Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.

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Published in J Clin Invest on June 01, 1997

Authors

G R Strohmeier1, W I Lencer, T W Patapoff, L F Thompson, S L Carlson, S J Moe, D K Carnes, R J Mrsny, J L Madara

Author Affiliations

1: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. GRStromei@BICS.BWH.Harvard.edu

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Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell (1992) 17.81

Regulated internalization of caveolae. J Cell Biol (1994) 5.77

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J Cell Biol (1994) 5.29

Polarized sorting in epithelia. Cell (1990) 4.72

Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol (1985) 4.21

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway. J Cell Biol (1990) 3.96

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J Biol Chem (1994) 3.67

Caveolae: where incoming and outgoing messengers meet. Proc Natl Acad Sci U S A (1993) 3.53

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. J Clin Invest (1993) 3.02

Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. Mol Biol Cell (1995) 2.74

Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. J Immunol (1992) 2.64

Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers. J Clin Invest (1987) 2.56

Established intestinal cell lines as model systems for electrolyte transport studies. Methods Enzymol (1990) 2.48

Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41

Digging into caveolae. Science (1995) 2.38

Glycophospholipid membrane anchoring provides clues to the mechanism of protein sorting in polarized epithelial cells. Trends Biochem Sci (1990) 2.27

Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae. J Cell Biol (1993) 2.17

Detergent insolubility of alkaline phosphatase during biosynthetic transport and endocytosis. Role of cholesterol. J Biol Chem (1993) 2.14

Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways. EMBO J (1992) 2.09

Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol (1993) 2.05

Biotinylation and assessment of membrane polarity: caveats and methodological concerns. Am J Physiol (1995) 2.02

Plasmalemmal caveolae and GPI-anchored membrane proteins. Curr Opin Cell Biol (1993) 1.88

Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J Cell Biol (1992) 1.87

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Nucleoside and nucleobase transport in animal cells. Biochim Biophys Acta (1988) 1.81

Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest (1992) 1.81

CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol (1996) 1.81

Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73). Tissue Antigens (1990) 1.57

Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol (1992) 1.55

Stabilization of F-actin prevents cAMP-elicited Cl- secretion in T84 cells. J Clin Invest (1991) 1.49

5'-Nucleotidase from smooth muscle of small intestine and from brain. Inhibition of nucleotides. Biochemistry (1975) 1.48

Transcytosis of cholera toxin subunits across model human intestinal epithelia. Proc Natl Acad Sci U S A (1995) 1.46

Studies of 5'-nucleotidase in the perfused rat heart. Including measurements of the enzyme in perfused skeletal muscle and liver. J Biol Chem (1976) 1.42

Differing effects of apical and basolateral adenosine on colonic epithelial cell line T84. Am J Physiol (1989) 1.35

Endocytosis of GPI-linked membrane folate receptor-alpha. J Cell Biol (1996) 1.31

Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier. Am J Pathol (1990) 1.30

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Antibodies to 5'-nucleotidase (CD73), a glycosyl-phosphatidylinositol-anchored protein, cause human peripheral blood T cells to proliferate. J Immunol (1989) 1.26

5'-Nucleotidase from rat heart. Biochemistry (1981) 1.16

Intestinal epithelia (T84) possess basolateral ligands for CD11b/CD18-mediated neutrophil adherence. Am J Physiol (1995) 1.10

Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapses. Nature (1987) 1.05

Isolation of plasma membrane fractions from the intestinal epithelial model T84. Am J Physiol (1993) 0.97

Immunolocalization of ecto-5'-nucleotidase in the kidney by a monoclonal antibody. Histochemistry (1990) 0.95

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Adenosine deaminase deficiency and severe combined immunodeficiency disease. Adv Enzymol Relat Areas Mol Biol (1980) 1.39

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