Published in Curr Biol on May 01, 1996
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta (2006) 7.33
Regulation and role of Raf-1/B-Raf heterodimerization. Mol Cell Biol (2006) 4.84
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol (1997) 4.36
MEK kinase activity is not necessary for Raf-1 function. EMBO J (2001) 2.36
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J (2000) 2.17
B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol (1999) 1.99
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol (1997) 1.69
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J (2010) 1.66
Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta (2007) 1.64
Noonan syndrome: clinical aspects and molecular pathogenesis. Mol Syndromol (2010) 1.60
Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms. Ann N Y Acad Sci (2010) 1.54
Characterization of Ser338 phosphorylation for Raf-1 activation. J Biol Chem (2008) 1.48
Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br J Cancer (2004) 1.47
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45
Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology. J Virol (1998) 1.35
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation. Oncogene (2009) 1.31
B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Mol Cell Biol (2004) 1.28
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19
Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence. Hum Mol Genet (2007) 1.17
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog (2010) 1.12
A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol Cell Biol (2007) 1.03
Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. Cancer Res (2010) 0.98
A-RAF kinase functions in ARF6 regulated endocytic membrane traffic. PLoS One (2009) 0.91
"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway. FEBS Lett (2014) 0.91
B-Raf-mediated signaling pathway regulates T cell development. Eur J Immunol (2008) 0.89
Genetics of papillary thyroid cancer initiation: implications for therapy. Trans Am Clin Climatol Assoc (2005) 0.88
Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Mol Cell Biol (2012) 0.87
Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proc Natl Acad Sci U S A (2010) 0.84
Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol (2006) 0.84
A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis. Mol Biol Cell (2008) 0.81
DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation. Proc Natl Acad Sci U S A (2014) 0.78
Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players. Dev Biol (2016) 0.77
Opioid receptor trafficking and signaling: what happens after opioid receptor activation? Cell Mol Neurobiol (2011) 0.77
C-Raf deficiency leads to hearing loss and increased noise susceptibility. Cell Mol Life Sci (2015) 0.76
Raf Kinases are Essential for Phosphate Induction of Erk1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem (2017) 0.75
The impact of the genetic background in the Noonan syndrome phenotype induced by K-Ras(V14I). Rare Dis (2015) 0.75
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med (1995) 7.52
IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A (2001) 6.91
Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet (1989) 6.58
Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol (1990) 6.23
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab (1982) 5.60
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol (1997) 4.36
Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry (2000) 4.35
Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet (1994) 4.28
Association between bovine digital dermatitis treponemes and a range of 'non-healing' bovine hoof disorders. Vet Rec (2011) 4.22
Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell (1997) 4.18
Testing hypotheses on specific environmental causal effects on behavior. Psychol Bull (2001) 3.31
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun (1995) 2.80
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res (2001) 2.78
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity (2000) 2.75
Impaired development of Th2 cells in IL-13-deficient mice. Immunity (1998) 2.68
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev (2000) 2.62
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett (2001) 2.57
Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev (2001) 2.56
Molecular analysis of a human interferon-inducible gene family. Eur J Biochem (1991) 2.46
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40
The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity (1997) 2.33
Interleukin-17. Int Rev Immunol (1998) 2.31
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell (2000) 2.30
Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry (2009) 2.29
Schizophrenia and Afro-Caribbeans. A case-control study. Br J Psychiatry (1991) 2.23
Psychosis with good prognosis in Afro-Caribbean people now living in the United Kingdom. BMJ (1995) 2.22
A Jamaican psychiatrist evaluates diagnoses at a London psychiatric hospital. Br J Psychiatry (1999) 2.18
Early and late weight gain following smoking cessation in the Lung Health Study. Am J Epidemiol (1998) 2.10
Psychopathological syndromes and familial morbid risk of psychosis. Br J Psychiatry (1997) 2.02
A computer-based record and clinical monitoring system for ambulatory care. Am J Public Health (1977) 1.99
Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia. Ann Neurol (1987) 1.96
Sexual dysfunction in patients taking conventional antipsychotic medication. Br J Psychiatry (2002) 1.94
Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev (1997) 1.88
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Mol Cell Biol (1995) 1.87
Transmission of serum hepatitis. JAMA (1970) 1.84
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev (1995) 1.79
Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry (1997) 1.70
Pathways to care and ethnicity. 1: Sample characteristics and compulsory admission. Report from the AESOP study. Br J Psychiatry (2005) 1.70
Psychiatrists' models of mental illness and their personal backgrounds. Psychol Med (1979) 1.70
Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J Exp Med (2000) 1.70
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol (1997) 1.69
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest (1995) 1.68
Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. J Clin Invest (1984) 1.68
Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics (1989) 1.67
A comparative study of 470 cases of early-onset and late-onset schizophrenia. Br J Psychiatry (1993) 1.67
Comparison of the outcome and treatment of psychosis in people of Caribbean origin living in the UK and British Whites. Report from the UK700 trial. Br J Psychiatry (2001) 1.63
Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest (1997) 1.62
Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol (1996) 1.60
Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure. EMBO J (1985) 1.59
Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. Am J Respir Cell Mol Biol (1999) 1.58
A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. Arch Intern Med (2000) 1.58
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene (2012) 1.57
Dietary compliance and cardiovascular risk reduction with a prepared meal plan compared with a self-selected diet. Am J Clin Nutr (1997) 1.57
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia (2003) 1.56
Thromboxane A2 synthesis in pregnancy-induced hypertension. Lancet (1990) 1.56
A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet (1996) 1.55
The challenge of patients' unmet palliative care needs in the final stages of chronic illness. Palliat Med (2007) 1.54
Seasonality of admissions in the psychoses: effect of diagnosis, sex, and age at onset. Br J Psychiatry (1992) 1.53
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia (2011) 1.51
Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a phase II trial. J Clin Oncol (2000) 1.50
Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood (1998) 1.50
Transmission of serum hepatitis. 1970. JAMA (1996) 1.49
Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection. Infect Immun (1996) 1.48
A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group. Psychol Med (1999) 1.47
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Mol Cell Biol (2000) 1.47
The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med (2008) 1.46
Integrated surveillance and potential sources of Salmonella enteritidis in human cases in Canada from 2003 to 2009. Epidemiol Infect (2011) 1.46
Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Mol Psychiatry (2011) 1.44
The relationship between patterns of alcohol consumption and body weight. Lung Health Study Research Group. Int J Epidemiol (1995) 1.43
Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem (1994) 1.42
Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry (2010) 1.41
The Thackrah lecture 1984. Sir Thomas Morison Legge--a disciple of Charles Turner Thackrah. J Soc Occup Med (1985) 1.40
Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: results of a phase III multicenter trial. J Nucl Cardiol (1996) 1.40
Caesarean sections in cattle attended by a practice in Cheshire. Vet Rec (1992) 1.40
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol Cell Biol (1999) 1.39
Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell Growth Differ (2000) 1.38
Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med (1995) 1.36
Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice. Infect Immun (1997) 1.34
Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells. J Virol (1986) 1.31
Urbanization and psychosis: a study of 1942-1978 birth cohorts in The Netherlands. Psychol Med (1998) 1.31
Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study. Br J Psychiatry (1993) 1.30
Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. J Biol Chem (1991) 1.30
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29
The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems. J Biol Chem (1990) 1.29
The cytokine stew and innate resistance to L. monocytogenes. Immunol Rev (1997) 1.29
Monoamine oxidase A gene and bipolar affective disorder. Am J Hum Genet (1994) 1.28
Antibody responses in viral hepatitis, type B. JAMA (1973) 1.23
Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Blood (1996) 1.23
Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis--associated antigen. Am J Med Sci (1972) 1.23
Lifestyle intervention on diet and exercise reduced excessive gestational weight gain in pregnant women under a randomised controlled trial. BJOG (2011) 1.22
Studies in the cholesterol content of normal human plasma: An improved macromethod for the estimation of cholesterol by digitonin. Biochem J (1938) 1.21
Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol (2001) 1.19