Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel.

PubWeight™: 4.24‹?› | Rank: Top 1%

🔗 View Article (PMC 2229332)

Published in J Gen Physiol on October 01, 1996

Authors

T Y Chen1, C Miller

Author Affiliations

1: Howard Hughes Medical Institute, Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA.

Articles citing this

Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation. J Gen Physiol (1999) 3.42

KcsA: it's a potassium channel. J Gen Physiol (2001) 3.23

The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia. J Gen Physiol (1999) 2.17

Uncoupling and turnover in a Cl-/H+ exchange transporter. J Gen Physiol (2007) 2.09

Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels. J Gen Physiol (2004) 2.04

Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. J Gen Physiol (1998) 2.02

Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig. J Physiol (2003) 1.95

Elimination of the slow gating of ClC-0 chloride channel by a point mutation. J Gen Physiol (1999) 1.89

Na+ block and permeation in a K+ channel of known structure. J Gen Physiol (2002) 1.80

Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J (2002) 1.80

Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle. Proc Natl Acad Sci U S A (2000) 1.78

Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels. J Gen Physiol (2001) 1.73

Fast and slow gating relaxations in the muscle chloride channel CLC-1. J Gen Physiol (2000) 1.73

Functional and structural conservation of CBS domains from CLC chloride channels. J Physiol (2004) 1.67

Conformational changes in the pore of CLC-0. J Gen Physiol (2003) 1.66

Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J Gen Physiol (2003) 1.58

Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating. J Gen Physiol (1998) 1.56

Ion-binding properties of the ClC chloride selectivity filter. EMBO J (2005) 1.56

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0. J Physiol (1997) 1.50

Involvement of helices at the dimer interface in ClC-1 common gating. J Gen Physiol (2003) 1.49

Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters. Nat Struct Mol Biol (2009) 1.47

Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J Gen Physiol (2003) 1.46

Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. J Gen Physiol (2005) 1.45

Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel. J Gen Physiol (2005) 1.42

Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic Inhibitor. J Gen Physiol (2003) 1.41

Intracellular proton regulation of ClC-0. J Gen Physiol (2008) 1.37

Structure and mechanism of a pentameric formate channel. Nat Struct Mol Biol (2009) 1.32

A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel. J Physiol (2003) 1.32

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism. J Physiol (2004) 1.29

Chloride dependence of hyperpolarization-activated chloride channel gates. J Physiol (1999) 1.26

Proton sensing of CLC-0 mutant E166D. J Gen Physiol (2006) 1.26

Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons. J Physiol (2002) 1.25

Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions. J Gen Physiol (1997) 1.24

Mechanism of anionic conduction across ClC. Biophys J (2004) 1.24

Mechanism of ion permeation in skeletal muscle chloride channels. J Gen Physiol (1997) 1.20

Independent gating of single pores in CLC-0 chloride channels. Biophys J (1997) 1.20

Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains. J Physiol (2008) 1.19

Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels. Biophys J (2005) 1.19

Permeant anions control gating of calcium-dependent chloride channels. J Membr Biol (2004) 1.18

Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB). J Gen Physiol (2001) 1.18

Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions. J Physiol (1999) 1.18

Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J Gen Physiol (2000) 1.18

Calcium-dependent gating of MthK, a prokaryotic potassium channel. J Gen Physiol (2006) 1.17

A preferred amplitude of calcium sparks in skeletal muscle. Biophys J (2001) 1.16

Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel. J Gen Physiol (2003) 1.14

Channel-like slippage modes in the human anion/proton exchanger ClC-4. J Gen Physiol (2009) 1.14

Anomalous effect of permeant ion concentration on peak open probability of cardiac Na+ channels. J Gen Physiol (1997) 1.14

Conduction mechanisms of chloride ions in ClC-type channels. Biophys J (2004) 1.13

Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel. Biophys J (2004) 1.10

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep (2004) 1.09

Intracellular Ca(2+) release as irreversible Markov process. Biophys J (2002) 1.09

Voltage-dependent charge movement associated with activation of the CLC-5 2Cl-/1H+ exchanger. FASEB J (2010) 1.09

Anion pathway and potential energy profiles along curvilinear bacterial ClC Cl- pores: electrostatic effects of charged residues. Biophys J (2004) 1.07

The mechanism of fast-gate opening in ClC-0. J Gen Physiol (2007) 1.03

Side-dependent inhibition of a prokaryotic ClC by DIDS. Biophys J (2005) 1.02

Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels. J Gen Physiol (2001) 1.02

Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. J Gen Physiol (2006) 1.01

Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. J Gen Physiol (2003) 1.00

Review. Proton-coupled gating in chloride channels. Philos Trans R Soc Lond B Biol Sci (2009) 0.98

Modulation of voltage-dependent properties of a swelling-activated Cl- current. J Gen Physiol (1997) 0.97

Evidence for the intracellular location of chloride channel (ClC)-type proteins: co-localization of ClC-6a and ClC-6c with the sarco/endoplasmic-reticulum Ca2+ pump SERCA2b. Biochem J (1998) 0.97

The fast gating mechanism in ClC-0 channels. Biophys J (2005) 0.96

K(+)-dependent composite gating of the yeast K(+) channel, Tok1. Biophys J (1999) 0.95

Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+. J Physiol (2003) 0.94

Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophys J (2005) 0.93

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0. Eur Biophys J (2009) 0.93

Interaction between the pore and a fast gate of the cardiac sodium channel. J Gen Physiol (1999) 0.93

On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporter. Biophys J (2012) 0.92

Knocking on channel's door. The permeating chloride ion acts as the gating charge in ClC-0. J Gen Physiol (1996) 0.92

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. J Physiol (2015) 0.91

Time-irreversible subconductance gating associated with Ba2+ block of large conductance Ca2+-activated K+ channels. J Gen Physiol (1998) 0.91

Ionic permeation free energy in gramicidin: a semimicroscopic perspective. Biophys J (2004) 0.91

Structure and gating of CLC channels and exchangers. J Physiol (2015) 0.90

Philosophy of voltage-gated proton channels. J R Soc Interface (2013) 0.90

Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J Biomed Biotechnol (2011) 0.89

Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. J Physiol (2001) 0.89

Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel. J Gen Physiol (2014) 0.89

A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State. J Biol Chem (2015) 0.89

Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix. Biochem J (2007) 0.88

Crystal structures of all-alpha type membrane proteins. Eur Biophys J (2009) 0.88

Influence of permeant ions on gating in cyclic nucleotide-gated channels. J Gen Physiol (2003) 0.88

The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating. J Gen Physiol (2007) 0.88

Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions. Biophys J (2011) 0.87

Modulation of CFTR gating by permeant ions. J Gen Physiol (2014) 0.86

Amphiphilic blockers punch through a mutant CLC-0 pore. J Gen Physiol (2008) 0.85

Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. J Gen Physiol (2016) 0.83

The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma. Biochemistry (2015) 0.83

Permeant anions contribute to voltage dependence of ClC-2 chloride channel by interacting with the protopore gate. J Physiol (2010) 0.82

Sequential interaction of chloride and proton ions with the fast gate steer the voltage-dependent gating in ClC-2 chloride channels. J Physiol (2012) 0.81

A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics. J Biol Chem (2014) 0.80

GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels. Biophys J (2014) 0.80

Mimicry of a host anion channel by a Helicobacter pylori pore-forming toxin. Biophys J (2005) 0.80

Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms. J Gen Physiol (2009) 0.80

Gating the glutamate gate of CLC-2 chloride channel by pore occupancy. J Gen Physiol (2015) 0.79

Regulation of a hyperpolarization-activated chloride current in murine respiratory ciliated cells. J Physiol (2000) 0.79

The dual role of calcium: pore blocker and modulator of gating. Proc Natl Acad Sci U S A (1999) 0.79

A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective. Plant Cell (2014) 0.78

Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophys J (2010) 0.78

ClC channels: reading eukaryotic function through prokaryotic spectacles. J Gen Physiol (2003) 0.78

Articles cited by this

The action of calcium on the electrical properties of squid axons. J Physiol (1957) 35.98

Molecular basis of charge movement in voltage-gated sodium channels. Neuron (1996) 6.61

Transmembrane movement of the shaker K+ channel S4. Neuron (1996) 6.61

Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. J Gen Physiol (1983) 5.30

Open-state substructure of single chloride channels from Torpedo electroplax. Philos Trans R Soc Lond B Biol Sci (1982) 5.26

K+ channels close more slowly in the presence of external K+ and Rb+. Nature (1981) 5.25

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature (1990) 4.55

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion. Nature (1995) 4.27

A common molecular basis for three inherited kidney stone diseases. Nature (1996) 4.26

Potassium blocks barium permeation through a calcium-activated potassium channel. J Gen Physiol (1988) 3.82

Single chloride channels from Torpedo electroplax. Activation by protons. J Gen Physiol (1983) 3.76

Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel. Nature (1991) 3.62

A chloride channel widely expressed in epithelial and non-epithelial cells. Nature (1992) 3.60

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Nature (1993) 3.27

Chloride conductance in normal and myotonic muscle fibres and the action of monocarboxylic aromatic acids. J Physiol (1971) 2.83

Steady-state coupling of ion-channel conformations to a transmembrane ion gradient. Science (1990) 2.80

Inactivation of muscle chloride channel by transposon insertion in myotonic mice. Nature (1991) 2.74

A voltage-gated anion channel from the electric organ of Torpedo californica. J Biol Chem (1979) 2.65

Molecular basis of Thomsen's disease (autosomal dominant myotonia congenita). Nat Genet (1993) 2.56

Interactions between intrinsic membrane protein and electric field. An approach to studying nerve excitability. Biophys J (1978) 2.46

A voltage-dependent chloride conductance channel from Torpedo electroplax membrane. Ann N Y Acad Sci (1980) 2.26

Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry (1994) 2.21

Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen). EMBO J (1994) 2.08

Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. J Biol Chem (1993) 2.01

Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA. Proc Natl Acad Sci U S A (1991) 1.91

Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron (1994) 1.89

Properties of voltage-gated chloride channels of the ClC gene family. J Physiol (1995) 1.82

On the inhibition of muscle membrane chloride conductance by aromatic carboxylic acids. J Gen Physiol (1977) 1.79

Molecular physiology of voltage-gated chloride channels. Physiol Rev (1994) 1.63

Nystatin-induced liposome fusion. A versatile approach to ion channel reconstitution into planar bilayers. Biophys J (1990) 1.50

Solubilization and functional reconstitution of a chloride channel from Torpedo californica electroplax. J Membr Biol (1991) 1.47

The nucleotide sequence of a voltage-gated chloride channel from the electric organ of Torpedo californica. Biochim Biophys Acta (1991) 1.06

Articles by these authors

(truncated to the top 100)

Consequences of reducing nonresponse in a national telephone survey. Public Opin Q (2000) 7.67

Conduction and selectivity in potassium channels. J Membr Biol (1983) 6.41

Open-state substructure of single chloride channels from Torpedo electroplax. Philos Trans R Soc Lond B Biol Sci (1982) 5.26

Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature (1985) 4.95

An improved technique for multiple organ harvesting. Surg Gynecol Obstet (1987) 4.73

Human p53 gene localized to short arm of chromosome 17. Nature (1986) 4.67

Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A (1987) 4.21

Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel. J Gen Physiol (1988) 4.05

Fertilization-independent seed development in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1997) 3.87

Potassium blocks barium permeation through a calcium-activated potassium channel. J Gen Physiol (1988) 3.82

Single chloride channels from Torpedo electroplax. Activation by protons. J Gen Physiol (1983) 3.76

Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. JAMA (2000) 3.64

Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol (1988) 3.48

Homodimeric architecture of a ClC-type chloride ion channel. Nature (1996) 3.47

Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol (1991) 3.45

Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation. J Gen Physiol (1999) 3.42

Consensus statement on the live organ donor. JAMA (2000) 3.29

Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle. Biophys J (1986) 3.24

KcsA: it's a potassium channel. J Gen Physiol (2001) 3.23

Dimeric structure of single chloride channels from Torpedo electroplax. Proc Natl Acad Sci U S A (1984) 3.22

Ionic selectivity, saturation, and block in a K+-selective channel from sarcoplasmic reticulum. J Gen Physiol (1980) 3.16

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med (1993) 3.13

Language discrimination by human newborns and by cotton-top tamarin monkeys. Science (2000) 2.89

Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol (1988) 2.87

Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel. J Gen Physiol (1982) 2.87

A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS. N Engl J Med (1997) 2.84

Problems associated with early discharge of newborn infants. Early discharge of newborns and mothers: a critical review of the literature. Pediatrics (1995) 2.82

Steady-state coupling of ion-channel conformations to a transmembrane ion gradient. Science (1990) 2.80

Silver as a probe of pore-forming residues in a potassium channel. Science (1995) 2.78

Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (1989) 2.75

Functional reconstitution of a prokaryotic K+ channel. J Gen Physiol (1998) 2.66

A voltage-gated anion channel from the electric organ of Torpedo californica. J Biol Chem (1979) 2.65

Voltage-gated cation conductance channel from fragmented sarcoplasmic reticulum: steady-state electrical properties. J Membr Biol (1978) 2.57

The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition. Neuron (1994) 2.55

Effects of phospholipid surface charge on ion conduction in the K+ channel of sarcoplasmic reticulum. Biophys J (1984) 2.46

Laboratory and bedside evaluation of portable glucose meters. Am J Clin Pathol (1995) 2.35

Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol (1992) 2.32

A voltage-dependent chloride conductance channel from Torpedo electroplax membrane. Ann N Y Acad Sci (1980) 2.26

Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+. J Gen Physiol (1984) 2.26

Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa. J Virol (1995) 2.25

Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry (1989) 2.25

Human immunodeficiency virus infection in disadvantaged adolescents. Findings from the US Job Corps. JAMA (1991) 2.24

Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry (1994) 2.21

Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons. Neurology (2010) 2.17

Food service and foods and beverages available at school: results from the School Health Policies and Programs Study 2000. J Sch Health (2001) 2.16

Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle. J Exp Biol (1986) 2.14

High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel. J Gen Physiol (1999) 2.12

Helical structure and packing orientation of the S2 segment in the Shaker K+ channel. J Gen Physiol (1999) 2.10

Thermodynamic and kinetic studies of the gating behavior of a K+-selective channel from the sarcoplasmic reticulum membrane. J Gen Physiol (1980) 2.06

Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia (2007) 2.06

Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol (2001) 2.05

A K+-selective, three-state channel from fragmented sarcoplasmic reticulum of frog leg muscle. J Membr Biol (1981) 2.04

Ca++-induced fusion of fragmented sarcoplasmic reticulum with artificial planar bilayers. J Membr Biol (1976) 2.04

Conduction and block by organic cations in a K+-selective channel from sarcoplasmic reticulum incorporated into planar phospholipid bilayers. J Gen Physiol (1982) 2.00

Mechanism of charybdotoxin block of a voltage-gated K+ channel. Biophys J (1993) 1.99

Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group. JAMA (2000) 1.98

Health service use among low-risk newborns after early discharge with and without nurse home visiting. J Am Board Fam Pract (1997) 1.97

Trapping single ions inside single ion channels. Biophys J (1987) 1.94

Tetrameric stoichiometry of a prokaryotic K+ channel. Biochemistry (1997) 1.94

More on epidural needle wings. Anaesthesia (2006) 1.92

Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol (2000) 1.90

Tethered blockers as molecular 'tape measures' for a voltage-gated K+ channel. Nat Struct Biol (2000) 1.89

Orthotopic liver transplantation for primary sclerosing cholangitis. Ann Surg (1988) 1.89

A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. Annu Rev Biophys Biomol Struct (2000) 1.89

Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel. Neuron (1992) 1.87

The lipid-protein interface of a Shaker K(+) channel. J Gen Physiol (2000) 1.85

Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins. J Gen Physiol (1984) 1.84

Communicating health information through the entertainment media. Health Aff (Millwood) (2001) 1.83

LR white resin and improved on-grid immunogold detection of vicilin, a pea seed storage protein. Cell Biol Int Rep (1984) 1.82

Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J Clin Endocrinol Metab (1999) 1.81

Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel. J Biol Chem (1986) 1.80

Isolated-patch recording from liposomes containing functionally reconstituted chloride channels from Torpedo electroplax. Proc Natl Acad Sci U S A (1982) 1.77

Role of rpoS (katF) in oxyR-independent regulation of hydroperoxidase I in Escherichia coli. Mol Microbiol (1994) 1.77

Distribution and activation of the Golgi apparatus in geotropism. Plant Physiol (1972) 1.75

Hepatic artery in liver transplantation. Transplant Proc (1987) 1.73

A large-scale, placebo-controlled, dose-ranging trial of peroral valaciclovir for episodic treatment of recurrent herpes genitalis. Valaciclovir HSV Study Group. Arch Intern Med (1996) 1.73

Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J Virol (2001) 1.73

A comparison of eubacterial and archaeal structure-specific 5'-exonucleases. J Biol Chem (1999) 1.72

Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin. Biochemistry (1994) 1.69

Surviving the sex trade: a comparison of HIV risk behaviours among street-involved women in two Canadian cities who inject drugs. AIDS Care (2003) 1.69

Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis (2011) 1.69

Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. Nucleic Acids Res (1987) 1.67

Be wary of subsidising nicotine replacement therapy. Tob Control (2002) 1.67

Probes of the conduction process of a voltage-gated Cl- channel from Torpedo electroplax. J Gen Physiol (1981) 1.66

The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol Cell Biol (1999) 1.66

The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block. Biophys J (1985) 1.65

Surveillance of symptoms following MMR vaccine in children. Practitioner (1989) 1.63

A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel. Neuron (1996) 1.63

Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel. Proc Natl Acad Sci U S A (1998) 1.62

Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry (1992) 1.61

Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles. Biophys J (1997) 1.58

Functional modification of a Ca2+-activated K+ channel by trimethyloxonium. Biochemistry (1989) 1.57

Attempts at prophylaxis for murine Pneumocystis carinii pneumonitis. Curr Ther Res Clin Exp (1973) 1.57

Hanging gondola structure of the T1 domain in a voltage-gated K(+) channel. Biochemistry (2000) 1.55

Human apolipoprotein B: partial amino acid sequence. FEBS Lett (1984) 1.54

Coupling of water and ion fluxes in a K+-selective channel of sarcoplasmic reticulum. Biophys J (1982) 1.54

Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block. Neuron (1991) 1.53

von Willebrand disease and other inherited bleeding disorders in women with diagnosed menorrhagia. Obstet Gynecol (2001) 1.51

Decamethonium and hexamethonium block K+ channels of sarcoplasmic reticulum. Nature (1980) 1.51

Nystatin-induced liposome fusion. A versatile approach to ion channel reconstitution into planar bilayers. Biophys J (1990) 1.50