Published in Cancer Genet Cytogenet on February 01, 1996
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J (2000) 2.21
Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res (2008) 2.18
The CDKN2A (p16) gene and human cancer. Mol Med (1997) 1.46
The genetics of osteosarcoma. Sarcoma (2012) 1.33
Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics (2008) 1.31
CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. Am J Pathol (1998) 1.03
The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res (2012) 0.96
Genetically engineered mouse models and human osteosarcoma. Clin Sarcoma Res (2012) 0.96
Animal models in osteosarcoma. Front Oncol (2014) 0.91
Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression. Front Oncol (2013) 0.88
Epigenetic regulation of apoptosis and cell cycle in osteosarcoma. Sarcoma (2010) 0.88
Osteosarcoma occurring in osteogenesis imperfecta. Virchows Arch (2004) 0.88
Autocrine Transforming Growth Factor-beta Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein. Sarcoma (2000) 0.82
Down-regulation of ribosomal protein L7A in human osteosarcoma. J Cancer Res Clin Oncol (2009) 0.81
Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies. Crit Rev Oncog (2015) 0.81
Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63. Chromosome Res (2008) 0.79
Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. EMBO Rep (2016) 0.78
Osteosarcoma: mouse models, cell of origin and cancer stem cell. Postdoc J (2014) 0.75
The sequence of the human genome. Science (2001) 101.55
Systematic determination of genetic network architecture. Nat Genet (1999) 25.45
A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell (1998) 19.67
Analysis of serial measurements in medical research. BMJ (1990) 16.69
Use of check lists in assessing the statistical content of medical studies. Br Med J (Clin Res Ed) (1986) 7.42
Transcriptional regulation and function during the human cell cycle. Nat Genet (2001) 5.89
Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry (1971) 4.70
Human p53 gene localized to short arm of chromosome 17. Nature (1986) 4.67
Red blood cell magnesium and chronic fatigue syndrome. Lancet (1991) 4.48
Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A (1987) 4.21
Public knowledge of AIDS and the DHSS advertisement campaign. Br Med J (Clin Res Ed) (1986) 3.92
Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. Science (1978) 3.91
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci U S A (1998) 3.46
Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci (1987) 3.39
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37
The role of the vitamin D endocrine system in health and disease. N Engl J Med (1989) 3.37
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature (1985) 2.96
Transcription, genomes, function. Trends Genet (2000) 2.86
Amygdalin (Laetrile): effect on clonogenic cells from human myeloid leukemia cell lines and normal human marrow. Cancer Treat Rep (1980) 2.86
Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry (1973) 2.84
Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med (1992) 2.73
Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res (1998) 2.67
Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain. BMJ (2006) 2.63
Recurrent brachial plexus neuropathy. Brain (1975) 2.63
Diabetes care from diagnosis: effects of training in patient-centred care on beliefs, attitudes and behaviour of primary care professionals. Patient Educ Couns (1999) 2.57
Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature (1986) 2.56
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am J Hum Genet (1989) 2.56
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem (1999) 2.47
Can general practitioners influence exercise habits? Controlled trial. Br Med J (Clin Res Ed) (1985) 2.29
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest (1993) 2.25
Electrophysiological study of dystrophia myotonica. J Neurol Neurosurg Psychiatry (1971) 2.20
Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature (1987) 2.14
A potential transcriptional activation element in the p53 protein. Oncogene (1990) 2.07
Posture, blood velocity in common femoral vein, and prophylaxis of venous thromboembolism. Lancet (1995) 2.01
1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol (1984) 2.01
Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood (1983) 2.01
Assessment of the psychological impact of a breast screening programme. Br J Radiol (1991) 2.00
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene (2008) 1.97
gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages. Biochem Biophys Res Commun (1985) 1.97
Human myeloid leukemia cell lines: a review. Blood (1980) 1.96
Absence of WAF1 mutations in a variety of human malignancies. Blood (1994) 1.95
p27/Kip1 mutation found in breast cancer. Cancer Res (1996) 1.94
Twenty years' screening for cancer of the uterine cervix in Great Britain, 1964-84: further evidence for its ineffectiveness. J Epidemiol Community Health (1988) 1.91
"Sick" motoneurones. A unifying concept of muscle disease. Lancet (1971) 1.89
1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A (1987) 1.89
The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes. Diabetologia (2012) 1.89
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood (1996) 1.89
Clinical significance not statistical significance: a simple Bayesian alternative to p values. J Epidemiol Community Health (1998) 1.89
Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils. Blood (1999) 1.88
An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1). Blood (1980) 1.86
Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas. Am J Surg Pathol (1997) 1.79
Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood (1995) 1.76
Mortality of men in the Rhondda Fach 1950-80. Br J Ind Med (1985) 1.70
Management of feverish children at home. BMJ (1992) 1.69
Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data. J Clin Epidemiol (2005) 1.68
Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. Nucleic Acids Res (1987) 1.67
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia (2006) 1.67
Randomized controlled trial of physiotherapy in 56 children with cerebral palsy followed for 18 months. Dev Med Child Neurol (2001) 1.66
Surface markers and prognostic factors in acute lymphoblastic leukemia. N Engl J Med (1976) 1.64
Sudden infant death syndrome and environmental temperature: an analysis using vital statistics. J Epidemiol Community Health (1987) 1.60
Relationship between type of simple coalworkers' pneumoconiosis and lung function. A nine-year follow-up study of subjects with small rounded opacities. Br J Ind Med (1981) 1.58
Functional compensation in partially denervated muscles. J Neurol Neurosurg Psychiatry (1971) 1.57
25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J Clin Endocrinol Metab (1987) 1.54
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. Blood (1997) 1.54
Molecular genetic advances in chronic myelogenous leukemia. Ann Intern Med (1990) 1.54
Hospital outpatient clinics: an efficient specialist service? A neurology audit. J Neurol Neurosurg Psychiatry (1991) 1.53
Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease. J Biol Chem (2001) 1.52
Asthma at the interface: bridging the gap between general practice and a district general hospital. Arch Dis Child (1994) 1.51
How common is repeat sudden infant death syndrome? Arch Dis Child (2007) 1.51
Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood (2001) 1.50
Contamination in trials of educational interventions. Health Technol Assess (2007) 1.50
Effect of transdermal glyceryl trinitrate on the survival of peripheral intravenous infusions: a double-blind prospective clinical study. Br J Surg (1988) 1.49
Candidate regulatory sequence elements for cell cycle-dependent transcription in Saccharomyces cerevisiae. Genome Res (1999) 1.49
DNA aneuploidy in morphologically normal colons from patients with colon cancer. Mod Pathol (1995) 1.48
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1). Oncogene (2006) 1.48
CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J Clin Invest (1999) 1.45
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res (1997) 1.44
Two cases of cryptococcal meningitis, one treated with 5-fluorocytosine. Br Med J (1969) 1.43
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol Cell Biol (1999) 1.43
Trials in primary care: statistical issues in the design, conduct and evaluation of complex interventions. Stat Methods Med Res (2010) 1.42
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma. Blood (1995) 1.42
Mortality indicators used to rank hospital performance. BMJ (2013) 1.41
Trends in asthma mortality. Data on seasonality of deaths due to asthma were omitted from paper but editorial's author did not know. BMJ (1997) 1.41
Myeloperoxidase: its structure and expression during myeloid differentiation. Blood (1985) 1.41
Circaseptennial rhythm is an artefact. BMJ (1997) 1.40
Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants. J Immunol (1986) 1.40
Characterization of a novel HTLV-infected cell line. Blood (1984) 1.40
A novel mutation that leads to a congenital factor XI deficiency in a Japanese family. Am J Hematol (2000) 1.39
Trigeminal neuralgia and multiple sclerosis. A complex diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1995) 1.39
Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. Blood (2000) 1.38