Published in Infect Immun on February 01, 1997
Characterization of a new region required for macrophage killing by Legionella pneumophila. Infect Immun (1997) 2.26
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect Immun (1998) 2.15
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06
IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76
The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol (2009) 1.76
The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages. Infect Immun (1998) 1.62
The road less traveled: transport of Legionella to the endoplasmic reticulum. J Cell Biol (2002) 1.54
The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter. EMBO J (2001) 1.45
Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect Immun (1999) 1.45
Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells. Infect Immun (2000) 1.44
Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect Immun (2005) 1.41
Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria. Front Microbiol (2011) 1.29
Erythromycin resistance-conferring plasmid pRSB105, isolated from a sewage treatment plant, harbors a new macrolide resistance determinant, an integron-containing Tn402-like element, and a large region of unknown function. Appl Environ Microbiol (2007) 1.25
LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23
A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles. PLoS Pathog (2009) 1.17
Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila. Infect Immun (2006) 1.15
The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol (2005) 1.11
Comparative analysis of Legionella pneumophila and Legionella micdadei virulence traits. Infect Immun (1999) 1.06
Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore. J Bacteriol (2011) 1.01
Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages. Cell Microbiol (2008) 1.01
Mutations in toxR and toxS that separate transcriptional activation from DNA binding at the cholera toxin gene promoter. J Bacteriol (1998) 0.99
Legionella pneumophila Mip, a surface-exposed peptidylproline cis-trans-isomerase, promotes the presence of phospholipase C-like activity in culture supernatants. Infect Immun (2006) 0.98
Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol (2014) 0.98
Crystal structure of Legionella DotD: insights into the relationship between type IVB and type II/III secretion systems. PLoS Pathog (2010) 0.97
Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement. Proc Natl Acad Sci U S A (2013) 0.92
Analysis of the pilU gene for the prepilin peptidase involved in the biogenesis of type IV pili encoded by plasmid R64. Mol Genet Genomics (2005) 0.89
Balamuthia mandrillaris, free-living ameba and opportunistic agent of encephalitis, is a potential host for Legionella pneumophila bacteria. Appl Environ Microbiol (2005) 0.87
Significant role for ladC in initiation of Legionella pneumophila infection. Infect Immun (2008) 0.86
Legionella pneumophila NudA Is a Nudix hydrolase and virulence factor. Infect Immun (2005) 0.86
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog (2014) 0.86
Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media. Appl Environ Microbiol (2003) 0.85
lvgA, a novel Legionella pneumophila virulence factor. Infect Immun (2003) 0.84
Molecular evolution of the dotA gene in Legionella pneumophila. J Bacteriol (2003) 0.80
Mosaic structure of pathogenicity islands in Legionella pneumophila. J Mol Evol (2003) 0.80
Functional organization of MobB, a small protein required for efficient conjugal transfer of plasmid R1162. J Bacteriol (2011) 0.79
Genomic Analysis Reveals Novel Diversity among the 1976 Philadelphia Legionnaires' Disease Outbreak Isolates and Additional ST36 Strains. PLoS One (2016) 0.77
Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9. Infect Immun (2015) 0.77
The Membrane Protein LasM Promotes the Culturability of Legionella pneumophila in Water. Front Cell Infect Microbiol (2016) 0.75
Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila. Infect Immun (2016) 0.75
Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis. Sci Rep (2017) 0.75
Life Stage-specific Proteomes of Legionella pneumophila Reveal a Highly Differential Abundance of Virulence-associated Dot/Icm effectors. Mol Cell Proteomics (2015) 0.75
Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane. MBio (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Legionnaires' disease: description of an epidemic of pneumonia. N Engl J Med (1977) 24.44
Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila. J Clin Microbiol (1979) 15.15
Beta-galactosidase gene fusions for analyzing gene expression in escherichia coli and yeast. Methods Enzymol (1983) 14.92
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J Clin Invest (1980) 12.41
Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. J Mol Biol (1992) 11.97
Solubilization of the cytoplasmic membrane of Escherichia coli by Triton X-100. J Bacteriol (1971) 10.87
TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci (1994) 10.03
Sequence of the lactose permease gene. Nature (1980) 9.67
A genetic approach to analyzing membrane protein topology. Science (1986) 9.01
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med (1983) 8.82
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Second symbiotic megaplasmid in Rhizobium meliloti carrying exopolysaccharide and thiamine synthesis genes. J Bacteriol (1986) 6.23
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99
Determinants of membrane protein topology. Proc Natl Acad Sci U S A (1987) 5.76
Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun (1995) 5.35
Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol (1984) 4.88
Fusions of secreted proteins to alkaline phosphatase: an approach for studying protein secretion. Proc Natl Acad Sci U S A (1985) 4.60
LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. J Bacteriol (1991) 3.43
Analysis of protein localization by use of gene fusions with complementary properties. J Bacteriol (1990) 3.36
Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci U S A (1992) 3.32
Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol Microbiol (1994) 3.16
Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J Exp Med (1987) 3.13
The nucleotide sequence of the gene for malF protein, an inner membrane component of the maltose transport system of Escherichia coli. Repeated DNA sequences are found in the malE-malF intercistronic region. J Biol Chem (1984) 2.79
The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages. Mol Microbiol (1994) 2.65
Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins. Proc Natl Acad Sci U S A (1992) 2.47
The ABC of channel regulation. Cell (1995) 2.46
Growth of Legionella pneumophila in a human macrophage-like (U937) cell line. Microb Pathog (1988) 2.38
Isolation and characterization of the cytoplasmic and outer membranes of the Legionnaires' disease bacterium (Legionella pneumophila). J Exp Med (1985) 2.37
Identification of the secY (prlA) gene product involved in protein export in Escherichia coli. Mol Gen Genet (1984) 1.88
Pontiac fever: isolation of the etiologic agent (Legionella pneumophilia) and demonstration of its mode of transmission. Am J Epidemiol (1981) 1.77
Genetic analysis of periplasmic binding protein dependent transport in Escherichia coli. Each lobe of maltose-binding protein interacts with a different subunit of the MalFGK2 membrane transport complex. J Mol Biol (1993) 1.28
Maltose transport system of Escherichia coli: an ABC-type transporter. FEBS Lett (1994) 1.23
Sequence-function relationships in MalG, an inner membrane protein from the maltose transport system in Escherichia coli. Mol Microbiol (1993) 1.01
PhoA gene fusions in Legionella pneumophila generated in vivo using a new transposon, MudphoA. Mol Microbiol (1992) 0.89
Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell (1987) 9.80
A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature (1985) 9.45
Conjugative transfer by the virulence system of Legionella pneumophila. Science (1998) 7.29
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99
Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun (1995) 5.35
Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells. Infect Immun (1987) 3.81
The interaction of bacteria with mammalian cells. Annu Rev Cell Biol (1992) 3.62
Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake. Mol Microbiol (1998) 3.41
Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol Microbiol (1994) 3.16
Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J (1990) 3.10
Regulation of Tn5 by the right-repeat proteins: control at the level of the transposition reaction? Cell (1982) 3.07
Evidence for pore-forming ability by Legionella pneumophila. Mol Microbiol (1998) 2.74
Replicon fusions promoted by the inverted repeats of Tn5. The right repeat is an insertion sequence. J Mol Biol (1981) 2.61
Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions. Infect Immun (2000) 2.46
Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect Immun (1997) 2.24
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect Immun (1998) 2.15
Crystal structure of invasin: a bacterial integrin-binding protein. Science (1999) 2.14
Cell biology of Legionella pneumophila. Curr Opin Microbiol (1999) 1.97
Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density. EMBO J (1993) 1.85
Identification of Legionella pneumophila mutants that have aberrant intracellular fates. Infect Immun (1996) 1.84
The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor. J Biol Chem (1991) 1.69
Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium. Infect Immun (1997) 1.68
Cellular internalization in the absence of invasin expression is promoted by the Yersinia pseudotuberculosis yadA product. Infect Immun (1993) 1.65
Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus. J Exp Med (2001) 1.58
DNA gyrase is a host factor required for transposition of Tn5. Cell (1982) 1.57
Recombination genes on the Escherichia coli sex factor specific for transposable elements. Proc Natl Acad Sci U S A (1980) 1.51
A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association. EMBO J (1999) 1.48
The psa locus is responsible for thermoinducible binding of Yersinia pseudotuberculosis to cultured cells. Infect Immun (1996) 1.47
The Legionella pneumophila IcmR protein exhibits chaperone activity for IcmQ by preventing its participation in high-molecular-weight complexes. Mol Microbiol (2001) 1.43
Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics (1995) 1.38
Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages. Ann N Y Acad Sci (1996) 1.35
Legionnaires' disease: the pore macrophage and the legion of terror within. Trends Microbiol (1998) 1.34
Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growth. Mol Microbiol (2001) 1.33
An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding. EMBO J (1995) 1.29
Mutations in the cytoplasmic domain of the integrin beta1 chain indicate a role for endocytosis factors in bacterial internalization. J Biol Chem (1996) 1.26
Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma. J Cell Physiol (1979) 1.24
Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry (1998) 1.23
Involvement of focal adhesion kinase in invasin-mediated uptake. Proc Natl Acad Sci U S A (1998) 1.22
Binding of cultured mammalian cells to immobilized bacteria. Infect Immun (1992) 1.22
Mapping and topographic localization of epitopes of the Yersinia pseudotuberculosis invasin protein. Infect Immun (1991) 1.19
Transcriptional regulation of the Yersinia pseudotuberculosis pH6 antigen adhesin by two envelope-associated components. Mol Microbiol (1997) 1.16
Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function. Mol Microbiol (2001) 1.16
Genetic analysis of bacterial virulence determinants in Bordetella pertussis and the pathogenetic Yersinia. Curr Top Microbiol Immunol (1985) 1.13
A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition. J Biol Chem (1993) 1.12
The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells. Infect Immun (1992) 1.09
Conferral of transposable properties to a chromosomal gene in Escherichia coli. J Mol Biol (1980) 1.08
Analysis of the intracellular fate of Legionella pneumophila mutants. Ann N Y Acad Sci (1996) 1.06
Compartmentalization of the proteins encoded by IS50R. J Biol Chem (1985) 1.05
Formation of the Legionella pneumophila replicative phagosome. Infect Agents Dis (1993) 1.05
An O antigen can interfere with the function of the Yersinia pseudotuberculosis invasin protein. Mol Microbiol (1991) 0.99
An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors. Infect Immun (2000) 0.98
Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host-pathogen interactions. Trends Microbiol (2000) 0.98
Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin. J Exp Med (1993) 0.97
A region of the Yersinia pseudotuberculosis invasin protein that contributes to high affinity binding to integrin receptors. J Biol Chem (1996) 0.92
Differential effects of integrin alpha chain mutations on invasin and natural ligand interaction. J Biol Chem (1998) 0.91
Analysis of the role of invasin during Yersinia pseudotuberculosis infection of mice. Ann N Y Acad Sci (1996) 0.90
New gene in Escherichia coli K-12 (drpA): does its product play a role in RNA synthesis? J Bacteriol (1985) 0.89
Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition. J Mol Biol (1985) 0.86
Isolation and identification of eukaryotic receptors promoting bacterial internalization. Methods Enzymol (1994) 0.86
Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade. J Cell Sci (2001) 0.84
Common entry mechanisms. Bacterial pathogenesis. Curr Biol (1996) 0.83
Intracellular survival by Legionella. Methods Cell Biol (1994) 0.81
Identification of Legionella pneumophila promoters regulated by the macrophage intracellular environment. Infect Agents Dis (1993) 0.80
SWIM analysis allows rapid identification of residues involved in invasin-mediated bacterial uptake. Gene (1998) 0.77
Integrin beta1-chain residues involved in substrate recognition and specificity of binding to invasin. Cell Microbiol (2000) 0.76
Delivering dangerous cargoes. Nat Struct Biol (2001) 0.75
Use of Staphylococcus aureus coated with invasin derivatives to assay invasin function. Methods Enzymol (1994) 0.75