Published in Nucleic Acids Res on May 15, 1997
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell (2008) 2.09
Localization of signal recognition particle RNA in the nucleolus of mammalian cells. Proc Natl Acad Sci U S A (1998) 1.89
Elongation arrest is a physiologically important function of signal recognition particle. EMBO J (2000) 1.40
Alu RNP and Alu RNA regulate translation initiation in vitro. Nucleic Acids Res (2006) 1.09
Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii. Nucleic Acids Res (2002) 1.03
Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. RNA (2001) 0.96
The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure. RNA (1999) 0.94
Protein secretion and the endoplasmic reticulum. Cold Spring Harb Perspect Biol (2012) 0.94
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Nucleic Acids Res (2004) 0.93
LINEs, SINEs and other retroelements: do birds of a feather flock together? Front Biosci (Landmark Ed) (2012) 0.93
Escherichia coli SRP, its protein subunit Ffh, and the Ffh M domain are able to selectively limit membrane protein expression when overexpressed. MBio (2010) 0.83
RNA gymnastics in mammalian signal recognition particle assembly. RNA Biol (2014) 0.81
Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle. Biochem J (2008) 0.78
Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation. RNA (2014) 0.76
Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits. Nucleic Acids Res (2015) 0.75
Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol (1990) 61.47
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Methods Enzymol (1988) 6.38
Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J (1988) 5.61
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol (1994) 5.54
Mechanism of protein translocation across the endoplasmic reticulum membrane. Annu Rev Cell Biol (1986) 5.28
Defining the inside and outside of a catalytic RNA molecule. Science (1989) 3.82
Disassembly and reconstitution of signal recognition particle. Cell (1983) 3.45
Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane. J Cell Biol (1985) 3.19
Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell (1988) 3.11
A protein complex required for signal-sequence-specific sorting and translocation. Nature (1994) 2.68
The secondary structure of the 7SL RNA in the signal recognition particle: functional implications. Nucleic Acids Res (1985) 2.33
Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact. Nature (1986) 2.21
Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate. J Cell Biol (1989) 2.13
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Nature (1996) 2.07
The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J (1988) 2.00
Signal recognition particle (SRP), a ubiquitous initiator of protein translocation. Eur J Biochem (1995) 1.99
Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. EMBO J (1994) 1.77
Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Mol Cell Biol (1990) 1.76
SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation. Cell (1995) 1.62
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol (1991) 1.61
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res (1988) 1.47
The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome. Curr Biol (1996) 1.38
Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane. J Mol Biol (1987) 1.26
Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing. RNA (1996) 1.21
A two-step recognition of signal sequences determines the translocation efficiency of proteins. EMBO J (1996) 1.19
The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Mol Biol Cell (1995) 1.18
A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins. EMBO J (1995) 1.14
Comparative analysis of tertiary structure elements in signal recognition particle RNA. Fold Des (1996) 1.08
The SRP9/14 subunit of the human signal recognition particle binds to a variety of Alu-like RNAs and with higher affinity than its mouse homolog. Nucleic Acids Res (1997) 1.01
Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions. Proc Natl Acad Sci U S A (1989) 1.00
The signal recognition particle and related small cytoplasmic ribonucleoprotein particles. J Cell Sci (1996) 0.97
The heterodimeric subunit SRP9/14 of the signal recognition particle functions as permuted single polypeptide chain. Nucleic Acids Res (1994) 0.92
Transcription termination and 3' processing: the end is in site! Cell (1985) 17.46
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature (1989) 4.25
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (1990) 3.55
The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing. EMBO J (1984) 3.36
Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Cell (1988) 2.31
Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3' processing of H3 pre-mRNA in the oocyte. EMBO J (1986) 2.29
Structure and assembly of the Alu domain of the mammalian signal recognition particle. Nature (2000) 1.92
Transcription of a cloned Xenopus laevis H4 histone gene in the homologous frog oocyte system depends on an evolutionary conserved sequence motif in the -50 region. Nucleic Acids Res (1983) 1.70
Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun (2007) 1.59
Useful 'junk': Alu RNAs in the human transcriptome. Cell Mol Life Sci (2007) 1.50
Crystallization and preliminary X-ray analysis of the 9 kDa protein of the mouse signal recognition particle and the selenomethionyl-SRP9. FEBS Lett (1996) 1.38
Detection of immunoglobulin light-chain mRNA in lymphoid tissues using a practical in situ hybridization method. Am J Pathol (1990) 1.28
New insights into signal recognition and elongation arrest activities of the signal recognition particle. Biol Chem (1999) 1.26
Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. J Virol (1996) 1.25
A two-step recognition of signal sequences determines the translocation efficiency of proteins. EMBO J (1996) 1.19
The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Mol Biol Cell (1995) 1.18
Amino acid changes in the Sindbis virus E2 glycoprotein that increase neurovirulence improve entry into neuroblastoma cells. J Virol (1997) 1.18
The SRP9/14 subunit of the human signal recognition particle binds to a variety of Alu-like RNAs and with higher affinity than its mouse homolog. Nucleic Acids Res (1997) 1.01
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14. EMBO J (1997) 0.98
The signal recognition particle and related small cytoplasmic ribonucleoprotein particles. J Cell Sci (1996) 0.97
Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. RNA (2001) 0.96
The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure. RNA (1999) 0.94
The heterodimeric subunit SRP9/14 of the signal recognition particle functions as permuted single polypeptide chain. Nucleic Acids Res (1994) 0.92
Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14. RNA (1997) 0.87
Mutational analysis of the protein subunits of the signal recognition particle Alu-domain. RNA (1997) 0.84
New rapid test for prenatal detection of trisomy 21 (Down's syndrome): preliminary report. BMJ (1992) 0.83
Detailed genetic characterization of the interleukin-23 receptor in psoriasis. Genes Immun (2008) 0.82
Analogues and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activity of analogues with different residues on the ring nitrogen and the amide nitrogen. J Med Chem (1987) 0.79
Fluorescence in situ hybridization with a chromosome 21-specific cosmid contig: 1-day detection of trisomy 21 in uncultured mesenchymal chorionic villus cells. Prenat Diagn (1994) 0.78
Crystallization and preliminary crystallographic analysis of the signal recognition particle SRPphi14-9 fusion protein. FEBS Lett (1996) 0.77
[Schnitzler syndrome: a rare cause of systemic urticaria]. Rev Med Interne (2000) 0.77
Fluorescence in-situ hybridization on enriched nucleated erythrocytes from newborn cord blood. Ann N Y Acad Sci (1994) 0.75
[Use of various electrochemical methods to study semi-precious and non-precious alloys]. J Biomater Dent (1986) 0.75