Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins.

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J (1997) 3.46

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol (1997) 2.74

Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. J Virol (1998) 2.00

Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). J Virol (2002) 1.77

RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Mol Biol Cell (1997) 1.69

Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc Natl Acad Sci U S A (2005) 1.65

Determination of functional domains in polypyrimidine-tract-binding protein. Biochem J (1998) 1.63

A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. Biochem J (2003) 1.45

Nuclear RNP complex assembly initiates cytoplasmic RNA localization. J Cell Biol (2004) 1.44

Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase. Mol Cell Biol (2005) 1.42

Heterogeneous nuclear ribonucleoprotein A1 regulates RNA synthesis of a cytoplasmic virus. EMBO J (2000) 1.38

Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol Cell Biol (1997) 1.24

Viral and host proteins involved in picornavirus life cycle. J Biomed Sci (2009) 1.24

Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain. J Virol (2001) 1.20

Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol (1998) 1.16

Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export. Mol Biol Cell (2001) 1.12

The hrp23 protein in the balbiani ring pre-mRNP particles is released just before or at the binding of the particles to the nuclear pore complex. J Cell Biol (1998) 1.08

Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3. J Virol (2004) 1.08

Nuclear transit of human zipcode-binding protein IMP1. Biochem J (2003) 1.07

A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. Mol Cell Biol (2010) 0.98

Multiple type A/B heterogeneous nuclear ribonucleoproteins (hnRNPs) can replace hnRNP A1 in mouse hepatitis virus RNA synthesis. J Virol (2003) 0.96

Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. J Virol (2001) 0.96

Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. Mol Cell Biol (2001) 0.92

Fungal virulence and development is regulated by alternative pre-mRNA 3'end processing in Magnaporthe oryzae. PLoS Pathog (2011) 0.92

RBP45 and RBP47, two oligouridylate-specific hnRNP-like proteins interacting with poly(A)+ RNA in nuclei of plant cells. RNA (2000) 0.92

Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export. Nucleic Acids Res (2015) 0.85

An out-of-frame overlapping reading frame in the ataxin-1 coding sequence encodes a novel ataxin-1 interacting protein. J Biol Chem (2013) 0.82

Human polypyrimidine tract-binding protein interacts with mitochondrial tRNAThr in the cytosol. Nucleic Acids Res (2015) 0.78

MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1. Exp Cell Res (2011) 0.78

Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO). PLoS One (2013) 0.77

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (1994) 36.53

Conserved structures and diversity of functions of RNA-binding proteins. Science (1994) 14.75

A cell cycle regulator potentially involved in genesis of many tumor types. Science (1994) 13.00

hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem (1993) 11.44

RNA-binding proteins as developmental regulators. Genes Dev (1989) 8.78

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science (1996) 8.71

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature (1992) 8.45

Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor. Nat Biotechnol (1999) 8.33

Construct design for efficient, effective and high-throughput gene silencing in plants. Plant J (2001) 7.73

mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol (1986) 7.07

BRCA1 mutations in primary breast and ovarian carcinomas. Science (1994) 6.81

A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science (2009) 6.62

A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell (1995) 6.19

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J (1994) 6.17

Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet (1997) 6.08

A novel receptor-mediated nuclear protein import pathway. Cell (1996) 6.04

Transport of proteins and RNAs in and out of the nucleus. Cell (1999) 6.02

Activation of the MAP kinase pathway by the protein kinase raf. Cell (1992) 5.95

Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev (1988) 5.73

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell (1997) 5.57

Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science (1986) 5.52

Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. Trends Biochem Sci (1988) 5.47

Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription. Mol Cell Biol (1984) 5.44

The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell (1997) 5.28

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J (1992) 4.97

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J (1992) 4.73

Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities. Mol Cell Biol (1988) 4.73

A novel nuclear structure containing the survival of motor neurons protein. EMBO J (1996) 4.72

A nuclear localization domain in the hnRNP A1 protein. J Cell Biol (1995) 4.51

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell (1998) 4.47

Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells. Cell (1981) 4.34

Structure and function of nuclear and cytoplasmic ribonucleoprotein particles. Annu Rev Cell Biol (1986) 4.33

The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res (1993) 4.31

RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26

Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells. J Cell Biol (1984) 4.18

Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies. Mol Cell Biol (1984) 4.11

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell (1993) 4.10

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science (2001) 4.06

Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. Mol Cell Biol (1987) 3.91

hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res (1992) 3.89

Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell (2000) 3.86

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature (1990) 3.63

Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature (1999) 3.57

The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol (1991) 3.57

Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly. Proc Natl Acad Sci U S A (1984) 3.51

Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proc Natl Acad Sci U S A (1989) 3.51

A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. J Cell Biol (1989) 3.47

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J (1997) 3.46

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36

Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet (1996) 3.35

The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol Cell Biol (2001) 3.27

Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. Mol Cell Biol (1992) 3.18

The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. Exp Cell Res (1994) 3.06

A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet (2004) 3.05

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat Genet (1994) 3.05

Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins. Science (1991) 3.03

Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell (1994) 3.01

SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol Cell (2001) 2.95

Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. J Cell Biol (1999) 2.93

Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene. J Biol Chem (2000) 2.85

Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol (1993) 2.84

Silicone breakdown and capsular synovial metaplasia in textured-wall saline breast prostheses. Plast Reconstr Surg (1994) 2.82

Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol (2000) 2.78

A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol (1997) 2.74

Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem (1999) 2.73

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol (1992) 2.66

Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1980) 2.63

Epidemiology of Helicobacter pylori in southern China: identification of early childhood as the critical period for acquisition. J Infect Dis (1992) 2.60

In vivo and in vitro arginine methylation of RNA-binding proteins. Mol Cell Biol (1995) 2.55

SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO J (2001) 2.51

Nuclear export of proteins and RNAs. Curr Opin Cell Biol (1997) 2.51

A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol (1999) 2.46

A functional interaction between the survival motor neuron complex and RNA polymerase II. J Cell Biol (2001) 2.44

The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J Cell Biol (1996) 2.39

CB2 cannabinoid receptor-mediated peripheral antinociception. Pain (2001) 2.38

Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J (1999) 2.37

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol (1994) 2.37

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J (2001) 2.37

RNA annealing activities in HeLa nuclei. EMBO J (1994) 2.35

Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA. Mol Cell Biol (2001) 2.32

Transportin-SR, a nuclear import receptor for SR proteins. J Cell Biol (1999) 2.31

The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol (2001) 2.29

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. Mol Cell Biol (1996) 2.26

Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. EMBO J (1992) 2.26

Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting. J Clin Microbiol (1995) 2.26

Genotypic and antigenic identification of two new strains of spotted fever group rickettsiae isolated from China. J Clin Microbiol (1993) 2.23