Published in Cell on December 27, 1996
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol (1997) 4.36
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J (1997) 4.17
The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol (2009) 2.43
The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes. Plant Cell (2005) 2.29
Cell cycle control of chorion gene amplification. Genes Dev (1998) 2.26
Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics (2003) 2.15
Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev (1997) 2.07
Functional antagonism between E2F family members. Genes Dev (2001) 2.03
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. J Cell Biol (2004) 1.88
The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J (1999) 1.83
p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proc Natl Acad Sci U S A (1999) 1.79
Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev (2000) 1.65
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J (2000) 1.63
Retinoblastoma family genes. Oncogene (2006) 1.61
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev (2002) 1.60
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics (2000) 1.52
A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics (1999) 1.51
Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci U S A (2001) 1.47
A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet (2009) 1.43
The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J (1999) 1.42
Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J (1998) 1.39
A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Proc Natl Acad Sci U S A (2002) 1.38
S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol (1997) 1.36
Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol (2007) 1.33
PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain. Nucleic Acids Res (1998) 1.32
Neural stem cell transcriptional networks highlight genes essential for nervous system development. EMBO J (2009) 1.31
p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol (1997) 1.31
The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles. EMBO J (2007) 1.30
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A (2007) 1.29
An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Genetics (2002) 1.27
Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc Natl Acad Sci U S A (1998) 1.23
Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J (2003) 1.23
Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J Cell Biol (1997) 1.22
Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol (1999) 1.19
Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). Mol Cell Biol (1999) 1.17
Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol (2001) 1.17
Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. EMBO J (1998) 1.16
A role for Ebi in neuronal cell cycle control. EMBO J (2000) 1.15
Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci U S A (2004) 1.15
Conserved RB functions in development and tumor suppression. Protein Cell (2011) 1.15
Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol Cell Biol (1998) 1.14
Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO J (2004) 1.14
G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes Dev (2003) 1.14
Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics (1998) 1.13
A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol (2006) 1.13
Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J Cell Biol (1998) 1.12
A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics (2000) 1.11
Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. J Cell Biol (2010) 1.10
A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J (2001) 1.10
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics (2004) 1.07
Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ (2009) 1.05
Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol (2013) 1.05
Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci (2011) 1.05
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev (2009) 1.04
Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development. Mol Cell Biol (2007) 1.01
A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target. Genetics (2001) 0.99
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J (2010) 0.97
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Cdks and the Drosophila cell cycle. Curr Opin Genet Dev (1997) 0.96
Ectopic expression of the Drosophila Cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development. Genetics (2002) 0.94
From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet (2014) 0.94
Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol (2007) 0.93
putzig is required for cell proliferation and regulates notch activity in Drosophila. Mol Biol Cell (2007) 0.92
Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo. Proc Natl Acad Sci U S A (2013) 0.92
A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol (2010) 0.92
Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Biol Open (2011) 0.91
Roughex mediates G(1) arrest through a physical association with cyclin A. Mol Cell Biol (2000) 0.90
Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development (2013) 0.90
Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Dev Biol (2007) 0.89
The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase. Mol Biol Cell (2009) 0.88
Protein kinase D regulates several aspects of development in Drosophila melanogaster. BMC Dev Biol (2007) 0.88
Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function. EMBO Rep (2006) 0.88
Modeling early Epstein-Barr virus infection in Drosophila melanogaster: the BZLF1 protein. Genetics (2005) 0.88
Connecting cell behavior to patterning: lessons from the cell cycle. Cell (1997) 0.87
Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87
A protein network-guided screen for cell cycle regulators in Drosophila. BMC Syst Biol (2011) 0.86
Cell-cycle regulation of NOTCH signaling during C. elegans vulval development. Mol Syst Biol (2012) 0.86
The miRNA Regulation of Stem Cells. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.84
Characterization of Drosophila mini-me, a gene required for cell proliferation and survival. Genetics (2006) 0.84
Cyclin D and cdk4 are required for normal development beyond the blastula stage in sea urchin embryos. Mol Cell Biol (2002) 0.82
The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. BMC Dev Biol (2010) 0.81
The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics (2009) 0.80
Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res (2015) 0.80
The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis. Elife (2015) 0.79
A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo. PLoS One (2011) 0.79
Control of cell cycle entry and exiting from the second mitotic wave in the Drosophila developing eye. BMC Dev Biol (2008) 0.79
Robustness of cell cycle control and flexible orders of signaling events. Sci Rep (2015) 0.78
A complex regulatory network coordinating cell cycles during C. elegans development is revealed by a genome-wide RNAi screen. G3 (Bethesda) (2014) 0.78
The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation. Mol Biol Cell (2013) 0.78
Drosophila embryonic cell-cycle mutants. G3 (Bethesda) (2013) 0.77
S-phase favours notch cell responsiveness in the Drosophila bristle lineage. PLoS One (2008) 0.77
Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mech Dev (2008) 0.77
DNA sequence templates adjacent nucleosome and ORC sites at gene amplification origins in Drosophila. Nucleic Acids Res (2015) 0.77
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development (2015) 0.77
dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E. PLoS One (2011) 0.76
The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation. G3 (Bethesda) (2016) 0.75
Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication. Development (2015) 0.75
Regulation of the number of cell division rounds by tissue-specific transcription factors and Cdk inhibitor during ascidian embryogenesis. PLoS One (2014) 0.75
Comparative genomics of the eukaryotes. Science (2000) 26.62
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature (2001) 3.50
Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science (1995) 2.32
Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science (1997) 2.30
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J (1989) 2.13
A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol (2000) 2.09
bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J (1990) 2.00
The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J (1999) 1.42
cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia. EMBO J (1987) 1.26
The coupling of cell growth to the cell cycle. Curr Opin Cell Biol (2001) 1.16
Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. Mech Dev (2000) 1.02
Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1. Proc Natl Acad Sci U S A (1997) 0.97
Of flies and men--studying human disease in Drosophila. Curr Opin Genet Dev (2001) 0.96
Transgenic mouse models for hematopoietic tumorigenesis. Curr Top Microbiol Immunol (1988) 0.92
Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev Biol (1993) 0.92
Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development. Proc Natl Acad Sci U S A (1997) 0.91
Analysis of the terminus region of the Bacillus subtilis chromosome. Nature (1981) 0.90
Conformation and segregation of nucleoids accompanying cell length extension after completion of a single round of DNA replication in germinated and outgrowing Bacillus subtilis spores. J Bacteriol (1982) 0.84
A dental-based, athletic trainer-mediated spit tobacco cessation program for professional baseball players. J Calif Dent Assoc (1998) 0.82
Prevalence of spit tobacco use across studies of professional baseball players. J Calif Dent Assoc (1998) 0.81
Analysis of the leukemogenic properties of the bcr-v-abl and GM-CSF genes using a new retroviral vector. Curr Top Microbiol Immunol (1989) 0.75