Genomewide association for schizophrenia in the CATIE study: results of stage 1.

PubWeight™: 4.14‹?› | Rank: Top 1%

🔗 View Article (PMC 3910086)

Published in Mol Psychiatry on March 18, 2008

Authors

P F Sullivan1, D Lin, J-Y Tzeng, E van den Oord, D Perkins, T S Stroup, M Wagner, S Lee, F A Wright, F Zou, W Liu, A M Downing, J Lieberman, S L Close

Author Affiliations

1: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA. pfsulliv@med.unc.edu

Associated clinical trials:

Relative Effectiveness of Schizophrenia Therapy Study (REST) | NCT01245348

Articles citing this

(truncated to the top 100)

A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry (2011) 5.15

A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet (2009) 5.01

Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry (2009) 4.74

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry (2008) 3.85

Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders. Trends Genet (2009) 3.25

Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08

Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder. Am J Hum Genet (2011) 2.85

Genome-wide association studies in ADHD. Hum Genet (2009) 2.58

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med (2009) 2.37

A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull (2008) 2.35

Genome-wide association scan for five major dimensions of personality. Mol Psychiatry (2008) 2.29

Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry (2010) 2.21

Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. BMC Genet (2009) 2.16

Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry (2009) 2.09

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res (2010) 1.98

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord (2009) 1.90

Gene × environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution. Biol Psychiatry (2013) 1.88

Meta-analysis of genome-wide association studies with overlapping subjects. Am J Hum Genet (2009) 1.83

Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. Am J Psychiatry (2010) 1.82

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res (2010) 1.79

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet (2009) 1.71

Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull (2009) 1.71

Genetics of psychosis; insights from views across the genome. Hum Genet (2009) 1.68

Schizophrenia gene networks and pathways and their applications for novel candidate gene selection. PLoS One (2010) 1.67

Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Am J Hum Genet (2012) 1.64

A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case. Bioinformatics (2009) 1.50

Follow-up association study of linkage regions reveals multiple candidate genes for carotid plaque in Dominicans. Atherosclerosis (2012) 1.47

Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur Child Adolesc Psychiatry (2010) 1.45

Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry (2009) 1.44

Schizophrenia genetics: where next? Schizophr Bull (2011) 1.42

Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropharmacology (2010) 1.41

A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol (2010) 1.40

Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Mol Psychiatry (2010) 1.39

SZGR: a comprehensive schizophrenia gene resource. Mol Psychiatry (2010) 1.36

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci (2012) 1.34

MicroRNA dysregulation in psychiatric disease. Brain Res (2010) 1.34

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron (2014) 1.30

A systematic method for estimating individual responses to treatment with antipsychotics in CATIE. Schizophr Res (2008) 1.30

Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychol Med (2011) 1.30

Multivariate phenotype association analysis by marker-set kernel machine regression. Genet Epidemiol (2012) 1.29

DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27

The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am (2010) 1.22

Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. Neuropsychopharmacology (2010) 1.19

Candidate gene-environment interaction research: reflections and recommendations. Perspect Psychol Sci (2015) 1.16

Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21. J Am Acad Child Adolesc Psychiatry (2010) 1.14

Questions about DISC1 as a genetic risk factor for schizophrenia. Mol Psychiatry (2013) 1.14

Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. PLoS Genet (2008) 1.11

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol Psychiatry (2008) 1.11

The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients. BMC Psychiatry (2010) 1.10

Genome-wide approaches to schizophrenia. Brain Res Bull (2010) 1.09

Genomewide association study of movement-related adverse antipsychotic effects. Biol Psychiatry (2009) 1.09

Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biol Psychiatry (2013) 1.09

The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes. Schizophr Bull (2010) 1.08

Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. Schizophr Bull (2010) 1.07

Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era. Appl Clin Genet (2012) 1.07

Genome-wide association study of antipsychotic-induced QTc interval prolongation. Pharmacogenomics J (2010) 1.04

New findings in the genetics of major psychoses. Dialogues Clin Neurosci (2010) 1.04

Immune system gene dysregulation in autism and schizophrenia. Dev Neurobiol (2012) 1.04

Deep resequencing and association analysis of schizophrenia candidate genes. Mol Psychiatry (2012) 1.00

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry (2010) 1.00

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations. Hum Mol Genet (2009) 0.97

Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. Behav Brain Funct (2009) 0.96

Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines. Eur J Hum Genet (2012) 0.96

Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees. Mol Autism (2010) 0.95

Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD). Neuropsychiatr Dis Treat (2010) 0.95

Network.assisted analysis to prioritize GWAS results: principles, methods and perspectives. Hum Genet (2014) 0.94

Control of population stratification by correlation-selected principal components. Biometrics (2010) 0.94

Genetic research in schizophrenia: new tools and future perspectives. Schizophr Bull (2008) 0.94

Genome-wide association studies of schizophrenia: does bigger lead to better results? Curr Opin Psychiatry (2012) 0.94

Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate. Hum Genet (2013) 0.94

Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype. Eur J Hum Genet (2009) 0.93

SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treatment response: data from the CATIE study. Schizophr Res (2011) 0.93

Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. Psychopharmacology (Berl) (2009) 0.93

Increased de novo copy number variants in the offspring of older males. Transl Psychiatry (2011) 0.92

Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample. Schizophr Res (2010) 0.92

Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study. Curr Pharmacogenomics Person Med (2009) 0.92

Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. PLoS One (2013) 0.90

DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients. Schizophr Res (2014) 0.90

Regulation of spine formation by ErbB4 in PV-positive interneurons. J Neurosci (2013) 0.90

The intersection of pharmacology, imaging, and genetics in the development of personalized medicine. Dialogues Clin Neurosci (2009) 0.89

Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PLoS One (2010) 0.88

Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response. Pharmacogenomics (2011) 0.88

The dice are rolling for schizophrenia genetics. Psychol Med (2008) 0.88

Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. Eur Arch Psychiatry Clin Neurosci (2013) 0.88

Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis. Brain Res Bull (2010) 0.86

Searching joint association signals in CATIE schizophrenia genome-wide association studies through a refined integrative network approach. BMC Genomics (2012) 0.85

Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study. PLoS One (2010) 0.85

Schizophrenia genetics: the search for a hard lead. Curr Opin Psychiatry (2008) 0.85

Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study. Schizophr Bull (2014) 0.85

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness. Nat Commun (2014) 0.85

A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. Am J Med Genet B Neuropsychiatr Genet (2010) 0.84

Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to bipolar disorder and schizophrenia. PLoS One (2011) 0.84

Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2013) 0.84

Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals. JAMA Psychiatry (2014) 0.84

New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia? Front Behav Neurosci (2010) 0.83

Influence of ANKK1 and DRD2 polymorphisms in response to haloperidol. Eur Arch Psychiatry Clin Neurosci (2012) 0.82

Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology (2013) 0.82

Targeted pharmacogenetic analysis of antipsychotic response in the CATIE study. Pharmacogenomics (2012) 0.82

Nature and nurture in neuropsychiatric genetics: where do we stand? Dialogues Clin Neurosci (2010) 0.82

Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint. PLoS One (2009) 0.82

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

A haplotype map of the human genome. Nature (2005) 105.70

Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64

Genomic control for association studies. Biometrics (1999) 64.39

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull (1987) 51.07

The structure of haplotype blocks in the human genome. Science (2002) 50.88

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Population structure and eigenanalysis. PLoS Genet (2006) 37.21

A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97

Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med (2005) 28.99

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07

Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22

Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet (1990) 19.91

A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet (2005) 18.98

Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2006) 18.85

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA (1997) 17.88

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36

Association mapping in structured populations. Am J Hum Genet (2000) 16.79

Replicating genotype-phenotype associations. Nature (2007) 16.11

The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88

The UCSC Known Genes. Bioinformatics (2006) 14.67

New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28

A tutorial on statistical methods for population association studies. Nat Rev Genet (2006) 12.49

Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40

The UCSC Genome Browser Database: update 2006. Nucleic Acids Res (2006) 11.05

Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry (2003) 10.44

Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90

Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet (2002) 7.40

Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16

Schizophrenia: a common disease caused by multiple rare alleles. Br J Psychiatry (2007) 7.00

A systematic review of the prevalence of schizophrenia. PLoS Med (2005) 6.99

Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet (2007) 6.55

Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol (2002) 6.09

Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med (2002) 5.00

A simple and improved correction for population stratification in case-control studies. Am J Hum Genet (2007) 4.29

Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet (2005) 4.15

The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development. Schizophr Bull (2003) 4.13

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet (2002) 4.03

A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet (2002) 3.52

Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol (2007) 2.95

False discovery rate in linkage and association genome screens for complex disorders. Genetics (2003) 2.89

Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med (2006) 2.75

Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A (2006) 2.71

Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry (2007) 2.70

Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology (2006) 2.70

Spurious genetic associations. Biol Psychiatry (2007) 2.62

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry (2005) 2.48

Controlling the proportion of false positives in multiple dependent tests. Genetics (2004) 2.46

Estimation of false discovery rates in multiple testing: application to gene microarray data. Biometrics (2003) 2.37

Methods of correcting for multiple testing: operating characteristics. Stat Med (1997) 2.33

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci (2006) 2.16

False discoveries and models for gene discovery. Trends Genet (2003) 2.03

Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet (2006) 1.98

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum Mol Genet (2003) 1.87

Comparative effectiveness of antipsychotic drugs. A commentary on: Cost Utility Of The Latest Antipsychotic Drugs In Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE). Arch Gen Psychiatry (2006) 1.82

The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. Am Psychol (2005) 1.71

The pseudoautosomal regions, SHOX and disease. Curr Opin Genet Dev (2006) 1.67

TAMAL: an integrated approach to choosing SNPs for genetic studies of human complex traits. Bioinformatics (2006) 1.57

Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol Psychiatry (2006) 1.36

Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet (2006) 1.30

Controlling false discoveries in genetic studies. Am J Med Genet B Neuropsychiatr Genet (2008) 1.27

Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study). Hum Hered (2004) 1.20

Clinical correlates of tardive dyskinesia in schizophrenia: baseline data from the CATIE schizophrenia trial. Schizophr Res (2005) 1.20

NCAM1 and neurocognition in schizophrenia. Biol Psychiatry (2006) 1.10

Comment on a simple and improved correction for population stratification. Am J Hum Genet (2008) 1.09

A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations. Hum Hered (2003) 0.98

The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition. Am J Med Genet B Neuropsychiatr Genet (2008) 0.97

Controlling false discoveries in candidate gene studies. Mol Psychiatry (2005) 0.95

Flavin monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism. Clin Pharmacol Ther (1999) 0.90

Articles by these authors

WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72

Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci U S A (2000) 19.39

The domain-specific probe EUB338 is insufficient for the detection of all Bacteria: development and evaluation of a more comprehensive probe set. Syst Appl Microbiol (1999) 11.01

Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58

Sex and gender bias in anatomy and physical diagnosis text illustrations. JAMA (1994) 7.51

7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images. Magn Reson Med (2001) 7.05

Nosocomial klebsiella infections: intestinal colonization as a reservoir. Ann Intern Med (1971) 6.55

In situ probing of gram-positive bacteria with high DNA G + C content using 23S rRNA-targeted oligonucleotides. Microbiology (1994) 6.36

Structural genomics: beyond the human genome project. Nat Genet (1999) 5.58

Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med (1975) 5.41

Phylogeny of all recognized species of ammonia oxidizers based on comparative 16S rRNA and amoA sequence analysis: implications for molecular diversity surveys. Appl Environ Microbiol (2000) 5.12

Construction and characterization of a recombinant plasmid encoding the gene for the thymidine kinase of Herpes simplex type 1 virus. Gene (1979) 5.09

Racial differences in the incidence of cardiac arrest and subsequent survival. The CPR Chicago Project. N Engl J Med (1993) 4.97

Combination of fluorescent in situ hybridization and microautoradiography-a new tool for structure-function analyses in microbial ecology. Appl Environ Microbiol (1999) 4.77

Phylogenetic probes for analyzing abundance and spatial organization of nitrifying bacteria. Appl Environ Microbiol (1996) 4.59

Case-finding for depression in primary care: a randomized trial. Am J Med (1999) 4.46

Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46

The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest (2001) 4.37

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34

Combined molecular and conventional analyses of nitrifying bacterium diversity in activated sludge: Nitrosococcus mobilis and Nitrospira-like bacteria as dominant populations. Appl Environ Microbiol (1998) 4.23

Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome. J Virol (2000) 4.09

Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus. Proc Natl Acad Sci U S A (1975) 4.00

Linkage mapping of autosomal dominant retinitis pigmentosa (RP1) to the pericentric region of human chromosome 8. Genomics (1991) 3.93

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry (2008) 3.85

Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75

Choosing caesarean section. Lancet (2000) 3.67

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J (1999) 3.65

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet (2001) 3.58

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med (1997) 3.55

Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res (1994) 3.54

Characterization of the multigene family encoding the mouse S16 ribosomal protein: strategy for distinguishing an expressed gene from its processed pseudogene counterparts by an analysis of total genomic DNA. Mol Cell Biol (1985) 3.48

Crystal structure of the yeast TFIIA/TBP/DNA complex. Science (1996) 3.45

Estimating the growth rate of slowly growing marine bacteria from RNA content. Appl Environ Microbiol (1993) 3.45

Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med (2000) 3.44

Listeriosis: a resurgent foodborne infection. Clin Microbiol Infect (2010) 3.40

Switchable ferroelectric diode and photovoltaic effect in BiFeO3. Science (2009) 3.39

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost (2007) 3.38

Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37

Molecular evidence for genus level diversity of bacteria capable of catalyzing anaerobic ammonium oxidation. Syst Appl Microbiol (2000) 3.36

Protein Data Bank (PDB): database of three-dimensional structural information of biological macromolecules. Acta Crystallogr D Biol Crystallogr (1998) 3.35

Linkage disequilibrium mapping in isolated populations: the example of Finland revisited. Proc Natl Acad Sci U S A (1998) 3.35

Molecular biology of mammalian glucose transporters. Diabetes Care (1990) 3.33

A test statistic to detect errors in sib-pair relationships. Am J Hum Genet (1998) 3.28

Genotypic identification and characterization of species and strains within the genus Candida by using random amplified polymorphic DNA. J Clin Microbiol (1992) 3.27

T-DNA insertional mutagenesis for functional genomics in rice. Plant J (2000) 3.25

A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab (2003) 3.24

A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol (2000) 3.23

p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol (2000) 3.20

Heterozygous and homozygous alpha-antitrypsin deficiency in patients with pulmonary emphysema. N Engl J Med (1969) 3.19

Statistical shape analysis of neuroanatomical structures based on medial models. Med Image Anal (2003) 3.17

In situ visualization of high genetic diversity in a natural microbial community. J Bacteriol (1996) 3.08

A Smad transcriptional corepressor. Cell (1999) 3.07

Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc Natl Acad Sci U S A (2001) 3.01

Cryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen. Clin Infect Dis (2011) 2.97

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site. Proc Natl Acad Sci U S A (1989) 2.92

The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol (2000) 2.90

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem (1999) 2.89

Identification and activities in situ of Nitrosospira and Nitrospira spp. as dominant populations in a nitrifying fluidized bed reactor. Appl Environ Microbiol (1998) 2.88

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med (2001) 2.87

Practical considerations in design of internal amplification controls for diagnostic PCR assays. J Clin Microbiol (2004) 2.86

Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study. Aliment Pharmacol Ther (2012) 2.80

The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1. Structure (2000) 2.80

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet (2001) 2.76

Gate-tuning of graphene plasmons revealed by infrared nano-imaging. Nature (2012) 2.75

Assessment and control for confounding by indication in observational studies. J Am Geriatr Soc (1999) 2.71

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science (1994) 2.70

A global witch-hunt. Lancet (1995) 2.69

The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients. J Exp Med (1996) 2.67

Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood (2000) 2.65

Paediatric hand fractures. J Hand Surg Eur Vol (2013) 2.65

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64

Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Antimicrob Agents Chemother (1998) 2.59

Abnormalities of the septum pellucidum on MR scans in first-episode schizophrenic patients. AJNR Am J Neuroradiol (1992) 2.58

A quasi-monoclonal mouse. Science (1996) 2.58

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol (1993) 2.57

Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Nat Genet (1997) 2.56

Mixed human immunodeficiency virus (HIV) infection in an individual: demonstration of both HIV type 1 and type 2 proviral sequences by using polymerase chain reaction. J Infect Dis (1988) 2.56

Diversity of sulfate-reducing bacteria in oxic and anoxic regions of a microbial mat characterized by comparative analysis of dissimilatory sulfite reductase genes. Appl Environ Microbiol (1999) 2.55

Control of HIV despite the discontinuation of antiretroviral therapy. N Engl J Med (1999) 2.54

Cytokinin action is coupled to ethylene in its effects on the inhibition of root and hypocotyl elongation in Arabidopsis thaliana seedlings. Plant Physiol (1995) 2.52

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils. J Exp Med (1991) 2.52

In situ characterization of Nitrospira-like nitrite-oxidizing bacteria active in wastewater treatment plants. Appl Environ Microbiol (2001) 2.52

Knowledge and attitudes about depression among non-generalists and generalists. J Fam Pract (1997) 2.51

Persistent genetic abnormalities in Barrett's esophagus after photodynamic therapy. Gastroenterology (2000) 2.50

A habitable fluvio-lacustrine environment at Yellowknife Bay, Gale crater, Mars. Science (2013) 2.50

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol (1993) 2.46

Commentary: the public health consequences of restricted induced abortion--lessons from Romania. Am J Public Health (1992) 2.44

Pancreatic fistula after pancreatic head resection. Br J Surg (2000) 2.44

Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology (2009) 2.41

High-versus low-dose erythropoietin in extremely low birth weight infants. The European Multicenter rhEPO Study Group. J Pediatr (1998) 2.41

Ohm's law survives to the atomic scale. Science (2012) 2.40

The mosaic organization of the apocytochrome b gene of Aspergillus nidulans revealed by DNA sequencing. Cell (1981) 2.38

Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc Natl Acad Sci U S A (2001) 2.38

Feasibility of NIH consensus criteria for chronic graft-versus-host disease. Leukemia (2008) 2.37