Published in J Biol Chem on November 15, 1996
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68
Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia. Sci Signal (2012) 1.42
ATP sensitivity of preBötzinger complex neurones in neonatal rat in vitro: mechanism underlying a P2 receptor-mediated increase in inspiratory frequency. J Physiol (2008) 0.95
The cellular building blocks of breathing. Compr Physiol (2012) 0.91
Damage-induced cell-cell communication in different cochlear cell types via two distinct ATP-dependent Ca waves. Purinergic Signal (2010) 0.87
Interaction of P2 purinergic receptors with cellular macromolecules. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.86
ATP can stimulate exocytosis in rat brown adipocytes without apparent increases in cytosolic Ca2+ or G protein activation. Biophys J (1999) 0.76
P2 receptor modulation of voltage-gated potassium currents in Brown adipocytes. J Gen Physiol (1999) 0.76
P2Y(1) receptor modulation of endogenous ion channel function in Xenopus oocytes: Involvement of transmembrane domains. Purinergic Signal (2004) 0.75
Personal use of drug samples by physicians and office staff. JAMA (1997) 6.82
Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J Biol Chem (2000) 2.86
Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. Pharmacol Rev (1983) 2.62
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. J Biol Chem (1989) 2.23
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Br J Pharmacol (1996) 2.12
Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol (1996) 2.10
Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci (1997) 2.09
Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. Mol Pharmacol (1991) 2.00
Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J Biol Chem (1997) 1.99
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. J Biol Chem (1980) 1.95
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem (2000) 1.85
P2-purinergic receptors: subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol (1995) 1.84
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J Med Chem (1993) 1.84
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem J (1985) 1.83
Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. J Biol Chem (1987) 1.82
Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol (1995) 1.81
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br J Pharmacol (1998) 1.80
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. Br J Pharmacol (1994) 1.77
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. Mol Pharmacol (1994) 1.76
Agonist action of adenosine triphosphates at the human P2Y1 receptor. Mol Pharmacol (1998) 1.74
Serological and bacteriological investigations of chickens from flocks naturally infected with Salmonella enteritidis. Vet Rec (1989) 1.65
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. Mol Pharmacol (1997) 1.63
Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol (1999) 1.61
Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. J Med Chem (1998) 1.61
Oxidation of glycerol differentiates African from European isolates of Mycoplasma mycoides subspecies mycoides SC (small colony) Vet Rec (1997) 1.61
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem (1998) 1.61
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors. Neuropharmacology (1997) 1.59
The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. J Biol Chem (1999) 1.54
Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s). Mol Pharmacol (1982) 1.47
Detection of salmonella. Vet Rec (1990) 1.46
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol (2000) 1.44
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. J Pharmacol Exp Ther (1993) 1.36
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. Mol Pharmacol (1982) 1.36
Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. J Biol Chem (1994) 1.33
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. J Med Chem (2001) 1.32
Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor. J Biol Chem (1989) 1.31
Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J Biol Chem (1997) 1.30
The snowboarder's foot and ankle. Am J Sports Med (1998) 1.29
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. Biochem J (1987) 1.28
Adenosine receptors on human airway epithelia and their relationship to chloride secretion. Br J Pharmacol (1992) 1.27
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. Biochem J (1985) 1.27
Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate. Br J Pharmacol (1996) 1.27
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. Biochem J (1987) 1.26
Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution. J Biol Chem (2001) 1.26
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. Science (1980) 1.25
Role of excitatory amino acids in rat vagal and sympathetic baroreflexes. Brain Res (1987) 1.25
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem (1999) 1.25
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. Mol Pharmacol (1985) 1.24
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br J Pharmacol (2000) 1.23
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. J Biol Chem (1979) 1.23
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J Biol Chem (1987) 1.23
In vitro study of beta-adrenergic receptors. Annu Rev Pharmacol Toxicol (1977) 1.22
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. J Biol Chem (1983) 1.22
How well do older persons tolerate moderate altitude? West J Med (1995) 1.20
UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proc Natl Acad Sci U S A (1997) 1.20
Beta gamma-subunit activation of G-protein-regulated phospholipase C. J Biol Chem (1992) 1.19
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits. J Biol Chem (2001) 1.19
Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. Mol Pharmacol (1984) 1.19
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. J Auton Pharmacol (1996) 1.18
Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein. J Biol Chem (1991) 1.17
Identification of the active site in penicillin-binding protein 3 of Escherichia coli. J Bacteriol (1985) 1.16
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. Proc Natl Acad Sci U S A (1984) 1.16
beta-adrenergic receptors in rat liver: effects of adrenalectomy. Proc Natl Acad Sci U S A (1976) 1.16
Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms. Mol Pharmacol (1984) 1.15
Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase. Br J Pharmacol (2001) 1.15
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. J Pharmacol Exp Ther (1978) 1.15
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. Biochem J (1986) 1.15
H1-histamine receptors on human astrocytoma cells. Mol Pharmacol (1986) 1.15
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. J Cyclic Nucleotide Res (1979) 1.14
Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart. Mol Pharmacol (1976) 1.13
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem (2001) 1.12
Cloning and characterization of the ponA gene encoding penicillin-binding protein 1 from Neisseria gonorrhoeae and Neisseria meningitidis. J Bacteriol (1997) 1.11
Functional expression of a cDNA encoding a human ecto-ATPase. Br J Pharmacol (1999) 1.09
Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. J Biol Chem (1989) 1.09
Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol (1996) 1.09
Vaccination of chickens with chicken-derived Salmonella enteritidis phage type 4 aroA live oral Salmonella vaccines. Vaccine (1992) 1.09
Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C. Br J Pharmacol (1997) 1.08
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. Mol Pharmacol (1989) 1.08
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go. Biochem J (1987) 1.08
Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. J Med Chem (2000) 1.08
Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits. J Biol Chem (1994) 1.07
Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells. J Biol Chem (1978) 1.06
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. J Biol Chem (2000) 1.06
Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. J Biol Chem (1981) 1.05
Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C. J Biol Chem (1989) 1.03
Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J Pharmacol Exp Ther (2001) 1.03
A comparison of calcium-activated potassium channel currents in cell-attached and excised patches. J Gen Physiol (1987) 1.03
A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. J Med Chem (1998) 1.02
The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochem Biophys Res Commun (1997) 1.02