The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions.

PubWeight™: 1.48‹?› | Rank: Top 4%

🔗 View Article (PMC 1207422)

Published in Genetics on August 01, 1996

Authors

H T Tran1, D A Gordenin, M A Resnick

Author Affiliations

1: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

Articles citing this

Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. Mol Cell Biol (1997) 3.60

Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. Mol Cell Biol (1997) 3.49

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t). Mol Cell Biol (1998) 2.51

The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.25

Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. Mol Cell Biol (1997) 1.87

Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair. Mol Cell Biol (1999) 1.54

Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.47

Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. Genetics (1997) 1.39

Recombination-dependent deletion formation in mammalian cells deficient in the nucleotide excision repair gene ERCC1. Proc Natl Acad Sci U S A (1997) 1.38

Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. Genetics (2001) 1.30

Suppression of intrachromosomal gene conversion in mammalian cells by small degrees of sequence divergence. Genetics (1999) 1.24

Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast. Genetics (1999) 1.19

Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader. Genetics (1999) 1.18

Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast. Mol Cell Biol (1997) 1.11

Recovery of arrested replication forks by homologous recombination is error-prone. PLoS Genet (2012) 1.05

A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast. Genetics (2000) 1.05

The chromosome bias of misincorporations during double-strand break repair is not altered in mismatch repair-defective strains of Saccharomyces cerevisiae. Genetics (1998) 0.96

Mapping the polarity of changes that occur in interrupted CAG repeat tracts in yeast. Mol Cell Biol (1998) 0.96

Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε. PLoS Genet (2010) 0.94

Efficient incorporation of large (>2 kb) heterologies into heteroduplex DNA: Pms1/Msh2-dependent and -independent large loop mismatch repair in Saccharomyces cerevisiae. Genetics (2001) 0.93

Mutator phenotypes due to DNA replication infidelity. Semin Cancer Biol (2010) 0.93

Genomic instability induced by mutations in Saccharomyces cerevisiae POL1. Genetics (2003) 0.90

The large loop repair and mismatch repair pathways of Saccharomyces cerevisiae act on distinct substrates during meiosis. Genetics (2005) 0.88

Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae. Genetics (2003) 0.88

Efficient repair of large DNA loops in Saccharomyces cerevisiae. Nucleic Acids Res (2001) 0.87

Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgrounds. Genetics (1998) 0.81

DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.81

Incorporation of large heterologies into heteroduplex DNA during double-strand-break repair in mouse cells. Genetics (2002) 0.79

Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nucleic Acids Res (2008) 0.79

Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae. Genetics (2008) 0.78

Articles cited by this

Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday. Cold Spring Harb Symp Quant Biol (1966) 14.57

Microsatellite instability in cancer of the proximal colon. Science (1993) 14.51

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (1993) 10.95

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell (1995) 5.54

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev (1996) 5.34

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (1995) 4.48

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics (1992) 3.97

Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J (1993) 3.57

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics (1994) 3.52

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. Nucleic Acids Res (1987) 3.52

Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment. Hum Genet (1991) 3.48

Triplet repeat mutations in human disease. Science (1992) 3.35

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science (1995) 3.34

Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes. Mol Cell Biol (1989) 3.28

Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli. Proc Natl Acad Sci U S A (1992) 3.21

Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science (1995) 3.03

Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae. Genetics (1995) 3.02

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli. Nat Genet (1995) 2.99

Survey of human and rat microsatellites. Genomics (1992) 2.92

Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli. Nature (1991) 2.83

The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae. Mol Gen Genet (1994) 2.73

Spontaneous mutation in the Escherichia coli lacI gene. Genetics (1991) 2.53

Frameshift mutation: determinants of specificity. Annu Rev Genet (1990) 2.44

Inverted DNA repeats: a source of eukaryotic genomic instability. Mol Cell Biol (1993) 2.30

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.29

DNA loop repair by human cell extracts. Science (1994) 2.19

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions. Genes Dev (1995) 2.06

Repair of heteroduplex plasmid DNA after transformation into Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.98

Transposon Tn5 excision in yeast: influence of DNA polymerases alpha, delta, and epsilon and repair genes. Proc Natl Acad Sci U S A (1992) 1.97

Mismatch correction catalyzed by cell-free extracts of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 1.89

Microsatellite instability in inherited and sporadic neoplasms. Curr Opin Oncol (1995) 1.87

The 80th year of fifth disease. Br Med J (Clin Res Ed) (1984) 1.86

DNA structure, mutations, and human genetic disease. Curr Opin Biotechnol (1992) 1.83

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol Gen Genet (1993) 1.82

Gene conversion in Escherichia coli. Resolution of heteroallelic mismatched nucleotides by co-repair. J Mol Biol (1986) 1.80

Greater susceptibility to mutations in lagging strand of DNA replication in Escherichia coli than in leading strand. Science (1993) 1.63

Methyl-directed repair of frameshift mutations in heteroduplex DNA. Proc Natl Acad Sci U S A (1986) 1.48

Polymerase delta variants in RER colorectal tumours. Nat Genet (1995) 1.47

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science (1994) 1.41

A DNA sequence conferring high postmeiotic segregation frequency to heterozygous deletions in Saccharomyces cerevisiae is related to sequences associated with eucaryotic recombination hotspots. Mol Cell Biol (1988) 1.40

Methyl-directed repair of frameshift heteroduplexes in cell extracts from Escherichia coli. J Bacteriol (1989) 1.36

Repair of heteroduplex DNA molecules with multibase loops in Escherichia coli. J Bacteriol (1993) 1.35

SOS mutator effect in E. coli mutants deficient in mismatch correction. EMBO J (1984) 1.25

Yeast mutants with increased bacterial transposon Tn5 excision. Yeast (1991) 1.21

Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli. J Mol Biol (1991) 1.17

Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase. Genetics (1995) 1.15

Nature of the SOS mutator activity: genetic characterization of untargeted mutagenesis in Escherichia coli. Mol Gen Genet (1988) 1.07

The mutator mut7-1 of Saccharomyces cerevisiae. Mutat Res (1993) 0.84

Articles by these authors

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Mol Gen Genet (1976) 6.89

The repair of double-strand breaks in DNA; a model involving recombination. J Theor Biol (1976) 6.63

Genetic control of radiation sensitivity in Saccharomyces cerevisiae. Genetics (1969) 4.58

In vivo site-directed mutagenesis using oligonucleotides. Nat Biotechnol (2001) 3.65

Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. Mol Cell Biol (1997) 3.60

Genes required for ionizing radiation resistance in yeast. Nat Genet (2001) 3.43

Unsaturated fatty acid mutants of Saccharomyces cerevisiae. J Bacteriol (1966) 3.35

Cell-cycle-specific repair of DNA double strand breaks in Saccharomyces cerevisiae. Radiat Res (1980) 3.07

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t). Mol Cell Biol (1998) 2.51

Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid. Proc Natl Acad Sci U S A (1993) 2.44

Inverted DNA repeats: a source of eukaryotic genomic instability. Mol Cell Biol (1993) 2.30

The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.25

Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes. Mol Cell Biol (1995) 2.21

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci U S A (2001) 2.16

Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae. Mutat Res (2000) 2.05

Inverted Alu repeats unstable in yeast are excluded from the human genome. EMBO J (2000) 2.01

Repair of pyrimidine dimer damage induced in yeast by ultraviolet light. J Bacteriol (1972) 2.01

Transposon Tn5 excision in yeast: influence of DNA polymerases alpha, delta, and epsilon and repair genes. Proc Natl Acad Sci U S A (1992) 1.97

Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability. Genome Res (2001) 1.97

Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination. Proc Natl Acad Sci U S A (1996) 1.86

Repeat expansion--all in a flap? Nat Genet (1997) 1.80

Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae. Genetics (1998) 1.78

Meiosis can induce recombination in rad52 mutants of Saccharomyces cerevisiae. Genetics (1986) 1.61

Induction of recombination between homologous and diverged DNAs by double-strand gaps and breaks and role of mismatch repair. Mol Cell Biol (1994) 1.60

Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability. Mutat Res (1998) 1.53

Changes in DNA during meiosis in a repair-deficient mutant (rad 52) of yeast. Science (1981) 1.53

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk. Mol Cell Biol (1999) 1.49

Transformation-associated recombination between diverged and homologous DNA repeats is induced by strand breaks. Yeast (1994) 1.46

Genetic effects of UV irradiation on excision-proficient and -deficient yeast during meiosis. Genetics (1983) 1.46

Meiotic DNA metabolism in wild-type and excision-deficient yeast following UV exposure. Genetics (1983) 1.42

ATP-independent DNA strand transfer catalyzed by protein(s) from meiotic cells of the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1988) 1.39

Similar responses to ionizing radiation of fungal and vertebrate cells and the importance of DNA doublestrand breaks. J Theor Biol (1978) 1.33

DNA polymerases, deoxyribonucleases, and recombination during meiosis in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.33

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc Natl Acad Sci U S A (1999) 1.32

Separation of spores from diploid cells of yeast by stable-flow free-boundary electrophoresis. Science (1967) 1.31

Changes in the chromosomal DNA of yeast during meiosis in repair mutants and the possible role of a deoxyribonuclease. Cold Spring Harb Symp Quant Biol (1984) 1.30

Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast. Proc Natl Acad Sci U S A (1997) 1.30

A photoreactivationless mutant of Saccharomyces cerevisiae. Photochem Photobiol (1969) 1.25

Highly selective isolation of human DNAs from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning. Proc Natl Acad Sci U S A (1996) 1.24

Repair of endonuclease-induced double-strand breaks in Saccharomyces cerevisiae: essential role for genes associated with nonhomologous end-joining. Genetics (1999) 1.21

Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA. Mol Cell Biol (1998) 1.21

p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements. Oncogene (2001) 1.20

A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality. Mol Cell Biol (1996) 1.19

Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast. Genetics (1999) 1.19

Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs). Nucleic Acids Res (1994) 1.19

An endo-exonuclease activity of yeast that requires a functional RAD52 gene. Mol Gen Genet (1988) 1.18

Functional copies of a human gene can be directly isolated by transformation-associated recombination cloning with a small 3' end target sequence. Proc Natl Acad Sci U S A (1998) 1.14

Postreplication repair in Saccharomyces cerevisiae. J Bacteriol (1981) 1.14

Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity. Nucleic Acids Res (1992) 1.14

Homologous and homeologous intermolecular gene conversion are not differentially affected by mutations in the DNA damage or the mismatch repair genes RAD1, RAD50, RAD51, RAD52, RAD54, PMS1 and MSH2. Genetics (1996) 1.14

Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res (1999) 1.13

Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast. Mol Cell Biol (1997) 1.11

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay. Oncogene (2001) 1.11

Direct cloning of human 10q25 neocentromere DNA using transformation-associated recombination (TAR) in yeast. Genomics (1998) 1.10

Induction of mutations in Saccharomyces cerevisiae by ultraviolet light. Mutat Res (1969) 1.10

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants. Oncogene (2001) 1.10

Long inverted repeats are an at-risk motif for recombination in mammalian cells. Genetics (1999) 1.07

Purification and characterization of an endo-exonuclease from Saccharomyces cerevisiae that is influenced by the RAD52 gene. J Biol Chem (1987) 1.06

A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast. Genetics (2000) 1.05

The detection of mitotic and meiotic aneuploidy in yeast using a gene dosage selection system. Mol Gen Genet (1988) 1.04

Mutator specificity and disease: looking over the FENce. Cell (1997) 1.02

Yeast as an honorary mammal. Mutat Res (2000) 1.00

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability. Hum Mol Genet (1999) 0.97

The repair of double-strand breaks in chromosomal DNA of yeast. Basic Life Sci (1975) 0.97

Highly mismatched molecules resembling recombination intermediates efficiently transform mismatch repair proficient Escherichia coli. Genetics (1997) 0.96

Molecular recombination and the repair of DNA double-strand breaks in CHO cells. Nucleic Acids Res (1979) 0.95

SIR functions are required for the toleration of an unrepaired double-strand break in a dispensable yeast chromosome. Mol Cell Biol (2001) 0.95

Photoreactivation and gene dosage in yeast. J Bacteriol (1972) 0.94

Repair of double-strand breaks and lethal damage in DNA of Ustilago maydis. Genet Res (1980) 0.92

Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson. Oncogene (2007) 0.92

Yeast and human genes that affect the Escherichia coli SOS response. Proc Natl Acad Sci U S A (1999) 0.90

Radial transformation-associated recombination cloning from the mouse genome: isolation of Tg.AC transgene with flanking DNAs. Genomics (2000) 0.89

Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals. Environ Mol Mutagen (1989) 0.88

A persistent double-strand break destabilizes human DNA in yeast and can lead to G2 arrest and lethality. Cancer Res (1997) 0.86

Integrity of human YACs during propagation in recombination-deficient yeast strains. Genomics (1999) 0.86

Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement. Cancer Res (1998) 0.85

Specific isolation of human rDNA genes by TAR cloning. Gene (1997) 0.84

Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. Environ Mol Mutagen (1989) 0.84

Rapid cloning of mouse DNA as yeast artificial chromosomes by transformation-associated recombination (TAR). Mamm Genome (1998) 0.83

[Phenotypic manifestations of yeast transposon insertion in the LYS2 gene and deletions resulting from imprecise excision of the transposon]. Genetika (1987) 0.83

Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae--an interlaboratory assessment of 12 chemicals. Mutat Res (1990) 0.82

[Mutability of LYS2 gene in diploid Saccharomyces yeasts. II. Frequency of mutants induced by 6-N-hydroxylaminopurine and propiolactone]. Genetika (1988) 0.82

Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen (1990) 0.82

Unrepaired double-strand breaks in nuclear DNA are not always lethal. Mutat Res (1977) 0.80