Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
|
Science
|
1993
|
19.80
|
2
|
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
|
J Exp Med
|
1991
|
7.52
|
3
|
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
|
Proc Natl Acad Sci U S A
|
1993
|
6.33
|
4
|
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.
|
J Exp Med
|
1993
|
5.71
|
5
|
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
|
J Exp Med
|
1993
|
4.04
|
6
|
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
|
J Exp Med
|
1996
|
3.82
|
7
|
Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.
|
Proc Natl Acad Sci U S A
|
1984
|
3.53
|
8
|
Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.
|
J Immunol
|
1992
|
3.15
|
9
|
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.
|
J Immunol
|
1994
|
2.68
|
10
|
Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro.
|
Science
|
1993
|
2.35
|
11
|
Studies of X chromosome DNA methylation in normal human cells.
|
Nature
|
1982
|
2.34
|
12
|
Effects of IL-12 on the response and susceptibility to experimental viral infections.
|
J Immunol
|
1994
|
2.31
|
13
|
Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.
|
J Exp Med
|
1992
|
2.26
|
14
|
IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism.
|
J Immunol
|
1995
|
2.12
|
15
|
Effects of IL-12 on helper T cell-dependent immune responses in vivo.
|
J Immunol
|
1994
|
2.11
|
16
|
Interleukin 12 at the site of disease in tuberculosis.
|
J Clin Invest
|
1994
|
1.98
|
17
|
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes.
|
Nature
|
1985
|
1.96
|
18
|
Isolation and characterization of cloned DNA sequences that hybridize to the human X chromosome.
|
Cell
|
1980
|
1.96
|
19
|
Characterization of a cloned DNA sequence that is present at centromeres of all human autosomes and the X chromosome and shows polymorphic variation.
|
Proc Natl Acad Sci U S A
|
1984
|
1.86
|
20
|
Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.
|
Infect Immun
|
1996
|
1.77
|
21
|
IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.
|
J Immunol
|
1994
|
1.75
|
22
|
IL-12 regulates T helper type 1 cytokine responses in human infectious disease.
|
J Immunol
|
1994
|
1.65
|
23
|
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.
|
Cancer Res
|
1994
|
1.64
|
24
|
Derepression with decreased expression of the G6PD locus on the inactive X chromosome in normal human cells.
|
Cell
|
1982
|
1.62
|
25
|
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.
|
J Immunol
|
1997
|
1.61
|
26
|
Incomplete X chromosome dosage compensation in chorionic villi of human placenta.
|
Proc Natl Acad Sci U S A
|
1985
|
1.53
|
27
|
Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.
|
Proc Natl Acad Sci U S A
|
1994
|
1.53
|
28
|
The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6.
|
Blood
|
1988
|
1.47
|
29
|
Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation.
|
Nucleic Acids Res
|
1984
|
1.42
|
30
|
IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.
|
J Immunol
|
1996
|
1.42
|
31
|
IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.
|
J Immunol
|
1995
|
1.40
|
32
|
Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells.
|
Eur J Immunol
|
1993
|
1.32
|
33
|
Modulation of perforin and granzyme messenger RNA expression in human natural killer cells.
|
J Immunol
|
1993
|
1.31
|
34
|
Nuclear metabolism of ribosomal RNA in growing, methionine-limited, and ethionine-treated HeLa cells.
|
Biochemistry
|
1977
|
1.24
|
35
|
Interleukin-12 gene expression after viral infection in the mouse.
|
J Virol
|
1995
|
1.22
|
36
|
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells.
|
Int Immunol
|
1995
|
1.17
|
37
|
Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity.
|
Eur J Immunol
|
2001
|
1.17
|
38
|
Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
|
Genomics
|
1992
|
1.15
|
39
|
Rapid hybridization kinetics of DNA attached to submicron latex particles.
|
Nucleic Acids Res
|
1987
|
1.13
|
40
|
IL-12 reverses cytokine and immune abnormalities in Sezary syndrome.
|
J Immunol
|
1995
|
1.06
|
41
|
Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.
|
Proc Natl Acad Sci U S A
|
1995
|
1.04
|
42
|
Implications for X-chromosome regulation from studies of human X-chromosome DNA.
|
Cold Spring Harb Symp Quant Biol
|
1983
|
1.02
|
43
|
Construction and characterization of retroviral vectors expressing biologically active human interleukin-12.
|
Hum Gene Ther
|
1994
|
1.00
|
44
|
Characterization of reiterated human DNA with respect to mammalian X chromosome homology.
|
Somat Cell Mol Genet
|
1984
|
0.99
|
45
|
Sequence similarity between NKSF and the IL-6/G-CSF family.
|
Immunol Today
|
1992
|
0.97
|
46
|
IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.
|
J Immunol
|
1995
|
0.96
|
47
|
Interleukin-12 stimulates B cell growth by inducing IFN-gamma.
|
Cell Immunol
|
1996
|
0.95
|
48
|
Localization of glucose-6-phosphate dehydrogenase in mouse and man by in situ hybridization: evidence for a single locus and transposition of homologous X-linked genes.
|
Cytogenet Cell Genet
|
1985
|
0.94
|
49
|
Interleukin (IL)-12 deficiency in susceptible mice infected with Mycobacterium avium and amelioration of established infection by IL-12 replacement therapy.
|
J Infect Dis
|
1996
|
0.94
|
50
|
Acute and chronic phases of Toxoplasma gondii infection in mice modulate the host immune responses.
|
Infect Immun
|
1998
|
0.90
|
51
|
Virulent Toxoplasma gondii strain RH promotes T-cell-independent overproduction of proinflammatory cytokines IL12 and gamma-interferon.
|
J Med Microbiol
|
2003
|
0.84
|
52
|
Interleukin-12 is capable of generating an antigen-specific Th1-type response in the presence of an ongoing infection-driven Th2-type response.
|
Infect Immun
|
1999
|
0.82
|
53
|
Hyperexpression of HPRT induced by 5-azacytidine in mouse-human hybrid reactivants.
|
Am J Hum Genet
|
1985
|
0.82
|
54
|
Evidence for a relationship between DNA methylation and DNA replication from studies of the 5-azacytidine-reactivated allocyclic X chromosome.
|
Exp Cell Res
|
1985
|
0.81
|
55
|
The use of denaturing gradient gel electrophoresis to screen for DNA sequence polymorphisms in the human factor VIII gene.
|
Electrophoresis
|
1989
|
0.81
|
56
|
FIZZ1 potentiates the carbachol-induced tracheal smooth muscle contraction.
|
Eur Respir J
|
2010
|
0.80
|
57
|
Dose-dependent and schedule-dependent effects of interleukin-12 on antigen-specific CD8 responses.
|
J Interferon Cytokine Res
|
2000
|
0.79
|
58
|
A new mouse model of experimental melanoma for vaccine and lymphokine therapy.
|
Int J Oncol
|
1998
|
0.79
|
59
|
Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy.
|
J Surg Res
|
1995
|
0.79
|
60
|
A CTL assay requiring only 150 microliter of mouse blood.
|
J Immunol Methods
|
2000
|
0.79
|
61
|
Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant.
|
Cancer Res
|
1999
|
0.78
|
62
|
IL-12-Dependent enhancement of CTL response to weak class I-restricted peptide immunogens requires coimmunization with T helper cell immunogens.
|
Clin Immunol
|
2000
|
0.78
|
63
|
The anti-tumor effect of interleukin-12 is enhanced by mild (fever-range) thermal therapy.
|
Immunol Invest
|
2005
|
0.78
|
64
|
Efficacy and mechanisms of action of rmB7.2-Ig as an antitumor agent in combination with Adriamycin and Cytoxan chemotherapy.
|
Clin Immunol
|
2001
|
0.78
|
65
|
Immunotherapy of mice with an irradiated melanoma vaccine coupled with interleukin-12.
|
Clin Exp Metastasis
|
1999
|
0.77
|
66
|
Interleukin-12 as vaccine adjuvant. Characteristics of primary, recall, and long-term responses.
|
Ann N Y Acad Sci
|
1996
|
0.77
|
67
|
The interleukin-12 beta subunit (p40) maps to mouse chromosome 11.
|
Mamm Genome
|
1996
|
0.75
|
68
|
Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3.
|
Mamm Genome
|
1996
|
0.75
|
69
|
Geochemical and cosmochemical materials.
|
Anal Chem
|
2001
|
0.75
|
70
|
Geochemical and cosmochemical materials.
|
Anal Chem
|
1999
|
0.75
|
71
|
Immune response enhancement by in vivo administration of B7.2Ig, a soluble costimulatory protein.
|
Clin Immunol
|
1999
|
0.75
|