Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates.

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Published in J Cell Biol on March 23, 1998

Authors

T M Magin1, R Schröder, S Leitgeb, F Wanninger, K Zatloukal, C Grund, D W Melton

Author Affiliations

1: Institut fuer Genetik, Abteilung Molekulargenetik, Universitat Bonn, Bonn, Germany. t.magin@uni-bonn.de

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Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27

Desmosomes and hemidesmosomes: constitutive molecular components. Annu Rev Cell Biol (1990) 2.25

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The preimplantation mammalian embryo: characterization of intercellular junctions and their appearance during development. Dev Biol (1975) 1.69

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Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation. Cell (1989) 1.42

Monoclonal antibody studies of mammalian epithelial keratins: a review. Ann N Y Acad Sci (1985) 1.39

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Translational products of mRNAs coding for non-epidermal cytokeratins. EMBO J (1983) 1.22

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Tailless keratins assemble into regular intermediate filaments in vitro. J Cell Sci (1990) 1.01

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Change of cytokeratin organization during development of Mallory bodies as revealed by a monoclonal antibody. Lab Invest (1986) 1.00

The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Hepatology (1994) 0.99

Tissue-specific and efficient expression of the human simple epithelial keratin 8 gene in transgenic mice. J Cell Sci (1995) 0.98

Suppression of endo B cytokeratin by its antisense RNA inhibits the normal coexpression of endo A cytokeratin. Proc Natl Acad Sci U S A (1987) 0.94

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Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody. Lab Invest (1992) 0.92

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Nucleotide sequence and structure of the mouse cytokeratin endoB gene. Gene (1988) 0.91

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A position- and orientation-dependent element in the first intron is required for expression of the mouse hprt gene in embryonic stem cells. Gene (1992) 0.89

Cytokeratins and cytokeratin filaments in subpopulations of cultured human and rodent cells of nonepithelial origin: modes and patterns of formation. Differentiation (1989) 0.88

Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction. Genomics (1990) 0.87

High molecular weight components are main constituents of Mallory bodies isolated with a fluorescence activated cell sorter. Lab Invest (1991) 0.86

Mallory bodies in experimental animals and man. Int Rev Exp Pathol (1979) 0.86

De novo formation of cytokeratin filaments in calf lens cells and cytoplasts after transfection with cDNAs or microinjection with mRNAs encoding human cytokeratins. Eur J Cell Biol (1990) 0.86

Altered distribution of plectin/HD1 in dystrophinopathies. Eur J Cell Biol (1997) 0.85

Maintenance of desmosomes in mouse hepatocytes after drug-induced rearrangement of cytokeratin filament material. Demonstration of independence of desmosomes and intermediate-sized filaments. Exp Cell Res (1985) 0.84

Human sarcomatous Wilms' tumor lines: evidence for epithelial differentiation in clear cell sarcoma of the kidney. Cancer Res (1989) 0.81

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Introduction: evolving roles for ubiquitin in cellular regulation. FASEB J (1997) 0.79

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Energy spectrum of cosmic-ray electrons at TeV energies. Phys Rev Lett (2008) 1.17

Characterisation of cDNA clones for hypoxanthine-guanine phosphoribosyltransferase from the human malarial parasite, Plasmodium falciparum: comparisons to the mammalian gene and protein. Nucleic Acids Res (1987) 1.17

Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle. J Cell Biol (1995) 1.16

The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol (2001) 1.16

Intermediate-sized filaments present in Sertoli cells are of the vimentin type. Eur J Cell Biol (1979) 1.16

Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer. Virchows Arch (2004) 1.16

A nucleolar skeleton of protein filaments demonstrated in amplified nucleoli of Xenopus laevis. J Cell Biol (1981) 1.15

The 22 S cylinder particles of Xenopus laevis. I. Biochemical and electron microscopic characterization. Eur J Cell Biol (1983) 1.15

Biobank governance: trends and perspectives. Pathobiology (2007) 1.15

The effect of overabundant projection directions on 3D reconstruction algorithms. J Struct Biol (2001) 1.14

SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway. J Pathol (2008) 1.14

Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol (1996) 1.14