Published in J Biol Chem on May 16, 1997
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe (2009) 4.24
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell (2009) 2.54
Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell (1998) 2.39
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol Biol Cell (2005) 2.39
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J (2009) 2.00
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell (2001) 1.99
Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq. J Gen Physiol (2004) 1.82
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell (2004) 1.76
Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell (2010) 1.74
Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol Cell Biol (1998) 1.69
Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J (2000) 1.61
Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol (2008) 1.59
Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis. Clin Cancer Res (2010) 1.46
PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. J Cell Biol (2012) 1.41
Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J (2008) 1.41
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. Mol Biol Cell (2004) 1.39
Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci (2012) 1.29
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. PLoS Pathog (2012) 1.23
Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion. Infect Immun (2010) 1.17
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem (2014) 1.15
Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Mol Biol Cell (2002) 1.08
Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum. Biochem J (2003) 1.06
Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth. Mol Biol Cell (2008) 1.05
Generation of unique poliovirus RNA replication organelles. MBio (2014) 1.02
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J (2004) 1.02
Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta. Traffic (2007) 1.02
Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug target. J Virol (2012) 1.01
GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol Biol Cell (2013) 1.00
Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current. Proc Natl Acad Sci U S A (2014) 0.94
Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase. Mol Cell Biol (1997) 0.93
Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development (2012) 0.93
Differential regulation of two Arabidopsis type III phosphatidylinositol 4-kinase isoforms. A regulatory role for the pleckstrin homology domain. Plant Physiol (2003) 0.91
Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. Mol Cell Biol (2008) 0.91
Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol (2013) 0.90
Phosphatidylinositol 4-kinase III-beta is required for Golgi maintenance and cytokinesis in Trypanosoma brucei. Eukaryot Cell (2007) 0.90
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. Prog Lipid Res (2013) 0.89
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells. Biochem J (2005) 0.88
A wheat PI4K gene whose product possesses threonine autophophorylation activity confers tolerance to drought and salt in Arabidopsis. J Exp Bot (2013) 0.87
Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. J Cell Sci (2010) 0.86
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog (2014) 0.86
Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication. J Virol (2014) 0.83
The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage. Front Neurosci (2015) 0.81
Molecular brightness analysis reveals phosphatidylinositol 4-Kinase IIβ association with clathrin-coated vesicles in living cells. Biophys J (2012) 0.81
c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides. Mol Biol Cell (2011) 0.79
A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane. BMC Cell Biol (2015) 0.75
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
PI3K pathway alterations in cancer: variations on a theme. Oncogene (2008) 9.94
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (1997) 8.81
Phosphoinositide kinases. Annu Rev Biochem (1998) 8.51
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science (1997) 8.16
PI3K: downstream AKTion blocks apoptosis. Cell (1997) 7.73
Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature (1997) 7.20
A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol (2001) 6.50
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell (1989) 6.26
Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol (1994) 6.04
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (1997) 5.40
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem (1977) 5.16
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell (1996) 5.10
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem (1990) 4.75
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem (1999) 4.62
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A (1994) 4.51
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol (1994) 4.49
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell (1995) 4.32
Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (1999) 4.20
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell (1999) 4.02
Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem (1997) 3.86
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci U S A (1984) 3.84
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (1997) 3.73
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem (1978) 3.67
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem (2000) 3.66
The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J (2000) 3.64
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol (2001) 3.63
Rho family GTPases bind to phosphoinositide kinases. J Biol Chem (1995) 3.49
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature (1997) 3.29
Phosphatidylinositol 3-kinase. Bioessays (1994) 3.27
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem (1997) 3.19
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem (1993) 3.14
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem (1994) 3.08
Phosphoinositide kinases. Curr Opin Cell Biol (1996) 3.01
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. Nat Biotechnol (2001) 2.93
Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol (1998) 2.90
In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol (2001) 2.89
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell (1985) 2.69
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol (1991) 2.69
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol (1998) 2.69
Interleukin 3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci U S A (1997) 2.64
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell (1994) 2.64
The erbB3 gene product is a receptor for heregulin. J Biol Chem (1994) 2.63
Phosphoinositide kinases. Biochemistry (1990) 2.56
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell (2001) 2.53
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol (1993) 2.47
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem (2000) 2.42
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J (1996) 2.42
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet (2000) 2.39
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell (1995) 2.34
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans (2003) 2.34
Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem Sci (1995) 2.31
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29
Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side. Nature (1978) 2.27
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science (1993) 2.25
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J (1997) 2.19
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J Biol Chem (1997) 2.16
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem (1989) 2.15
The use of peptide library for the determination of kinase peptide substrates. Methods Mol Biol (1998) 2.12
Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell (1995) 2.11
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J (1997) 2.09
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem (2000) 2.08
Lipid second messengers. Cell (1994) 2.07
Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. Biochemistry (1977) 2.07
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol (2000) 2.00
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol Cell Biol (1993) 1.95
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem (1997) 1.87
Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol (2012) 1.83
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 1.83
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J Biol Chem (1994) 1.82
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene (1993) 1.79
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem (1991) 1.71
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants. Mol Cell Biol (1991) 1.68
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods Enzymol (2000) 1.66
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A (1993) 1.62
Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol Cell Biol (1998) 1.60
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A (1997) 1.57
Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem (1995) 1.57
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem (1995) 1.57
Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell (1998) 1.56
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem (1997) 1.54
Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. J Biol Chem (1989) 1.53
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem (1992) 1.52
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest (2001) 1.51
The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem (1997) 1.47
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem (1994) 1.47
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell (1999) 1.47
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics (1996) 1.47
Signal transduction. Grabbing phosphoproteins. Nature (1999) 1.46
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem (1992) 1.44
SH2 domain specificity and activity modified by a single residue. Nature (1994) 1.44
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem (1998) 1.40
Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem (1997) 1.40
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J Biol Chem (2001) 1.38