Published in EMBO J on November 15, 1995
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell (2008) 2.09
Protein targeting to the bacterial cytoplasmic membrane. Microbiol Mol Biol Rev (1999) 2.04
Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor. EMBO J (1997) 1.99
Signal recognition particle components in the nucleolus. Proc Natl Acad Sci U S A (2000) 1.95
Signal recognition particle mediates post-translational targeting in eukaryotes. EMBO J (2004) 1.46
Elongation arrest is a physiologically important function of signal recognition particle. EMBO J (2000) 1.40
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY. RNA (2001) 1.25
Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing. RNA (1996) 1.21
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J Cell Sci (2009) 1.15
A truncation in the 14 kDa protein of the signal recognition particle leads to tertiary structure changes in the RNA and abolishes the elongation arrest activity of the particle. Nucleic Acids Res (1997) 1.05
Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. Nucleic Acids Res (1997) 0.99
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Nucleic Acids Res (2004) 0.93
Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania. Biochem J (1998) 0.92
Transport of the intracisternal A-type particle Gag polyprotein to the endoplasmic reticulum is mediated by the signal recognition particle. J Virol (2003) 0.87
Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol (1990) 61.47
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol (1994) 5.54
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature (1989) 4.25
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle. Nature (1986) 3.86
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell (1992) 3.78
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (1990) 3.55
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci U S A (1986) 3.55
The E. coli ffh gene is necessary for viability and efficient protein export. Nature (1992) 3.45
Disassembly and reconstitution of signal recognition particle. Cell (1983) 3.45
A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature (1992) 3.20
Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell (1988) 3.11
Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties. Methods Enzymol (1983) 2.87
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide. Cell (1989) 2.73
A protein complex required for signal-sequence-specific sorting and translocation. Nature (1994) 2.68
Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein. J Cell Biol (1986) 2.44
Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature (1994) 2.37
The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. EMBO J (1990) 2.35
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle. Cell (1990) 2.22
Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking. J Cell Biol (1987) 2.21
Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact. Nature (1986) 2.21
Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length. Nucleic Acids Res (1986) 2.21
Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate. J Cell Biol (1989) 2.13
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J (1994) 2.13
The organization of the 7SL RNA in the signal recognition particle. Nucleic Acids Res (1983) 2.03
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature (1992) 2.02
Signal recognition particle (SRP), a ubiquitous initiator of protein translocation. Eur J Biochem (1995) 1.99
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain. J Cell Biol (1990) 1.95
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science (1991) 1.94
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature (1993) 1.88
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences. EMBO J (1992) 1.85
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem (1993) 1.85
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol (1991) 1.61
Requirements for the membrane insertion of signal-anchor type proteins. J Cell Biol (1991) 1.59
Protein translocation across wheat germ microsomal membranes requires an SRP-like component. EMBO J (1987) 1.51
The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER. J Cell Biol (1991) 1.51
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res (1988) 1.47
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum. Proc Natl Acad Sci U S A (1995) 1.45
Transcription of full-length and truncated mRNA transcripts to study protein translocation across the endoplasmic reticulum. Methods Cell Biol (1991) 1.40
Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor. J Cell Biol (1992) 1.39
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. Proc Natl Acad Sci U S A (1993) 1.38
Evolutionary conserved nucleotides within the E.coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo. Nucleic Acids Res (1992) 1.27
Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane. J Mol Biol (1987) 1.26
Small cytoplasmic RNA of Bacillus subtilis: functional relationship with human signal recognition particle 7S RNA and Escherichia coli 4.5S RNA. J Bacteriol (1992) 1.23
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding. J Cell Biol (1993) 1.22
Signal recognition-like particles are present in maize. J Biol Chem (1988) 1.06
Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA. FEBS Lett (1994) 1.03
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Secretory protein translocation across membranes-the role of the "docking protein'. Nature (1982) 7.23
Common principles of protein translocation across membranes. Science (1996) 7.00
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin. Cell (1979) 4.72
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell (1990) 3.85
Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell (1982) 3.36
Signal sequences: more than just greasy peptides. Trends Cell Biol (1998) 3.18
Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol (1978) 3.16
A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane. J Cell Biol (1980) 3.09
Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J (1983) 3.07
Functional interaction of plant ribosomes with animal microsomal membranes. Biochem Biophys Res Commun (1977) 2.77
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
Transfer of proteins across membranes, Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur J Biochem (1978) 2.62
Analysis of peptidoglycan structure from vegetative cells of Bacillus subtilis 168 and role of PBP 5 in peptidoglycan maturation. J Bacteriol (1999) 2.43
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell (1995) 2.27
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle. Cell (1990) 2.22
Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length. Nucleic Acids Res (1986) 2.21
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J (1994) 2.13
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Nature (1996) 2.07
The membrane-spanning segment of invariant chain (I gamma) contains a potentially cleavable signal sequence. Cell (1986) 2.04
The organization of the 7SL RNA in the signal recognition particle. Nucleic Acids Res (1983) 2.03
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature (1992) 2.02
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain. J Cell Biol (1990) 1.95
Structure of C-terminal half of two H-2 antigens from cloned mRNA. Nature (1981) 1.90
cDNA clone coding for part of a mouse H-2d major histocompatibility antigen. Proc Natl Acad Sci U S A (1981) 1.90
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences. EMBO J (1992) 1.85
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem (1993) 1.85
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain. Proc Natl Acad Sci U S A (1982) 1.75
Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains. Proc Natl Acad Sci U S A (1996) 1.69
The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J Cell Sci (1993) 1.69
The morphological transition of Helicobacter pylori cells from spiral to coccoid is preceded by a substantial modification of the cell wall. J Bacteriol (1999) 1.69
A tripartite structure of the signals that determine protein insertion into the endoplasmic reticulum membrane. J Cell Biol (1989) 1.61
Requirements for the membrane insertion of signal-anchor type proteins. J Cell Biol (1991) 1.59
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus. J Cell Biol (1986) 1.54
The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER. J Cell Biol (1991) 1.51
Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production. Proc Natl Acad Sci U S A (1977) 1.51
Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J (1984) 1.51
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res (1988) 1.47
Translation efficiency of zein mRNA is reduced by hybrid formation between the 5'- and 3'-untranslated region. EMBO J (1985) 1.39
Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA. J Cell Biol (1993) 1.37
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. J Cell Biol (1990) 1.35
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. J Cell Biol (1993) 1.35
The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle. J Cell Biol (1991) 1.35
Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin. EMBO J (1997) 1.33
Mammalian and Escherichia coli signal recognition particles. Mol Microbiol (1994) 1.32
Probing individual localization centers in an InGaN/GaN quantum well. Phys Rev Lett (2004) 1.27
Signal and membrane anchor functions overlap in the type II membrane protein I gamma CAT. J Cell Biol (1988) 1.26
The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains. J Biol Chem (1999) 1.26
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J (1999) 1.24
Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lett (1999) 1.23
Structure and biosynthesis of the signal-sequence receptor. Eur J Biochem (1990) 1.19
Signal recognition particle arrests elongation of nascent secretory and membrane proteins at multiple sites in a transient manner. J Biol Chem (1987) 1.17
Disassembly and domain structure of the proteins in the signal-recognition particle. Eur J Biochem (1987) 1.12
Structural requirements for membrane assembly of proteins spanning the membrane several times. J Cell Biol (1989) 1.12
Snapshots of membrane-translocating proteins. Trends Cell Biol (1996) 1.12
Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80 S ribosome; a cryoelectron microscopic reconstruction of the rabbit reticulocyte ribosome at 21 A resolution. J Mol Biol (1998) 1.12
Signal sequence processing in rough microsomes. J Biol Chem (1995) 1.10
An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation. Nucleic Acids Res (1988) 1.08
Mechanisms that determine the transmembrane disposition of proteins. Curr Opin Cell Biol (1992) 1.06
The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. J Cell Biol (1999) 1.03
Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA. FEBS Lett (1994) 1.03
Identification of an H-2Kd gene using a specific cDNA probe. EMBO J (1982) 1.02
The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins. FEBS Lett (1990) 0.97
The gene encoding the Ia-associated invariant chain is located on chromosome 18 in the mouse. Immunogenetics (1985) 0.97
MHC class II invariant chains in antigen processing and presentation. Trends Biochem Sci (1989) 0.95
A block in degradation of MHC class II-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment. J Cell Sci (1992) 0.94
Structural analysis of Bacillus megaterium KM spore peptidoglycan and its dynamics during germination. Microbiology (1999) 0.93
Prion protein contains a second endoplasmic reticulum targeting signal sequence located at its C terminus. J Biol Chem (2001) 0.91
Phosphorylation of components of the ER translocation site. Eur J Biochem (1999) 0.91
The attachment of polyribosomes to membranes of the hypocotyl of Phaseolus vulgaris. Biochim Biophys Acta (1974) 0.91
Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR. J Immunol (1995) 0.90
Protein transport. On the beaten pathway. Nature (1994) 0.88
Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies. Mol Pharmacol (2001) 0.85
Inhalation of vasoactive intestinal peptide in pulmonary hypertension. Eur Respir J (2008) 0.85
Dynamical spin response in semimagnetic quantum dots. Phys Rev Lett (2001) 0.84
Material and doping transitions in single GaAs-based nanowires probed by Kelvin probe force microscopy. Nanotechnology (2009) 0.83
Structure and function of signal recognition particle (SRP). Mol Biol Rep (1993) 0.82
Structure and biosynthesis of histocompatibility antigens (H-2, HLA). Philos Trans R Soc Lond B Biol Sci (1982) 0.80
Protein insertion into the membrane of the endoplasmic reticulum: the architecture of the translocation site. Cold Spring Harb Symp Quant Biol (1995) 0.80
Dynamic nuclear spin resonance in n-GaAs. Phys Rev Lett (2011) 0.79
Proteins mediating vectorial translocation: purification of the active domain of the endoplasmic reticulum docking protein. Methods Enzymol (1983) 0.78
Antigen processing. Who needs peptide transporters? Nature (1992) 0.78
A lysophospholipase specific for exocrine pancreatic cells is stored in zymogen granules and secreted into pancreatic juice. Eur J Cell Biol (1990) 0.78
Quantum optical studies on individual acceptor bound excitons in a semiconductor. Phys Rev Lett (2002) 0.78
Time course and cellular site of mitotic activity in the exocrine pancreas of the rat during sustained hormone stimulation. Cell Tissue Res (1987) 0.78
Cloning of a signal-recognition-particle subunit of Schistosoma mansoni. Parasitol Res (1995) 0.77
Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific small GTPase. Gene (1995) 0.77
Assembly of membrane proteins. Prog Clin Biol Res (1982) 0.75
Structure and function of signal recognition particle (SRP). Mol Biol Rep (1990) 0.75