Published in JAMA on April 02, 1997
Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care (2005) 3.96
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med (2014) 3.02
An economic evaluation of prolonged mechanical ventilation. Crit Care Med (2007) 2.93
Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78
The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med (2005) 2.57
Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA (2015) 2.53
Brazilian Sepsis Epidemiological Study (BASES study). Crit Care (2004) 2.49
The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med (2004) 2.24
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med (2014) 1.95
Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65
Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood (2007) 1.64
How do you choose antibiotic treatment? BMJ (1999) 1.60
Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness. Crit Care (2004) 1.60
Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood (2004) 1.44
Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics (2011) 1.38
Mortality and quality of life in the five years after severe sepsis. Crit Care (2013) 1.36
HMGB1 mediates cognitive impairment in sepsis survivors. Mol Med (2012) 1.33
C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. PLoS One (2013) 1.25
Septic mice are susceptible to pulmonary aspergillosis. Am J Pathol (2003) 1.25
Genetics and genomics in pediatric septic shock. Crit Care Med (2012) 1.23
Pediatric sepsis: challenges and adjunctive therapies. Crit Care Clin (2013) 1.19
Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest (2009) 1.17
Late mortality after sepsis: propensity matched cohort study. BMJ (2016) 1.09
Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram. Intensive Care Med (2008) 1.07
Long-term survival and healthcare utilization outcomes attributable to sepsis and pneumonia. BMC Health Serv Res (2012) 1.03
Subsequent infections in survivors of sepsis: epidemiology and outcomes. J Intensive Care Med (2012) 1.01
Presence of preexisting antibodies mediates survival in sepsis. Shock (2012) 1.01
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am J Pathol (2006) 0.99
Early activation of hepatic NFkappaB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality. Ann Surg (1999) 0.99
Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation. Crit Care (2009) 0.97
Impaired CD4+ T-cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Eur J Immunol (2010) 0.96
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol (2013) 0.95
Model for predicting short-term mortality of severe sepsis. Crit Care (2009) 0.95
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol (2014) 0.95
Impact of sepsis on CD4 T cell immunity. J Leukoc Biol (2014) 0.94
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Crit Rev Immunol (2013) 0.91
Cost-effectiveness of activated protein C in real-life clinical practice. Crit Care (2007) 0.91
Sepsis: from bench to bedside. Clinics (Sao Paulo) (2008) 0.91
Identifying which septic patients have increased mortality risk using severity scores: a cohort study. BMC Anesthesiol (2014) 0.89
Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies. Crit Care (2016) 0.89
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors. J Intern Med (2013) 0.89
A historical perspective on sepsis. Am J Pathol (2012) 0.88
Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression? Brain Behav Immun (2013) 0.88
A brief elevation of serum amyloid A is sufficient to increase atherosclerosis. J Lipid Res (2014) 0.88
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. Crit Care (2007) 0.87
Anti-endotoxin vaccines: back to the future. Virulence (2013) 0.86
Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation. PLoS One (2011) 0.84
Economic burden of mucormycosis in the United States: can a vaccine be cost-effective? Med Mycol (2009) 0.84
Neuroimmune Function and the Consequences of Alcohol Exposure. Alcohol Res (2015) 0.84
Functional outcomes of general medical patients with severe sepsis. BMC Infect Dis (2013) 0.83
Sepsis-induced long-term immune paralysis - results of a descriptive, explorative study. Crit Care (2016) 0.82
STAT3-mediated IL-17 production by postseptic T cells exacerbates viral immunopathology of the lung. Shock (2012) 0.82
Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion. J Immunol (2015) 0.81
Long term outcomes following hospital admission for sepsis using relative survival analysis: a prospective cohort study of 1,092 patients with 5 year follow up. PLoS One (2014) 0.81
Health related quality of life six months following surgical treatment for secondary peritonitis--using the EQ-5D questionnaire. Health Qual Life Outcomes (2007) 0.81
Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock. Crit Care (2015) 0.81
Inadequate exercise as a risk factor for sepsis mortality. PLoS One (2013) 0.80
[The cost of sepsis]. Anaesthesist (2006) 0.80
Year in review 2007: Critical Care--multiple organ failure and sepsis. Crit Care (2008) 0.80
Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis. BMC Infect Dis (2015) 0.79
Complement inhibition decreases early fibrogenic events in the lung of septic baboons. J Cell Mol Med (2015) 0.79
CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. PLoS One (2015) 0.78
Choice of Fluids in Severe Septic Patients - A Cost-effectiveness Analysis Informed by Recent Clinical Trials. Rev Recent Clin Trials (2014) 0.77
Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa. Vasc Health Risk Manag (2006) 0.77
Mobilization in severe sepsis: an integrative review. J Hosp Med (2015) 0.77
Sepsis after Scotland: enough with the averages, show us the effect modifiers. Crit Care (2013) 0.77
Experimental sepsis impairs humoral memory in mice. PLoS One (2013) 0.77
Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway. Redox Biol (2016) 0.76
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity. Crit Rev Immunol (2016) 0.76
Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J Immunol (2016) 0.76
Effect of sepsis therapies on health-related quality of life. Crit Care (2008) 0.76
Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster. Intensive Care Med Exp (2016) 0.76
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nat Commun (2017) 0.75
The brain at risk: the sepsis syndrome and lessons from preclinical experiments. Immunol Res (2015) 0.75
Long term mortality following sepsis. Ann Transl Med (2016) 0.75
Trends in mortality and early central line placement in septic shock: true, true, and related?*. Crit Care Med (2013) 0.75
Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock (2017) 0.75
Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis. Vaccine (2015) 0.75
Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial. Trials (2014) 0.75
The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study. Crit Care (2017) 0.75
Pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species. BMC Infect Dis (2017) 0.75
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog (2017) 0.75
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med (2005) 17.06
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med (1996) 5.25
Importance of functional measures in predicting mortality among older hospitalized patients. JAMA (1998) 4.33
A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. JAMA (1991) 3.25
Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine. Crit Care Med (1995) 3.19
Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med (1993) 2.84
A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit Care Med (1995) 2.48
Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med (1990) 2.04
Risk of right bundle-branch block and complete heart block during pulmonary artery catheterization. Crit Care Med (1989) 1.62
Fulminant hepatic failure from a sea anemone sting. Ann Intern Med (1994) 1.43
Prior healthcare utilization as a predictor of survival for medical intensive care unit patients. Crit Care Med (2000) 1.42
Treatment of death in the analysis of longitudinal studies of gerontological outcomes. J Gerontol A Biol Sci Med Sci (2010) 1.35
ICU survival of patients with the acquired immunodeficiency syndrome. Crit Care Med (1986) 1.24
Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group. J Infect Dis (1996) 1.21
Presenting manifestations, cigarette smoking, and detection bias in age at diagnosis of lung cancer. Ann Epidemiol (2001) 1.01
Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. Chest (1987) 0.90
Distribution of proteins in pulmonary edema. The value of fractional concentrations. Am Rev Respir Dis (1987) 0.89
Amino acid alterations and encephalopathy in the sepsis syndrome. Crit Care Med (1991) 0.88
Preoperative predictors of operative mortality for coronary bypass grafting in patients with unstable angina pectoris. Am J Cardiol (1977) 0.87
A stepwise variable selection procedure for nonlinear regression models. Biometrics (1980) 0.86
Quality control for cardiac surgery in the Veterans Administration. Ann Thorac Surg (1986) 0.85
Upper and lower bounds for correlations in 2 X 2 tables--revisited. J Chronic Dis (1983) 0.82
Incidence and mortality of perioperative myocardial infarction in patients undergoing coronary artery bypass grafting. Circulation (1977) 0.81
Incidence and susceptibility of pathogenic bacteria vary between intensive care units within a single hospital: implications for empiric antibiotic strategies. J Trauma (2000) 0.81
Immunotherapy of sepsis: flawed concept or faulty implementation? Vaccine (1999) 0.81
Recurrent portopulmonary hypertension after liver transplantation: management with epoprostenol and resolution after retransplantation. Liver Transpl (2001) 0.79
Practice parameters for sustained neuromuscular blockade in the adult critically ill patient: an executive summary. Society of Critical Care Medicine. Crit Care Med (1995) 0.78
Fulminant neuropathy and lactic acidosis associated with nucleoside analog therapy. Neurology (1999) 0.78
Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement Inflamm (1989) 0.78
Trace element homeostasis during continuous sedation with propofol containing EDTA versus other sedatives in critically ill patients. Intensive Care Med (2000) 0.78
Spurious hyperchloremia and hyperbicarbonatemia in a patient receiving pyridostigmine bromide therapy for myasthenia gravis. Am J Kidney Dis (1990) 0.75
Predictors of operative mortality for coronary bypass grafting in patients with ischemic heart disease. Yale J Biol Med (1978) 0.75
Severe chronic disease with acute physiologic disturbance: a role for intensive care. Crit Care Med (2000) 0.75
Clinical investigation of the cardiovascular system in the critically ill. Invasive techniques. Crit Care Clin (1985) 0.75
Effects of exogenous lipids on blood gas measurements. Crit Care Med (1993) 0.75
Pulmonary edema associated with electrical injury. Chest (1990) 0.75
Anatomical relationships between type II pneumonocytes and alveolar septal gaps in the human lung. Anat Rec (1985) 0.75
Five-year changes in coronary arteries of medical and surgical patients of the Veterans Administration Randomized Study of Bypass Surgery. Circulation (1988) 0.75
Validation of a risk function to predict mortality in a VA population with coronary artery disease. Control Clin Trials (1982) 0.75
Ventricular arrhythmias during pulmonary artery catheterization in the intensive care unit. Am J Med (1985) 0.75