Published in Biochem J on March 15, 1996
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res (2008) 1.36
Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem (2008) 1.10
Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil). Evid Based Complement Alternat Med (2012) 0.98
DNA ligases as therapeutic targets. Transl Cancer Res (2013) 0.85
SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst) (2016) 0.84
Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina. Botanics (2015) 0.78
ent-Kaurane glycosides from Tricalysia okelensis. Chem Pharm Bull (Tokyo) (2010) 0.75
Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature (1978) 4.28
Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol (1983) 3.60
Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell Biol (1995) 2.61
Mammalian DNA ligases. Annu Rev Biochem (1992) 2.49
Location of the active site for enzyme-adenylate formation in DNA ligases. Proc Natl Acad Sci U S A (1991) 2.32
Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1990) 2.15
Regulation of DNA ligase activity by poly(ADP-ribose). Nature (1982) 1.91
Mammalian DNA ligases. Catalytic domain and size of DNA ligase I. J Biol Chem (1990) 1.84
Three distinct DNA ligases in mammalian cells. J Biol Chem (1991) 1.79
Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II). Biochemistry (1988) 1.76
Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines. Cancer Res (1988) 1.55
Inhibition of DNA ligase activity by arsenite: a possible mechanism of its comutagenesis. Mol Toxicol (1989) 1.35
DNA unwinding and inhibition of T4 DNA ligase by anthracyclines. Nucleic Acids Res (1988) 1.22
Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol. Biochem Pharmacol (1990) 1.21
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. J Nat Prod (1995) 1.18
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod (1991) 1.16
Eukaryotic DNA ligase. Purification and properties of the enzyme from bovine thymus, and immunochemical studies of the enzyme from animal tissues. J Biol Chem (1982) 1.08
Multiple roles of DNA ligase at the replication fork. Biochim Biophys Acta (1988) 1.08
Evidence that a single DNA ligase is involved in replication and recombination in yeast. Proc Natl Acad Sci U S A (1979) 1.04
A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells. Proc Natl Acad Sci U S A (1991) 1.04
Berberine: complex with DNA. Science (1969) 0.98
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J Nat Prod (1995) 0.94
Defective DNA ligase I in Bloom's syndrome cells. Simultaneous analysis using immunoblotting and the ligase-[32P]AMP adduct assay. J Biol Chem (1988) 0.94
Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae). J Pharm Sci (1972) 0.93
Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus. J Nat Prod (1985) 0.91
Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases. Experientia (1988) 0.87
Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia. J Nat Prod (1991) 0.87
HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. Biochem Biophys Res Commun (1992) 0.85
Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate. J Biol Chem (1992) 0.84
Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. J Biol Chem (1991) 0.83
Association of a possible DNA ligase deficiency with T-cell acute leukemia. Cancer Res (1988) 0.82
Keynote address: mechanisms of cellular resistance to cytotoxic drugs and X-irradiation. Int J Radiat Oncol Biol Phys (1991) 0.82
Inhibition of DNA ligase from human thymocytes and normal or leukemic lymphocytes by antileukemic drugs. Cancer Res (1985) 0.79
Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana. J Nat Prod (1994) 0.78
Interaction of the antileukemic alkaloid, 2-hydroxy-3,8,9-trimethoxy-5-methylbenzo[c]phenanthridine (fagaronine), with nucleic acids. Chem Biol Interact (1983) 0.78
Isolation and structural elucidation of pentacyclic triterpenoids from Maprounea africana. J Nat Prod (1995) 0.77
Antineoplastic drugs in 1990. A review (Part I). Drugs (1990) 0.77
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89
Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA (1998) 11.90
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 10.90
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A (1997) 7.52
Sex and gender bias in anatomy and physical diagnosis text illustrations. JAMA (1994) 7.51
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Nosocomial klebsiella infections: intestinal colonization as a reservoir. Ann Intern Med (1971) 6.55
Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science (2001) 6.47
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A (1980) 6.31
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68
Genetic diversity and disease control in rice. Nature (2000) 5.34
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol (2009) 5.08
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell (1999) 4.76
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54
Case-finding for depression in primary care: a randomized trial. Am J Med (1999) 4.46
Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology (2002) 4.45
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature (1999) 4.29
Demethylation-induced developmental pleiotropy in Arabidopsis. Science (1996) 4.25
Overland heroin trafficking routes and HIV-1 spread in south and south-east Asia. AIDS (2000) 4.24
Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry (2008) 4.14
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys (1992) 4.12
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler (1994) 4.09
A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coli. J Bacteriol (1995) 3.92
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med (2000) 3.89
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J (2005) 3.84
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell (1989) 3.83
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75
Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy (2007) 3.75
Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control (2001) 3.74
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med (1997) 3.55
Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature (1999) 3.51
Crystal structure of the yeast TFIIA/TBP/DNA complex. Science (1996) 3.45
Estimating the growth rate of slowly growing marine bacteria from RNA content. Appl Environ Microbiol (1993) 3.45
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Switchable ferroelectric diode and photovoltaic effect in BiFeO3. Science (2009) 3.39
Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2. Proc Natl Acad Sci U S A (1998) 3.34
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J Exp Med (1998) 3.32
T-DNA insertional mutagenesis for functional genomics in rice. Plant J (2000) 3.25
A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab (2003) 3.24
Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar. Appl Environ Microbiol (1994) 3.24
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09
Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol (2000) 3.08
A Smad transcriptional corepressor. Cell (1999) 3.07
Oxidative chemistry of peroxynitrite. Methods Enzymol (1994) 3.03
Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation. J Cell Biol (1981) 3.02
Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia (2003) 3.00
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res (1994) 2.98
Cryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen. Clin Infect Dis (2011) 2.97
Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation (2000) 2.97
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
Rates of dementia in three ethnoracial groups. Int J Geriatr Psychiatry (1999) 2.92
The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol (2000) 2.90
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A (1999) 2.83
Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet (1998) 2.81
Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study. Aliment Pharmacol Ther (2012) 2.80
The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1. Structure (2000) 2.80
VDJ recombination. Immunol Today (1992) 2.74
Cloning and sequencing of Serratia protease gene. Nucleic Acids Res (1986) 2.72
Bcl-2 family proteins are essential for platelet survival. Cell Death Differ (2007) 2.67
Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol (1995) 2.66
Clinical and genetic studies of Birt-Hogg-Dubé syndrome. J Med Genet (2002) 2.65
Paediatric hand fractures. J Hand Surg Eur Vol (2013) 2.65
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64
Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature (1997) 2.64
The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter. Plant Cell (2001) 2.63
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med (2000) 2.61
The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut (1999) 2.60
A quasi-monoclonal mouse. Science (1996) 2.58
Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev (1996) 2.58