Published in Cell on May 30, 1997
The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol Cell Biol (2000) 3.44
Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on MSL-1 for chromosome association. Genetics (1997) 2.35
Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell (2009) 2.32
The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complex. EMBO J (2002) 2.31
Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nat Rev Genet (2012) 2.29
A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA. Mol Cell Biol (2000) 2.08
Quantitative analysis of gene function in the Drosophila embryo. Genetics (2000) 1.71
X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males. PLoS Biol (2004) 1.59
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Mol Cell Biol (2002) 1.55
RNA binding protein sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation. Microbiol Mol Biol Rev (2003) 1.53
The MSL complex levels are critical for its correct targeting to the chromosomes in Drosophila melanogaster. Chromosoma (2003) 1.53
Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2. Mol Cell Biol (1998) 1.53
Sex determination in Drosophila: The view from the top. Fly (Austin) (2010) 1.51
Sequence-specific targeting of MSL complex regulates transcription of the roX RNA genes. EMBO J (2004) 1.44
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA. RNA (1998) 1.37
Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro. RNA (1999) 1.34
The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA. Genes Dev (2001) 1.33
Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila. Genetics (1999) 1.23
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev (2006) 1.22
Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal. Proc Natl Acad Sci U S A (1999) 1.19
Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal. RNA (2000) 1.18
Somatic sex-specific transcriptome differences in Drosophila revealed by whole transcriptome sequencing. BMC Genomics (2011) 1.17
Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65) recognize polypyrimidine tracts using multiple modes of binding. RNA (2003) 1.17
The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein. Mol Cell Biol (2000) 1.16
Modulation of MSL1 abundance in female Drosophila contributes to the sex specificity of dosage compensation. Genetics (1998) 1.11
Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation. Genes Dev (2006) 1.06
The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. RNA (2004) 1.06
The right dose for every sex. Chromosoma (2006) 1.05
Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. Mol Cell Biol (1999) 1.05
Evidence for 3' untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAV. Genetics (1998) 1.04
Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Mol Cell Biol (1999) 1.03
A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA. EMBO J (2003) 1.02
Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation. Mol Cell Biol (2001) 1.02
Dosage compensation in Drosophila. Cold Spring Harb Perspect Biol (2015) 1.01
Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids. Genetics (2006) 1.01
Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila. Genetics (2000) 1.00
Activities of the Sex-lethal protein in RNA binding and protein:protein interactions. Nucleic Acids Res (1998) 0.99
Sex determination in beetles: production of all male progeny by parental RNAi knockdown of transformer. Sci Rep (2012) 0.98
From cis-regulatory elements to complex RNPs and back. Cold Spring Harb Perspect Biol (2012) 0.98
An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal. Mol Cell Biol (1999) 0.98
DNA copy number evolution in Drosophila cell lines. Genome Biol (2014) 0.97
Modulation of msl-2 5' splice site recognition by Sex-lethal. RNA (2001) 0.96
The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE. Genetics (2004) 0.96
The MLE subunit of the Drosophila MSL complex uses its ATPase activity for dosage compensation and its helicase activity for targeting. Mol Cell Biol (2007) 0.95
The gene Sex-lethal of the Sciaridae family (order Diptera, suborder Nematocera) and its phylogeny in dipteran insects. Genetics (2004) 0.93
Down regulation of extramacrochaetae mRNA by a Drosophila neural RNA binding protein Rbp9 which is homologous to human Hu proteins. Nucleic Acids Res (1998) 0.90
Functional domains of Drosophila UNR in translational control. RNA (2008) 0.89
Requirement of male-specific dosage compensation in Drosophila females--implications of early X chromosome gene expression. PLoS Genet (2010) 0.89
A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity. Genetics (2014) 0.89
Drosophila dosage compensation: males are from Mars, females are from Venus. Fly (Austin) (2011) 0.87
The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet (2011) 0.87
Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster. G3 (Bethesda) (2013) 0.86
Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of Drosophila melanogaster. Cytogenet Genome Res (2009) 0.86
Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Genetics (2004) 0.85
msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster. Nucleic Acids Res (2011) 0.84
Autoregulation of the Drosophila Noncoding roX1 RNA Gene. PLoS Genet (2012) 0.84
Studies on the short range spreading of the male specific lethal (MSL) complex on the X chromosome in Drosophila. Cytogenet Genome Res (2009) 0.82
Mechanisms of x chromosome dosage compensation. J Genomics (2015) 0.82
Specific binding of Drosophila nuclear protein PEP (protein on ecdysone puffs) to hsp70 DNA and RNA. Nucleic Acids Res (1998) 0.82
Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Genetics (2001) 0.80
Solution structure of MSL2 CXC domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases. PLoS One (2012) 0.79
The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes. BMC Mol Biol (2007) 0.79
Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila. BMC Mol Biol (2010) 0.79
Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW. Genes Dev (2013) 0.79
Dosage Compensation in the African Malaria Mosquito Anopheles gambiae. Genome Biol Evol (2016) 0.78
Role of the ATPase/helicase maleless (MLE) in the assembly, targeting, spreading and function of the male-specific lethal (MSL) complex of Drosophila. Epigenetics Chromatin (2011) 0.78
Balancing sex chromosome expression and satisfying the sexes. Fly (Austin) (2012) 0.77
The wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster. BMC Syst Biol (2015) 0.77
Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. PLoS One (2015) 0.77
Biochemical and functional analysis of Drosophila-sciara chimeric sex-lethal proteins. PLoS One (2013) 0.76
Specific RNP capture with antisense LNA/DNA mixmers. RNA (2017) 0.76
Drosophila enhancer-Gal4 lines show ectopic expression during development. R Soc Open Sci (2017) 0.75
X-marks the spot: X-chromosome identification during dosage compensation. Biochim Biophys Acta (2014) 0.75
Computational characterization of Iron metabolism in the Tsetse disease vector, Glossina morsitans: IRE stem-loops. BMC Genomics (2016) 0.75
Intron retention as a component of regulated gene expression programs. Hum Genet (2017) 0.75
Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics (1972) 22.68
The genetic control of meiosis. Annu Rev Genet (1976) 10.21
Genetic analysis of sex chromosomal meiotic mutants in Drosophilia melanogaster. Genetics (1972) 7.86
Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics (1980) 4.81
Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell (1989) 4.15
Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes Dev (1989) 3.50
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem (1999) 3.35
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell (1996) 3.30
Sex determination and dosage compensation in Drosophila melanogaster. Annu Rev Genet (1983) 3.01
The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell (1991) 2.98
Epidermal T lymphocytes and HLA-DR expression in psoriasis. Br J Dermatol (1984) 2.93
The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell (1988) 2.83
T-cell subpopulations in the blood and skin of patients with psoriasis. Br J Dermatol (1984) 2.54
Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. Genes Dev (1990) 2.49
The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila. Mol Cell (1999) 2.40
The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins. Cell (1989) 2.39
Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster. Proc Natl Acad Sci U S A (1976) 2.39
The evolutionary dynamics of sex determination. Science (1998) 2.35
Paternal loss (pal): a meiotic mutant in Drosophila melanogaster causing loss of paternal chromosomes. Genetics (1975) 2.28
The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J (1995) 2.25
Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation. Genes Dev (1991) 2.21
Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Development (1995) 2.16
The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development (1995) 2.13
Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens? Immunol Today (1995) 2.09
The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. EMBO J (1991) 2.02
The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Genes Dev (1992) 1.90
The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Dev Cell (2001) 1.79
Clearance of psoriasis with low dose cyclosporin. Br Med J (Clin Res Ed) (1986) 1.75
Autoregulation and multifunctionality among trans-acting factors that regulate alternative pre-mRNA processing. J Biol Chem (1992) 1.71
Cloning and characterization of the scarlet gene of Drosophila melanogaster. Genetics (1989) 1.68
The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes. Nature (1996) 1.68
Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach. Mol Cell Biol (1993) 1.64
Behavioral and neurobiological implications of sex-determining factors in Drosophila. Dev Genet (1994) 1.63
The evolution of dosage-compensation mechanisms. Bioessays (2000) 1.62
Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila. Genes Dev (1991) 1.60
Psoriasis and streptococci: the natural selection of psoriasis revisited. Br J Dermatol (2009) 1.58
The maternal and zygotic control of development by cinnamon, a new mutant in Drosophila melanogaster. Dev Biol (1973) 1.57
A molecular analysis of transformer, a gene in Drosophila melanogaster that controls female sexual differentiation. Cell (1987) 1.54
Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2. Mol Cell Biol (1998) 1.53
The effects of cyclosporin A on T lymphocyte and dendritic cell sub-populations in psoriasis. Br J Dermatol (1987) 1.53
Sex-specific regulation of yolk protein gene expression in Drosophila. Cell (1985) 1.52
Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster. Basic Life Sci (1980) 1.50
The lethal(1)TW-6cs mutation of Drosophila melanogaster is a dominant antimorphic allele of nod and is associated with a single base change in the putative ATP-binding domain. Genetics (1991) 1.48
Long-term cyclosporin for psoriasis. Br J Dermatol (1989) 1.42
The Drosophila gene rbp9 encodes a protein that is a member of a conserved group of putative RNA binding proteins that are nervous system-specific in both flies and humans. J Neurosci (1993) 1.41
Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics (2001) 1.39
Cyclosporin toxicity. Lancet (1990) 1.38
Relationships among chromatid interchanges, sister chromatid exchanges, and meiotic recombination in Drosophila melanogaster. Proc Natl Acad Sci U S A (1980) 1.32
Sex determination in Drosophila melanogaster: analysis of transformer-2, a sex-transforming locus. Proc Natl Acad Sci U S A (1982) 1.30
Control of sexual differentiation in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1985) 1.29
The mutability of the minute loci of Drosophila melanogaster with ethyl methanesulfonate. Mutat Res (1976) 1.29
napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. Cell (1991) 1.29
Epidermal T lymphocytes and dendritic cells in chronic plaque psoriasis: the effects of PUVA treatment. Clin Exp Immunol (1985) 1.29
Sequences expressed sex-specifically in Drosophila melanogaster adults. Dev Biol (1987) 1.28
Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell (1993) 1.27
Mutations in genes encoding essential mitotic functions in Drosophila melanogaster. Genetics (1985) 1.26
Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes Dev (1990) 1.25
Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm. Development (1996) 1.23
Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster. Proc Natl Acad Sci U S A (1987) 1.22
Developmental and regional expression of thyroid hormone receptor genes during Xenopus metamorphosis. Development (1991) 1.19
The dual functions of a sex determination gene in Drosophila melanogaster. Dev Biol (1983) 1.18
Sex-lethal, master and slave: a hierarchy of germ-line sex determination in Drosophila. Development (1993) 1.17
Dosage compensation and chromatin structure in Drosophila. Curr Opin Genet Dev (1996) 1.17
The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sex-specifically in the genital imaginal disc. Development (2001) 1.15
Region-specific effects on chromosome integrity of mutations at essential loci in Drosophila melanogaster. Proc Natl Acad Sci U S A (1982) 1.15
Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster. Genetics (2000) 1.15
A gene controlling condensation of heterochromatin in Drosophila melanogaster. Science (1983) 1.15
The effects of mutagen-sensitive mutants of Drosophila melanogaster in nonmutagenized cells. Genetics (1979) 1.15
Origin and evolution of the regulatory gene male-specific lethal-3. Mol Biol Evol (2000) 1.08
A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics (1996) 1.07
Renal function and biopsy findings after 5 years' treatment with low-dose cyclosporin for psoriasis. Br J Dermatol (1993) 1.06
How flies make one equal two: dosage compensation in Drosophila. Trends Genet (1994) 1.05
Autoinduction of nuclear receptor genes and its significance. J Steroid Biochem Mol Biol (1993) 1.04
Dosage compensation rox! Curr Opin Cell Biol (2000) 1.04
Restricted T-cell receptor V beta gene usage in the skin of patients with guttate and chronic plaque psoriasis. Br J Dermatol (1993) 1.04
A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females. Genetics (1995) 1.03
The effects of topical treatment with steroids or dithranol on epidermal T lymphocytes and dendritic cells in psoriasis. Scand J Immunol (1985) 1.01
Compartmental organization of the Drosophila genital imaginal discs. Development (1997) 1.00
Cytogenetic analysis of chromosome region 73AD of Drosophila melanogaster. Genetics (1990) 1.00
Specificity of immunoglobulin E in coccidioidomycosis and correlation with disease involvement. Infect Immun (1982) 0.96
Epidermal rupture is the initiating factor for the Koebner response in psoriasis. Acta Derm Venereol (1990) 0.96
On the Control of the Distribution of Meiotic Exchange in DROSOPHILA MELANOGASTER. Genetics (1982) 0.93
hermaphrodite and doublesex function both dependently and independently to control various aspects of sexual differentiation in Drosophila. Development (1998) 0.92
Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo. Proc Natl Acad Sci U S A (1996) 0.92
Four years of experience with cyclosporin A for psoriasis. Br J Dermatol (1990) 0.90
Evolutionary conservation of regulatory strategies for the sex determination factor transformer-2. Mol Cell Biol (1997) 0.90
The role of cytokines in the generation of skin lesions in dermatitis herpetiformis. Br J Dermatol (1993) 0.90
Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues. Dev Biol (1991) 0.89
In vivo analysis of the functional domains of the Drosophila splicing regulator RBP1. Proc Natl Acad Sci U S A (1997) 0.89
Tissue transglutaminase antibodies in dermatitis herpetiformis. Gastroenterology (1999) 0.88
A comparison of the stimulatory effects of cytokines on normal and psoriatic keratinocytes in vitro. Arch Dermatol Res (1995) 0.88
Is chronic plaque psoriasis triggered by microbiota in the skin? Br J Dermatol (2013) 0.87
Molecular genetic aspects of sex determination in Drosophila. Bioessays (1987) 0.86
Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Genetics (2004) 0.85
Vitellogenin as a multigene family. Not all Xenopus vitellogenin genes may be in an "expressible" configuration. J Biol Chem (1980) 0.84
Skin CD4+ T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic plaque psoriasis. J Invest Dermatol (2000) 0.83
Psoriasis and extra domain A fibronectin loops. Br J Dermatol (2010) 0.83
Developmental and hormonal regulation of the Xenopus liver-type arginase gene. Eur J Biochem (1993) 0.83
Effect of an integrated support programme on the concerns and wellbeing of women with breast cancer: a national service evaluation. Complement Ther Clin Pract (2011) 0.82
The effects of recombination-defective meiotic mutants in Drosophila melanogaster on gonial recombination in males. Mutat Res (1979) 0.82