4106 and lapine rotavirus strain 30/96 provides evidence for interspecies transmission. J Virol (2006) 1.61
Immunology of gut mucosal vaccines. Immunol Rev (2011) 1.59
Rotavirus vaccines: an overview. Clin Microbiol Rev (2008) 1.58
Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A (2005) 1.56
Silencing the morphogenesis of rotavirus. J Virol (2005) 1.55
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia. Proc Natl Acad Sci U S A (2000) 1.54
Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol (2006) 1.49
Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? Pflugers Arch (2007) 1.47
Gene expression pattern in Caco-2 cells following rotavirus infection. J Virol (2002) 1.46
Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol (2006) 1.43
Whole genome sequence and phylogenetic analyses reveal human rotavirus G3P[3] strains Ro1845 and HCR3A are examples of direct virion transmission of canine/feline rotaviruses to humans. Virology (2008) 1.43
Rotavirus antigenemia in children is associated with viremia. PLoS Med (2007) 1.42
Characterization of G10P[11] rotaviruses causing acute gastroenteritis in neonates and infants in Vellore, India. J Clin Microbiol (2004) 1.41
The rotavirus nonstructural glycoprotein NSP4 possesses membrane destabilization activity. J Virol (1996) 1.38
A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells. J Virol (2000) 1.37
BiP (GRP78) and endoplasmin (GRP94) are induced following rotavirus infection and bind transiently to an endoplasmic reticulum-localized virion component. J Virol (1998) 1.36
Rotavirus infection induces an increase in intracellular calcium concentration in human intestinal epithelial cells: role in microvillar actin alteration. J Virol (2000) 1.34
Viral calciomics: interplays between Ca2+ and virus. Cell Calcium (2009) 1.33
Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq. J Clin Microbiol (2011) 1.33
Rotavirus infection reduces sucrase-isomaltase expression in human intestinal epithelial cells by perturbing protein targeting and organization of microvillar cytoskeleton. J Virol (1998) 1.33
Rotavirus genome segment 7 (NSP3) is a determinant of extraintestinal spread in the neonatal mouse. J Virol (2002) 1.32
Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia. J Biol Chem (2006) 1.31
Changes in small intestinal homeostasis, morphology, and gene expression during rotavirus infection of infant mice. J Virol (2003) 1.31
Anoctamins. Pflugers Arch (2011) 1.29
Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic. Appl Environ Microbiol (2001) 1.25
Controlled production of stable heterologous proteins in Lactococcus lactis. Appl Environ Microbiol (2002) 1.23
Mutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence. J Virol (1998) 1.23
Rotavirus NSP5: mapping phosphorylation sites and kinase activation and viroplasm localization domains. J Virol (2002) 1.23
A clinical perspective of necrotizing enterocolitis: past, present, and future. Clin Perinatol (2013) 1.22
NSP4 enterotoxin of rotavirus induces paracellular leakage in polarized epithelial cells. J Virol (2001) 1.22
Immune responses to rotavirus infection and vaccination and associated correlates of protection. J Infect Dis (2011) 1.20
Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains. J Virol (2001) 1.19
Characterization of serotype G9 rotavirus strains isolated in the United States and India from 1993 to 2001. J Clin Microbiol (2003) 1.19
Determinants of bluetongue virus virulence in murine models of disease. J Virol (2011) 1.18
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A (2008) 1.15
Immobilization of the early secretory pathway by a virus glycoprotein that binds to microtubules. EMBO J (2000) 1.15
Generation of a mutant infectious bursal disease virus that does not cause bursal lesions. J Virol (1998) 1.14
The genome segments of a group D rotavirus possess group A-like conserved termini but encode group-specific proteins. J Virol (2010) 1.14
Rotavirus nonstructural glycoprotein NSP4 alters plasma membrane permeability in mammalian cells. J Virol (1997) 1.14
Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science (2014) 1.12
Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein. J Virol (2006) 1.11
VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol (2002) 1.10
Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice. J Clin Microbiol (1996) 1.10
Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol (2002) 1.10
Infectious diarrhea: Cellular and molecular mechanisms. Gut Microbes (2010) 1.08
How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea? Virol J (2007) 1.08
Evidence for genetic linkage between the gene segments encoding NSP4 and VP6 proteins in common and reassortant human rotavirus strains. J Clin Microbiol (2003) 1.06
Diarrhea-inducing activity of avian rotavirus NSP4 glycoproteins, which differ greatly from mammalian rotavirus NSP4 glycoproteins in deduced amino acid sequence in suckling mice. J Virol (2002) 1.05
The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1. J Virol (2006) 1.04
New lessons for rotavirus vaccines. Science (1996) 1.03
Direct inhibitory effect of rotavirus NSP4(114-135) peptide on the Na(+)-D-glucose symporter of rabbit intestinal brush border membrane. J Virol (2000) 1.02
Focus on acute diarrhoeal disease. World J Gastroenterol (2009) 1.01
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch (2011) 1.00
Rotavirus non-structural proteins: structure and function. Curr Opin Virol (2012) 0.99
The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. Viruses (2011) 0.99
The molecular chaperone calnexin interacts with the NSP4 enterotoxin of rotavirus in vivo and in vitro. J Virol (1998) 0.98
Rotavirus nonstructural glycoprotein NSP4 is secreted from the apical surfaces of polarized epithelial cells. J Virol (2006) 0.98
Rotavirus infection induces cytoskeleton disorganization in human intestinal epithelial cells: implication of an increase in intracellular calcium concentration. J Virol (2000) 0.98
Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology (2007) 0.98
Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4. J Virol (1998) 0.98
Modification of rotavirus multiplex RT-PCR for the detection of G12 strains based on characterization of emerging G12 rotavirus strains from South India. J Med Virol (2007) 0.96
Carbohydrates facilitate correct disulfide bond formation and folding of rotavirus VP7. J Virol (1998) 0.96
Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea. Gut (2004) 0.96
Expression of nonstructural rotavirus protein NSP4 mimics Ca2+ homeostasis changes induced by rotavirus infection in cultured cells. J Virol (2008) 0.95
NSP4 gene analysis of rotaviruses recovered from infected children with and without diarrhea. J Clin Microbiol (2000) 0.95
Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut (2013) 0.95
Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene. J Virol (1997) 0.94
Full-length, glycosylated NSP4 is localized to plasma membrane caveolae by a novel raft isolation technique. J Virol (2007) 0.94
Rotavirus enterotoxin NSP4 binds to the extracellular matrix proteins laminin-beta3 and fibronectin. J Virol (2004) 0.94
Probing the structure of rotavirus NSP4: a short sequence at the extreme C terminus mediates binding to the inner capsid particle. J Virol (2000) 0.94
Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol (2015) 0.94
Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol (2012) 0.93
Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings. Mucosal Immunol (2014) 0.93
Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathog (2011) 0.92
Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes. Biochem J (2004) 0.91
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol (2015) 0.90
Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin. J Virol (2007) 0.90
Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea. J Virol (1998) 0.90
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One (2016) 0.89
Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection. J Biol Chem (2012) 0.89
Novel pentameric structure of the diarrhea-inducing region of the rotavirus enterotoxigenic protein NSP4. J Virol (2011) 0.88
Rotavirus NSP4: Cell type-dependent transport kinetics to the exofacial plasma membrane and release from intact infected cells. Virol J (2011) 0.88
Prevalence and genetic heterogeneity of porcine group C rotaviruses in nursing and weaned piglets in Ohio, USA and identification of a potential new VP4 genotype. Vet Microbiol (2013) 0.88
Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder. World J Gastroenterol (2001) 0.87
Viral determinants of rotavirus pathogenicity in pigs: evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host. J Virol (1998) 0.87
Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol (2009) 0.87
Virulence-associated genome mutations of murine rotavirus identified by alternating serial passages in mice and cell cultures. J Virol (2014) 0.86
Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection. Toxins (Basel) (2010) 0.85
Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J Virol (1992) 8.35
Rotavirus gene structure and function. Microbiol Rev (1989) 6.95
X-ray crystallographic structure of the Norwalk virus capsid. Science (1999) 6.58
Sequence and genomic organization of Norwalk virus. Virology (1993) 6.25
Norwalk virus genome cloning and characterization. Science (1990) 5.83
Rotaviruses: a review. Curr Top Microbiol Immunol (1983) 5.24
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet (2003) 5.03
Proteolytic enhancement of rotavirus infectivity: molecular mechanisms. J Virol (1981) 4.87
Structural polypeptides of simian virus 40. J Virol (1971) 4.83
In vitro transcription and translation of simian rotavirus SA11 gene products. J Virol (1980) 4.40
Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis (1994) 4.37
Taxonomy of the caliciviruses. J Infect Dis (2000) 3.94
Detection of Norwalk virus in stool by polymerase chain reaction. J Clin Microbiol (1992) 3.82
Rotavirus infections in infants as protection against subsequent infections. N Engl J Med (1996) 3.61
Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses. Clin Microbiol Rev (2001) 3.28
Specific enzyme-linked immunoassay for rotavirus serotypes 1 and 3. J Clin Microbiol (1985) 3.23
Norwalk virus open reading frame 3 encodes a minor structural protein. J Virol (2000) 2.96
Ultrastructural localization of rotavirus antigens using colloidal gold. Virus Res (1984) 2.95
Localization of VP4 neutralization sites in rotavirus by three-dimensional cryo-electron microscopy. Nature (1990) 2.77
Detection of Norwalk virus and hepatitis A virus in shellfish tissues with the PCR. Appl Environ Microbiol (1995) 2.73
Correlation of patient immune responses with genetically characterized small round-structured viruses involved in outbreaks of nonbacterial acute gastroenteritis in the United States, 1990 to 1995. J Med Virol (1997) 2.70
Detection of enteric viruses in oysters by using the polymerase chain reaction. Appl Environ Microbiol (1993) 2.69
Identification, synthesis, and modifications of simian rotavirus SA11 polypeptides in infected cells. J Virol (1982) 2.67
A plaque assay for the simian rotavirus SAII. J Gen Virol (1979) 2.65
Three-dimensional visualization of mRNA release from actively transcribing rotavirus particles. Nat Struct Biol (1997) 2.63
Comparison of the reactivities of baculovirus-expressed recombinant Norwalk virus capsid antigen with those of the native Norwalk virus antigen in serologic assays and some epidemiologic observations. J Clin Microbiol (1993) 2.58
Recombinant Norwalk virus-like particles given orally to volunteers: phase I study. Gastroenterology (1999) 2.54
Attachment and entry of recombinant Norwalk virus capsids to cultured human and animal cell lines. J Virol (1996) 2.51
Rotavirus stability and inactivation. J Gen Virol (1979) 2.48
Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells. J Virol (1994) 2.48
Three-dimensional structure of baculovirus-expressed Norwalk virus capsids. J Virol (1994) 2.46
Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus. Nature (1996) 2.45
Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology (1984) 2.42
Expression of rotavirus VP2 produces empty corelike particles. J Virol (1991) 2.38
Synthesis and immunogenicity of the rotavirus major capsid antigen using a baculovirus expression system. J Virol (1987) 2.29
Application of PCR to detect Norwalk virus in fecal specimens from outbreaks of gastroenteritis. J Clin Microbiol (1994) 2.27
Structure and function of the polypeptides in simian virus 40. I. Existence of subviral deoxynucleoprotein complexes. J Virol (1972) 2.16
Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology--a trip of over 50 years. Annu Rev Microbiol (1995) 2.13
Evaluation of a degenerate primer for the PCR detection of human caliciviruses. Arch Virol (1996) 2.11
Identification of the simian rotavirus SA11 genome segment 3 product. Virology (1988) 2.10
Receptor activity of rotavirus nonstructural glycoprotein NS28. J Virol (1989) 2.09
Functional and topographical analyses of epitopes on the hemagglutinin (VP4) of the simian rotavirus SA11. J Virol (1988) 2.08
Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis (2000) 2.02
Antigenic mapping of the recombinant Norwalk virus capsid protein using monoclonal antibodies. Virology (1996) 2.01
Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci U S A (1996) 2.00
Detection of hepatitis A virus by hybridization with single-stranded RNA probes. Appl Environ Microbiol (1987) 1.98
Rotavirus virus-like particles administered mucosally induce protective immunity. J Virol (1997) 1.96
Identification of minireovirus as a Norwalk-like virus in pediatric patients with gastroenteritis. J Virol (1994) 1.93
Concentration and detection of hepatitis A virus and rotavirus from shellfish by hybridization tests. Appl Environ Microbiol (1991) 1.91
Detection of hepatitis A virus in seeded estuarine samples by hybridization with cDNA probes. Appl Environ Microbiol (1986) 1.89
Biochemical mapping of the simian rotavirus SA11 genome. J Virol (1983) 1.88
The rotavirus nonstructural glycoprotein NSP4 mobilizes Ca2+ from the endoplasmic reticulum. J Virol (1995) 1.87
Nucleotide sequence of bovine rotavirus gene 1 and expression of the gene product in baculovirus. Virology (1989) 1.83
Three-dimensional structural analysis of recombinant rotavirus-like particles with intact and amino-terminal-deleted VP2: implications for the architecture of the VP2 capsid layer. J Virol (1997) 1.81
Proteolytic enhancement of rotavirus infectivity: biology mechanism. Virology (1980) 1.81
Ultrastructural study of rotavirus replication in cultured cells. J Gen Virol (1980) 1.81
Biochemical characterization of a smaller form of recombinant Norwalk virus capsids assembled in insect cells. J Virol (1997) 1.80
Molecular characterization and expression of the capsid protein of a Norwalk-like virus recovered from a Desert Shield troop with gastroenteritis. Virology (1994) 1.80
Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J Virol (1998) 1.80
Simian rotavirus SA11 replication in cell cultures. J Virol (1979) 1.79
The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production. Proc Natl Acad Sci U S A (1997) 1.78
Expression and self-assembly of Grimsby virus: antigenic distinction from Norwalk and Mexico viruses. Clin Diagn Lab Immunol (1999) 1.77
Detection of antigenically distinct rotaviruses from infants. Infect Immun (1983) 1.77
Use of heat release and an internal RNA standard control in reverse transcription-PCR detection of Norwalk virus from stool samples. J Clin Microbiol (1997) 1.77
The uptake of SV40 DNA by nonpermissive cells in the presence of DEAE-dextran. Biochim Biophys Acta (1971) 1.76
The nonstructural glycoprotein of rotavirus affects intracellular calcium levels. J Virol (1994) 1.75
The molecular epidemiology of rotavirus gastroenteritis. Prog Med Virol (1984) 1.74
Human and most animal rotavirus strains do not require the presence of sialic acid on the cell surface for efficient infectivity. J Gen Virol (1999) 1.73
NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice. Am J Physiol (1999) 1.72
Specific proteolytic cleavage of recombinant Norwalk virus capsid protein. J Virol (1995) 1.69
Comparison of the polymerase region of small round structured virus strains previously classified in three antigenic types by solid-phase immune electron microscopy. Arch Virol (1994) 1.68
Trypsin cleavage stabilizes the rotavirus VP4 spike. J Virol (2001) 1.68
Characterization of SRSVs using RT-PCR and a new antigen ELISA. Arch Virol (1995) 1.67
Distribution of Norwalk virus within shellfish following bioaccumulation and subsequent depuration by detection using RT-PCR. J Food Prot (1998) 1.66
Prevalence of antibodies to Norwalk virus in England: detection by enzyme-linked immunosorbent assay using baculovirus-expressed Norwalk virus capsid antigen. J Clin Microbiol (1993) 1.66
Human calicivirus genogroup II capsid sequence diversity revealed by analyses of the prototype Snow Mountain agent. Arch Virol (1997) 1.65
Subclass-specific serum antibody responses to recombinant Norwalk virus capsid antigen (rNV) in adults infected with Norwalk, Snow Mountain, or Hawaii virus. J Clin Microbiol (1993) 1.63
Effects of tunicamycin on rotavirus morphogenesis and infectivity. J Virol (1983) 1.61
Detection and analysis of a small round-structured virus strain in oysters implicated in an outbreak of acute gastroenteritis. Appl Environ Microbiol (1996) 1.60
Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses. J Virol (2001) 1.59
Phenotypes of rotavirus reassortants depend upon the recipient genetic background. Proc Natl Acad Sci U S A (1989) 1.58
Infant morbidity in an Indian slum birth cohort. Arch Dis Child (2007) 1.58
Two types of glycoprotein precursors are produced by the simian rotavirus SA11. Virology (1983) 1.57
Antigenic characterization and ELISA detection of adult diarrhea rotaviruses. J Infect Dis (1986) 1.56
Extraintestinal rotavirus infections in children with immunodeficiency. J Pediatr (1992) 1.56
Structural proteins of simian virus 40. I. Histone characteristics of low-molecular-weight polypeptides. J Virol (1975) 1.56
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Template-dependent, in vitro replication of rotavirus RNA. J Virol (1994) 1.54
Specific interactions between rotavirus outer capsid proteins VP4 and VP7 determine expression of a cross-reactive, neutralizing VP4-specific epitope. J Virol (1992) 1.53
Structural studies of recombinant Norwalk capsids. J Infect Dis (2000) 1.52
Investigation of association of mycobacteria with inflammatory bowel disease by nucleic acid hybridization. J Clin Microbiol (1987) 1.51
Norwalk virus-associated gastroenteritis traced to ice consumption aboard a cruise ship in Hawaii: comparison and application of molecular method-based assays. J Clin Microbiol (1994) 1.51
Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol (2006) 1.49