Published in Infect Immun on July 01, 1996
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev (1996) 13.91
The alternative sigma factor, sigmaE, is critically important for the virulence of Salmonella typhimurium. Infect Immun (1999) 2.67
Alternative sigma factors and their roles in bacterial virulence. Microbiol Mol Biol Rev (2005) 2.15
The alternative sigma factor sigma(E) plays an important role in intestinal survival and virulence in Vibrio cholerae. Infect Immun (2002) 2.04
Phosphorylation-independent activity of the response regulators AlgB and AlgR in promoting alginate biosynthesis in mucoid Pseudomonas aeruginosa. J Bacteriol (1998) 1.69
An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. J Bacteriol (1997) 1.63
Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium. Infect Immun (2004) 1.30
Cross-sectional analysis of clinical and environmental isolates of Pseudomonas aeruginosa: biofilm formation, virulence, and genome diversity. Infect Immun (2004) 1.27
Identification of AlgR-regulated genes in Pseudomonas aeruginosa by use of microarray analysis. J Bacteriol (2004) 1.22
Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa. J Bacteriol (2004) 1.16
A simple alfalfa seedling infection model for Pseudomonas aeruginosa strains associated with cystic fibrosis shows AlgT (sigma-22) and RhlR contribute to pathogenesis. Proc Natl Acad Sci U S A (2002) 1.15
Activation of the Pseudomonas aeruginosa AlgU regulon through mucA mutation inhibits cyclic AMP/Vfr signaling. J Bacteriol (2010) 1.10
The transcriptional regulator AlgR is essential for Pseudomonas aeruginosa pathogenesis. Infect Immun (2002) 1.10
Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN. J Bacteriol (2011) 1.06
Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) regulon and its implications for pathogen persistence in the host and syphilis pathogenesis. J Bacteriol (2012) 0.99
The RpoT regulon of Pseudomonas putida DOT-T1E and its role in stress endurance against solvents. J Bacteriol (2006) 0.98
Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17. BMC Microbiol (2009) 0.93
Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1. Mol Microbiol (2011) 0.91
Evidence for a role of rpoE in stressed and unstressed cells of marine Vibrio angustum strain S14. J Bacteriol (2000) 0.88
Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms. BMC Infect Dis (2011) 0.86
A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence. BMC Genomics (2011) 0.86
Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner. J Bacteriol (2009) 0.86
Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli. J Bacteriol (2011) 0.85
Effect of inactivation of degS on Salmonella enterica serovar typhimurium in vitro and in vivo. Infect Immun (2005) 0.84
The algT gene of Pseudomonas syringae pv. glycinea and new insights into the transcriptional organization of the algT-muc gene cluster. J Bacteriol (2006) 0.81
Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosa. BMC Microbiol (2013) 0.80
Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia. Antimicrob Agents Chemother (2016) 0.77
The Pseudomonas aeruginosa AlgZR two-component system coordinates multiple phenotypes. Front Cell Infect Microbiol (2014) 0.77
Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay. Antimicrob Agents Chemother (2014) 0.75
Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors. Microbes Infect (2017) 0.75
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (1995) 68.34
Infections caused by Pseudomonas aeruginosa. Rev Infect Dis (1983) 7.19
Microbiology of airway disease in patients with cystic fibrosis. Clin Microbiol Rev (1991) 7.12
Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect Immun (1983) 6.24
Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression. Genes Dev (1989) 5.95
Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase sigma factors involved in the regulation of extracytoplasmic functions. Proc Natl Acad Sci U S A (1994) 4.89
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc Natl Acad Sci U S A (1993) 4.78
Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J Bacteriol (1989) 4.71
rpoE, the gene encoding the second heat-shock sigma factor, sigma E, in Escherichia coli. EMBO J (1995) 3.59
The role of a stress-response protein in Salmonella typhimurium virulence. Mol Microbiol (1991) 3.52
Bactericidal activity of aerobic and anaerobic polymorphonuclear neutrophils. Infect Immun (1974) 3.49
Alginate synthesis in mucoid Pseudomonas aeruginosa: a chromosomal locus involved in control. J Gen Microbiol (1980) 3.37
Pathogenesis of cystic fibrosis. Lancet (1993) 3.34
The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli. EMBO J (1995) 3.29
Conversion of Pseudomonas aeruginosa to mucoidy in cystic fibrosis: environmental stress and regulation of bacterial virulence by alternative sigma factors. J Bacteriol (1994) 3.15
Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor. J Bacteriol (1993) 2.96
Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation. J Bacteriol (1994) 2.78
Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J Bacteriol (1994) 2.37
A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species. J Bacteriol (1993) 2.31
Microbiology of lung infection in cystic fibrosis. Br Med Bull (1992) 2.22
Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy. Mol Microbiol (1993) 2.22
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA. J Bacteriol (1996) 2.13
Mycobacterium marinum persists in cultured mammalian cells in a temperature-restricted fashion. Infect Immun (1994) 2.12
Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J Infect Dis (1994) 2.12
Pseudomonas aeruginosa sodA and sodB mutants defective in manganese- and iron-cofactored superoxide dismutase activity demonstrate the importance of the iron-cofactored form in aerobic metabolism. J Bacteriol (1995) 1.99
Alginate inhibition of the uptake of Pseudomonas aeruginosa by macrophages. J Gen Microbiol (1988) 1.97
Hypochlorite scavenging by Pseudomonas aeruginosa alginate. Infect Immun (1987) 1.96
Flagella and motility alterations in Pseudomonas aeruginosa strains from patients with cystic fibrosis: relationship to patient clinical condition. Infect Immun (1985) 1.91
Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. J Bacteriol (1995) 1.83
Scavenging by alginate of free radicals released by macrophages. Free Radic Biol Med (1989) 1.77
Avirulence and altered physiological properties of cystic fibrosis strains of Pseudomonas aeruginosa. Infect Immun (1985) 1.74
Intracellular and extracellular degranulation of human polymorphonuclear azurophil and specific granules induced by immune complexes. Infect Immun (1974) 1.73
Differential inactivation of Escherichia coli membrane dehydrogenases by a myeloperoxidase-mediated antimicrobial system. Biochemistry (1990) 1.72
Lung infection with alginate-producing, mucoid Pseudomonas aeruginosa in cystic fibrosis. APMIS Suppl (1992) 1.71
Multiple promoters and induction by heat shock of the gene encoding the alternative sigma factor AlgU (sigma E) which controls mucoidy in cystic fibrosis isolates of Pseudomonas aeruginosa. J Bacteriol (1995) 1.69
Simple model for the study of Pseudomonas aeruginosa infections in leukopenic mice. Infect Immun (1983) 1.57
Seasonal onset of initial colonisation and chronic infection with Pseudomonas aeruginosa in patients with cystic fibrosis in Denmark. Thorax (1992) 1.42
Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis. Trends Microbiol (1995) 1.41
Determination of median lethal and infectious doses in animal model systems. Methods Enzymol (1994) 1.27
Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection. Infect Immun (1995) 1.20
Inflammatory reaction and airway damage in cystic fibrosis. J Lab Clin Med (1976) 1.02
Biologic activities of antibodies to the neutral-polysaccharide component of the Pseudomonas aeruginosa lipopolysaccharide are blocked by O side chains and mucoid exopolysaccharide (alginate). Infect Immun (1995) 0.92
Alginate may accumulate in cystic fibrosis lung because the enzymatic and free radical capacities of phagocytic cells are inadequate for its degradation. Biochem Mol Biol Int (1993) 0.92
Reactive oxygen species in the killing of Pseudomonas aeruginosa by human leukocytes. Curr Microbiol (1995) 0.89
Increased phagocytic cell chemiluminescence in patients with cystic fibrosis. Am J Dis Child (1989) 0.86
Bacteremic pneumonia due to gram-negative bacilli. Arch Intern Med (1983) 0.84
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev (1996) 13.91
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc Natl Acad Sci U S A (1993) 4.78
Gene algD coding for GDPmannose dehydrogenase is transcriptionally activated in mucoid Pseudomonas aeruginosa. J Bacteriol (1987) 4.03
Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J Biol Chem (1997) 3.32
Conversion of Pseudomonas aeruginosa to mucoidy in cystic fibrosis: environmental stress and regulation of bacterial virulence by alternative sigma factors. J Bacteriol (1994) 3.15
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J Cell Biol (2001) 3.14
Effects of cytokines on mycobacterial phagosome maturation. J Cell Sci (1998) 3.05
Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor. J Bacteriol (1993) 2.96
Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities. Antimicrob Agents Chemother (1997) 2.70
Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene. Nucleic Acids Res (1987) 2.63
Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. J Bacteriol (1996) 2.43
Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J Bacteriol (1994) 2.37
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. Mol Microbiol (1995) 2.25
Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy. Mol Microbiol (1993) 2.22
Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc Natl Acad Sci U S A (2001) 2.17
An essential two-component signal transduction system in Mycobacterium tuberculosis. J Bacteriol (2000) 2.16
Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection. Infect Immun (1997) 2.14
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA. J Bacteriol (1996) 2.13
Gene expression in mycobacteria: transcriptional fusions based on xylE and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis. Mol Microbiol (1994) 2.03
Role of the far-upstream sites of the algD promoter and the algR and rpoN genes in environmental modulation of mucoidy in Pseudomonas aeruginosa. J Bacteriol (1990) 1.85
Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. J Bacteriol (1995) 1.83
Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc Natl Acad Sci U S A (1996) 1.77
Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidy. J Bacteriol (1994) 1.75
Multiple promoters and induction by heat shock of the gene encoding the alternative sigma factor AlgU (sigma E) which controls mucoidy in cystic fibrosis isolates of Pseudomonas aeruginosa. J Bacteriol (1995) 1.69
Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors. Infect Immun (1999) 1.65
Gene amplification induces mucoid phenotype in rec-2 Pseudomonas aeruginosa exposed to kanamycin. J Bacteriol (1986) 1.62
DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats. J Bacteriol (1990) 1.59
Elements of signal transduction in Mycobacterium tuberculosis: in vitro phosphorylation and in vivo expression of the response regulator MtrA. J Bacteriol (1996) 1.57
AlgR-binding sites within the algD promoter make up a set of inverted repeats separated by a large intervening segment of DNA. J Bacteriol (1992) 1.56
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol (2001) 1.56
Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG. Mol Microbiol (2001) 1.53
Interactions of OxyR with the promoter region of the oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis. J Bacteriol (1997) 1.52
Broad-host-range plasmid and M13 bacteriophage-derived vectors for promoter analysis in Escherichia coli and Pseudomonas aeruginosa. Gene (1988) 1.49
AlgR, a response regulator controlling mucoidy in Pseudomonas aeruginosa, binds to the FUS sites of the algD promoter located unusually far upstream from the mRNA start site. J Bacteriol (1991) 1.48
Dual regulation of mucoidy in Pseudomonas aeruginosa and sigma factor antagonism. Mol Microbiol (2000) 1.43
Characterization of the genes coding for the putative sigma factor AlgU and its regulators MucA, MucB, MucC, and MucD in Azotobacter vinelandii and evaluation of their roles in alginate biosynthesis. J Bacteriol (1996) 1.42
Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. J Bacteriol (1998) 1.36
In vitro phosphorylation of AlgR, a regulator of mucoidy in Pseudomonas aeruginosa, by a histidine protein kinase and effects of small phospho-donor molecules. Mol Microbiol (1992) 1.34
Overproduction and assay of Pseudomonas aeruginosa phosphomannose isomerase. J Bacteriol (1986) 1.34
Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages. Microbiology (2002) 1.33
Membrane-to-cytosol redistribution of ECF sigma factor AlgU and conversion to mucoidy in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Mol Microbiol (2000) 1.31
Gene-scrambling mutagenesis: generation and analysis of insertional mutations in the alginate regulatory region of Pseudomonas aeruginosa. J Bacteriol (1990) 1.29
Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. Infect Immun (2001) 1.29
Isoniazid induces expression of the antigen 85 complex in Mycobacterium tuberculosis. Antimicrob Agents Chemother (1996) 1.28
Toll-like receptors in control of immunological autophagy. Cell Death Differ (2009) 1.26
Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity. Microbiology (1997) 1.24
Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Mol Microbiol (1997) 1.23
Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis. Infect Immun (2000) 1.15
Conversion to mucoidy in Pseudomonas aeruginosa. Biotechnology (N Y) (1993) 1.15
Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages. J Bacteriol (2001) 1.12
CFTR and pseudomonas infections in cystic fibrosis. Front Biosci (2001) 1.12
Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates. Mol Med (1996) 1.11
Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge. Infect Immun (1998) 1.11
Biochemical characterization and posttranslational modification of AlgU, a regulator of stress response in Pseudomonas aeruginosa. Biochem Biophys Res Commun (1995) 1.10
The algD promoter: regulation of alginate production by Pseudomonas aeruginosa in cystic fibrosis. Cell Mol Biol Res (1993) 1.08
Immunocytochemical analysis of AlgP (Hp1), a histonelike element participating in control of mucoidy in Pseudomonas aeruginosa. J Bacteriol (1992) 1.07
Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block. Electrophoresis (2000) 1.05
Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung. Proc Natl Acad Sci U S A (2001) 1.04
In vitro interactions of the histone-like protein IHF with the algD promoter, a critical site for control of mucoidy in Pseudomonas aeruginosa. Biochem Biophys Res Commun (1992) 1.01
Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis. Mol Microbiol (1990) 1.01
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR. Mol Gen Genet (1994) 0.99
Identification of the algZ gene upstream of the response regulator algR and its participation in control of alginate production in Pseudomonas aeruginosa. J Bacteriol (1997) 0.97
A description and analysis of the operation and validity of the psychological stress evaluator. J Forensic Sci (1980) 0.88
Conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Methods Enzymol (2001) 0.85
Green fluorescent protein. A tool for gene expression and cell biology in mycobacteria. Methods Mol Biol (1998) 0.82
Alginate production by the mucoid Pseudomonas aeruginosa associated with cystic fibrosis. Microbiol Sci (1987) 0.80
An unusual autoerotic death: asphyxia with an abdominal ligature. J Forensic Sci (1984) 0.78
Forensic hypnosis: to hypnotize, or not to hypnotize, that is the question! Am J Clin Hypn (1984) 0.75