Published in J Exp Med on November 01, 1987
Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome. Proc Natl Acad Sci U S A (1998) 5.65
Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun (1995) 5.35
Identification of Legionella pneumophila genes required for growth within and killing of human macrophages. Infect Immun (1993) 3.97
Expression of Legionella pneumophila virulence traits in response to growth conditions. Infect Immun (1998) 3.39
Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci U S A (1992) 3.32
A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection. Infect Immun (1989) 3.18
Phenotypic modulation by Legionella pneumophila upon infection of macrophages. Infect Immun (1993) 2.79
Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii. Appl Environ Microbiol (1997) 2.45
A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii. Infect Immun (1992) 2.44
Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect Immun (1999) 2.32
Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa. Infect Immun (1997) 2.29
Characterization of a new region required for macrophage killing by Legionella pneumophila. Infect Immun (1997) 2.26
Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect Immun (1997) 2.24
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect Immun (1998) 2.15
Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes. Infect Immun (1988) 2.10
The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum. Appl Environ Microbiol (1996) 2.04
Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev (2010) 2.04
Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. J Exp Med (1989) 1.91
Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells. Infect Immun (1991) 1.88
Identification of Legionella pneumophila mutants that have aberrant intracellular fates. Infect Immun (1996) 1.84
IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76
The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii. J Bacteriol (1999) 1.76
Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila. Infect Immun (1998) 1.75
Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. Infect Immun (2000) 1.71
Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. J Exp Med (2000) 1.69
Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum. J Clin Invest (1990) 1.66
Functional similarities between the icm/dot pathogenesis systems of Coxiella burnetii and Legionella pneumophila. Infect Immun (2003) 1.66
The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing. Infect Immun (1990) 1.65
Virulence factors of the family Legionellaceae. Microbiol Rev (1992) 1.56
Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model. Infect Immun (1998) 1.50
Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection. Infect Immun (2001) 1.50
Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages. Infect Immun (1997) 1.46
Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease. J Clin Invest (1993) 1.41
Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease. Infect Immun (1999) 1.39
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog (2009) 1.37
Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes. Infect Immun (1993) 1.35
Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression. J Bacteriol (2002) 1.35
Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7. Infect Immun (2000) 1.31
Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc Natl Acad Sci U S A (2012) 1.30
Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophila. J Bacteriol (2003) 1.30
Characterization of the icmH and icmF genes required for Legionella pneumophila intracellular growth, genes that are present in many bacteria associated with eukaryotic cells. Infect Immun (2004) 1.23
Multiplication of different Legionella species in Mono Mac 6 cells and in Acanthamoeba castellanii. Appl Environ Microbiol (1997) 1.21
The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol (2005) 1.11
Plaque assay for virulent Legionella pneumophila. J Clin Microbiol (1989) 1.08
The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization. Infect Immun (2009) 1.07
A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge. J Clin Invest (1989) 1.07
Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cells. Infect Immun (1991) 1.05
Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway. Infect Immun (2001) 1.01
Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages. Infect Immun (2003) 1.00
Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophila. Infect Immun (1995) 0.99
Characterization of a major 31-kilodalton peptidoglycan-bound protein of Legionella pneumophila. J Bacteriol (1990) 0.98
Heat stress alters the virulence of a rifampin-resistant mutant of Francisella tularensis LVS. Infect Immun (1995) 0.93
Signal transduction during Legionella pneumophila entry into human monocytes. Infect Immun (1998) 0.88
Virulence conversion of Legionella pneumophila by conjugal transfer of chromosomal DNA. J Bacteriol (2003) 0.87
Invasion of eukaryotic cells by Legionella pneumophila: A common strategy for all hosts? Can J Infect Dis (1997) 0.85
Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis. Infect Immun (2009) 0.84
Genetic and physical mapping of the mouse host resistance locus Lgn1. Mamm Genome (1997) 0.83
Antibacterial effects of levofloxacin, erythromycin, and rifampin in a human monocyte system against Legionella pneumophila. Antimicrob Agents Chemother (1998) 0.82
Investigation of Legionella Contamination in Bath Water Samples by Culture, Amoebic Co-Culture, and Real-Time Quantitative PCR Methods. Int J Environ Res Public Health (2015) 0.78
Evaluation of impermeant, DNA-binding dye fluorescence as a real-time readout of eukaryotic cell toxicity in a high throughput screening format. Assay Drug Dev Technol (2014) 0.78
Promotion and Rescue of Intracellular Brucella neotomae Replication during Coinfection with Legionella pneumophila. Infect Immun (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med (1977) 25.00
Resolution of bacterial proteins by polyacrylamide gel electrophoresis on slabs. Membrane, soluble, and periplasmic fractions. J Biol Chem (1974) 13.30
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J Clin Invest (1980) 12.41
Primary isolation media for Legionnaires disease bacterium. J Clin Microbiol (1978) 11.86
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med (1983) 8.82
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Influence of the Escherichia coli capsule on complement fixation and on phagocytosis and killing by human phagocytes. J Clin Invest (1980) 6.61
Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol (1984) 4.88
Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell (1984) 4.00
Virulent to avirulent conversion of Legionnaires' disease bacterium (Legionella pneumophila)--its effect on isolation techniques. J Infect Dis (1979) 3.96
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J Clin Invest (1984) 3.59
Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro. Science (1976) 3.55
Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody, and complement. J Exp Med (1981) 3.27
Fusion of host cell secondary lysosomes with the parasitophorous vacuoles of Leishmania mexicana-infected macrophages. J Protozool (1975) 2.93
Isolation and characterization of the cytoplasmic and outer membranes of the Legionnaires' disease bacterium (Legionella pneumophila). J Exp Med (1985) 2.37
Cell-mediated immunity in Legionnaires' disease. J Clin Invest (1983) 2.30
Dose-response of guinea pigs experimentally infected with aerosols of Legionella pneumophila. J Infect Dis (1980) 2.07
Virulence conversion of Legionella pneumophila serogroup 1 by passage in guinea pigs and embryonated eggs. Infect Immun (1982) 1.81
Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth. Science (1985) 1.48
Abilities of human oligodendroglial cells and mouse Schwann cells to phagocytose Mycobacterium leprae and other mycobacteria. Infect Immun (1986) 1.02