Published in J Gen Virol on August 01, 1996
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature (2009) 4.49
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J Virol (2002) 3.37
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex. J Virol (2004) 2.30
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure. Nucleic Acids Res (1996) 1.89
3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci U S A (2003) 1.88
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol (2000) 1.86
The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol (2011) 1.74
In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex. J Virol (2005) 1.73
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol (1997) 1.71
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res (2007) 1.62
Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. J Virol (2006) 1.45
Identification of novel influenza A virus proteins translated from PA mRNA. J Virol (2012) 1.42
Detection and characterization of influenza A virus PA-PB2 interaction through a bimolecular fluorescence complementation assay. J Virol (2009) 1.30
Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case. PLoS One (2013) 1.30
Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription. J Virol (2003) 1.27
The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice. J Virol (2012) 0.91
Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae. J Virol (2014) 0.88
Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens. J Virol (2014) 0.85
The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome. Front Microbiol (2013) 0.81
Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation. J Virol (2015) 0.80
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus. Bioinformation (2008) 0.77
My Cousin, My Enemy: quasispecies suppression of drug resistance. Curr Opin Virol (2016) 0.76
Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome. PLoS One (2013) 0.76
Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity. PLoS One (2012) 0.76
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet (2000) 3.44
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review. Gene (1985) 3.42
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J (1994) 3.26
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology (1983) 3.04
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet (2000) 2.93
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol (2000) 2.48
Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance. Nucleic Acids Res (1986) 2.45
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus. Gene (1980) 2.44
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J Virol (1995) 2.16
Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1984) 2.10
Factors related to the development of CMV-specific CD8+ T cell response in CMV-seropositive solid organ transplant candidates. Am J Transplant (2015) 2.08
Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker. Gene (1988) 2.03
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit. J Gen Virol (1994) 2.03
The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport. J Neurosci (1999) 2.03
Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. J Virol (1995) 2.02
[Identification of gaps in the clinical patient care of asthma in Spain. Results of the OPTIMA-GEMA survey]. An Sist Sanit Navar (2016) 2.02
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates. EMBO J (1999) 2.00
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J Virol (2001) 1.98
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome. Gene (1980) 1.95
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure. Nucleic Acids Res (1996) 1.89
Allergy testing in children: why, who, when and how? Allergy (2003) 1.86
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol (2000) 1.86
Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology (1985) 1.84
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system. J Gen Virol (1994) 1.83
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis. J Virol (1996) 1.79
Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J Gen Virol (1997) 1.79
International consensus on (ICON) pediatric asthma. Allergy (2012) 1.79
Inactivation of phosphofructokinase by glucagon in rat hepatocytes. J Biol Chem (1979) 1.76
Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses. J Gen Virol (1993) 1.74
A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol Cell Biol (1999) 1.74
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol (1997) 1.71
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis. J Virol (2000) 1.69
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II. J Virol (2007) 1.64
Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype. Gene (1983) 1.64
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. J Virol (1992) 1.61
Direct measurement of antibody affinity distribution by hapten-inhibition enzyme immunoassay. Mol Immunol (1984) 1.61
Nuclear transport of influenza virus polymerase PA protein. Virus Res (1992) 1.59
Codon 178 mutation in ethnically diverse Creutzfeldt-Jakob disease families. Lancet (1991) 1.56
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle. EMBO Rep (2001) 1.55
Structural determinants of KvLQT1 control by the KCNE family of proteins. J Biol Chem (2000) 1.54
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene (1986) 1.53
Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain. J Virol (1999) 1.52
Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus. J Virol (1989) 1.50
Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains. Virus Res (1989) 1.49
pac gene as efficient dominant marker and reporter gene in mammalian cells. Methods Enzymol (1992) 1.48
The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation. Nucleic Acids Res (1997) 1.48
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replication. J Virol (1999) 1.47
Lung histopathological findings in fatal pandemic influenza A (H1N1). Med Intensiva (2011) 1.46
Viruses and bacteria in acute asthma exacerbations--a GA² LEN-DARE systematic review. Allergy (2010) 1.45
Activation of phospholipid methyltransferase by glucagon in rat hepatocytes. J Biol Chem (1980) 1.41
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development (2000) 1.41
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. J Virol (1996) 1.38
Two classes of MHC class II interactions with the TCR. Immunol Today (1998) 1.38
Fetal cardiotocography and acid-base status during cesarean section. Eur J Obstet Gynecol Reprod Biol (1998) 1.38
Allergy to latex in spina bifida: a multivariate study of associated factors in 100 consecutive patients. J Allergy Clin Immunol (1996) 1.38
Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Ann Oncol (2011) 1.36
The PA influenza virus polymerase subunit is a phosphorylated protein. J Gen Virol (1998) 1.33
A set of recombinant antigens from Echinococcus granulosus with potential for use in the immunodiagnosis of human cystic hydatid disease. Clin Exp Immunol (2003) 1.33
Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res (1999) 1.32
Regulated M1 mRNA splicing in influenza virus-infected cells. J Gen Virol (1991) 1.28
Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: a retrospective multicentric study. Eur J Cancer (2011) 1.27
Replication of orthomyxoviruses. Adv Virus Res (1999) 1.27
In vitro reconstitution of active influenza virus ribonucleoprotein complexes using viral proteins purified from infected cells. J Gen Virol (1992) 1.26
Improved immunodiagnosis of cystic hydatid disease by using a synthetic peptide with higher diagnostic value than that of its parent protein, Echinococcus granulosus antigen B. J Clin Microbiol (2000) 1.26
The synthesis of influenza virus negative-strand RNA takes place in insoluble complexes present in the nuclear matrix fraction. Virus Res (1990) 1.24
Molecular characterisation of a novel 8-kDa subunit of Echinococcus granulosus antigen B. Mol Biochem Parasitol (1996) 1.22
Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoff. J Gen Virol (1992) 1.19
Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components. J Gen Virol (1995) 1.18
Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer delays third-line chemotherapy and prolongs the platinum-free interval. Ann Oncol (2010) 1.15
New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred. Lancet (1991) 1.13
In vitro synthesis of full-length influenza virus complementary RNA. EMBO J (1985) 1.13
IL-6 promoter polymorphisms in rheumatoid arthritis. Genes Immun (2000) 1.13
Two different 8 kDa monomers are involved in the oligomeric organization of the native Echinococcus granulosus antigen B. Parasite Immunol (1996) 1.12
Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett (2000) 1.12
Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer. Ann Oncol (2011) 1.11
Cross-links in African swine fever virus DNA. J Virol (1979) 1.10
Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8). Gene (1985) 1.10
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis. J Virol (1996) 1.09