Published in Proc Natl Acad Sci U S A on June 10, 1997
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A (1999) 3.96
Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A (2001) 2.16
Emerging roles of PGE2 receptors in models of neurological disease. Prostaglandins Other Lipid Mediat (2009) 1.69
Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. Br J Pharmacol (2007) 1.32
Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci U S A (1998) 1.30
Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des (2008) 1.26
Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. J Exp Med (2004) 1.19
Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog Neurobiol (2008) 1.18
A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma. Br J Ophthalmol (2001) 1.17
Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway. Neurobiol Dis (2007) 1.16
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Proc Natl Acad Sci U S A (2006) 1.06
Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem (2011) 1.06
Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression. J Exp Med (2000) 1.04
Inflammation after stroke: mechanisms and therapeutic approaches. Transl Stroke Res (2010) 1.01
The role of glutamate in neuronal ischemic injury: the role of spark in fire. Neurol Sci (2011) 0.97
Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain. Brain Behav Immun (2007) 0.94
Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke. Antioxid Redox Signal (2010) 0.94
Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death. J Neurotrauma (2002) 0.93
Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. J Neuroinflammation (2010) 0.91
Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius. Neuroscience (2007) 0.90
The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism. Inflammopharmacology (2005) 0.87
Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. Brain Res (2009) 0.86
Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm (2006) 0.86
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. Br J Pharmacol (2010) 0.84
Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells. Int J Nanomedicine (2011) 0.82
Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. Epilepsia (2011) 0.81
Effect of acute administration of Pistacia lentiscus L. essential oil on rat cerebral cortex following transient bilateral common carotid artery occlusion. Lipids Health Dis (2012) 0.81
Neural controls of prostaglandin 2 pyrogenic, tachycardic, and anorexic actions are anatomically distributed. Endocrinology (2011) 0.80
Focus on therapy of primary stabbing headache. J Headache Pain (2010) 0.79
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. J Neurosci Res (2013) 0.79
Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells. Biomark Insights (2008) 0.79
Angiotensin-(1-7)-induced plasticity changes in the lateral amygdala are mediated by COX-2 and NO. Learn Mem (2007) 0.78
Immunohistochemical increase in cyclooxygenase-2 without apoptosis in different brain areas of subchronic nicotine- and D-amphetamine-treated rats. J Neural Transm (Vienna) (2008) 0.78
Differential effects of treadmill exercise on cyclooxygenase-2 in the rat hippocampus at early and chronic stages of diabetes. Lab Anim Res (2011) 0.77
Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. J Neurotrauma (2012) 0.76
Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats. Neurochem Res (2012) 0.76
NF-kappaB induces PGE2-synthesizing enzymes in neurons. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.76
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats. Exp Anim (2015) 0.76
A novel combinational approach of microstimulation and bioluminescence imaging to study the mechanisms of action of cerebral electrical stimulation in mice. J Physiol (2015) 0.75
NSAIDs in the Acute Treatment of Migraine: A Review of Clinical and Experimental Data. Pharmaceuticals (Basel) (2010) 0.75
Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response. Sci Rep (2016) 0.75
Serum deprivation and re-addition: effects on cyclooxygenase inhibitor sensitivity in cultured glia. Inflammopharmacology (2005) 0.75
Chronic intracerebroventricular delivery of the secretory phospholipase A2 inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats. Exp Brain Res (2007) 0.75
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (1995) 11.16
Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol (1972) 4.91
Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron (1993) 3.30
Effect of anoxia on ion distribution in the brain. Physiol Rev (1985) 3.28
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol (1995) 3.11
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci U S A (1994) 2.99
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem (1992) 2.97
Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem (1995) 2.60
Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol (1995) 1.94
Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J Biol Chem (1993) 1.65
Inhibition of phospholipase. Br Med Bull (1983) 1.65
NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature (1988) 1.55
Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem (1996) 1.24
Arachidonic acid as a neurotoxic and neurotrophic substance. Prog Neurobiol (1995) 1.22
Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J Neurochem (1996) 1.15
Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. J Biol Chem (1996) 1.14
Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex. Exp Neurol (1984) 1.13
Mediators of injury in neurotrauma: intracellular signal transduction and gene expression. J Neurotrauma (1995) 1.09
Altered gene expression in brain ischemia. Neuroreport (1997) 1.04
The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat. J Cereb Blood Flow Metab (1992) 1.03
Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. J Cereb Blood Flow Metab (1996) 1.02
Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol (1987) 0.99
Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801. J Neurosci (1996) 0.98
Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. Circ Res (1993) 0.97
Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab (1992) 0.95
Spreading depression as a contributor to ischemic brain damage. Adv Neurol (1996) 0.92
Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Stroke (1989) 0.91
Exposure to N-methyl-D-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes. Brain Res (1990) 0.88
LY178002 reduces rat brain damage after transient global forebrain ischemia. Stroke (1991) 0.87
The biochemical basis of cerebral ischemic damage. J Neurosurg Anesthesiol (1995) 0.86
Migraine to the year 2000. Cephalalgia (1995) 0.79
In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet (1995) 6.60
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A (1998) 4.14
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A (1999) 3.96
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci (2001) 3.55
Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons. J Pharm Pharmacol (1973) 3.54
Peptidergic neurones. Nature (1980) 3.36
Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand (1982) 3.25
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci U S A (2000) 3.04
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A (1998) 2.91
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res (1975) 2.72
Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine. Eur J Pharmacol (1969) 2.61
Immunohistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat. Neuroscience (1976) 2.56
Substance p: localization in the central nervous system and in some primary sensory neurons. Science (1975) 2.33
Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine. Eur J Pharmacol (1969) 2.26
Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry (1992) 2.15
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci U S A (1977) 2.11
Evidence for dopamine receptor stimulation by apomorphine. J Pharm Pharmacol (1967) 2.08
Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res (1984) 2.05
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla. Neuroscience (1978) 2.01
Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci U S A (1980) 2.00
Distribution of substance P-like immunoreactivity in the central nervous system of the rat--I. Cell bodies and nerve terminals. Neuroscience (1978) 1.99
Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol (1985) 1.97
Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci U S A (1982) 1.95
Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat. Neuroscience (1976) 1.92
High nitric oxide production in human paranasal sinuses. Nat Med (1995) 1.90
Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol (1998) 1.87
A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections. J Neurosci Methods (1999) 1.84
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. Int J Cancer (1997) 1.82
Climate change and the integrity of science. Science (2010) 1.80
Flare and itch induced by substance P in human skin. J Invest Dermatol (1978) 1.72
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett (1983) 1.68
Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience (1978) 1.67
A galanin-like peptide in the central nervous system and intestine of the rat. Neurosci Lett (1984) 1.63
On the occurrence of substance P-containing fibers in sympathetic ganglia: immunohistochemical evidence. Brain Res (1977) 1.55
Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience (2007) 1.51
Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man. Peptides (1984) 1.51
Supravaginal uterine amputation vs. hysterectomy. Effects on libido and orgasm. Acta Obstet Gynecol Scand (1983) 1.50
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes. Neurosci Lett (1986) 1.49
In vitro studies on central and peripheral monoamine neurons at the ultrastructural level. Z Zellforsch Mikrosk Anat (1968) 1.48
Distribution of galaninlike immunoreactivity in the rat central nervous system. J Comp Neurol (1986) 1.46
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat Biotechnol (1998) 1.44
Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J Neurosci (1986) 1.43
Peptide neurons in the vagus, splanchnic and sciatic nerves. Acta Physiol Scand (1978) 1.42
Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques. Proc Natl Acad Sci U S A (2001) 1.41
Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides (1987) 1.41
Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience (1984) 1.41
Localisation of lysozyme mRNA in rheumatoid synovial membrane by in situ hybridisation. Ann Rheum Dis (1989) 1.40
Immunohistochemical evidence for the localization of somatostatin--like immunoreactivity in a cell population of the pancreatic islets. Med Biol (1974) 1.40
Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci (1998) 1.40
Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia. Science (1974) 1.38
Effect of apomorphine on the GABA turnover in the DA cell group rich area of the mesencephalon. Evidence for the involvement of an inhibitory gabergic feedback control of the ascending DA neurons. Neurosci Lett (1975) 1.38
Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. Proc Natl Acad Sci U S A (1987) 1.37
Proximal tubule Na+-K+-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am J Physiol (1988) 1.36
A quantitative study on the nigro-neostriatal dopamine neuron system in the rat. Acta Physiol Scand (1967) 1.35
Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig. Regul Pept (1985) 1.35
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem (2001) 1.35
Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1-cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol Suppl (Copenh) (1975) 1.34
Evidence for a central noradrenaline receptor stimulation by clonidine. Life Sci (1970) 1.33
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res (1995) 1.32
Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol (1993) 1.32
Histochemical amd biochemical effects of diethyldithiocarbamate on tissue catecholamines. J Pharm Pharmacol (1966) 1.29
Maternal antibodies in human foetal sera at different stages of gestation. Immunology (1968) 1.29
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc Natl Acad Sci U S A (2001) 1.29
Chemical anatomy of the brain. Science (1984) 1.28
Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. J Neurosci (1994) 1.27
Characterization and tissue localization of catecholamine synthesizing enzymes. Pharmacol Rev (1972) 1.27
Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res (1987) 1.27
Effects of prolactin and ergot alkaloids on the tubero-infundibular dopamine (DA) neurons. Neuroendocrinology (1972) 1.27
Distribution of thyrotropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistry. Eur J Pharmacol (1975) 1.27
Enkephalin immunoreactive nerve fibres and cell bodies in sympathetic ganglia of the guinea-pig and rat. Neuroscience (1979) 1.26
Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma. Proc Natl Acad Sci U S A (1979) 1.26
Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin. Neuroscience (1989) 1.26
Enkephalin-like immunoreactivity in nerve terminals in sympathetic ganglia and adrenal medulla and in adrenal medullary gland cells. Acta Physiol Scand (1978) 1.26
Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary. Proc Natl Acad Sci U S A (1985) 1.24
Galanin-like immunoreactivity in cholinergic neurons of the septum-basal forebrain complex projecting to the hippocampus of the rat. Brain Res (1985) 1.24
Evidence for coexistence of dopamine and CCK in meso-limbic neurones. Nature (1980) 1.24
Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci (1995) 1.23
Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: evidence from combined immunohistochemistry and acetylcholinesterase staining. Neuroscience (1979) 1.23
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. J Neurochem (2007) 1.23
The effect of some psychoactive drugs on central monoamine neurons. Eur J Pharmacol (1967) 1.23
Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: an in situ hybridization study. Neuroscience (1993) 1.22
Cell-mediated lympholysis by fetal and neonatal lymphocytes in sheep and man. Cell Immunol (1980) 1.22
The effect of immobilization stress on the activity of central monoamine neurons. Life Sci (1968) 1.22
Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species. Cell Tissue Res (1985) 1.22
Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study. Exp Brain Res (1979) 1.22
NADPH-diaphorase: a selective histochemical marker for striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivities. J Comp Neurol (1983) 1.20
Ergocornine and 2-Br-alpha-ergocryptine. Evidence for prolonged dopamine receptor stimulation. Med Biol (1974) 1.20
Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems. Proc Natl Acad Sci U S A (1993) 1.19
Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress. Proc Natl Acad Sci U S A (1989) 1.19
Calcitonin gene-related peptide is a potent inhibitor of substance P degradation. Eur J Pharmacol (1985) 1.19
Immunohistochemical evidence for a local VIP-ergic neuron system in the adrenal gland of the rat. Acta Physiol Scand (1981) 1.19
Substance P-, VIP-, and enkephalin-like immunoreactivity in the human vagus nerve. Gastroenterology (1979) 1.19
Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience (2002) 1.18
Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience (1995) 1.18
VIP-, enkephalin-, substance P- and somatostatin-like immunoreactivity in neurons intrinsic to the intestine: immunohistochemical evidence from organotypic tissue cultures. Brain Res (1978) 1.18
A possible role played by central monoamine neurones in thermo-regulation. Acta Physiol Scand (1968) 1.17