Published in Cell Death Differ on May 15, 2009
Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev (2011) 2.58
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell (2009) 2.28
PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev (2012) 2.24
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem (2011) 1.74
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
The many roles of NOX2 NADPH oxidase-derived ROS in immunity. Semin Immunopathol (2010) 1.36
Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J Biol Chem (2010) 1.29
Dengue virus and autophagy. Viruses (2011) 1.10
Selective autophagy and viruses. Autophagy (2011) 1.07
Divergent roles of autophagy in virus infection. Cells (2013) 1.01
The complex interplay between autophagy and NF-κB signaling pathways in cancer cells. Am J Cancer Res (2011) 1.01
Immune modulation by different types of β2→1-fructans is toll-like receptor dependent. PLoS One (2013) 1.00
Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes. Virology (2013) 0.99
Autophagy and bacterial infectious diseases. Exp Mol Med (2012) 0.98
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS Pathog (2014) 0.98
Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J (2011) 0.94
The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention. Clin Dev Immunol (2013) 0.93
Cell death-associated molecular-pattern molecules: inflammatory signaling and control. Mediators Inflamm (2014) 0.93
Modulation of pathogen recognition by autophagy. Front Immunol (2012) 0.90
Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One (2011) 0.89
CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury. J Immunol (2014) 0.87
CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. J Immunol (2013) 0.86
Autophagy and the regulation of the immune response. Pharmacol Res (2012) 0.86
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep (2015) 0.85
Lipopolysaccharide stimulates p62-dependent autophagy-like aggregate clearance in hepatocytes. Biomed Res Int (2014) 0.83
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. J Virol (2015) 0.83
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82
Autophagy, inflammation and innate immunity in inflammatory myopathies. PLoS One (2014) 0.82
IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes. Nat Commun (2015) 0.81
Gene-expression profiling of calves 6 and 9 months after inoculation with Mycobacterium avium subspecies paratuberculosis. Vet Res (2014) 0.81
Cytadherence of Mycoplasma pneumoniae induces inflammatory responses through autophagy and toll-like receptor 4. Infect Immun (2014) 0.81
Innate Immunity Holding the Flanks until Reinforced by Adaptive Immunity against Mycobacterium tuberculosis Infection. Front Microbiol (2016) 0.80
Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy. World J Gastroenterol (2015) 0.79
Autophagy in innate recognition of pathogens and adaptive immunity. Yonsei Med J (2012) 0.79
How bacteria-induced apoptosis of intestinal epithelial cells contributes to mucosal inflammation. Int J Inflam (2010) 0.79
Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells. PLoS One (2013) 0.78
Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol (2011) 0.78
Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response. Viruses (2016) 0.77
Interactions between Autophagy and Bacterial Toxins: Targets for Therapy? Toxins (Basel) (2015) 0.77
Sensors of Infection: Viral Nucleic Acid PRRs in Fish. Biology (Basel) (2015) 0.77
Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. Cell Mol Neurobiol (2016) 0.77
Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages. MBio (2016) 0.76
The role of autophagy in Crohn's disease. Cells (2012) 0.76
Direct Regulation of TLR5 Expression by Caveolin-1. Mol Cells (2015) 0.76
Autophagy: New Questions from Recent Answers. ISRN Mol Biol (2012) 0.75
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71
Toll-like receptors in innate immunity. Int Immunol (2005) 12.24
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science (2006) 9.17
FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab (2007) 8.90
Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol (2005) 8.06
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep (2001) 7.13
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell (2007) 7.11
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity (2006) 6.17
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity (2007) 5.36
Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science (2004) 5.10
Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem (2007) 4.56
Toll-like receptors control autophagy. EMBO J (2008) 4.50
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
Innate and adaptive immunity through autophagy. Immunity (2007) 4.11
MDA5/RIG-I and virus recognition. Curr Opin Immunol (2008) 4.05
The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A (2007) 3.93
Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol (2008) 3.78
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci U S A (2005) 3.75
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep (2009) 3.69
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem (2006) 3.67
Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity (2007) 3.26
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A (2004) 2.89
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity (2008) 2.88
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem (2008) 2.63
The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy (2007) 2.48
Autophagy in innate and adaptive immunity. Trends Immunol (2005) 2.48
Eating the enemy within: autophagy in infectious diseases. Cell Death Differ (2008) 2.17
Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol (2004) 1.38
Autophagy in CD4+ T-cell immunity and tolerance. Cell Death Differ (2008) 1.16
Now I know my CpGs. Trends Microbiol (2001) 1.06
Maintaining T lymphocyte homeostasis: another duty of autophagy. Autophagy (2007) 1.04
Autophagosome and phagosome. Methods Mol Biol (2008) 1.00
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev (1996) 13.91
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc Natl Acad Sci U S A (1993) 4.78
Gene algD coding for GDPmannose dehydrogenase is transcriptionally activated in mucoid Pseudomonas aeruginosa. J Bacteriol (1987) 4.03
Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J Biol Chem (1997) 3.32
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J Cell Biol (2001) 3.14
Effects of cytokines on mycobacterial phagosome maturation. J Cell Sci (1998) 3.05
Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor. J Bacteriol (1993) 2.96
Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities. Antimicrob Agents Chemother (1997) 2.70
Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene. Nucleic Acids Res (1987) 2.63
Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. J Bacteriol (1996) 2.43
Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J Bacteriol (1994) 2.37
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. Mol Microbiol (1995) 2.25
Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy. Mol Microbiol (1993) 2.22
Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc Natl Acad Sci U S A (2001) 2.17
An essential two-component signal transduction system in Mycobacterium tuberculosis. J Bacteriol (2000) 2.16
Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection. Infect Immun (1997) 2.14
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA. J Bacteriol (1996) 2.13
Gene expression in mycobacteria: transcriptional fusions based on xylE and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis. Mol Microbiol (1994) 2.03
Role of the far-upstream sites of the algD promoter and the algR and rpoN genes in environmental modulation of mucoidy in Pseudomonas aeruginosa. J Bacteriol (1990) 1.85
Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. J Bacteriol (1995) 1.83
Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc Natl Acad Sci U S A (1996) 1.77
Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidy. J Bacteriol (1994) 1.75
Multiple promoters and induction by heat shock of the gene encoding the alternative sigma factor AlgU (sigma E) which controls mucoidy in cystic fibrosis isolates of Pseudomonas aeruginosa. J Bacteriol (1995) 1.69
Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors. Infect Immun (1999) 1.65
Gene amplification induces mucoid phenotype in rec-2 Pseudomonas aeruginosa exposed to kanamycin. J Bacteriol (1986) 1.62
DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats. J Bacteriol (1990) 1.59
Elements of signal transduction in Mycobacterium tuberculosis: in vitro phosphorylation and in vivo expression of the response regulator MtrA. J Bacteriol (1996) 1.57
AlgR-binding sites within the algD promoter make up a set of inverted repeats separated by a large intervening segment of DNA. J Bacteriol (1992) 1.56
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol (2001) 1.56
Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG. Mol Microbiol (2001) 1.53
Interactions of OxyR with the promoter region of the oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis. J Bacteriol (1997) 1.52
Broad-host-range plasmid and M13 bacteriophage-derived vectors for promoter analysis in Escherichia coli and Pseudomonas aeruginosa. Gene (1988) 1.49
AlgR, a response regulator controlling mucoidy in Pseudomonas aeruginosa, binds to the FUS sites of the algD promoter located unusually far upstream from the mRNA start site. J Bacteriol (1991) 1.48
Dual regulation of mucoidy in Pseudomonas aeruginosa and sigma factor antagonism. Mol Microbiol (2000) 1.43
Characterization of the genes coding for the putative sigma factor AlgU and its regulators MucA, MucB, MucC, and MucD in Azotobacter vinelandii and evaluation of their roles in alginate biosynthesis. J Bacteriol (1996) 1.42
Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. J Bacteriol (1998) 1.36
Overproduction and assay of Pseudomonas aeruginosa phosphomannose isomerase. J Bacteriol (1986) 1.34
Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages. Microbiology (2002) 1.33
Virulence properties of Pseudomonas aeruginosa lacking the extreme-stress sigma factor AlgU (sigmaE). Infect Immun (1996) 1.31
Membrane-to-cytosol redistribution of ECF sigma factor AlgU and conversion to mucoidy in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Mol Microbiol (2000) 1.31
Gene-scrambling mutagenesis: generation and analysis of insertional mutations in the alginate regulatory region of Pseudomonas aeruginosa. J Bacteriol (1990) 1.29
Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. Infect Immun (2001) 1.29
Isoniazid induces expression of the antigen 85 complex in Mycobacterium tuberculosis. Antimicrob Agents Chemother (1996) 1.28
Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity. Microbiology (1997) 1.24
Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Mol Microbiol (1997) 1.23
Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis. Infect Immun (2000) 1.15
Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages. J Bacteriol (2001) 1.12
CFTR and pseudomonas infections in cystic fibrosis. Front Biosci (2001) 1.12
Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates. Mol Med (1996) 1.11
Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge. Infect Immun (1998) 1.11
Biochemical characterization and posttranslational modification of AlgU, a regulator of stress response in Pseudomonas aeruginosa. Biochem Biophys Res Commun (1995) 1.10
The algD promoter: regulation of alginate production by Pseudomonas aeruginosa in cystic fibrosis. Cell Mol Biol Res (1993) 1.08
Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block. Electrophoresis (2000) 1.05
Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung. Proc Natl Acad Sci U S A (2001) 1.04
In vitro interactions of the histone-like protein IHF with the algD promoter, a critical site for control of mucoidy in Pseudomonas aeruginosa. Biochem Biophys Res Commun (1992) 1.01
Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis. Mol Microbiol (1990) 1.01
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR. Mol Gen Genet (1994) 0.99
Identification of the algZ gene upstream of the response regulator algR and its participation in control of alginate production in Pseudomonas aeruginosa. J Bacteriol (1997) 0.97
Conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Methods Enzymol (2001) 0.85
Green fluorescent protein. A tool for gene expression and cell biology in mycobacteria. Methods Mol Biol (1998) 0.82
Alginate production by the mucoid Pseudomonas aeruginosa associated with cystic fibrosis. Microbiol Sci (1987) 0.80