Published in J Biol Chem on March 15, 1996
Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol (2002) 1.66
Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal (2006) 1.50
Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning. Br J Pharmacol (1999) 1.12
Macrophage migration inhibitory factor contributes to host defense against acute Trypanosoma cruzi infection. Infect Immun (2006) 1.05
Signals for the induction of nitric oxide synthase in astrocytes. Neurochem Int (2006) 1.04
The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. Br J Pharmacol (2004) 0.96
Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. Br J Pharmacol (2000) 0.90
Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: influence of cell differentiation. Br J Pharmacol (1999) 0.83
Inducible nitric oxide synthase links NF-kappaB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing. Lipids Health Dis (2005) 0.80
Lymphotoxin inhibits Chlamydia pneumoniae growth in HEp-2 cells. Infect Immun (1999) 0.80
Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern? Circ Res (2010) 0.79
Regulation of inducible nitric oxide synthase expression in beta cells by environmental factors: heavy metals. Biochem J (1999) 0.78
Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10. Stem Cell Res (2013) 0.77
Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage. Sci Rep (2017) 0.75
Evaluation of iNOS Expression in Esophageal Cancer Patients. Gastrointest Tumors (2016) 0.75
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 4.50
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A (1991) 2.58
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett (1993) 2.14
Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ Res (1986) 2.14
Nitric oxide in the pathogenesis of vascular disease. J Pathol (2000) 2.10
Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide (1997) 1.85
LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J Pharmacol Exp Ther (1988) 1.71
Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol Pharmacol (1992) 1.63
Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition. J Cardiovasc Pharmacol (1985) 1.62
Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J Biol Chem (2000) 1.57
A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. Am J Physiol (1991) 1.47
Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. Proc Natl Acad Sci U S A (1999) 1.41
Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut. Neurosci Lett (1992) 1.40
Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol (2000) 1.39
The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflugers Arch (1984) 1.39
Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. Biochem Biophys Res Commun (1991) 1.39
The endothelium-dependent vasodilator effect of acetylcholine: characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism. Eur J Pharmacol (1984) 1.37
Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res (1987) 1.35
Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry (1997) 1.33
Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol (1993) 1.29
Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability. Circ Res (2000) 1.27
Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. Br J Pharmacol (1991) 1.25
A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative. Neurosci Lett (1993) 1.25
Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B. Mol Pharmacol (1996) 1.21
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB. FASEB J (2001) 1.18
Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience (1993) 1.18
Species-dependent differences in the nature of endothelium-derived vascular relaxing factor. Eur J Pharmacol (1984) 1.17
Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications. Biochem J (1994) 1.14
Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension (1998) 1.14
The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels. Br J Pharmacol (1984) 1.14
Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ Res (1995) 1.13
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways. Br J Pharmacol (1998) 1.13
Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. J Pharmacol Exp Ther (1986) 1.10
Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. Eur J Pharmacol (1988) 1.10
Nitric oxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity. Biochem Biophys Res Commun (1993) 1.09
Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery. Br J Pharmacol (1987) 1.09
Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol (1998) 1.07
Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation. Biochem Biophys Res Commun (1991) 1.06
Endothelial cyclic GMP and cyclic AMP do not regulate the release of endothelium-derived relaxing factor/nitric oxide from bovine aortic endothelial cells. J Pharmacol Exp Ther (1991) 1.06
The endothelium-dependent relaxation of rabbit aorta: effects of antioxidants and hydroxylated eicosatetraenoic acids. Br J Pharmacol (1984) 1.05
Ca2+/calmodulin-regulated nitric oxide synthases. Cell Calcium (1992) 1.03
Endothelium-dependent vasodilation by melittin: are lipoxygenase products involved? Am J Physiol (1985) 1.02
Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets. Thromb Haemost (1997) 1.02
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles. Am J Physiol Heart Circ Physiol (2005) 1.01
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ (2012) 1.01
Production of an EDRF-like activity in the cytosol of N1E-115 neuroblastoma cells. FASEB J (1990) 1.01
Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells. Cell Death Dis (2011) 1.00
Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res (1994) 0.99
Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description. Cell Tissue Res (1994) 0.99
Endothelium-derived relaxing factor influences renal vascular resistance. Am J Physiol (1990) 0.97
The role of endothelial and non-endothelial prostaglandins in the relaxation of isolated blood vessels of the rabbit induced by acetylcholine and bradykinin. Br J Pharmacol (1986) 0.97
Endothelial nitric oxide synthase is myristylated. FEBS Lett (1992) 0.97
Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure. J Am Coll Cardiol (1998) 0.95
Involvement of NO in contact hypersensitivity. Int Immunol (1998) 0.95
Immunochemical detection of inducible NO synthase in human lung. Am J Physiol (1994) 0.94
Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha. Psychopharmacology (Berl) (1983) 0.94
Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine. Eur J Pharmacol (1986) 0.94
Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats. Stroke (1993) 0.94
Inducible NO synthase II and neuronal NO synthase I are constitutively expressed in different structures of guinea pig skeletal muscle: implications for contractile function. FASEB J (1996) 0.93
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. FASEB J (2000) 0.92
Colocalization of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurones. Neuroreport (1992) 0.92
Nitric oxide synthase immunoreactivity in rat pontine medullary neurons. Neuroscience (1994) 0.92
Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of biologically active endothelin-1 by rapid bioassay. Mol Pharmacol (1992) 0.92
The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C. Br J Pharmacol (2001) 0.91
Nitric oxide synthase immunoreactivity in rat superior cervical ganglia and adrenal glands. Neurosci Lett (1993) 0.91
Properties and mechanisms of production and action of endothelium-derived relaxing factor. J Cardiovasc Pharmacol (1986) 0.91
Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. Br J Pharmacol (2000) 0.90
EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells. Adv Second Messenger Phosphoprotein Res (1990) 0.90
Potential functional significance of brain-type and muscle-type nitric oxide synthase I expressed in adventitia and media of rat aorta. Arterioscler Thromb Vasc Biol (1999) 0.90
Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages. Mol Pharmacol (1992) 0.90
Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart. Neurosci Lett (1992) 0.89
Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation. Neurosci Lett (2000) 0.88
Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung. Am J Physiol (1994) 0.88
Neuronal-type NO synthase: transcript diversity and expressional regulation. Nitric Oxide (1998) 0.88
Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases. Br J Pharmacol (1997) 0.88
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat. Br J Pharmacol (1997) 0.87
Functional coupling of nitric oxide synthase and soluble guanylyl cyclase in controlling catecholamine secretion from bovine chromaffin cells. Neuroscience (1998) 0.87
Expression of inducible nitric oxide synthase in failing and non-failing human heart. J Mol Cell Cardiol (1996) 0.87
Formation and elimination of prostacyclin metabolites in the cat in vivo as determined by radioimmunoassay of unextracted plasma. Eur J Pharmacol (1981) 0.87
Elimination from the circulation of cats of 6-keto-prostaglandin E1 compared with prostaglandins E2 and I2. J Pharm Pharmacol (1983) 0.87
Involvement of protein kinases in the induction of NO synthase II in human DLD-1 cells. Br J Pharmacol (1998) 0.86
Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat. Brain Res (1994) 0.86
The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy. Naunyn Schmiedebergs Arch Pharmacol (1989) 0.85
Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord. Neuroscience (2000) 0.85
Colocalization of nitric oxide synthase and somatostatin immunoreactivity in rat dentate hilar neurons. Proc Natl Acad Sci U S A (1994) 0.84
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. FASEB J (2001) 0.84
The importance of Ca2+-mediated phospholipase A2 activation for stimulus-evoked PGE2-release from rabbit splenic capsular strips. Naunyn Schmiedebergs Arch Pharmacol (1979) 0.84
Chemotactic peptide FMLP contracts human coronary arteries via cyclooxygenase products. Am J Physiol (1990) 0.83
Endothelium-dependent vasodilatation in human epicardial coronary arteries: effect of prolonged exposure to glyceryl trinitrate or SIN-1. J Cardiovasc Pharmacol (1989) 0.82
NG-methyl-L-arginine decreases contractility, cGMP and cAMP in isoproterenol-stimulated rat hearts in vitro. Eur J Pharmacol (1992) 0.82
Ontogeny of nitric oxide synthase in the lumbosacral spinal cord of the neonatal rat. Brain Res Dev Brain Res (1994) 0.81