Published in EMBO J on July 01, 1985
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Alternative poly(A) site selection in complex transcription units: means to an end? Nucleic Acids Res (1997) 5.64
Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes. Microbiol Mol Biol Rev (1998) 3.26
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene. EMBO J (1988) 2.66
The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice. Mol Cell Biol (1989) 2.50
Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine. Mol Cell Biol (1988) 1.78
Transcriptional analyses of interferon-inducible mRNAs. Mol Cell Biol (1987) 1.50
Transcriptional stimulation by CaPO4-DNA precipitates. Nucleic Acids Res (1988) 1.47
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection. J Virol (1998) 1.44
Regulation of synthesis and turnover of an interferon-inducible mRNA. Mol Cell Biol (1986) 1.43
Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy. EMBO J (1986) 1.36
Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J (1987) 1.17
p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res (1998) 1.17
The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res (1991) 1.14
The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage. Mol Cell Biol (1993) 1.11
Expression of interferon-inducible genes in RD-114 cells. J Virol (1987) 1.08
Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse. EMBO J (1987) 1.01
Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor. EMBO J (1992) 0.99
Alpha-interferon inhibits the expression of heavy chain mu messenger RNA in Daudi cells. EMBO J (1988) 0.93
Expression of interferon-induced genes in different tissues of mice. J Virol (1988) 0.92
DNA hybridisation of routinely processed tissue for detecting HPV DNA in anal squamous cell carcinomas over 40 years. J Clin Pathol (1990) 0.88
Production of a monoclonal antibody directed against an interferon-induced 56,000-dalton protein and its use in the study of this protein. J Virol (1988) 0.84
Clonal derivatives of the RD-114 cell line differ in their antiviral and gene-inducing responses to interferons. J Virol (1987) 0.80
Regulation of macrophage growth and antiviral activity by interferon-gamma. J Cell Biol (1989) 0.80
Absence of the 40-kDa form of (2'-5')oligoadenylate synthetase and its corresponding mRNA from skin fibroblasts derived from Alzheimer disease patients. Proc Natl Acad Sci U S A (1991) 0.76
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature (1983) 5.20
Selective isolation of cosmid clones by homologous recombination in Escherichia coli. Proc Natl Acad Sci U S A (1984) 4.11
Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell (1978) 3.53
Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell (1983) 3.32
Alternative transcription and two modes of splicing results in two myosin light chains from one gene. Nature (1984) 3.31
Changes in somatic cell nuclei inserted into growing and maturing amphibian oocytes. J Embryol Exp Morphol (1968) 3.27
Gene transfer in amphibian eggs and oocytes. Annu Rev Genet (1981) 2.52
Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease. Nature (1981) 2.49
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature (1979) 2.01
Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells. Proc Natl Acad Sci U S A (1983) 1.73
3' end structure of the human (2'-5') oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression. Nucleic Acids Res (1985) 1.63
Synthesis and breakdown of pppA2'p5'A2'p5'A and transient inhibiton of protein synthesis in extracts from interferon-treated and control cells. Eur J Biochem (1978) 1.54
Interferon action: two (2'-5')(A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon. Cell (1983) 1.37
Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation. Eur J Biochem (1985) 1.19
The ppp(A2'p)nA and protein kinase systems in wild-type and interferon-resistant Daudi cells. Eur J Biochem (1982) 1.18
Expression of a chemically synthesized human alpha 1 interferon gene. Proc Natl Acad Sci U S A (1982) 1.17
An improved method for purifying 2',5'-oligoadenylate synthetases. J Biol Chem (1984) 1.11
Inhibition of cell division by interferons: Changes in the transport and intracellular metabolism of thymidine in human lymphoblastoid (Daudi) cells. Eur J Biochem (1981) 1.09
Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccines. J Virol (1984) 0.94
Assay of (2'-5')-oligo(A) synthesized in vitro and the analysis of naturally occurring (2'-5')-oligo(A) from intact cells. Methods Enzymol (1981) 0.86
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell (1990) 7.12
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol (2001) 6.19
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc Natl Acad Sci U S A (1994) 4.53
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res (2001) 4.47
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol (1997) 4.36
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis (2003) 3.73
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2. EMBO J (1992) 3.65
Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell (1978) 3.53
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. Proc Natl Acad Sci U S A (2000) 3.51
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. Virology (1999) 3.44
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
A single DNA response element can confer inducibility by both alpha- and gamma-interferons. Proc Natl Acad Sci U S A (1989) 3.33
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res (2001) 2.78
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol (2000) 2.71
Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J (1998) 2.68
Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene. EMBO J (1988) 2.66
Collagen fibril formation. Optimal in vitro conditions and preliminary kinetic results. J Biol Chem (1978) 2.65
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev (2000) 2.62
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett (2001) 2.57
Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev (2001) 2.56
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system. Mol Cell Biol (1991) 2.55
Molecular analysis of a human interferon-inducible gene family. Eur J Biochem (1991) 2.46
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell (2000) 2.30
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A (1992) 2.20
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J (1999) 2.07
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res (1998) 2.04
Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol (2000) 2.03
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature (1979) 2.01
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J (2000) 1.98
Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev (1997) 1.88
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Mol Cell Biol (1995) 1.87
Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways. Mol Cell Biol (2000) 1.83
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev (1995) 1.79
Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA. J Biol Chem (1997) 1.77
Collagen fibril formation. Evidence for a multistep process. J Biol Chem (1979) 1.77
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science (1994) 1.72
Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection. J Infect Dis (1986) 1.72
The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. Proc Natl Acad Sci U S A (1995) 1.70
DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. J Biol Chem (1999) 1.70
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol (1997) 1.69
A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. EMBO J (2000) 1.68
Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR. Mol Cell Biol (1998) 1.64
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology (1994) 1.63
Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons. Nucleic Acids Res (1991) 1.60
Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. Am J Respir Cell Mol Biol (1999) 1.58
A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. Arch Intern Med (2000) 1.58
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene (2012) 1.57
Dietary compliance and cardiovascular risk reduction with a prepared meal plan compared with a self-selected diet. Am J Clin Nutr (1997) 1.57
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR. Virology (1995) 1.56
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia (2003) 1.56
Synthesis and breakdown of pppA2'p5'A2'p5'A and transient inhibiton of protein synthesis in extracts from interferon-treated and control cells. Eur J Biochem (1978) 1.54
The challenge of patients' unmet palliative care needs in the final stages of chronic illness. Palliat Med (2007) 1.54
Highly efficient generation of recombinant baculoviruses by enzymatically medicated site-specific in vitro recombination. Nucleic Acids Res (1992) 1.52
Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR. J Biol Chem (1995) 1.50
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest (1997) 1.48
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Mol Cell Biol (2000) 1.47
Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr Biol (1996) 1.47
Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression. J Interferon Res (1989) 1.45
Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem (1994) 1.42
The respective roles of the protein kinase and pppA2' p5' A2' p5 A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates. Nucleic Acids Res (1979) 1.42
Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: results of a phase III multicenter trial. J Nucl Cardiol (1996) 1.40
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol Cell Biol (1999) 1.39
The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum. Br J Cancer Suppl (1978) 1.38
Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell Growth Differ (2000) 1.38
The role of WT1 in Wilms tumorigenesis. FASEB J (1993) 1.37
Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med (1995) 1.36
Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy. EMBO J (1986) 1.36
Molecular characterization of cytogenetic alterations associated with the Beckwith-Wiedemann syndrome (BWS) phenotype refines the localization and suggests the gene for BWS is imprinted. Hum Mol Genet (1993) 1.36
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR. Mol Cell Biol (2000) 1.35
Reconstitution of virus-mediated expression of interferon alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7. J Biol Chem (2000) 1.35
Inhibition of protein synthesis by 2'-5' linked adenine oligonucleotides in intact cells. Nature (1978) 1.35
Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J Biol Chem (1998) 1.34
Roles of globotriosyl- and galabiosylceramide in verotoxin binding and high affinity interferon receptor. J Biol Chem (1987) 1.34
RFLP detected by an X-linked cDNA encoding erythroid-potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP). Nucleic Acids Res (1986) 1.33
Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells. J Virol (1986) 1.31
Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling. J Biol Chem (1995) 1.30
Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. J Biol Chem (1991) 1.30
Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. Science (1990) 1.29
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29
Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts. Science (1990) 1.28
RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway. J Immunol (2001) 1.27
Assignment of the alpha and beta chains of human propionyl-CoA carboxylase to genetic complementation groups. Am J Hum Genet (1983) 1.27
Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis. Hum Mol Genet (1998) 1.25
Signal transduction in the interferon system. Semin Oncol (1998) 1.23
Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol (2001) 1.19