Published in Cell on June 01, 1982
Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A (1984) 3.53
Specific methylation pattern at the 3' end of the human housekeeping gene for glucose 6-phosphate dehydrogenase. EMBO J (1984) 1.75
Incomplete X chromosome dosage compensation in chorionic villi of human placenta. Proc Natl Acad Sci U S A (1985) 1.53
Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA. EMBO J (1988) 1.50
Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation. Nucleic Acids Res (1984) 1.42
Expression of genes from the human active and inactive X chromosomes. Am J Hum Genet (1997) 1.38
Noninactivation of a selectable human X-linked gene that complements a murine temperature-sensitive cell cycle defect. Am J Hum Genet (1989) 1.22
Frequency of reactivation and variability in expression of X-linked enzyme loci. Am J Hum Genet (1984) 1.09
X chromosome inactivation of the human TIMP gene. Nucleic Acids Res (1990) 1.06
Complete reactivation of X chromosomes from human chorionic villi with a switch to early DNA replication. Proc Natl Acad Sci U S A (1986) 1.03
Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome. Genome Biol (2013) 0.99
Lack of X inactivation associated with maternal X isodisomy: evidence for a counting mechanism prior to X inactivation during human embryogenesis. Am J Hum Genet (1996) 0.97
Unusual (CGG)n expansion and recombination in a family with fragile X and DiGeorge syndrome. J Med Genet (1995) 0.86
The single active X in human cells: evolutionary tinkering personified. Hum Genet (2011) 0.83
The great escape. Am J Hum Genet (1997) 0.82
Hyperexpression of HPRT induced by 5-azacytidine in mouse-human hybrid reactivants. Am J Hum Genet (1985) 0.82
Differential activation of the hprt gene on the inactive X chromosome in primary and transformed Chinese hamster cells. Mol Cell Biol (1989) 0.81
Cell surface abnormality in clones of skin fibroblasts from a carrier of Duchenne muscular dystrophy. J Med Genet (1985) 0.75
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (1993) 19.80
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med (1991) 7.52
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med (1993) 5.71
Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci U S A (1998) 4.92
Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med (1993) 4.04
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med (1996) 3.82
Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A (1984) 3.53
Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. J Immunol (1992) 3.15
DNA restriction endonuclease analysis for localization of human beta- and delta-globin genes on chromosome 11. Proc Natl Acad Sci U S A (1979) 3.02
Adrenoleukodystrophy: evidence for X linkage, inactivation, and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A (1981) 2.83
X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: heterozygote has two clonal populations. Science (1968) 2.69
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 2.68
The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease. Am J Hum Genet (1976) 2.51
Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation. Proc Natl Acad Sci U S A (1980) 2.48
Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science (1993) 2.35
Studies of X chromosome DNA methylation in normal human cells. Nature (1982) 2.34
Effects of IL-12 on the response and susceptibility to experimental viral infections. J Immunol (1994) 2.31
Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity. Proc Natl Acad Sci U S A (1975) 2.30
Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J Exp Med (1992) 2.26
IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism. J Immunol (1995) 2.12
Effects of IL-12 on helper T cell-dependent immune responses in vivo. J Immunol (1994) 2.11
D-valine as a selective agent for normal human and rodent epithelial cells in culture. Cell (1975) 2.05
Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome. Chromosoma (1985) 2.04
Interleukin 12 at the site of disease in tuberculosis. J Clin Invest (1994) 1.98
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Nature (1985) 1.96
Human-mouse somatic cell hybrids with single human chromosome (group E): link with thymidine kinase activity. Science (1968) 1.96
Isolation and characterization of cloned DNA sequences that hybridize to the human X chromosome. Cell (1980) 1.96
Characterization of a cloned DNA sequence that is present at centromeres of all human autosomes and the X chromosome and shows polymorphic variation. Proc Natl Acad Sci U S A (1984) 1.86
Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect Immun (1996) 1.77
Differential expression of steroid sulphatase locus on active and inactive human X chromosome. Nature (1982) 1.75
IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J Immunol (1994) 1.75
Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc Natl Acad Sci U S A (2001) 1.67
IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol (1994) 1.65
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res (1994) 1.64
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. J Immunol (1997) 1.61
Genetic inactivation of the alpha-galactosidase locus in carriers of Fabry's disease. Science (1970) 1.61
Sex difference in methylation of single-copy genes in human meiotic germ cells: implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations. Somat Cell Mol Genet (1990) 1.58
Effect of ageing on reactivation of the human X-linked HPRT locus. Nature (1988) 1.55
Mechanism of origin of complete hydatidiform moles. Nature (1980) 1.55
Incomplete X chromosome dosage compensation in chorionic villi of human placenta. Proc Natl Acad Sci U S A (1985) 1.53
Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci U S A (1994) 1.53
Complex chromosome rearrangements. Report of a new case and literature review. Clin Genet (1980) 1.51
Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA. EMBO J (1988) 1.50
Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse. Proc Natl Acad Sci U S A (1981) 1.48
The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6. Blood (1988) 1.47
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer. Cancer Res (1998) 1.45
Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation. Nucleic Acids Res (1984) 1.42
IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J Immunol (1996) 1.42
Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers. Science (1979) 1.42
IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes. J Immunol (1995) 1.40
Stability of X chromosomal inactivation in human somatic cells. Nature (1972) 1.38
Human thymidine kinase gene locus: assignment to chromosome 17 in a hybrid of man and mouse cells. Science (1971) 1.37
Evidence for the inactivation of an X chromosome early in the development of the human female. Am J Hum Genet (1975) 1.32
Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur J Immunol (1993) 1.32
Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J Immunol (1993) 1.31
Short arm deletions in group E and chromosomal "deletion" syndromes. J Pediatr (1966) 1.31
Haptoglobin: a locus on the D1 chromosome? Am J Hum Genet (1967) 1.30
Studies of skin fibroblasts from 10 families with HGPRT deficiency, with reference in X-chromosomal inactivation. Am J Hum Genet (1971) 1.29
Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP) Am J Hum Genet (1993) 1.25
Nuclear metabolism of ribosomal RNA in growing, methionine-limited, and ethionine-treated HeLa cells. Biochemistry (1977) 1.24
Interleukin-12 gene expression after viral infection in the mouse. J Virol (1995) 1.22
DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: evidence for multistep maintenance of mammalian X dosage compensation. Proc Natl Acad Sci U S A (1987) 1.22
Genetic complementation after fusion of Tay-Sachs and Sandhoff cells. Nature (1974) 1.22
Selection against lethal alleles in females heterozygous for incontinentia pigmenti. Am J Hum Genet (1989) 1.21
Isolation and analysis of somatic hybrids derived from two human diploid cells. Proc Natl Acad Sci U S A (1974) 1.18
Asynchronous replication of homologous loci on human active and inactive X chromosomes. Proc Natl Acad Sci U S A (1990) 1.17
Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity. Eur J Immunol (2001) 1.17
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells. Int Immunol (1995) 1.17
The Hunter syndrome in females: is there an autosomal recessive form of iduronate sulfatase deficiency? Am J Hum Genet (1977) 1.17
X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: detection of heterozygotes by selective medium. Biochem Genet (1970) 1.16
The Barr body is a looped X chromosome formed by telomere association. Proc Natl Acad Sci U S A (1991) 1.15
Effect of intercellular communication on the selection of intraspecific human hybrids in HAT and ouabain. Somatic Cell Genet (1978) 1.15
Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics (1992) 1.15
Cytogenetic follow-up after bone marrow transplantation for Philadelphia-positive chronic myeloid leukemia. Cancer Genet Cytogenet (1989) 1.14
Interferon production and action in mouse, hamster and somatic hybrid mouse-hamster cells. Science (1968) 1.13
Rapid hybridization kinetics of DNA attached to submicron latex particles. Nucleic Acids Res (1987) 1.13
Comparison of factor IX methylation on human active and inactive X chromosomes: implications for X inactivation and transcription of tissue-specific genes. EMBO J (1986) 1.13
Assignment of the haemophilia B (factor IX) locus to the q26-qter region of the X chromosome. Ann Hum Genet (1984) 1.10
Signal sequence and DNA-mediated expression of human lysosomal alpha-galactosidase A. Eur J Biochem (1987) 1.09
Stability of the "two active X" phenotype in triploid somatic cells. Cell (1979) 1.07
Quantitation of contact-feeding between somatic cells in culture. Exp Cell Res (1975) 1.07
X-linked Hunter syndrome: the heterozygous phenotype in cell culture. Am J Hum Genet (1977) 1.07
Clonal evolution in human lymphoblast cultures. Am J Hum Genet (1988) 1.07
IL-12 reverses cytokine and immune abnormalities in Sezary syndrome. J Immunol (1995) 1.06
The human NTT gene: identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4+ T cells. Genomics (1997) 1.06
In search of non-random X inactivation: studies of fetal membranes heterozygous for glucose-6-phosphate dehydrogenase. Am J Hum Genet (1979) 1.06