Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.

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Published in Mol Cell Biol on February 01, 1995

Authors

R I Scheinman1, A Gualberto, C M Jewell, J A Cidlowski, A S Baldwin

Author Affiliations

1: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599.

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T-cell growth factor. Immunol Rev (1980) 8.11

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A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb. EMBO J (1989) 1.78

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters. J Virol (1997) 1.78

The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem (1999) 1.76

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1. J Biol Chem (1993) 1.74

Application of a protein-blotting procedure to the study of human glucocorticoid receptor interactions with DNA. Proc Natl Acad Sci U S A (1987) 1.73

Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys (2001) 1.67

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem (2001) 1.63

Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem (1995) 1.59

Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa B/Rel family proteins. J Virol (1995) 1.57

Structure, evolution, and regulation of a fast skeletal muscle troponin I gene. Proc Natl Acad Sci U S A (1985) 1.56

Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc Natl Acad Sci U S A (1996) 1.56

The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition. Mol Cell Biol (2001) 1.55

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B. J Biol Chem (1991) 1.55

The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B. Mol Cell Biol (1994) 1.54

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J (1999) 1.52

Regulation of MHC gene expression. Curr Opin Immunol (1993) 1.52

Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J Biol Chem (1997) 1.50

Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis. J Biol Chem (1999) 1.49

Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene (2009) 1.48

Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Mol Cell Biol (1997) 1.46

Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol (2000) 1.45

Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem (2001) 1.44

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am J Physiol (1996) 1.42

Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways. J Biol Chem (1999) 1.41

Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death. J Biol Chem (2001) 1.40

Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle. Mol Cell Biol (1993) 1.38

Apoptotic volume decrease and the incredible shrinking cell. Cell Death Differ (2002) 1.35

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential "lysis gene" product. J Biol Chem (1987) 1.34

Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation. Cancer Res (2000) 1.32

Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. J Biol Chem (1997) 1.31

Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL. J Immunol (1993) 1.31

Ras regulation of NF-kappa B and apoptosis. Methods Enzymol (2001) 1.30

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. Am J Physiol (1997) 1.28

Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. Endocrinology (1986) 1.28

Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase. J Immunol (2001) 1.26

Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis. J Biol Chem (2000) 1.24

Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor. Endocrinology (1997) 1.23

p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat. J Biol Chem (1995) 1.20