Published in Proc Natl Acad Sci U S A on January 07, 1997
Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study. Biophys J (2000) 4.14
SNAREs in opposing bilayers interact in a circular array to form conducting pores. Biophys J (2002) 1.69
Time scales of membrane fusion revealed by direct imaging of vesicle fusion with high temporal resolution. Proc Natl Acad Sci U S A (2006) 1.50
Visualization of regulated exocytosis with a granule-membrane probe using total internal reflection microscopy. Mol Biol Cell (2004) 1.44
Gradient of rigidity in the lamellipodia of migrating cells revealed by atomic force microscopy. Biophys J (2005) 1.43
Kiss-and-coat and compartment mixing: coupling exocytosis to signal generation and local actin assembly. Mol Biol Cell (2006) 1.43
Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity. Proc Natl Acad Sci U S A (2004) 1.41
Structure and composition of the fusion pore. Biophys J (2003) 1.38
Size of supramolecular SNARE complex: membrane-directed self-assembly. J Am Chem Soc (2005) 1.35
Dynamics of surfactant release in alveolar type II cells. Proc Natl Acad Sci U S A (1998) 1.33
A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide. Proc Natl Acad Sci U S A (1998) 1.24
CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. Neoplasia (2009) 1.21
Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci U S A (2002) 1.20
Reconstituted fusion pore. Biophys J (2003) 1.19
Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells. Mol Biol Cell (2007) 1.18
Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc Natl Acad Sci U S A (1997) 1.16
Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane. J Clin Invest (2001) 1.16
Quantification of the force of nanoparticle-cell membrane interactions and its influence on intracellular trafficking of nanoparticles. Biomaterials (2008) 1.14
Topography and nanomechanics of live neuronal growth cones analyzed by atomic force microscopy. Biophys J (2009) 1.13
Cell viability and probe-cell membrane interactions of XR1 glial cells imaged by atomic force microscopy. Biophys J (1997) 1.09
Membrane fusion in cells: molecular machinery and mechanisms. J Cell Mol Med (2006) 0.96
Secretion machinery at the cell plasma membrane. Curr Opin Struct Biol (2007) 0.92
Mechanical forces impeding exocytotic surfactant release revealed by optical tweezers. Biophys J (2003) 0.92
High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events. Sci Rep (2013) 0.90
Neuronal porosome proteome: Molecular dynamics and architecture. J Proteomics (2012) 0.89
Cellular and molecular mechanics by atomic force microscopy: capturing the exocytotic fusion pore in vivo? Proc Natl Acad Sci U S A (1997) 0.88
High-resolution three-dimensional imaging of the rich membrane structures of bone marrow-derived mast cells. Ultramicroscopy (2008) 0.86
The story of cell secretion: events leading to the discovery of the 'porosome' - the universal secretory machinery in cells. J Cell Mol Med (2006) 0.86
Discovery of the 'porosome'; the universal secretory machinery in cells. J Cell Mol Med (2006) 0.86
3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex. Histochem Cell Biol (2012) 0.86
Applications of atomic force microscopy in biophysical chemistry of cells. J Phys Chem B (2010) 0.86
Porosome: the secretory portal in cells. Biochemistry (2009) 0.82
Landmark discoveries in intracellular transport and secretion. J Cell Mol Med (2007) 0.82
Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy. J Membr Biol (2003) 0.81
Porosome in astrocytes. J Cell Mol Med (2008) 0.81
Cell secretion - finally sees the light. J Cell Mol Med (2006) 0.81
Identification of the porosome complex in the hair cell. Cell Biol Int Rep (2010) (2011) 0.80
Imaging CFTR in its native environment. Pflugers Arch (2007) 0.80
'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion. J Cell Mol Med (2015) 0.79
Neuronal porosome lipidome. J Cell Mol Med (2014) 0.79
Cell secretion: an update. J Cell Mol Med (2008) 0.79
Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). J Proteomics (2013) 0.79
Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis. Micron (2013) 0.78
Cellular secretion studied by force microscopy. J Cell Mol Med (2006) 0.78
Measurement of changes in membrane surface morphology associated with exocytosis using scanning ion conductance microscopy. Biophys J (2006) 0.77
Neuronal Porosome-The Secretory Portal at the Nerve Terminal: It's Structure-Function, Composition, and Reconstitution. J Mol Struct (2014) 0.77
Atomic force microscopy: Unraveling the fundamental principles governing secretion and membrane fusion in cells. Ultramicroscopy (2009) 0.76
Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells. Endocrinology (2015) 0.75
Porosome in Cystic Fibrosis. Discoveries (Craiova) (2015) 0.75
The neuronal porosome complex in health and disease. Exp Biol Med (Maywood) (2015) 0.75
How do you recognize and reconstitute a synaptic vesicle after fusion? F1000Res (2017) 0.75
In vitro secretion of zymogens by bovine pancreatic acini and ultra-structural analysis of exocytosis. Biochem Biophys Rep (2015) 0.75
Atomic force microscope. Phys Rev Lett (1986) 32.69
Mechanisms of intracellular protein transport. Nature (1994) 13.54
The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature (1995) 7.48
Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature (1985) 5.41
Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells. Nature (1992) 5.23
Biomolecular imaging with the atomic force microscope. Annu Rev Biophys Biomol Struct (1994) 4.89
Release of secretory products during transient vesicle fusion. Nature (1993) 4.57
Currents through the fusion pore that forms during exocytosis of a secretory vesicle. Nature (1987) 3.97
Actin-dependent organelle movement in squid axoplasm. Nature (1992) 3.51
Simultaneous electrical and optical measurements show that membrane fusion precedes secretory granule swelling during exocytosis of beige mouse mast cells. Proc Natl Acad Sci U S A (1987) 3.37
Actin filament dynamics in living glial cells imaged by atomic force microscopy. Science (1992) 3.31
Final steps in exocytosis observed in a cell with giant secretory granules. Proc Natl Acad Sci U S A (1987) 3.01
Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J Cell Biol (1995) 2.90
Stereological analysis of the guinea pig pancreas. I. Analytical model and quantitative description of nonstimulated pancreatic exocrine cells. J Cell Biol (1974) 2.70
Studies on dispersed pancreatic exocrine cells. I. Dissociation technique and morphologic characteristics of separated cells. J Cell Biol (1974) 2.55
Arrest of membrane fusion events in mast cells by quick-freezing. J Cell Biol (1980) 2.46
Exocytosis. Annu Rev Physiol (1990) 2.42
Structural changes after transmitter release at the frog neuromuscular junction. J Cell Biol (1981) 2.37
Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion. Curr Opin Cell Biol (1995) 2.31
The exocytotic fusion pore. J Cell Biol (1992) 2.10
Granula motion and membrane spreading during activation of human platelets imaged by atomic force microscopy. Biophys J (1994) 1.92
SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J Cell Biol (1993) 1.91
Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein. J Cell Biol (1993) 1.89
Exocytotic fusion pores exhibit semi-stable states. J Membr Biol (1993) 1.62
Transmitter release from synapses: does a preassembled fusion pore initiate exocytosis? Neuron (1990) 1.55
Three-dimensional imaging of living neurons and glia with the atomic force microscope. J Cell Sci (1993) 1.48
Gelsolin inhibition of fast axonal transport indicates a requirement for actin microfilaments. Nature (1984) 1.37
Microfilamentous system and secretion of enzyme in the exocrine pancreas. Effect of cytochalasin B. J Cell Biol (1975) 1.36
Slow cellular dynamics in MDCK and R5 cells monitored by time-lapse atomic force microscopy. Biophys J (1994) 1.32
Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o). J Biol Chem (1993) 1.31
Subcellular localization of CFTR to endosomes in a ductal epithelium. Am J Physiol (1994) 1.23
Coated vesicles: a diversity of form and function. FASEB J (1995) 1.16
Redistribution of a rab3-like GTP-binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis. J Cell Biol (1994) 1.11
Protein tyrosine phosphatase stimulates Ca(2+)-dependent amylase secretion from pancreatic acini. J Biol Chem (1991) 1.10
The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis. J Biol Chem (1995) 1.06
Imaging real-time neurite outgrowth and cytoskeletal reorganization with an atomic force microscope. Am J Physiol (1995) 1.04
The exocytotic fusion pore interface: a model of the site of neurotransmitter release. Mol Membr Biol (1995) 1.02
Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy. Pflugers Arch (1993) 0.91
Mechanisms of catecholamine secretion from adrenal chromaffin cells. J Physiol Pharmacol (1995) 0.86
Scanning force microscopy on live cultured cells: imaging and force-versus-distance investigations. J Microsc (1994) 0.82
Patch clamp detection of transcription factor translocation along the nuclear pore complex channel. J Membr Biol (1995) 2.17
Molecular weights of individual proteins correlate with molecular volumes measured by atomic force microscopy. Pflugers Arch (1998) 1.82
Unusual permeability properties of gastric gland cells. Nature (1994) 1.74
Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli. Cell Microbiol (2001) 1.65
Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties. Pflugers Arch (1994) 1.46
Electrical dimension of the nuclear envelope. Physiol Rev (2001) 1.41
Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proc Natl Acad Sci U S A (1987) 1.25
Fluid absorption in isolated perfused colonic crypts. J Clin Invest (1995) 1.23
Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc Natl Acad Sci U S A (1997) 1.16
Endothelial barrier function under laminar fluid shear stress. Lab Invest (2000) 1.14
Unique permeability barrier of the apical surface of parietal and chief cells in isolated perfused gastric glands. J Exp Biol (1994) 1.11
New structure involved in transient membrane fusion and exocytosis. Ann N Y Acad Sci (2002) 1.11
An apical permeability barrier to NH3/NH4+ in isolated, perfused colonic crypts. Proc Natl Acad Sci U S A (1995) 1.10
Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells. J Clin Invest (1994) 1.10
Imaging ROMK1 inwardly rectifying ATP-sensitive K+ channel protein using atomic force microscopy. Proc Natl Acad Sci U S A (1996) 1.09
Volume dynamics in migrating epithelial cells measured with atomic force microscopy. Pflugers Arch (2000) 1.07
Continuous detection of extracellular ATP on living cells by using atomic force microscopy. Proc Natl Acad Sci U S A (1999) 1.05
Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance. Proc Natl Acad Sci U S A (1996) 1.05
Phenotypically and karyotypically distinct Madin-Darby canine kidney cell clones respond differently to alkaline stress. J Cell Physiol (1995) 1.01
Anthracene-9-carboxylic acid inhibits renal chloride reabsorption. Pflugers Arch (1983) 1.00
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem (2001) 1.00
Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1. Biochemistry (1993) 1.00
Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing. Surgery (1992) 1.00
Polarized ion transport during migration of transformed Madin-Darby canine kidney cells. Pflugers Arch (1995) 0.99
Mechanism of distal tubular chloride transport in Amphiuma kidney. Am J Physiol (1982) 0.99
Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biol Int (1997) 0.99
Evidence for Ca2+- and ATP-sensitive peripheral channels in nuclear pore complexes. FASEB J (2001) 0.97
ATP-Induced shape change of nuclear pores visualized with the atomic force microscope. J Membr Biol (1998) 0.97
Fusion of renal epithelial cells: a model for studying cellular mechanisms of ion transport. Proc Natl Acad Sci U S A (1986) 0.97
17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange. Cardiovasc Res (2006) 0.96
Intracellular pH in diluting segment of frog kidney. Pflugers Arch (1985) 0.93
Cellular Mechanism of the furosemide sensitive transport system in the kidney. Klin Wochenschr (1982) 0.93
Nuclear pore function viewed with atomic force microscopy. Pflugers Arch (2000) 0.92
Cell membrane potential: a signal to control intracellular pH and transepithelial hydrogen ion secretion in frog kidney. Pflugers Arch (1987) 0.92
Potassium transport in the early distal tubule of Amphiuma kidney. Effects of potassium adaptation. Pflugers Arch (1983) 0.92
Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology (1999) 0.92
The native membrane fusion machinery in cells. Cell Biol Int (1998) 0.91
Mechanism of hydrogen ion transport in the diluting segment of frog kidney. Pflugers Arch (1984) 0.91
EM 3D contour maps provide protein assembly at the nanoscale within the neuronal porosome complex. J Microsc (2008) 0.91
Chloride activity in cells of isolated perfused cortical thick ascending limbs of rabbit kidney. Pflugers Arch (1983) 0.90
Secretion pores in human endothelial cells during acute hypoxia. J Membr Biol (2002) 0.90
Relationship between cell volume and ion transport in the early distal tubule of the Amphiuma kidney. J Gen Physiol (1985) 0.90
Ouabain decreases apparent potassium-conductance in proximal tubules of the amphibian kidney. Pflugers Arch (1985) 0.89
The effect of phenylalanine on the electrical properties of proximal tubule cells in the frog kidney. Pflugers Arch (1985) 0.89
Imaging excised apical plasma membrane patches of MDCK cells in physiological conditions with atomic force microscopy. Pflugers Arch (1997) 0.89
Resistance properties of the diluting segment of Amphiuma kidney: influence of potassium adaptation. J Membr Biol (1985) 0.89
Cytoplasmic Ca2+ determines the rate of Ca2+ entry into Mardin-Darby canine kidney-focus (MDCK-F) cells. Pflugers Arch (1994) 0.89
Immunolocalization of lamins and nuclear pore complex proteins by atomic force microscopy. Pflugers Arch (1995) 0.89
Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells. Proc Natl Acad Sci U S A (1998) 0.88
Intracellular Ca2+ distribution in migrating transformed epithelial cells. Pflugers Arch (1997) 0.88
Whole-cell potassium currents in single early distal tubule cells. Am J Physiol (1988) 0.88
Nuclear hourglass technique: an approach that detects electrically open nuclear pores in Xenopus laevis oocyte. Proc Natl Acad Sci U S A (1999) 0.87
Effects of inhibition of chloride transport on intracellular sodium activity in distal amphibian nephron. Pflugers Arch (1982) 0.87
The amphibian diluting segment. Am J Physiol (1988) 0.87
Evidence for Na+ dependent rheogenic HCO3- transport in fused cells of frog distal tubules. Pflugers Arch (1987) 0.87
Quantitative morphodynamics of endothelial cells within confluent cultures in response to fluid shear stress. Biophys J (2000) 0.87
The effect of furosemide on luminal sodium, chloride and potassium transport in the early distal tubule of Amphiuma kidney. Effects of potassium adaptation. Pflugers Arch (1983) 0.87
High-resistance MDCK-C7 monolayers used for measuring invasive potency of tumour cells. Pflugers Arch (2000) 0.87
Pushing, pulling, dragging, and vibrating renal epithelia by using atomic force microscopy. Am J Physiol Renal Physiol (2000) 0.86
The effect of ouabain on intracellular activities of K+, Na+, Cl-, H+ and Ca2+ in proximal tubules of frog kidneys. Pflugers Arch (1984) 0.86
Aldosterone receptor sites on plasma membrane of human vascular endothelium detected by a mechanical nanosensor. Pflugers Arch (2008) 0.86
Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts. J Membr Biol (1999) 0.86
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells. Am J Physiol (1997) 0.86
Calcium, ATP and nuclear pore channel gating. Pflugers Arch (2000) 0.85
Using atomic force microscopy to investigate patch-clamped nuclear membrane. Cell Biol Int (1997) 0.85
20-OH-ecdysone swells nuclear volume by alkalinization in salivary glands of Drosophila melanogaster. Cell Tissue Res (1993) 0.85
Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina. Proc Natl Acad Sci U S A (2008) 0.84
Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. Am J Physiol Renal Physiol (2002) 0.84
Inefficacy of bicarbonate infusions on the course of postischaemic acute renal failure in the rat. Eur J Clin Invest (1981) 0.84
Ochratoxin A impairs "postproximal" nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflugers Arch (1993) 0.84
Activation of luminal Na+/H+ exchange in distal nephron of frog kidney. An early response to aldosterone. Pflugers Arch (1987) 0.84
Bradykinin shifts endothelial fluid passage from para- to transcellular routes. Pflugers Arch (2006) 0.84
Handling of oxalate by the rat kidney. Pflugers Arch (1978) 0.84
Evidence for an amiloride sensitive Na+ pathway in the amphibian diluting segment induced by K+ adaptation. Pflugers Arch (1983) 0.84
The effect of respiratory and metabolic acid-base changes on ionized calcium concentration: in vivo and in vitro experiments in man and rat. Eur J Clin Invest (1982) 0.83
Distal site of calcium reabsorption in the rat nephron. Pflugers Arch (1978) 0.83
Plasma membrane protein clusters appear in CFTR-expressing Xenopus laevis oocytes after cAMP stimulation. J Membr Biol (2001) 0.83
Patch clamp and atomic force microscopy demonstrate TATA-binding protein (TBP) interactions with the nuclear pore complex. J Membr Biol (1995) 0.83
Amiloride reduces potassium conductance in frog kidney via inhibition of Na+-H+ exchange. Am J Physiol (1986) 0.83
Aldosterone signaling pathway across the nuclear envelope. Proc Natl Acad Sci U S A (2002) 0.82
Electrophoretic plugging of nuclear pores by using the nuclear hourglass technique. J Membr Biol (2001) 0.82
Relationship between luminal Na+/H+ exchange and luminal K+ conductance in diluting segment of frog kidney. Pflugers Arch (1985) 0.82
Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol (2006) 0.82
Fusion of cultured dog kidney (MDCK) cells: I. Technique, fate of plasma membranes and of cell nuclei. J Membr Biol (1989) 0.82
Extracellular detection of K+ release during migration of transformed Madin-Darby canine kidney cells. Pflugers Arch (1997) 0.82
Hypotonic stress-induced release of KHCO3 in fused renal epitheloid (MDCK) cells. Kidney Int (1991) 0.82
Impaired hepatocyte glucose transport protein (GLUT2) internalization in chronic pancreatitis. Pancreas (2001) 0.82
Evidence for an acid pH in rat renal inner medulla: paired measurements with liquid ion-exchange microelectrodes on collecting ducts and vasa recta. Pflugers Arch (1994) 0.82
Spontaneous membrane potential oscillations in Madin-Darby canine kidney cells transformed by alkaline stress. Pflugers Arch (1992) 0.81
Migrating transformed MDCK cells are able to structurally polarize a voltage-activated K+ channel. Proc Natl Acad Sci U S A (1998) 0.81
Localization of amiloride-sensitive sodium channels in A6 cells by atomic force microscopy. Am J Physiol (1997) 0.81
Effect of luminal potassium on cellular sodium activity in the early distal tubule of Amphiuma kidney. Pflugers Arch (1983) 0.81
Carbonic anhydrase activity in Madin Darby canine kidney cells. Evidence for intercalated cell properties. Ren Physiol Biochem (1990) 0.81