Published in Cell on September 22, 1989
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol (1994) 5.18
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol (1998) 4.54
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A (1992) 4.27
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J (1990) 4.25
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol (1993) 4.04
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88
Cell cycle regulation of the human cdc2 gene. EMBO J (1992) 3.69
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol Cell Biol (1992) 3.58
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol (1995) 3.55
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol (1993) 3.54
Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol (1995) 3.41
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci U S A (1990) 3.40
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A (1999) 3.26
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. J Virol (1995) 3.18
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol Cell Biol (1992) 3.06
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol (1992) 2.97
Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell (1998) 2.93
Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J (1991) 2.84
An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1. J Virol (1995) 2.82
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J (1990) 2.80
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol (1992) 2.78
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J (1993) 2.70
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell (1997) 2.67
Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol (1995) 2.62
Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J (1995) 2.57
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc Natl Acad Sci U S A (1990) 2.46
Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J (1994) 2.44
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol (1993) 2.37
Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A (1996) 2.30
Multiple myeloma: increasing evidence for a multistep transformation process. Blood (1998) 2.29
Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis. Proc Natl Acad Sci U S A (1990) 2.27
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol Cell Biol (1990) 2.27
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc Natl Acad Sci U S A (1991) 2.26
Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J (1990) 2.26
E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol (1995) 2.26
Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol Cell Biol (1996) 2.23
Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J Virol (1991) 2.14
Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13
Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. EMBO J (1992) 2.11
Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci U S A (1994) 2.09
The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. Proc Natl Acad Sci U S A (1994) 2.06
Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J Virol (1992) 2.02
Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Mol Cell Biol (1991) 1.99
Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol Cell Biol (1993) 1.98
The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol (1995) 1.97
The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc Natl Acad Sci U S A (1992) 1.94
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol (1993) 1.92
Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc Natl Acad Sci U S A (1993) 1.89
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol (1995) 1.87
The paramyxovirus simian virus 5 V protein slows progression of the cell cycle. J Virol (2000) 1.85
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci U S A (1993) 1.84
Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol (1996) 1.81
The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J Cell Biol (1994) 1.80
The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol Cell Biol (1994) 1.73
Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A (1996) 1.72
Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription. Mol Cell Biol (2000) 1.71
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev (2002) 1.70
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A (1997) 1.67
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J (1994) 1.67
Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc Natl Acad Sci U S A (1995) 1.64
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol (1998) 1.63
The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol (1996) 1.63
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator. Mol Cell Biol (1994) 1.62
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest (1995) 1.61
Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci U S A (1992) 1.61
TGF-beta: problems and prospects. Cell Regul (1990) 1.59
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci U S A (1990) 1.57
BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. Mol Cell Biol (2004) 1.57
Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. Proc Natl Acad Sci U S A (1992) 1.54
Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol Cell Biol (1997) 1.53
Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification. Mol Cell Biol (1991) 1.52
Cyclin D1 and human neoplasia. Mol Pathol (1998) 1.50
Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Mol Cell Biol (1993) 1.48
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol Cell Biol (2002) 1.44
Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol (1996) 1.43
Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function. Mol Cell Biol (1991) 1.43
Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol (1999) 1.42
E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol (1991) 1.41
Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. Proc Natl Acad Sci U S A (1992) 1.41
The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene (2006) 1.41
The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol (1992) 1.40
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol Cell Biol (1996) 1.40
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci U S A (1993) 1.38
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev (2012) 1.37
Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis. J Virol (1997) 1.37
G1/S control of anchorage-independent growth in the fibroblast cell cycle. J Cell Biol (1991) 1.33
Cyclin E, a redundant cyclin in breast cancer. Proc Natl Acad Sci U S A (1996) 1.32
Protein-peptide interactions analyzed with the yeast two-hybrid system. Nucleic Acids Res (1995) 1.31
A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc Natl Acad Sci U S A (1997) 1.31
The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J Virol (1993) 1.29
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells. Proc Natl Acad Sci U S A (1991) 1.29
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (1997) 8.43
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell (1991) 6.55
Immunoaffinity chromatography of proteins. Methods Enzymol (1974) 6.40
Who should measure quality of life, the doctor or the patient? Br J Cancer (1988) 6.32
Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol (1994) 6.04
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell (1987) 5.84
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci U S A (1991) 5.83
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell (1992) 5.05
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05
T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40
In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science (1992) 4.04
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem (1997) 4.03
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01
Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet (1994) 3.89
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell (1989) 3.88
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell (1998) 3.86
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Case-control study of infections with Salmonella enteritidis phage type 4 in England. BMJ (1989) 3.79
Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med (2000) 3.72
Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2001) 3.69
Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell (1980) 3.62
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. Circulation (1996) 3.58
Regulation of human placental development by oxygen tension. Science (1997) 3.49
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem (2000) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell (1991) 3.47
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A (1996) 3.43
Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature (1998) 3.36
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest (1981) 3.34
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32
Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29
p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev (1996) 3.24
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24
Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol (1972) 3.23
p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci U S A (1992) 3.20
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell (1990) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J (1991) 3.16
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (1989) 3.07
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res (2000) 3.06
The p400 complex is an essential E1A transformation target. Cell (2001) 3.05
E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05
Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev (1995) 3.02
Flow of mitochondrial DNA across a species boundary. Proc Natl Acad Sci U S A (1983) 2.91
An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell (1989) 2.78
Head drop and camptocormia. J Neurol Neurosurg Psychiatry (2002) 2.78
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell (1995) 2.70
Autosomal dominant "Opitz" GBBB syndrome due to a 22q11.2 deletion. Am J Med Genet (1995) 2.70
Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science (1993) 2.70
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70
cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science (1990) 2.59
Membrane flow and differentiation: origin of Golgi apparatus membranes from endoplasmic reticulum. Adv Cytopharmacol (1974) 2.58
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev (1996) 2.58
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell (1993) 2.57
cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol Biol Cell (1992) 2.56
BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1997) 2.55
Control of Saccharomyces cerevisiae 2microN DNA replication by cell division cycle genes that control nuclear DNA replication. J Mol Biol (1977) 2.55
HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. N Engl J Med (1980) 2.52
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev (1999) 2.51
The effect of adjunctive fresh frozen plasma administration on coagulation parameters and survival in a canine model of antivenom-treated brown snake envenoming. Anaesth Intensive Care (2005) 2.49
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48
Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites. Cell (1976) 2.47
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell (2001) 2.47
The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes (1985) 2.46
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol (1994) 2.44
Normal flow (TIMI-3) before mechanical reperfusion therapy is an independent determinant of survival in acute myocardial infarction: analysis from the primary angioplasty in myocardial infarction trials. Circulation (2001) 2.43