Published in J Clin Invest on January 01, 1997
Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34
Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. EMBO J (1998) 1.80
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol (1998) 1.65
Keratins in health and cancer: more than mere epithelial cell markers. Oncogene (2010) 1.61
"IF-pathies": a broad spectrum of intermediate filament-associated diseases. J Clin Invest (2009) 1.55
Cryptogenic chronic hepatitis and its changing guise in adults. Dig Dis Sci (2011) 1.50
Incidental medical information in whole-exome sequencing. Pediatrics (2012) 1.48
Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. J Cell Biol (2001) 1.42
Simple epithelium keratins are required for maintenance of hepatocyte integrity. Am J Pathol (1997) 1.36
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
Functional differences between keratins of stratified and simple epithelia. J Cell Biol (1998) 1.22
Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies. Am J Pathol (2000) 1.21
Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice. J Cell Biol (1998) 1.20
Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments. Mol Biol Cell (2002) 1.17
Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol (2000) 1.14
Bile acid-induced Mallory body formation in drug-primed mouse liver. Am J Pathol (2002) 1.03
Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells. Mol Cell Biol (2004) 1.01
Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc Natl Acad Sci U S A (2003) 1.00
Increased levels of keratin 16 alter epithelialization potential of mouse skin keratinocytes in vivo and ex vivo. Mol Biol Cell (2001) 0.95
Genetic disorders of palm skin and nail. J Anat (2003) 0.84
Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice. Comp Hepatol (2004) 0.83
Establishment and molecular characterization of mesenchymal stem cell lines derived from human visceral & subcutaneous adipose tissues. J Stem Cells Regen Med (2010) 0.81
Defining Molecular Phenotypes of Mesenchymal and hematopoietic Stem Cells derived from Peripheral blood of Acute Lymphocytic Leukemia patients for regenerative stem cell therapy. J Stem Cells Regen Med (2011) 0.77
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell (1982) 19.91
Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem (1994) 6.32
Molecular and cellular biology of intermediate filaments. Annu Rev Biochem (1988) 5.48
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell (1991) 2.98
Mid-gestational lethality in mice lacking keratin 8. Genes Dev (1993) 2.24
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8. Mol Cell Biol (1989) 2.00
Intermediate filaments in disease. Curr Opin Cell Biol (1995) 1.98
Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol (1990) 1.88
Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Nat Genet (1995) 1.83
Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol (1995) 1.71
Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation. Differentiation (1986) 1.49
Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. J Clin Invest (1996) 1.43
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum Mol Genet (1994) 1.42
Of mice and men: genetic skin diseases of keratin. Cell (1992) 1.40
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Nat Genet (1995) 1.31
Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. J Cell Biol (1994) 1.29
Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. Eur J Cell Biol (1988) 1.29
Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients. J Cell Sci (1995) 1.14
A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Nat Genet (1995) 1.12
The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner. J Biol Chem (1995) 1.11
Characterization of the human gene encoding cytokeratin 17 and its expression pattern. Eur J Cell Biol (1992) 1.10
Cryptogenic liver disease in the United States: further evidence for non-A, non-B, and non-C hepatitis. Am J Gastroenterol (1994) 1.06
Synthesis and fate of keratins 8 and 18 in nonepithelial cells transfected with cDNA. Exp Cell Res (1988) 1.02
Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities. J Cell Biol (1995) 0.98
Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression. Differentiation (1993) 0.98
Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Nat Genet (1995) 0.95
Genetic skin diseases caused by mutations in keratin intermediate filaments. Trends Genet (1993) 0.92
Cracks in the foundation: keratin filaments and genetic disease. Trends Cell Biol (1994) 0.90
The complete sequence of the gene encoding mouse cytokeratin 15. Gene (1994) 0.81
Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression. Mol Biol Rep (1987) 0.79
Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med (1999) 5.32
Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc Natl Acad Sci U S A (1981) 4.34
Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med (2000) 3.74
"Occult" hepatitis B virus as source of infection in liver transplant recipients. Lancet (1994) 3.33
Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci U S A (1999) 3.30
Molecular virology and pathogenesis of hepatitis B. Lancet (1993) 3.27
Patient, center and geographic characteristics of nationally placed livers. Am J Transplant (2012) 3.16
Biosynthesis of the human transferrin receptor in cultured cells. J Biol Chem (1981) 2.83
Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. J Exp Med (1981) 2.66
HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol (2000) 2.60
Human homologue of murine T200 glycoprotein. J Exp Med (1980) 2.57
Covalent binding of fatty acid to the transferrin receptor in cultured human cells. J Biol Chem (1981) 2.51
HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant (2007) 2.50
Effect of sulindac on sporadic colonic polyps. Gastroenterology (1995) 2.27
Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis. Aliment Pharmacol Ther (2014) 2.18
Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases. Liver Transpl Surg (1997) 2.16
Disposition of T200 glycoprotein in the plasma membrane of a murine lymphoma cell line. J Biol Chem (1980) 2.01
Human cell-surface glycoprotein with unusual properties. Nature (1980) 1.94
Gastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndrome. Endoscopic and autopsy findings. Gastroenterology (1985) 1.90
Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. Gastroenterology (2000) 1.84
Acute hepatitis C. Hepatology (2001) 1.82
Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model. J Clin Invest (1996) 1.81
Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. EMBO J (1998) 1.80
Apoptosis generates stable fragments of human type I keratins. J Biol Chem (1997) 1.72
Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol (1995) 1.71
The clinical course of transplantation-associated de novo hepatitis B infection in the liver transplant recipient. Liver Transpl Surg (1997) 1.68
The impact of pretransplantation hepatitis C infection on the outcome of renal transplantation. Transplantation (1995) 1.67
T200 cell surface glycoprotein of the mouse. Polymorphism defined by the Ly-5 system of alloantigens. J Exp Med (1980) 1.66
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. J Clin Invest (1991) 1.64
Frailty predicts waitlist mortality in liver transplant candidates. Am J Transplant (2014) 1.62
The cytoskeleton of digestive epithelia in health and disease. Am J Physiol (1999) 1.61
Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med (2001) 1.55
A controlled study of hepatitis C transmission by organ transplantation. The New England Organ Bank Hepatitis C Study Group. Lancet (1995) 1.54
Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection. J Viral Hepat (2004) 1.52
Outcomes of interferon alpha and ribavirin treatment for chronic hepatitis C in patients with normal serum aminotransaminases. Gut (2003) 1.51
Are infectious agents involved in primary biliary cirrhosis? A PCR approach. J Hepatol (1999) 1.50
Efficacy and safety of pegylated (40-kd) interferon alpha-2a compared with interferon alpha-2a in noncirrhotic patients with chronic hepatitis C. Hepatology (2001) 1.49
14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor. J Cell Biol (1996) 1.48
Evolution of hepatitis C virus quasispecies in patients with severe cholestatic hepatitis after liver transplantation. Hepatology (1999) 1.48
Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium. Environ Mol Mutagen (2000) 1.46
Are HCV-infected individuals candidates for hepatitis A vaccine? Lancet (1998) 1.46
Characterization of non-transferrin-bound iron clearance by rat liver. J Biol Chem (1986) 1.46
Intermediate filaments take the heat as stress proteins. Trends Cell Biol (2010) 1.44
Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. J Clin Invest (1996) 1.43
Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. J Biol Chem (1992) 1.43
Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure. Hepatology (1992) 1.41
Hepatitis C and liver transplantation. J Hepatol (2001) 1.40
Pruritus as a symptom of hepatitis C. J Am Acad Dermatol (1994) 1.39
A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab (2014) 1.34
Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide. J Bacteriol (2001) 1.33
Keratins turn over by ubiquitination in a phosphorylation-modulated fashion. J Cell Biol (2000) 1.33
Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase. J Biol Chem (2000) 1.32
Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states. J Clin Invest (1985) 1.32
Fetal microchimerism alone does not contribute to the induction of primary biliary cirrhosis. Hepatology (1999) 1.30
The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol (2001) 1.30
A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. Hepatology (2001) 1.29
Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. J Cell Biol (1994) 1.29
A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility. J Cell Sci (1993) 1.28
Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol (2008) 1.28
Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells. J Biol Chem (1997) 1.27
Liver transplantation for patients with hepatitis B: what have we learned from our results? Hepatology (1991) 1.21
A multicenter, randomized trial of daily high-dose interferon-alfa 2b for the treatment of chronic hepatitis c: pretreatment stratification by viral burden and genotype. Am J Gastroenterol (2000) 1.21
Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice. J Cell Biol (1998) 1.20
Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: relationship to genotype and level of viremia. Hepatology (1996) 1.19
Prophylaxis in liver transplant recipients using a fixed dosing schedule of hepatitis B immunoglobulin. Hepatology (1996) 1.17
Successful orthotopic liver transplantation for lamivudine-associated YMDD mutant hepatitis B virus. Gastroenterology (2000) 1.17
Multicenter study of lamivudine therapy for hepatitis B after liver transplantation. Lamivudine Transplant Group. Hepatology (1999) 1.17
Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues. J Cell Biol (1995) 1.16
Implications of intermediate filament protein phosphorylation. Cancer Metastasis Rev (1996) 1.16
Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology (1991) 1.15
Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431. J Biol Chem (1997) 1.15
Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol (2000) 1.14
Incidence and severity of acute cellular rejection in recipients undergoing adult living donor or deceased donor liver transplantation. Am J Transplant (2008) 1.13
Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic. Hepatology (1998) 1.11
HBV core sequence: definition of genotype-specific variability and correlation with geographical origin. J Viral Hepat (2004) 1.11
The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner. J Biol Chem (1995) 1.11
Empigen BB: a useful detergent for solubilization and biochemical analysis of keratins. Biochem Biophys Res Commun (1995) 1.10
Characterization of hepatitis G virus (GB-C virus) particles: evidence for a nucleocapsid and expression of sequences upstream of the E1 protein. J Virol (1998) 1.09
Effect of mutation and phosphorylation of type I keratins on their caspase-mediated degradation. J Biol Chem (2001) 1.09
Mitotic arrest-associated enhancement of O-linked glycosylation and phosphorylation of human keratins 8 and 18. J Biol Chem (1993) 1.08
Heat stress or rotavirus infection of human epithelial cells generates a distinct hyperphosphorylated form of keratin 8. Exp Cell Res (1995) 1.07
Incidence and clinical consequences of surface and polymerase gene mutations in liver transplant recipients on hepatitis B immunoglobulin. Hepatology (1998) 1.05
Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV coinfected transplant recipients. Am J Transplant (2010) 1.05
Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity. Hepatology (1998) 1.04
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy. J Viral Hepat (2011) 1.04
Hepatitis C viral infection in liver transplant recipients. Hepatology (1992) 1.04
Hepatitis C virus: quantitation and distribution in liver. J Med Virol (1997) 1.03
Prevalence and risk factors for hepatitis C virus infection at an urban Veterans Administration medical center. Hepatology (2001) 1.03
Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models. Am J Physiol Gastrointest Liver Physiol (2000) 1.03
Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob Agents Chemother (2002) 1.03
Hepatitis C and liver transplantation. Gut (1999) 1.03
Altered sodium-hydrogen exchange activity is a mechanism for acid-induced hyperproliferation in Barrett's esophagus. Am J Physiol (1998) 1.02
Identification and mutational analysis of the glycosylation sites of human keratin 18. J Biol Chem (1995) 1.02