Published in Nat Med on January 01, 1997
The equilibrative nucleoside transporter family, SLC29. Pflugers Arch (2003) 3.00
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med (2005) 2.35
Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23
Ribavirin and interferon alfa-2b in chronic hepatitis C: assessment of possible pharmacokinetic and pharmacodynamic interactions. Br J Clin Pharmacol (1998) 1.72
In vivo labeling of fission yeast DNA with thymidine and thymidine analogs. Methods (2004) 1.54
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR. Nucleic Acids Res (2003) 1.51
Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol (2011) 1.36
Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. Proc Natl Acad Sci U S A (1998) 1.30
Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res (2003) 1.23
Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem J (1997) 1.17
Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Am J Physiol Gastrointest Liver Physiol (2006) 1.14
Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1). J Biol Chem (2011) 1.04
Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity. Proc Natl Acad Sci U S A (2001) 1.03
Regulation of DNA replication machinery by Mrc1 in fission yeast. Genetics (2006) 1.01
The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice. Genes Brain Behav (2007) 1.00
Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection. Am J Physiol Heart Circ Physiol (2009) 0.99
Lack of the nucleoside transporter ENT1 results in the Augustine-null blood type and ectopic mineralization. Blood (2015) 0.98
Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res (2011) 0.98
Nutrient transport and pathogenesis in selected parasitic protozoa. Eukaryot Cell (2011) 0.98
ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol (2012) 0.98
Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Cancer Res (2010) 0.95
Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment. Blood (2005) 0.93
An essential role for adenosine signaling in alcohol abuse. Curr Drug Abuse Rev (2010) 0.92
Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochem J (2003) 0.90
Two nucleoside uptake systems in Lactococcus lactis: competition between purine nucleosides and cytidine allows for modulation of intracellular nucleotide pools. J Bacteriol (2003) 0.89
Transmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1). J Biol Chem (2010) 0.89
Adenosine down-regulates the surface expression of dipeptidyl peptidase IV on HT-29 human colorectal carcinoma cells: implications for cancer cell behavior. Am J Pathol (2004) 0.88
Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. J Membr Biol (2003) 0.87
Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. Nucleic Acids Res (2002) 0.86
Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cells. Br J Pharmacol (2004) 0.86
Excretion of biliary compounds during intrauterine life. World J Gastroenterol (2009) 0.85
Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Biochem J (2000) 0.85
Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. Biochem J (2001) 0.84
Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1. J Physiol (2003) 0.84
The role of transporters in the toxicity of nucleoside and nucleotide analogs. Expert Opin Drug Metab Toxicol (2012) 0.82
Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity? World J Biol Psychiatry (2013) 0.81
The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells. PLoS One (2016) 0.80
Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2. Biochem J (2005) 0.80
Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors. Br J Pharmacol (2001) 0.80
Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem Pharmacol (2013) 0.80
Uneven distribution of nucleoside transporters and intracellular enzymatic degradation prevent transport of intact [14C] adenosine across the sheep choroid plexus epithelium as a monolayer in primary culture. Cerebrospinal Fluid Res (2006) 0.80
Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development. Int J Parasitol Drugs Drug Resist (2015) 0.80
Inhibiting the growth of pancreatic adenocarcinoma in vitro and in vivo through targeted treatment with designer gold nanotherapeutics. PLoS One (2013) 0.80
A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer. J Biol Chem (2009) 0.79
Regulation of adenosine transport by D-glucose in human fetal endothelial cells: involvement of nitric oxide, protein kinase C and mitogen-activated protein kinase. J Physiol (2000) 0.79
A case of serendipity*. Purinergic Signal (2007) 0.78
The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters. PLoS One (2015) 0.78
Purine import into malaria parasites as a target for antimalarial drug development. Ann N Y Acad Sci (2014) 0.78
Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression. Am J Nucl Med Mol Imaging (2013) 0.77
2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling. Br J Pharmacol (2002) 0.77
Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells. ChemMedChem (2014) 0.77
Seeking the nucleoside transporter. Nat Med (1997) 0.76
Novel regulation of equlibrative nucleoside transporter 1 (ENT1) by receptor-stimulated Ca2+-dependent calmodulin binding. Am J Physiol Cell Physiol (2016) 0.76
Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors. Bioorg Med Chem (2007) 0.75
Ticagrelor Does Not Inhibit Adenosine Transport at Relevant Concentrations: A Randomized Cross-Over Study in Healthy Subjects In Vivo. PLoS One (2015) 0.75
Functional characterization of human equilibrative nucleoside transporter 1. Protein Cell (2016) 0.75
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding. Br J Cancer (1999) 0.75
Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1. Mol Pharmacol (2016) 0.75
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00
Sequence and structure of a human glucose transporter. Science (1985) 8.03
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature (1993) 7.39
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Med (2015) 4.95
Mammalian and bacterial sugar transport proteins are homologous. Nature (1987) 4.46
Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A (1994) 4.06
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem (1995) 3.78
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc Natl Acad Sci U S A (1985) 3.31
Membrane transport proteins: implications of sequence comparisons. Curr Opin Cell Biol (1992) 3.13
Heterotopic ossification: a review. Skeletal Radiol (2005) 2.86
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nat Genet (2001) 2.81
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology (1990) 2.77
Microrheology, stress fluctuations, and active behavior of living cells. Phys Rev Lett (2003) 2.62
Perforin: structure and function. Immunol Today (1995) 2.42
Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature (1986) 2.41
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell (1986) 2.38
GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron (1998) 2.34
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res (1998) 2.32
2500 Outpatient diagnostic hysteroscopies. Obstet Gynecol (1996) 2.26
The gastrointestinal stimulus to insulin release. I. Secretin. J Clin Invest (1969) 2.24
Illicit transport: the oligopeptide permease. Proc Natl Acad Sci U S A (1973) 2.22
Cytolytic pore-forming proteins and peptides: is there a common structural motif? Trends Biochem Sci (1991) 2.22
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities. Science (1986) 2.21
Properties of the major outer membrane protein from Neisseria gonorrhoeae incorporated into model lipid membranes. Proc Natl Acad Sci U S A (1983) 2.20
Epiphora during the first year of life. Eye (Lond) (1991) 2.17
Cell death mechanisms and the immune system. Immunol Rev (1991) 2.07
Electrocardiographs in general practice. BMJ (1989) 2.07
Measurement and manipulation of pulmonary artery wedge pressure in adult respiratory distress syndrome. Anaesthesia (1991) 2.01
Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane. Biochim Biophys Acta (1974) 2.00
Development of the concept of a liquid pulmonary alveolar lining layer. Br J Anaesth (2001) 2.00
Multiple mechanisms of lymphocyte-mediated killing. Immunol Today (1988) 1.95
Functional assembly of gap junction conductance in lipid bilayers: demonstration that the major 27 kd protein forms the junctional channel. Cell (1987) 1.94
Comparison of mortality prediction models after open abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg (2006) 1.94
Prospective evaluation of stapled haemorrhoidopexy versus transanal haemorrhoidal dearterialisation for stage II and III haemorrhoids: three-year outcomes. Tech Coloproctol (2011) 1.92
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol (1999) 1.91
Characterization of a membrane pore-forming protein from Entamoeba histolytica. J Exp Med (1982) 1.85
The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis. Proc Natl Acad Sci U S A (1984) 1.83
Extracellular ATP as a trigger for apoptosis or programmed cell death. J Cell Biol (1991) 1.80
Identification of a new glucosinolate-rich cell type in Arabidopsis flower stalk. Plant Physiol (2000) 1.76
The management of Chlamydia trachomatis: combined community and hospital study. Sex Transm Infect (2000) 1.72
Macrophage membrane potential changes associated with gamma 2b/gamma 1 Fc receptor-ligand binding. Proc Natl Acad Sci U S A (1983) 1.70
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proc Natl Acad Sci U S A (2005) 1.65
Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy. Nutrition (2003) 1.65
Mouse macrophage Fc receptor for IgG gamma 2b/gamma 1 in artificial and plasma membrane vesicles functions as a ligand-dependent ionophore. Proc Natl Acad Sci U S A (1983) 1.64
Soft-tissue masses: histologic basis for decreased signal (short T2) on T2-weighted MR images. AJR Am J Roentgenol (1987) 1.64
A randomised controlled trial of the effect of continuous electronic physiological monitoring on the adverse event rate in high risk medical and surgical patients. Anaesthesia (2006) 1.63
Isolation and characterization of a serine esterase from cytolytic T cell granules. Cell (1986) 1.63
Assessing the validity, responsiveness and meaningfulness of the Hidradenitis Suppurativa Clinical Response (HiSCR) as the clinical endpoint for hidradenitis suppurativa treatment. Br J Dermatol (2014) 1.63
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir. Nat Struct Biol (1995) 1.62
Utility of CT-guided abdominal aspiration procedures. AJR Am J Roentgenol (1982) 1.62
A survey of basic resuscitation knowledge among resident paediatricians. Arch Dis Child (1993) 1.61
Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J Exp Med (1989) 1.60
Outcome measures for adult critical care: a systematic review. Health Technol Assess (2000) 1.59
Role for mouse macrophage IgG Fc receptor as ligand-dependent ion channel. Nature (1984) 1.58
Nucleoside transporters: molecular biology and implications for therapeutic development. Mol Med Today (1999) 1.58
Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity. J Exp Med (1987) 1.58
Peptide-specific antibodies as probes of the orientation of the glucose transporter in the human erythrocyte membrane. J Biol Chem (1987) 1.57
Nucleoside transport in animal cells. Biosci Rep (1983) 1.56
Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion. Bone Marrow Transplant (2001) 1.54
Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J Neurotrauma (1997) 1.53
Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line. J Exp Med (1994) 1.53
Positron emission tomography in Alzheimer's disease. Neurology (1986) 1.52
Identification, isolation, and characterization of a novel cytotoxin in murine cytolytic lymphocytes. Cell (1987) 1.48
Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils. FEMS Immunol Med Microbiol (1994) 1.48
Is provisional stenting the effective option? The WIDEST study (Wiktor stent in de novo stenosis). Widest Trial Investigators' Group. Heart (2000) 1.48
Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins. Xenobiotica (2008) 1.48
Purified perforin induces target cell lysis but not DNA fragmentation. J Exp Med (1989) 1.47
Evaluation of the sporicidal activity of different chemical disinfectants used in hospitals against Clostridium difficile. J Hosp Infect (2011) 1.47
Identification and characterization of a membrane-bound cytotoxin of murine cytolytic lymphocytes that is related to tumor necrosis factor/cachectin. Proc Natl Acad Sci U S A (1989) 1.47
Detection of trisomy 18 and Y-derived sequences in fetal nucleated cells obtained by transcervical flushing. Lancet (1993) 1.46
Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channels. Biophys J (2001) 1.45
Current oxygenation practice in ventilated patients-an observational cohort study. Anaesth Intensive Care (2013) 1.45
Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem (2000) 1.44
Serum nitrates as markers of postoperative morbidity. Lancet (1994) 1.44
Transport of nucleoside drugs in animal cells. Pharmacol Ther (1981) 1.44
Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp Cell Res (1991) 1.43
Functional channel formation associated with cytotoxic T-cell granules. Proc Natl Acad Sci U S A (1986) 1.43
Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis. FASEB J (1994) 1.43
Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg (1992) 1.43
Extracellular ATP perturbs transmembrane ion fluxes, elevates cytosolic [Ca2+], and inhibits phagocytosis in mouse macrophages. J Biol Chem (1985) 1.43
Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion. J Comp Neurol (1984) 1.42
Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther (2013) 1.42
Reproducibility of the measurement of submucous fibroid protrusion into the uterine cavity using three-dimensional saline contrast sonohysterography. Ultrasound Obstet Gynecol (2006) 1.41
Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells. J Exp Med (1986) 1.41
Synovial sarcoma: MR imaging findings in 34 patients. AJR Am J Roentgenol (1993) 1.41
Amino acid transport in human and in sheep erythrocytes. Proc R Soc Lond B Biol Sci (1980) 1.41
Topical lincomycin gel in acne vulgaris: a multicentric placebo controlled study. Indian J Dermatol Venereol Leprol (2007) 1.40
Right heart catheterization in intensive care. Br J Anaesth (2001) 1.40
The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol Membr Biol (2001) 1.40
Nitrobenzylthionionosine binding sites in the erythrocyte membrane. Biochim Biophys Acta (1976) 1.39