Published in J Biol Chem on May 09, 1997
Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer (2009) 5.31
The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol (2013) 2.65
Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene (2003) 2.30
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol (1998) 2.29
Beta-catenin--a linchpin in colorectal carcinogenesis? Am J Pathol (2002) 2.18
Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res (2009) 2.04
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene (2012) 2.03
MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene (2010) 1.99
Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. Br J Cancer (2004) 1.77
MUC1 and MUC2 in pancreatic neoplasia. J Clin Pathol (2004) 1.55
MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol (2004) 1.52
MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway. Cancer Biol Ther (2008) 1.51
Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis (2008) 1.50
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J (2006) 1.42
Functional targeting of the MUC1 oncogene in human cancers. Cancer Biol Ther (2009) 1.39
MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol (2009) 1.33
Mucin-interacting proteins: from function to therapeutics. Trends Biochem Sci (2009) 1.31
MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem (2012) 1.31
MUC1 oncoprotein is a druggable target in human prostate cancer cells. Mol Cancer Ther (2009) 1.30
MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling. Mol Cancer Res (2006) 1.27
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
The catenin family at a glance. J Cell Sci (2010) 1.24
Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol (2011) 1.24
MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1. Clin Exp Metastasis (2005) 1.23
Intracellular MUC1 peptides inhibit cancer progression. Clin Cancer Res (2009) 1.23
Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids. Gut (2002) 1.22
Release of membrane-associated mucins from ocular surface epithelia. Invest Ophthalmol Vis Sci (2008) 1.18
Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy. J Transl Med (2011) 1.17
Desmosomes at a glance. J Cell Sci (2009) 1.14
MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8. Cancer Res (2008) 1.10
MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion. Int J Oncol (2009) 1.07
Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies. Diagn Pathol (2010) 1.06
Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation. J Anat (2009) 1.05
Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro: potential role in metastasis. Clin Exp Metastasis (2002) 1.03
Influence of cystic fibrosis transmembrane conductance regulator on gene expression in response to Pseudomonas aeruginosa infection of human bronchial epithelial cells. Infect Immun (2005) 1.03
Immunobiology of human mucin 1 in a preclinical ovarian tumor model. Oncogene (2012) 1.01
MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells. Int J Oncol (2008) 1.01
Mucin gene expression in human male urogenital tract epithelia. Hum Reprod (2006) 1.01
miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death. Int J Oncol (2010) 0.98
MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells. Prostate (2012) 0.97
MUC genes are differently expressed during onset and maintenance of inflammation in dextran sodium sulfate-treated mice. Dig Dis Sci (2006) 0.97
Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. J Pathol (2012) 0.96
AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. Oncogene (2012) 0.95
Prostate cancer relevant antigens and enzymes for targeted drug delivery. J Control Release (2014) 0.93
MUC1 expression and anti-MUC1 serum immune response in head and neck squamous cell carcinoma (HNSCC): a multivariate analysis. BMC Cancer (2006) 0.93
Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis. Cancer Res (2013) 0.92
MUC1 in carcinoma-host interactions. Glycoconj J (2001) 0.92
Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells. Am J Pathol (2010) 0.92
Androgen-dependent regulation of human MUC1 mucin expression. Neoplasia (2002) 0.91
MUC1-C drives MYC in multiple myeloma. Blood (2016) 0.91
Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth. J Biol Chem (2013) 0.90
MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism. Biochim Biophys Acta (2007) 0.90
Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas. Cancer Res (2016) 0.89
Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells. Br J Cancer (2011) 0.89
Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Cancer Biol Ther (2010) 0.87
Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther (2010) 0.87
Genetic markers of malignant transformation in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. Pancreas (2012) 0.86
MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells. J Biol Chem (2014) 0.84
ECM1 regulates tumor metastasis and CSC-like property through stabilization of β-catenin. Oncogene (2015) 0.84
Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells. Neoplasia (2003) 0.83
Characterisation and internalisation of recombinant humanised HMFG-1 antibodies against MUC1. Br J Cancer (2005) 0.83
Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: an unholy nexus. Carcinogenesis (2016) 0.83
MUC16 mucin (CA125) regulates the formation of multicellular aggregates by altering β-catenin signaling. Am J Cancer Res (2014) 0.82
MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. PLoS One (2012) 0.82
MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin. Oncogenesis (2014) 0.82
The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of β-catenin. PLoS One (2011) 0.81
Detection of circulating anti-mucin 1 (MUC1) antibodies in breast tumor patients by indirect enzyme-linked immunosorbent assay using a recombinant MUC1 protein containing six tandem repeats and expressed in Escherichia coli. Clin Vaccine Immunol (2010) 0.80
Molecular Interactions between MUC1 Epithelial Mucin, β-Catenin, and CagA Proteins. Front Immunol (2012) 0.80
The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice. Breast Cancer (Auckl) (2008) 0.79
MUC1-C activates BMI1 in human cancer cells. Oncogene (2016) 0.78
MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes Cancer (2010) 0.78
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am J Physiol Cell Physiol (2013) 0.77
MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway. Mol Cancer Res (2016) 0.77
Expression signature of epidermolysis bullosa simplex. Hum Genet (2011) 0.77
Effects of Kras activation and Pten deletion alone or in combination on MUC1 biology and epithelial-to-mesenchymal transition in ovarian cancer. Oncogene (2016) 0.77
MUC1 drives c-Met-dependent migration and scattering. Mol Cancer Res (2012) 0.76
MUC1 plays a role in tumor maintenance in aggressive thyroid carcinomas. Surgery (2005) 0.76
Antigenic differences between metastatic cells in bone marrow and primary tumours and the anti-MUC1 humoral immune response induced in breast cancer patients. Clin Exp Metastasis (2004) 0.76
Protein mislocalization: mechanisms, functions and clinical applications in cancer. Biochim Biophys Acta (2014) 0.76
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci (2017) 0.75
C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis. Oncotarget (2016) 0.75
Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3. Biochem J (2004) 0.75
Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer (2017) 0.75
Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells. Oncol Lett (2016) 0.75
Interaction of extravillous trophoblast galectin-1 and mucin(s)-Is there a functional relevance? Cell Adh Migr (2015) 0.75
Helicobacter pylori and Gastric Inflammation: Role of MUC1 Mucin. J Pediatr Biochem (2012) 0.75
An Efficient Method to Identify Conditionally Activated Transcription Factors and their Corresponding Signal Transduction Pathway Segments. Bioinform Biol Insights (2009) 0.75
An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma. Int J Genomics (2015) 0.75
Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol (2016) 0.75
Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer. J Innate Immun (2017) 0.75
MUC1-C is a target in lenalidomide resistant multiple myeloma. Br J Haematol (2017) 0.75
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 5.99
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
A simple method for clinical assay of superoxide dismutase. Clin Chem (1988) 5.66
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60
Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum (2001) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol (1992) 5.19
Spin-torque switching with the giant spin Hall effect of tantalum. Science (2012) 5.18
Extensive variation of human immunodeficiency virus type-1 in vivo. Nature (1988) 5.02
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 4.64
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
Femtosecond electronic response of atoms to ultra-intense X-rays. Nature (2010) 4.46
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol (1998) 4.26
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res (1999) 4.20
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell (2001) 3.97
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79
Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma (1984) 3.74
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
Auxin-induced expression of the soybean GH3 promoter in transgenic tobacco plants. Plant Mol Biol (1991) 3.67
Green fluorescent protein as a noninvasive intracellular pH indicator. Biophys J (1998) 3.61
Significance of premature stop codons in env of simian immunodeficiency virus. J Virol (1989) 3.60
Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol (1990) 3.56
A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature (1995) 3.56
The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol (2005) 3.56
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature (1999) 3.55
Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review. BJOG (2010) 3.54
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52
Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum (1996) 3.40
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J (1999) 3.35
Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS (1999) 3.28
Generating yeast transcriptional activators containing no yeast protein sequences. Nature (1991) 3.21
A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res (1999) 3.19
Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol (2000) 3.07
Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med (1997) 3.07
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell (2001) 2.92
Antiviral RNA interference in mammalian cells. Science (2013) 2.89
Schistosomiasis in the People's Republic of China: prospects and challenges for the 21st century. Clin Microbiol Rev (2001) 2.85
Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci (2001) 2.84
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell (1992) 2.83
Genetic properties of chromosomally integrated 2 mu plasmid DNA in yeast. Cell (1982) 2.78
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med (1999) 2.74
Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol (2001) 2.72
Interaction between ATM protein and c-Abl in response to DNA damage. Nature (1997) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens. Infect Immun (2001) 2.68
Simian immunodeficiency virus from African green monkeys. J Virol (1988) 2.65
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol (1997) 2.64
Hyperammonaemia and Helicobacter pylori. Lancet (1995) 2.59
Cancer trial enrollment after state-mandated reimbursement. J Natl Cancer Inst (2004) 2.56
Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther (2004) 2.55
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet (2001) 2.55
Comparison of simian immunodeficiency virus isolates. Nature (1988) 2.55
RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA). Proc Natl Acad Sci U S A (1972) 2.55
Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides. J Virol (1987) 2.53
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport (2000) 2.49
CTD kinase associated with yeast RNA polymerase II initiation factor b. Cell (1991) 2.48
Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med (1994) 2.48
Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology (2006) 2.48
Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1. Cell (1999) 2.46
Protein-RNA interactions in an icosahedral virus at 3.0 A resolution. Science (1989) 2.45
Viral integration near c-myc in 10-20% of mcf 247-induced AKR lymphomas. Proc Natl Acad Sci U S A (1984) 2.44
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem (2000) 2.44
Virtual Cell modelling and simulation software environment. IET Syst Biol (2008) 2.43
Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell (1997) 2.43
Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med (1996) 2.42
Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease. Am J Hum Genet (1999) 2.42
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A (2001) 2.40
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci (1998) 2.39
The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem (2001) 2.37
The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol (1997) 2.33
Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene (1999) 2.33