Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease.

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J (1997) 2.42

Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. J Virol (1999) 2.16

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication. J Virol (2004) 1.94

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase. J Virol (2004) 1.79

HIV DNA integration. Cold Spring Harb Perspect Med (2012) 1.73

Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J Virol (2002) 1.68

Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. J Virol (1997) 1.55

Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase. J Virol (1999) 1.52

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A (2013) 1.49

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell (2016) 1.41

Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase. J Virol (2005) 1.30

Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase. J Virol (2005) 1.28

Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. J Virol (1997) 1.27

Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly. J Virol (2005) 1.27

Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. J Virol (2009) 1.26

Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. J Virol (2005) 1.26

Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant. J Virol (2003) 1.21

Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly. J Virol (1998) 1.20

Assessment of the role of the central DNA flap in human immunodeficiency virus type 1 replication by using a single-cycle replication system. J Virol (2004) 1.19

Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance. J Virol (2004) 1.14

Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein. J Virol (1997) 1.10

von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step. Proc Natl Acad Sci U S A (2007) 1.08

Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. J Virol (2010) 1.07

Analysis of the viral elements required in the nuclear import of HIV-1 DNA. J Virol (2009) 1.05

Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import. Retrovirology (2005) 1.04

Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells. J Virol (2001) 1.03

Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase. J Biol Chem (2009) 1.03

Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription. J Virol (2007) 1.03

Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein. J Virol (1997) 1.01

Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation. J Virol (1998) 0.99

Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1. J Virol (2011) 0.97

Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. J Virol (1999) 0.96

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation. J Virol (2015) 0.95

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect. J Biol Chem (2011) 0.95

Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1. J Virol (2004) 0.94

HIV-1 replication in cell lines harboring INI1/hSNF5 mutations. Retrovirology (2006) 0.92

Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus. J Virol (2012) 0.92

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles. Retrovirology (2005) 0.92

Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integration. J Virol (2000) 0.91

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology (2014) 0.90

Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis. J Virol (2003) 0.88

Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag. J Virol (2011) 0.87

The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus. J Virol (2009) 0.87

The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome. PLoS One (2014) 0.85

A single amino acid substitution in HIV-1 reverse transcriptase significantly reduces virion release. J Virol (2009) 0.85

The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: role for RNA-Gag binding in the early stages of assembly. J Virol (2009) 0.85

Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1. J Virol (1999) 0.84

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. J Biol Chem (2014) 0.83

Altered viral fitness and drug susceptibility in HIV-1 carrying mutations that confer resistance to nonnucleoside reverse transcriptase and integrase strand transfer inhibitors. J Virol (2014) 0.82

HIV-1 integrase multimerization as a therapeutic target. Curr Top Microbiol Immunol (2015) 0.81

Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production. PLoS One (2012) 0.80

INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. Retrovirology (2013) 0.79

Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication. Retrovirology (2008) 0.79

Natural single-nucleotide polymorphisms in the 3' region of the HIV-1 pol gene modulate viral replication ability. J Virol (2014) 0.79

Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication. J Virol (2015) 0.78

Functional analysis of N-terminal residues of ty1 integrase. J Virol (2009) 0.78

Targeting human immunodeficiency virus type 1 assembly, maturation and budding. Drug Target Insights (2007) 0.77

An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability. J Virol (2016) 0.75

Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52

Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol (1987) 12.66

Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1989) 12.54

Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci U S A (1988) 10.77

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release. Proc Natl Acad Sci U S A (1991) 10.05

Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells. Cell (1989) 9.68

Form, function, and use of retroviral gag proteins. AIDS (1991) 9.24

Myristoylation-dependent replication and assembly of human immunodeficiency virus 1. Proc Natl Acad Sci U S A (1990) 8.23

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J Virol (1995) 6.87

Functional association of cyclophilin A with HIV-1 virions. Nature (1994) 6.82

The gag gene products of human immunodeficiency virus type 1: alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursors. J Virol (1988) 5.94

An assembly domain of the Rous sarcoma virus Gag protein required late in budding. J Virol (1994) 5.87

Assembly and morphology of HIV: potential effect of structure on viral function. AIDS (1991) 4.73

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol (1995) 4.27

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell (1995) 4.25

Retrovirus envelope glycoproteins. Curr Top Microbiol Immunol (1990) 4.22

Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc Natl Acad Sci U S A (1993) 3.63

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J Virol (1995) 3.56

Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis. J Virol (1994) 3.48

HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems. Cell (1988) 3.36

Integration is not necessary for expression of human immunodeficiency virus type 1 protein products. J Virol (1990) 3.32

Retroviral RNA packaging: sequence requirements and implications. Curr Top Microbiol Immunol (1990) 3.22

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. J Virol (1996) 2.82

Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production. J Virol (1991) 2.65

Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J Virol (1995) 2.43

The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811. J Virol (1996) 2.43

Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc Natl Acad Sci U S A (1991) 2.28

Genetic analysis of the human immunodeficiency virus type 1 integrase protein. J Virol (1994) 2.26

Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother (1991) 2.16

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. J Virol (1994) 1.84

Generation and characterization of the human immunodeficiency virus type 1 mutants. Arch Virol (1991) 1.62

Analysis of human immunodeficiency virus type 1 integrase mutants. Virology (1995) 1.58

Site-directed mutagenesis of the P2 region of the Rous sarcoma virus gag gene: effects on Gag polyprotein processing. Virology (1994) 1.11

Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers. J Virol (1995) 1.04

A role for the aspartyl protease from the human immunodeficiency virus type 1 (HIV-1) in the orchestration of virus assembly. Ann N Y Acad Sci (1990) 0.90

The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells. J Virol (1994) 2.22

Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles. J Virol (1994) 2.20

Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes. J Virol (1994) 2.18

Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export. J Virol (1992) 2.05

Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 1.47

Rex-dependent nucleolar accumulation of HTLV-I mRNAs. New Biol (1991) 1.07

The T open reading frame of human immunodeficiency virus type 1. J Acquir Immune Defic Syndr (1990) 0.88

In vivo and in vitro labelling of epithelial tumor cells with anti 17-1A monoclonal antibodies in bone marrow of cancer patients. Hybridoma (1986) 0.81

Biochemical and epitope analysis of the 17-1A membrane antigen. Hybridoma (1986) 0.81