Published in Postgrad Med J on January 01, 1977
The clinical pharmacology of mexiletine. Br J Clin Pharmacol (1978) 2.56
Mexiletine in normal volunteers. Br J Clin Pharmacol (1978) 0.97
The effect of metoclopramide and atropine on the absorption of orally administered mexiletine. Br J Clin Pharmacol (1980) 0.94
Pharmacokinetics of mexiletine in renal insufficiency. Br J Clin Pharmacol (1982) 0.93
Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol (1998) 0.91
The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation. Br J Clin Pharmacol (1991) 0.89
Stereoselective disposition of mexiletine in man. Br J Clin Pharmacol (1986) 0.87
Therapeutic drug monitoring: antiarrhythmic drugs. Br J Clin Pharmacol (1998) 0.85
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br J Pharmacol (2006) 0.83
Evaluation of antagonism of aconitine-induced dysrhythmias in mice as a method of detecting and assessing antidysrhythmic activity. Br J Pharmacol (1980) 0.80
Enhanced metabolism of mexiletine after phenytoin administration. Br J Clin Pharmacol (1982) 0.77
Absorption of mexiletine after treatment with gastric antacids. Br J Clin Pharmacol (1982) 0.76
Mexiletine disposition: individual variation in response to urine acidification and alkalinisation. Br J Clin Pharmacol (1983) 0.75
Dose independent pharmacokinetics of mexiletine in healthy volunteers. Br J Clin Pharmacol (1986) 0.75
Pharmacokinetics and haemodynamic effects of tocainide in patients with acute myocardial infarction complicated by left ventricular failure. Br J Clin Pharmacol (1985) 0.75
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J (1979) 6.45
Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet (1971) 4.40
Successful treatment of severe paracetamol overdosage with cysteamine. Lancet (1974) 3.83
Mefenamic acid nephropathy. Lancet (1980) 3.80
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J (1973) 3.77
Neonatal pulmonary ischemia. I. Clinical and physiological studies. Pediatrics (1967) 3.60
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet (1976) 3.41
Should methionine be added to every paracetamol tablet? BMJ (1997) 3.33
The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol (1973) 3.26
Treatment of drug overdosage with naloxone, a specific narcotic antagonist. Lancet (1973) 3.16
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (1977) 3.00
Treatment of salicylate poisoning with repeated oral charcoal. Br Med J (Clin Res Ed) (1985) 2.90
Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J (Clin Res Ed) (1982) 2.90
Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J (1966) 2.68
Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res (1976) 2.63
Assessment of the risk of the respiratory-distress syndrome by a rapid test for surfactant in amniotic fluid. N Engl J Med (1972) 2.56
Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem (2001) 2.56
Nucleotide and amino acid sequences of pulmonary surfactant protein SP 18 and evidence for cooperation between SP 18 and SP 28-36 in surfactant lipid adsorption. Proc Natl Acad Sci U S A (1987) 2.43
Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther (1978) 2.41
Rapid gas-liquid chromatographic estimation of antipyrine in plasma. J Pharm Pharmacol (1973) 2.31
Dose of inhaled budesonide required to produce clinical suppression of plasma cortisol. Eur J Respir Dis (1987) 2.26
Narcotic analgesics and delayed gastric emptying during labour. Lancet (1975) 2.24
Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol (1975) 2.18
Gas-liquid chromatographic estimation of paracetamol. J Pharm Pharmacol (1971) 2.16
Pharmacokinetic drug interactions. Lancet (1969) 2.07
Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet (1979) 2.06
Treatment of ventricular arrhythmias with mexiletine (Kö 1173). Lancet (1973) 2.04
Henry Matthew: the father of modern clinical toxicology. J R Coll Physicians Edinb (2009) 2.04
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage. Health Bull (Edinb) (1978) 2.03
Surface active materials from dog lung. II. Composition and physiological correlations. Am J Physiol (1972) 2.03
Paracetamol metabolism following overdosage: application of high performance liquid chromatography. J Pharm Pharmacol (1977) 2.01
Acute haemolysis and renal failure after nomifensine overdosage. Br Med J (1980) 2.00
Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells. J Biol Chem (1987) 1.88
Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol (1980) 1.87
Opioid-induced delay in gastric emptying: a peripheral mechanism in humans. Anesthesiology (1997) 1.87
Direct determination of surface tension in the lung. Proc Natl Acad Sci U S A (1976) 1.83
Functions of the alveolar lining. Am Rev Respir Dis (1977) 1.81
High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol (1978) 1.78
Pharmacokinetics and analgesic effects of i.m. and oral ketamine. Br J Anaesth (1981) 1.71
Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs (1983) 1.70
Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination. Q J Med (1985) 1.65
Alveolar lining layer is thin and continuous: low-temperature scanning electron microscopy of rat lung. J Appl Physiol (1985) (1995) 1.61
Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments. BMJ (1998) 1.57
Metabolism and turnover of lung surfactant. Am Rev Respir Dis (1987) 1.56
Generic inequivalence--clinical observations. Acta Pharmacol Toxicol (Copenh) (1971) 1.55
Pulmonary surfactant and its apoproteins. J Clin Invest (1990) 1.55
Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet (1982) 1.54
Effects of non-narcotic analgesics on the liver. Drugs (1986) 1.50
Isolation of apoproteins from canine surface active material. Am J Physiol (1973) 1.49
Gastrointestinal absorption of drugs. Med Clin North Am (1974) 1.49
Evaluation of pressure-driven captive bubble surfactometer. J Appl Physiol (1985) (1994) 1.48
Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol (1986) 1.48
Pulmonary surface film stability and composition. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.48
Drugs prescribed for self poisoners. Br Med J (Clin Res Ed) (1985) 1.44
Ontogeny of tracheal fluid, pulmonary surfactant, and plasma corticoids in the fetal lamb. J Appl Physiol (1975) 1.41
Subfractionation of lung surfactant. Implications for metabolism and surface activity. Biochim Biophys Acta (1983) 1.40
Simplified radioimmunoassay for serum aldosterone utilizing increased antibody specificity. J Clin Endocrinol Metab (1974) 1.40
Analgesic abuse and renal disease in North-East Scotland. Lancet (1966) 1.40
Paracetamol and aspirin absorption from Safapryn and Safapryn-Co. Br J Clin Pharmacol (1979) 1.39
Renal papillary necrosis and aspirin. Scott Med J (1969) 1.38
Spectrophotofluorometric and gas-liquid chromatographic methods for the estimation of mexiletine (Kö 1173) in plasma and urine. J Pharm Pharmacol (1973) 1.36
Long-term treatment of ventricular arrhythmias with oral mexiletine. Am Heart J (1976) 1.36
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript. Hum Genet (2011) 1.32
Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences. Proc Natl Acad Sci U S A (1987) 1.31
Rates of replacement of lecithins and alveolar instability in rat lungs. Am J Physiol (1967) 1.29
The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine. J Pharm Pharmacol (1971) 1.29
Direct determination of volume- and time-dependence of alveolar surface tension in excised lungs. Proc Natl Acad Sci U S A (1978) 1.29
Enhancement of oxygen toxicity by the herbicide paraquat. Am Rev Respir Dis (1973) 1.28
Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. Int J Cancer (2000) 1.28
Surface active materials from dog lung. I. Method of isolation. Am J Physiol (1972) 1.26
Treatment of phenobarbitone poisoning with repeated oral administration of activated charcoal. Q J Med (1986) 1.26
Lung surfactant proteins, SP-B and SP-C, alter the thermodynamic properties of phospholipid membranes: a differential calorimetry study. Biochemistry (1993) 1.25
Death and blindness due to overdose of quinine. Br Med J (Clin Res Ed) (1985) 1.25
Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. Lancet (1975) 1.25
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J (1973) 1.25
Alveolar subphase pH in the lungs of anesthetized rabbits. Proc Natl Acad Sci U S A (1981) 1.25
Why do patients still die from paracetamol poisoning? Br Med J (Clin Res Ed) (1986) 1.25
Isolation and properties of type II alveolar cells from rat lung. Am Rev Respir Dis (1977) 1.24
The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol (1983) 1.24
Fatal pulmonary aspiration of oral activated charcoal. BMJ (1988) 1.24
A pharmacokinetic study of doxapram in patients and volunteers. Br J Clin Pharmacol (1979) 1.22
Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure. Br Med J (1976) 1.20
Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis. Br J Clin Pharmacol (1979) 1.19
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci (1982) 1.18
Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of beta endorphin in spleen macrophages. J Clin Invest (1986) 1.17
Studies of the structure of lung surfactant protein SP-A. Am J Physiol (1989) 1.16
New approaches in managing drug overdosage and poisoning. Br Med J (Clin Res Ed) (1983) 1.15
Fulminant hyperkalaemia and multiple complications following ibuprofen overdose. Med Toxicol Adverse Drug Exp (1990) 1.15
Protein composition of rabbit alveolar surfactant subfractions. Biochim Biophys Acta (1984) 1.14
The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol (1984) 1.14
Rapid gas--liquid chromatographic estimation of doxapram in plasma. J Chromatogr (1977) 1.14
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics. Drugs (1982) 1.14
Initial clinical trial of EXOSURF, a protein-free synthetic surfactant, for the prophylaxis and early treatment of hyaline membrane disease. Pediatrics (1991) 1.13
Ventilation enhances pulmonary alveolar clearance of radioactive dipalmitoyl phosphatidylcholine in liposomes. Am Rev Respir Dis (1980) 1.13
Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit. Am Rev Respir Dis (1978) 1.12
Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol (1981) 1.12
Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med (1981) 1.11