Published in Biochem J on June 15, 1995
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J (2003) 5.11
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol (1998) 3.61
Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev (1998) 3.44
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Sugar control of the plant cell cycle: differential regulation of Arabidopsis D-type cyclin gene expression. Mol Cell Biol (2000) 2.21
c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol (1998) 1.97
Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem (2003) 1.76
Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol Cell Biol (2004) 1.76
Plant cyclins: a unified nomenclature for plant A-, B- and D-type cyclins based on sequence organization. Plant Mol Biol (1996) 1.73
In stent restenosis: bane of the stent era. J Clin Pathol (2006) 1.71
The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes. Mol Cell Biol (1997) 1.59
Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins. Plant Physiol (2004) 1.56
Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol (2002) 1.54
p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell (2007) 1.54
Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev (1999) 1.43
Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J (1997) 1.42
Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex. Mol Cell Biol (2000) 1.41
Cell cycle regulation of cyclin-dependent kinases in tobacco cultivar Bright Yellow-2 cells. Plant Physiol (2001) 1.38
Phosphorylation of retinoblastoma-related protein by the cyclin D/cyclin-dependent kinase complex is activated at the G1/S-phase transition in tobacco. Plant Cell (2002) 1.35
Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell (1999) 1.33
Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Mol Biol Cell (1998) 1.30
Genome-wide annotation and expression profiling of cell cycle regulatory genes in Chlamydomonas reinhardtii. Plant Physiol (2005) 1.28
GADD45 proteins: central players in tumorigenesis. Curr Mol Med (2012) 1.26
Distinct cyclin D genes show mitotic accumulation or constant levels of transcripts in tobacco bright yellow-2 cells. Plant Physiol (1999) 1.23
Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells. Asian J Androl (2009) 1.21
Differential expression of genes for cyclin-dependent protein kinases in rice plants. Plant Physiol (1999) 1.20
Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). Genes Dev (1998) 1.19
CycD1, a putative G1 cyclin from Antirrhinum majus, accelerates the cell cycle in cultured tobacco BY-2 cells by enhancing both G1/S entry and progression through S and G2 phases. Plant Cell (2004) 1.19
A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit. PLoS One (2007) 1.17
New insights into the role of the maize ameiotic1 locus. Genetics (1997) 1.16
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue. Plant Cell (2007) 1.15
Varicella-zoster virus Fc receptor component gI is phosphorylated on its endodomain by a cyclin-dependent kinase. J Virol (1999) 1.13
Targeting the cell cycle for cancer therapy. Br J Cancer (2002) 1.12
The schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function. Mol Cell Biol (1999) 1.11
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression. Mol Biol Cell (2000) 1.11
A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana. Proc Natl Acad Sci U S A (1998) 1.09
Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infect Immun (2003) 1.07
Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Gastroenterology (2009) 1.06
The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family. RNA (1999) 1.05
Characterization of a new family of cyclin-dependent kinase activators. Biochem J (2005) 1.04
Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs. Cell Cycle (2012) 1.04
Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana. Ann Bot (2004) 1.02
A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana. PLoS Genet (2012) 1.01
Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi. Mol Genet Genomics (2006) 0.97
Retinoblastoma related1 regulates asymmetric cell divisions in Arabidopsis. Plant Cell (2012) 0.96
DNA-binding activity of the transcription factor upstream stimulatory factor 1 (USF-1) is regulated by cyclin-dependent phosphorylation. Biochem J (1999) 0.96
Genome-wide analysis of cyclin family in rice (Oryza Sativa L.). Mol Genet Genomics (2006) 0.95
Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding. Mol Biol Cell (2000) 0.95
Early increase in cyclin-D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen 1, 4-Bis[2-(3,5-Dichloropyridyloxy)] benzene. Am J Pathol (2000) 0.93
Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines. World J Gastroenterol (2007) 0.92
Control of the meiotic cell division program in plants. Plant Reprod (2013) 0.92
Analyses of phylogeny, evolution, conserved sequences and genome-wide expression of the ICK/KRP family of plant CDK inhibitors. Ann Bot (2011) 0.92
Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages. BMC Evol Biol (2014) 0.90
Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase. Biochem J (1996) 0.89
Nuclear PTEN levels and G2 progression in melanoma cells. Melanoma Res (2009) 0.89
Role of cdc2 kinase phosphorylation and conserved N-terminal proteolysis motifs in cytoplasmic polyadenylation-element-binding protein (CPEB) complex dissociation and degradation. Biochem J (2003) 0.89
Biochemical characterization of Cdk2-Speedy/Ringo A2. BMC Biochem (2005) 0.87
Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila) (2014) 0.86
The rice cyclin-dependent kinase-activating kinase R2 regulates S-phase progression. Plant Cell (2002) 0.85
Structural and functional relationship between the Ph1 locus protein 5B2 in wheat and CDK2 in mammals. Funct Integr Genomics (2010) 0.85
The regulatory network of cell-cycle progression is fundamentally different in plants versus yeast or metazoans. Plant Signal Behav (2010) 0.85
Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex. J Virol (2003) 0.85
Speedy/Ringo C regulates S and G2 phase progression in human cells. Cell Cycle (2008) 0.85
Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells. Vasc Cell (2011) 0.85
Cyclin-stimulated binding of Cks proteins to cyclin-dependent kinases. Mol Cell Biol (1998) 0.84
CAK-independent activation of CDK6 by a viral cyclin. Mol Biol Cell (2001) 0.84
Genome-wide identification and comprehensive analyses of the kinomes in four pathogenic microsporidia species. PLoS One (2014) 0.82
Salicylic acid antagonizes abscisic acid inhibition of shoot growth and cell cycle progression in rice. Sci Rep (2014) 0.82
A recombined protein (rSj16) derived from Schistosoma japonicum induces cell cycle arrest and apoptosis of murine myeloid leukemia cells. Parasitol Res (2013) 0.81
Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis. Clin Exp Immunol (2005) 0.81
Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. PLoS One (2013) 0.81
Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases. Neurobiol Dis (2009) 0.80
Characterization of novel mutations at the Schizosaccharomyces pombe cdc2 regulatory phosphorylation site, tyrosine 15. Mol Biol Cell (1996) 0.79
Functional Conservation in the SIAMESE-RELATED Family of Cyclin-Dependent Kinase Inhibitors in Land Plants. Plant Cell (2015) 0.79
Growth-inhibitory effect of cyclic GMP- and cyclic AMP-dependent vasodilators on rat vascular smooth muscle cells: effect on cell cycle and cyclin expression. Br J Pharmacol (1999) 0.79
Aberrant Meiotic Prophase I Leads to Genic Male Sterility in the Novel TE5A Mutant of Brassica napus. Sci Rep (2016) 0.78
Hysteresis meets the cell cycle. Proc Natl Acad Sci U S A (2003) 0.78
S phase of the cell cycle: a key phase for the regulation of thermodormancy in barley grain. J Exp Bot (2012) 0.78
Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol (2007) 0.76
Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle. J Cell Physiol (2016) 0.75
Systemic control of cell division and endoreduplication by NAA and BAP by modulating CDKs in root tip cells of Allium cepa. Biomed Res Int (2014) 0.75
Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592. Biochemistry (2016) 0.75
Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture. Cytotechnology (2001) 0.75
Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt's lymphoma cells via membrane surface Gb3. Glycoconj J (2016) 0.75
Cloning, sequencing, and expression of the genomic DNA encoding the protein phosphatase cdc25 in Dictyostelium discoideum. Dev Genes Evol (2004) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20
Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68
A cell cycle regulator potentially involved in genesis of many tumor types. Science (1994) 13.00
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (1989) 11.90
G1 phase progression: cycling on cue. Cell (1994) 11.62
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell (1994) 11.08
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (1992) 10.28
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell (1983) 9.90
The ubiquitin-proteasome proteolytic pathway. Cell (1994) 9.75
G1 events and regulation of cell proliferation. Science (1989) 9.73
Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell (1994) 9.25
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
Mammalian G1 cyclins. Cell (1993) 9.04
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell (1986) 8.82
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell (1987) 8.76
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev (1994) 8.52
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (1994) 8.22
Distinct roles for cyclin-dependent kinases in cell cycle control. Science (1993) 8.13
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03
A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature (1991) 7.98
An essential G1 function for cyclin-like proteins in yeast. Cell (1989) 7.43
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev (1993) 7.41
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev (1993) 7.40
D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol (1994) 7.35
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell (1994) 7.05
Mitotic forces control a cell-cycle checkpoint. Nature (1995) 6.93
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell (1993) 6.84
Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci U S A (1983) 6.74
Animal cell cycles and their control. Annu Rev Biochem (1992) 6.60
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell (1989) 6.43
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J Cell Biol (1994) 6.38
Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J (1993) 6.38
A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science (1993) 6.37
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell (1991) 6.36
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell (1991) 6.32
Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J Cell Biol (1993) 6.28
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res (1994) 6.16
The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J (1988) 6.09
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell (1992) 6.08
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (1994) 6.06
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
Association of human cyclin E with a periodic G1-S phase protein kinase. Science (1992) 5.98
The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J (1992) 5.92
CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev (1993) 5.62
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell (1990) 5.42
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32
Physical interaction of the retinoblastoma protein with human D cyclins. Cell (1993) 5.31
CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev (1992) 5.23
Crystal structure of cyclin-dependent kinase 2. Nature (1993) 5.21
Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol (1994) 5.18
DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol Cell Biol (1988) 5.08
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell (1994) 5.05
Mitosis in transition. Cell (1994) 5.03
A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell (1991) 4.85
Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81
Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell (1993) 4.75
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev (1994) 4.64
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature (1991) 4.60
In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell (1990) 4.57
The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell (1991) 4.53
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell (1991) 4.44
The cdc25 protein contains an intrinsic phosphatase activity. Cell (1991) 4.39
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell (1991) 4.33
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J (1993) 4.33
Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell (1990) 4.27
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature (1988) 4.24
Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science (1994) 4.24
Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature (1995) 4.20
Premature p34cdc2 activation required for apoptosis. Science (1994) 4.15
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Cell (1990) 4.12
Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell (1989) 4.10
p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell (1994) 4.07
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell (1994) 4.05
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J (1991) 4.04
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01
Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts. J Cell Biol (1992) 3.99
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev (1992) 3.96
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature (1994) 3.95
Cell cycle regulated transcription in yeast. Curr Opin Cell Biol (1994) 3.94
S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature (1993) 3.92
Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene. EMBO J (1985) 3.87
Ordering S phase and M phase in the cell cycle. Cell (1994) 3.87
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell (1994) 3.86
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell (1987) 3.82
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK. Cell (1994) 3.81
Cyclin from sea urchins to HeLas: making the human cell cycle. Biochem Soc Trans (1996) 1.03
Cyclins and their associated cyclin-dependent kinases in the human cell cycle. Biochem Soc Trans (1993) 1.00